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1. 发明授权

US10139399B2 Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy 有权
公开(公告)号：US10139399B2
公开(公告)日：2018-11-27
申请号：US15906839
申请日：2018-02-27
申请人： Horizon Pharma Rheumatology LLC
发明人： Theresa Rosario-Jansen , David Erick Wright
IPC分类号： C12Q1/62 , G01N33/53 , G01N33/68 , A61K9/00 , A61K38/44 , A61K47/60
摘要： Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response during intravenous PEGylated uricase therapy in gout patients is provided. Routine SUA monitoring can be used to identify patients receiving PEGylated uricase who may no longer benefit from treatment and who are at greater risk for infusion reactions.

2. 发明申请

US20180282707A1 MUTANT-TYPE URICASE, PEG MODIFIED MUTANT-TYPE URICASE, AND APPLICATION THEREOF 审中-公开
公开(公告)号：US20180282707A1
公开(公告)日：2018-10-04
申请号：US15764495
申请日：2016-08-19
申请人： SHANGHAI INSTITUTE OF BIOLOGICAL PRODUCTS CO., LTD.
发明人： Yun JIANG , Linqiu HUANG , Jueren LOU
IPC分类号： C12N9/06 , A61K47/60 , C12Q1/62
摘要： A mutant-type uricase, PEG modified mutant-type uricase, and application thereof. The mutant-type uricase has a cysteine residue introduced by recombination, the cysteine residue is located at an inactive region of the uricase, and one or more PEGs are coupled to the mutant-type uricase. The resulting PEGylated mutant-type uricase has characteristics of a half-life extension, product uniformity, and stable enzyme activity. Therefore, the present invention has a wide future application range.

3. 发明申请

US20170211125A1 Devices and Formulations for Detecting, Screening and Monitoring Levels of Certain Constituents in Bodily Fluids and Method 审中-公开
公开(公告)号：US20170211125A1
公开(公告)日：2017-07-27
申请号：US15481782
申请日：2017-04-07
申请人： Pop Test LLC
发明人： Randice Lisa Altschul , Neil David Theise , Myron Rapkin , Rebecca O'Brien
IPC分类号： C12Q1/62 , G01N33/52 , G01N33/98 , C12Q1/60 , C12Q1/54
CPC分类号： C12Q1/52 , C12Q1/54 , C12Q1/60 , C12Q1/62 , C12Y206/01001 , C12Y206/01002 , G01N21/29 , G01N21/78 , G01N33/52 , G01N33/523 , G01N33/558 , G01N33/57438 , G01N33/66 , G01N33/92 , G01N33/98 , G01N2021/752 , G01N2333/91188 , G01N2800/085
摘要： A device is disclosed for conducting a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid. An indicator formulation of the device changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A carrier substrate of the device is constructed of a material having voids providing a high void volume within the substrate. The device is made by applying a chromagen to the carrier substrate to create a chromagen-laden carrier member. Then, a selected reagent having a particular constituent-specific formulation is applied to the chromagen-laden member. The selected reagent then combines with the chromagen thereby establishing the indicator formulation within the carrier substrate in place for reception of a sample of the bodily fluid.

