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1. 发明授权

US11967495B2 Low-power mass interrogation system and assay for determining Vitamin D levels 有权
公开(公告)号：US11967495B2
公开(公告)日：2024-04-23
申请号：US17544599
申请日：2021-12-07
申请人： Leidoc, Inc.
发明人： Noah Peter Christian
IPC分类号： H01J49/00 , H01J49/02 , H01J49/06 , H01J49/16 , H01J49/20 , H01J49/24 , H01J49/30
CPC分类号： H01J49/004 , H01J49/025 , H01J49/067 , H01J49/16 , H01J49/20 , H01J49/24 , H01J49/0013 , H01J49/30
摘要： A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

2. 发明申请

US20200312651A1 MASS SEPARATOR 审中-公开
公开(公告)号：US20200312651A1
公开(公告)日：2020-10-01
申请号：US16815048
申请日：2020-03-11
申请人： Nissin Ion Equipment Co., Ltd.
发明人： Daiki Takashima , Ippei Nishimura
IPC分类号： H01J49/30 , H01J49/02
摘要： Provided is a mass separator (100) for performing mass separation for an ion beam (IB). The mass separator (100) includes a transfer structure (30) that is a component of a yoke (13) and move at least one of an upper yoke (13a) positioned over the beam path (L), a lower yoke (13b) positioned under the beam path (L), and a side yoke (13c, 13d) positioned at a side of the beam path (L) between a normal position (P) in the traveling of the ion beam (IB) and a retracted position (Q) that does not overlap with at least a part of the normal position (P); the yoke (13) is surrounding the beam path (L) and is made of a magnetic body.

3. 发明授权

US10748753B2 Accelerator mass spectrometry system and associated method 有权
公开(公告)号：US10748753B2
公开(公告)日：2020-08-18
申请号：US16439817
申请日：2019-06-13
申请人： High Voltage Engineering Europa B.V.
发明人： Dirk Jozef Willem Mous
IPC分类号： H01J49/00 , H01J49/30
摘要： An accelerator mass spectrometry system for measuring an isotopic ratio of a chemical element in a sample. The system includes an ion source generating a beam of negative ions of the chemical element containing ions of first and second isotopes of the chemical element, a first analyzer section, comprising a first mass analyzer; a tandem accelerator comprising a first accelerating section, a charge stripping section for converting the negative ions into positive ions, and a second accelerating section behind the charge stripping section. A second analyzer section includes a second mass analyzer and an electrostatic analyzer; a particle detector; and a controller system configured to control the first mass analyzer section and the second analyzer section such that the ions of the first and second isotopes traverse the tandem accelerator and ions of only one of the first and second isotopes enter the particle detector. An additional analyzer is located in between the charge stripping section and the second accelerating section and is configured to receive positive ions that have exited the charge stripping section and to separate positive ions having a charge state corresponding to a predetermined charge-state value from positive ions having a charge state not corresponding to the predetermined charge-state value, so as to transmit ions with different charge states in mutually different directions such that only ions having a charge state corresponding to the predetermined charge-state value are transmitted towards the particle detector.

4. 发明授权

US10658169B2 Methods, apparatus, and system for mass spectrometry 有权
公开(公告)号：US10658169B2
公开(公告)日：2020-05-19
申请号：US16351700
申请日：2019-03-13
申请人： Massachusetts Institute of Technology
发明人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
IPC分类号： H01J49/30 , H01J49/02 , H01J49/00 , H01J49/14 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

5. 发明授权

US10176978B2 Control of magnetic sector mass spectrometer magnet 有权
公开(公告)号：US10176978B2
公开(公告)日：2019-01-08
申请号：US15532935
申请日：2015-12-03
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jürgen Jaeschke , Michael Deerberg , Hans-Jürgen Schlüter
IPC分类号： H01J49/26 , G21K5/04 , H01J49/30 , H01J49/00 , G01R33/07 , G01R33/09
摘要： A control system for controlling a magnet of a magnetic sector mass spectrometer comprises a magnetic field sensor for sensing the magnetic field of the magnet and generating an output representative thereof; a set point generator configured to generate an output representative of, or related to, a desired magnetic field of the magnet; and a digital controller configured to receive a variable digital input signal from the output of the magnetic field sensor and a set point digital input signal from the output of the set point generator, and to generate a digital output from which is derived a control signal for controlling a current to the magnet so as to control the magnetic field thereof. The control system is arranged to apply to the digital controller a selected one of a plurality of different controller settings, in accordance with the desired magnetic field of the magnet.

