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1. 发明授权

US11536707B2 Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest 有权
公开(公告)号：US11536707B2
公开(公告)日：2022-12-27
申请号：US15503823
申请日：2015-09-23
申请人： Tearlab Research, Inc.
发明人： Benjamin Sullivan , Steve Zmina , Melissa Lee , Brandon Westerberg , Matthew Daniel Solomon , Christian Potzner , Sebastiaan Garst , Matthew Springer , Jason Hayes , Peter Munster , Erol Craig Harvey , Michael Wilkinson , Joanna Slowinska , Derek Lee , Peter Van Ruijven
IPC分类号： G01N33/543 , G01N33/487 , G01N13/04 , B01L3/00 , B81B1/00 , G01N35/10 , G01N35/00
摘要： Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

2. 发明申请

US20210231548A1 TIME-DOMAIN REFLECTOMETRY MATRIX SUCTION SENSOR 有权
公开(公告)号：US20210231548A1
公开(公告)日：2021-07-29
申请号：US16776342
申请日：2020-01-29
申请人： Whitney Skaling
发明人： Whitney Skaling
IPC分类号： G01N13/04
摘要： A TDR matrix suction sensor measures the matrix suction exhibited by a porous medium surrounding the sensor. The sensor is constructed from a TDR matrix suction sensor probe, which includes two or more elongated conductors and a jacket that encases the conductors. The jacket is made of a hydrophilic, non-conductive, porous (HN-CP) material. In operation, a pulse delay time is computed for an electrical pulse injected into the proximal end of the conductors and reflected when reaching their distal ends. The pulse delay time and a delay-to-matrix suction profile of the HN-CP jacket material are used to compute the matrix suction exhibited by the probe jackets. An indicator of the current value of the matrix suction exhibited by the porous medium is then established based on the matrix suction computed for the HN-CP jackets.

3. 发明申请

US20110120214A1 TRANSDERMAL DIFFUSION CELL TESTING VESSEL AND METHODS USING SAME 审中-公开
标题翻译：超声扩散电池测试容器及使用方法
公开(公告)号：US20110120214A1
公开(公告)日：2011-05-26
申请号：US12623763
申请日：2009-11-23
申请人： Luke Lee , Yu Sheng Zhang , Jose Castro
发明人： Luke Lee , Yu Sheng Zhang , Jose Castro
IPC分类号： G01N13/04
CPC分类号： G01N13/04
摘要： Vessel for transdermal diffusion cell testing includes a container defining an interior chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is arranged above the inlet port of the chamber, proximate the opening of the chamber, and is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. Tilting of the vessel prior to or during introduction of solution prevents air bubbles from remaining between the skin and the solution.
摘要翻译：用于透皮扩散细胞测试的容器包括限定内部腔室的容器，所述内部腔室具有放置皮肤的开口，以及部分地围绕容器的一部分设置并且与所述容器的一部分间隔开以在其间限定隔室的壳体。该室保留盐水溶液并且不与水循环通过的隔室流动连通。该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。腔室的出口设置在腔室的入口附近，靠近腔室的开口，并且相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。在引入溶液之前或期间，容器的倾斜防止气泡残留在皮肤和溶液之间。

4. 发明授权

US07886582B2 Device for measuring load loss in reverse osmosis membrane containers 有权
标题翻译：用于测量反渗透膜容器的负荷损失的装置
公开(公告)号：US07886582B2
公开(公告)日：2011-02-15
申请号：US12106442
申请日：2008-04-21
申请人： Enric Palacios Doñaque
发明人： Enric Palacios Doñaque
IPC分类号： G01N13/04 , G01N15/08
CPC分类号： B01D61/022 , B01D61/025 , B01D61/08 , B01D61/10 , B01D61/12 , B01D2311/14 , B01D2319/022
摘要： An interconnector coupled to a permeate water collection tube, establishing first and second groups of membranes, has open and closed ends, and orifices arranged circumferentially and located at a peripheral area in an intermediate section of the interconnector. The orifices establish a connection with an axial chamber provided in the interconnector and oriented towards the open end. The open end has a coupling nut connected to a pressure tube extending along the inside of the water collection tube section located between the interconnector and a feed inlet end. The pressure tube extends outside the pressure container through a closing cap of the end of the pressure container and ends in a T-shaped connection including a sensor for measuring the pressure of the non-treated reject water corresponding to the first group of membranes located between the feed inlet end and an assembly point of the interconnector.
摘要翻译：连接到渗透水收集管的互连器，其建立第一和第二组膜，其具有开口和封闭端部，并且周向布置并位于互连器的中间部分中的周边区域。所述孔与设置在所述互连器中并且朝向所述开口端定向的轴向室建立连接。开口端具有连接螺母，其连接到沿着位于互连器和进料入口端之间的集水管部分的内部延伸的压力管。压力管通过压力容器的端部的封闭盖延伸到压力容器的外部，并且以T形连接结束，T形连接包括用于测量对应于第一组膜的未经处理的废水的压力的传感器，进料入口端和互连器的组装点。