4. 发明申请

US20060240500A1 Diagnosis of kidney damage and protection against same 审中-公开
标题翻译：诊断肾损害和保护相同
公开(公告)号：US20060240500A1
公开(公告)日：2006-10-26
申请号：US10524237
申请日：2003-08-04
申请人： John Kopchick , Karen Coschigano , Amy Wetzel
发明人： John Kopchick , Karen Coschigano , Amy Wetzel
IPC分类号： A61K48/00 , A61K38/54 , C12Q1/62
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/177 , A61K38/465 , A61K38/53 , C07K14/47 , G01N2800/347
摘要： Various nucleic acids and proteins have been identified by differential hybridization methods as useful as markers for diagnosing kidney damage. The identified marker proteins include (I) androgen related protein, SON protein, FUSE binding Protein 1, claudin10, heat shock protein, phospho triesterase related protein, ubiquitin protein ligase Nedd-4, and Ac39/physophilin, and (II) disabled-2 p96, palmitylated serine/threonine kinase, tumor differentially expressed 1 protein, cytochrome oxidase III, TLH 39 protein precursor, hydroxysteroid dehydrogenase 4 delta -3 beta, and glutathione peroxidase III. The proteins of group (I), and antagonists of the proteins of group (II), are useful for protecting mammals against kidney damage.
摘要翻译：已经通过差异杂交方法鉴定了各种核酸和蛋白质，作为用于诊断肾损伤的标记物。鉴定的标记蛋白包括（I）雄激素相关蛋白，SON蛋白，FUSE结合蛋白1，claudin10，热休克蛋白，磷酸三酯酶相关蛋白，泛素蛋白连接酶Nedd-4和Ac39 / physophilin，和（II）残基-2 p96，棕榈酰丝氨酸/苏氨酸激酶，肿瘤差异表达1蛋白，细胞色素氧化酶III，TLH 39蛋白前体，羟基类固醇脱氢酶4Δ5β-3β和谷胱甘肽过氧化物酶III。组（I）的蛋白质和组（II）的蛋白质的拮抗剂可用于保护哺乳动物免受肾损伤。

5. 发明授权

US5897993A Method of determining the number of bacteria quickly and a device for determining the number of bacteria 失效
标题翻译：快速测定细菌数量的方法和确定细菌数量的装置
公开(公告)号：US5897993A
公开(公告)日：1999-04-27
申请号：US894820
申请日：1997-08-29
申请人： Mikio Sato , Tomomi Ito
发明人： Mikio Sato , Tomomi Ito
IPC分类号： C12M1/34 , C12Q1/06 , C12Q1/02 , C12Q1/54 , C12Q1/62 , G01N33/53
CPC分类号： C12Q1/06 , Y10S435/968 , Y10S435/975
摘要： A method of determining the number of bacteria in a sample which involves introducing a sample containing bacteria into a tubular filtering vessel holding therein a hydrophobic filter for bacterial detection, a coloring composition is disposed on the side of the filter where the sample is introduced into the vessel, and a support for the filter is disposed on the opposite side of the filter from the coloring composition. The bacteria is subjected to and the sample is filtered dyeing sample by suction from the support to collect the dyed bacteria on the filter and remove the excess of coloring matter. The number of the bacteria in the sample is determined from the degree of staining of the filter.
摘要翻译： PCT No.PCT / JP96 / 00815 Sec。 371日期1997年8月29日 102（e）日期1997年8月29日PCT提交1996年3月28日PCT公布。公开号WO96 / 30542 日期1996年10月3日一种确定样品中细菌数量的方法，其包括将含有细菌的样品引入到其中容纳用于细菌检测的疏水性过滤器的管状过滤容器中，着色组合物设置在过滤器的侧面，将样品引入容器中，并且用于过滤器的载体设置在过滤器与着色组合物相反的一侧。对细菌进行处理，并通过抽吸从载体上过滤染色样品，以将染色的细菌收集在过滤器上并除去过量的着色物质。样品中细菌的数量由过滤器的染色程度决定。