6. 发明申请

US20180082828A1 ACCELERATOR MASS SPECTROMETRY DEVICE FOR SIMULTANEOUSLY MEASURING ISOTOPES 审中-公开
公开(公告)号：US20180082828A1
公开(公告)日：2018-03-22
申请号：US15562892
申请日：2015-04-01
申请人： CHINA INSTITUTE OF ATOMIC ENERGY
发明人： Shan JIANG , Yiwen BAO , Ming HE , Shengyong SU , Qubo YOU , Yueming HU , Daqing CUI
IPC分类号： H01J49/00 , H01J49/48 , H01J49/30 , H01J49/10
CPC分类号： H01J49/0086 , H01J49/004 , H01J49/10 , H01J49/30 , H01J49/48
摘要： The present invention provides an accelerator mass spectrometry device for simultaneously measuring isotopes. In one embodiment, the device comprises a sputtering negative ion source for generating negative ions; the sputtering negative ion source being connected to an accelerating tube for simultaneously accelerating a plurality of isotopic ions; an output end of the accelerating tube being connected to an isotope mass resolution system; the isotope mass resolution system being connected to a charge conversion analysis and multi-receiving measurement system; the charge conversion analysis and multi-receiving measurement system being connected to an ion detection system. The present invention is capable of accelerating a plurality of isotopic negative ions simultaneously. The accelerated isotopic negative ions are separated. Stable isotopic negative ions are measured by a stable isotope receiver. Unstable isotope negative ions are converted to positive ions and then measured by a detector.

7. 发明申请

US20160172180A1 METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY 有权
标题翻译：方法，装置和大容量光谱系统
公开(公告)号：US20160172180A1
公开(公告)日：2016-06-16
申请号：US15045883
申请日：2016-02-17
申请人： The Massachusetts Institute of Technology
发明人： Ian W. Hunter , Brian Hemond , Harold F. Hemond
IPC分类号： H01J49/30 , H01J49/02 , H01J49/24 , H01J49/00 , H01J49/14
CPC分类号： H01J49/30 , H01J49/0013 , H01J49/0031 , H01J49/022 , H01J49/147 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
摘要翻译：一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。可变几何机械滤镜允许可变分辨率。机载离子泵不需要外部泵浦源。磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。

8. 发明授权

US08963101B2 Apparatus and method for thermal assisted desorption ionization systems 有权
标题翻译：热辅助解吸电离系统的装置和方法
公开(公告)号：US08963101B2
公开(公告)日：2015-02-24
申请号：US14455611
申请日：2014-08-08
申请人： Jordan Krechmer , Brian D. Musselman
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/30 , H01J37/08 , H01J49/04 , H01J27/26 , H01J49/12
CPC分类号： H01J49/049 , G01N27/622 , G01N27/626 , G01N27/64 , H01J27/26 , H01J49/004 , H01J49/04 , H01J49/0431 , H01J49/10 , H01J49/126 , H01J49/14 , H01J49/24 , Y10T436/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
摘要翻译：本发明涉及一种使用热解析分析物以允许分析物分子解吸的方法和装置，其中解吸的分析物分子与环境温度电离物质电离。在本发明的各种实施方案中，电流通过其上存在分析物分子的网。电流加热网格并导致分析物分子的解吸，然后分析物分子与气相亚稳态的中性分子或原子相互作用以形成分析物分子特征的分析物离子。

9. 发明申请

US20100320372A1 MOLECULE MASS DETECTION VIA FIELD EMISSION OF ELECTRONS FROM MEMBRANES 有权
标题翻译：通过膜的电子发射的分子质量检测
公开(公告)号：US20100320372A1
公开(公告)日：2010-12-23
申请号：US12489037
申请日：2009-06-22
申请人： Robert H. BLICK
发明人： Robert H. BLICK
IPC分类号： H01J49/26 , H01J49/40 , H01J49/42 , H01J49/30
CPC分类号： G01N23/00 , H01J47/001 , H01J49/025
摘要： An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons.
摘要翻译：基于通过场发射（FE）和/或二次电子发射（SEE）产生电子，在室温或室温下检测分子（包括大分子如蛋白质和寡核苷酸）的主动检测器和方法。检测器包括具有与一个或多个分子接触的外表面的半导体膜和具有薄金属层或其它类型的电子发射层的内表面。接触半导体膜的分子的动能通过膜转移并诱导从发射层发射电子。可选地包括用于电子放大的装置的电子检测器被定位成检测发射的电子。

10. 发明授权

US07645985B1 Method and apparatus for magnetic separation of ions 有权
标题翻译：用于磁离子离子的方法和装置
公开(公告)号：US07645985B1
公开(公告)日：2010-01-12
申请号：US11843446
申请日：2007-08-22
申请人： Charles E. Brokaw , Thomas E. Brokaw , Crystal D. Brokaw
发明人： Charles E. Brokaw , Thomas E. Brokaw , Crystal D. Brokaw
IPC分类号： H01J49/30
CPC分类号： C01B3/042 , B01D2259/814 , C01B3/50 , C01B13/0207 , C01B13/0248 , C01B2203/0465 , C01B2210/0053 , C02F1/48 , Y02E60/364
摘要： The disclosed device is directed toward an apparatus for the separation of ions. The apparatus for the separation of ions comprises a vessel including an inlet fluidly coupled to an outlet. A magnetic field is applied substantially orthogonal to the flow of the fluid. The magnetic field applies a force that separates the oppositely charged ions.
摘要翻译：所公开的装置指向用于分离离子的装置。用于分离离子的装置包括容器，其包括流体耦合到出口的入口。施加大致正交于流体流动的磁场。磁场施加分离带电荷的离子的力。

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