5. 发明授权

US07793535B2 Devices and methods to simulate an ocular environment 有权
标题翻译：用于模拟眼睛环境的设备和方法
公开(公告)号：US07793535B2
公开(公告)日：2010-09-14
申请号：US11923680
申请日：2007-10-25
申请人： Dharmesh K. Dubey , Lauren May
发明人： Dharmesh K. Dubey , Lauren May
IPC分类号： G01N15/08 , G01N13/04
CPC分类号： G01N13/00 , A61K9/0051 , G01N33/442 , G01N2013/006
摘要： Methods and devices used to simulate the use of an ophthalmic lens contained in an ocular environment are disclosed herein.
摘要翻译：本文公开了用于模拟包含在眼睛环境中的眼用透镜的使用的方法和装置。

6. 发明申请

US20100071446A1 SOLUTE CONCENTRATION MEASUREMENT DEVICE AND RELATED METHODS 有权
标题翻译：溶解浓度测量装置及相关方法
公开(公告)号：US20100071446A1
公开(公告)日：2010-03-25
申请号：US12563046
申请日：2009-09-18
申请人： David Brown
发明人： David Brown
IPC分类号： G01N13/04 , G01N1/10
CPC分类号： G01N13/04 , G01N1/4055 , G01N2001/4061
摘要： A solute concentration measurement device is disclosed. The device may comprise a filter membrane, an exchange chamber, a sensing chamber, a separator, and a sensor. The device may be configured to be placed in fluid communication with a sample solution containing a solute and a solvent. The filter membrane may provide selective fluid communication between the solution and the exchange chamber. The separator may separate the exchange chamber from the sensing chamber and cause a change in a condition of the sensing chamber corresponding to a change of a condition of the exchange chamber. The sensor may sense the condition pertaining to the sensing chamber and calculate the concentration of the sample solution corresponding to this change.
摘要翻译：公开了一种溶质浓度测定装置。该装置可以包括过滤膜，交换室，感测室，分离器和传感器。该装置可以被配置为与含有溶质和溶剂的样品溶液流体连通。过滤膜可以在溶液和交换室之间提供选择性的流体连通。分离器可以将交换室与感测室分开，并且使得感应室的状态改变对应于交换室的状态的改变。传感器可以感测与感测室相关的状态，并计算与该变化相对应的样品溶液的浓度。

7. 发明申请

US20080289403A1 DEVICE FOR MEASURING LOAD LOSS IN REVERSE OSMOSIS MEMBRANE CONTAINERS 有权
标题翻译：用于测量反渗透膜容器中的负荷损失的装置
公开(公告)号：US20080289403A1
公开(公告)日：2008-11-27
申请号：US12106442
申请日：2008-04-21
申请人： Enric PALACIOS DONAQUE
发明人： Enric PALACIOS DONAQUE
IPC分类号： G01N13/04
CPC分类号： B01D61/022 , B01D61/025 , B01D61/08 , B01D61/10 , B01D61/12 , B01D2311/14 , B01D2319/022
摘要： The device is applicable to systems that comprise a pressure containing tube (1), inside which there are two membrane groups (2) and (2′) that are correlatively interconnected by means of a permeate water collection tube (3). The pressure containing tube (1) includes an inlet end (5) that feeds the water to be treated into the system and an outlet end (6) to discharge the reject water and the permeate water.The device comprises an interconnector (7) placed in between the two membrane groups (2) and (2′), on which a pressure tube (13) is coupled concentrically to the permeate water tube (3). At the discharge end of pressure tube (13) there is a pressure gauge sensor (16) that measures the pressure of the reject water at the point of assembly of the interconnector (7). The device also includes pressure meters (18) and flow meters (19) that in combination with the pressure meter (21) located at the inlet point and a pressure meter (22) located at the outlet point, allows for the calculation of the osmotic pressure of the water coming out of the last membrane of the group of membranes (2), and also to calculate the load losses experienced by both membrane groups (2) and (2′), and even to calculate the total load loss and the net feed pressure for the entire membrane system.
摘要翻译：该装置适用于包含压力管（1）的系统，其中有两个通过渗透水收集管（3）相互连接的膜组（2）和（2'）。压力容纳管（1）包括将待处理的水进料到系统中的入口端（5）和排出废水和渗透水的出口端（6）。该装置包括放置在两个膜组（2）和（2'）之间的互连器（7），压力管（13）同心地连接到渗透水管（3）上。在压力管（13）的排放端，有一个压力传感器（16），用于测量互连器（7）组装点处的废水压力。该装置还包括与位于入口点处的压力计（21）和位于出口点处的压力计（22）组合的压力计（18）和流量计（19），允许计算渗透压从膜组（2）的最后一个膜出来的水的压力，并计算两个膜组（2）和（2'）所经历的负荷损失，甚至计算总负荷损失和整个膜系统的净进料压力。

8. 发明授权

US07449307B2 Raised surface assay plate 失效
标题翻译：升高的表面测定板
公开(公告)号：US07449307B2
公开(公告)日：2008-11-11
申请号：US10694639
申请日：2003-10-27
申请人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasti , J. Richard Gyory , Anthony V. Lemmo , Julie Monagle
发明人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasti , J. Richard Gyory , Anthony V. Lemmo , Julie Monagle
IPC分类号： A61K9/70 , G01N13/04 , G01N1/28 , C12Q1/24
CPC分类号： B01L3/5085 , B01L3/5025 , B01L3/5088 , B01L2300/0609 , B01L2300/0819 , B01L2300/0829
摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.
摘要翻译：测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。还提供了使用上述测定板的方法。一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。随后使用凸起垫上的样品进行实验。

9. 发明申请

US20080053206A1 METHOD AND APPARATUS FOR POINT OF CARE OSMOLARITY TESTING 审中-公开
标题翻译：方法和装置用于治疗心理测试
公开(公告)号：US20080053206A1
公开(公告)日：2008-03-06
申请号：US11930270
申请日：2007-10-31
申请人： Govindarajan Natarajan , James Humenik , Scott Partington , Srinivasa Reddy
发明人： Govindarajan Natarajan , James Humenik , Scott Partington , Srinivasa Reddy
IPC分类号： G01N13/04 , G01N27/00 , G01N27/26
CPC分类号： G01N13/04 , Y10T436/11
摘要： An apparatus and a method are disclosed for providing point of care testing for osmolarity of a bodily fluid. An apparatus is disclosed as having a fluid pathway passing through it for receiving and testing a sample fluid. The invention permits osmolarity testing of a sample fluid wherein the sample fluid has a volume of less than approximately 30 nL, and implements a method and device to measure fluid osmolarity in a clinical setting quickly and accurately, while also reducing evaporation of the fluid.
摘要翻译：公开了一种用于提供用于体液的渗透压的护理测试点的装置和方法。公开了一种具有通过它的流体路径用于接收和测试样品流体的装置。本发明允许样品流体的渗透压测试，其中样品流体具有小于约30nL的体积，并且实现了在临床设置中快速且准确地测量流体渗透压的方法和装置，同时还减少了流体的蒸发。

10. 发明授权

US07182509B2 Nanoliter osmometer and method of operation 有权
标题翻译：纳升渗透压计及其操作方法
公开(公告)号：US07182509B2
公开(公告)日：2007-02-27
申请号：US11115115
申请日：2005-04-27
申请人： Christopher J. Corbett
发明人： Christopher J. Corbett
IPC分类号： A61B5/01 , G01N33/48 , G01N13/04 , G01N25/04
CPC分类号： G01N25/06 , G01N13/04
摘要： The invention is an apparatus for determining a temperature at which a phase change occurs in a fluid sample, a method for measuring a temperature at which a phase change occurs in a sample and a sample cell. An apparatus for determining a temperature at which a phase change occurs in a fluid sample 60′ in accordance with the invention includes a sample cell (12′)for providing direct collection of the sample from a sample source (74) which is collected and retained at a collecting end thereof by capillary attraction between the collecting end and the sample, the sample cell including a longitudinal passage (78) extending from the collecting end to a far end through which light is transmitted to provide an image of the sample as retained at the collecting end of the passage and with a cross sectional area of the passage being greater at the far end than at the collecting end; a heating and cooling assembly (14), including a temperature sensing device (44), the heating and cooling assembly holding and thermally contacting the sample cell during the determining of the temperature by the temperature measuring device at which the phase change occurs while the sample is positioned in the collecting end; and an illumination system (16) for directing a light beam to the collecting end, through the sample, through the longitudinal passage and out of the far end to permit viewing of the sample from the far end to determine the temperature at which the phase change occurs.
摘要翻译：本发明是一种用于确定流体样品中发生相变的温度的装置，用于测量在样品和样品池中发生相变的温度的方法。用于确定在根据本发明的流体样品60'中发生相变的温度的装置包括用于从采集和保留的样品源（74）直接收集样品的样品池（12'）在收集端和样品之间的毛细管吸引的收集端处，样品池包括从收集端延伸到远端的纵向通道（78），通过该远端透射光以提供保留在样品中的样品的图像通道的收集端和通道的横截面积在远端比在收集端处更大; 包括温度感测装置（44）的加热和冷却组件（14），所述加热和冷却组件在由相变发生的温度测量装置确定温度期间保持并热接触样品池，而样品位于收集端; 以及照明系统（16），用于将光束通过样品通过所述纵向通道引导到所述收集端，并且远离所述远端以允许从所述远端观察所述样品，以确定所述相变的温度发生。

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