6. 发明授权

US5858644A Analysis of analytes in biological fluids 失效
标题翻译：分析生物液体中的分析物
公开(公告)号：US5858644A
公开(公告)日：1999-01-12
申请号：US452831
申请日：1995-05-30
申请人： Fu-Tai Albert Chen
发明人： Fu-Tai Albert Chen
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/62 , G01N27/447 , G01N33/48
CPC分类号： C12Q1/00 , C12Q1/62 , G01N27/44721 , G01N27/44747 , Y10T436/103332
摘要： A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1) subjecting a first aliquot of the sample to an analytical technique such as capillary electrophoresis, which generates a first output such as an electropherogram; (2) reacting a second aliquot of the sample in an enzyme-catalyzed reaction converting the analyte into a product, the product being detectable by the analytical technique; (3) subjecting the second aliquot to the analytical technique to generate a second output; (4) in the case of electrophoresis, measuring the absorbance of the first and second outputs (electropherograms) as a function of migration distance along the electropherogram at at least one wavelength at which either the analyte or the product absorbs to produce a first absorbance scan and a second absorbance scan; and (5) comparing the first absorbance scan with the second absorbance scan to detect the analyte. The reaction can involve a coenzyme and the analytical technique can be directed to the coenzyme. Alternatively, at least two enzymes can be used, the first enzyme generating a first product that is then acted upon by the second enzyme.
摘要翻译：用于检测样品中的分析物的方法使用酶反应的特异性和毛细管电泳的分离能力。通常，该方法包括：（1）使样品的第一等分试样进行诸如毛细管电泳的分析技术，其产生诸如电泳图的第一输出; （2）使样品的第二等分试样在酶分析反应中转化为产物，该产物可通过分析技术检测; （3）对第二等分试样进行分析技术以产生第二输出; （4）在电泳的情况下，测量第一和第二输出（电泳图）的吸光度，作为在分析物或产物吸收的至少一个波长处沿着电泳图的迁移距离的函数，以产生第一吸光度扫描和第二吸光度扫描; 和（5）将第一吸光度扫描与第二吸光度扫描进行比较以检测分析物。该反应可以涉及辅酶，分析技术可以涉及辅酶。或者，可以使用至少两种酶，第一种酶产生随后被第二种酶作用的第一种产物。

7. 发明授权

US5384248A Process for measuring an analyte with an oxidase and an oxidizable color reagent and surfactants 失效
标题翻译：用氧化酶和可氧化着色试剂和表面活性剂测量分析物的方法
公开(公告)号：US5384248A
公开(公告)日：1995-01-24
申请号：US228002
申请日：1994-04-15
申请人： Yoshitsugu Sakata , Toshiro Hanada , Ryosuke Matsuda , Yoshiyuki Matsuda
发明人： Yoshitsugu Sakata , Toshiro Hanada , Ryosuke Matsuda , Yoshiyuki Matsuda
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/34 , C12Q1/44 , C12Q1/46 , C12Q1/54 , C12Q1/60 , C12Q1/61 , C12Q1/62 , C12Q1/36
CPC分类号： C12Q1/28
摘要： A substrate or an enzymatic activity in a body fluid can be measured accurately without influences of interfering substances such as bilirubin by reacting an oxidase corresponding to an analyte with the analyte or an oxidase corresponding to a substance produced by enzymatic reaction with the substance in a measuring system containing one or more cationic and/or amphoteric surfactants, followed by optical measurement of hydrogen peroxide produced by the reaction.
摘要翻译：体液中的底物或酶活性可以通过将与分析物相应的氧化酶与分析物相反应的氧化酶或对应于通过与物质的酶反应产生的物质的氧化酶在测量中与物质反应而精确地测量而不受干扰物质例如胆红素的影响含有一种或多种阳离子和/或两性表面活性剂的体系，然后光学测量由反应产生的过氧化氢。

8. 发明授权

US5369013A Method, reagent mixture and kit for determining the presence of bacterial or somatic cells in urine 失效
标题翻译：用于测定尿中细菌或体细胞存在的方法，试剂混合物和试剂盒
公开(公告)号：US5369013A
公开(公告)日：1994-11-29
申请号：US919925
申请日：1992-07-27
申请人： Nathan Citri
发明人： Nathan Citri
IPC分类号： C12Q1/30 , C12Q1/44 , C12Q1/62
CPC分类号： C12Q1/30 , Y10S435/81
摘要： A method, reagent mixture and test kit are provided for testing a urine sample for the presence of bacterial or somatic cells, by reacting a urine sample with a catalase-free alkaline protease enzyme and a detergent compatible therewith, so as to disrupt any such cells present in the sample and release active catalase therefrom. The presence of catalase is detected by the formation of foam upon the addition of H.sub.2 O.sub.2. The reaction of the sample with the protease enzyme and the detergent is conducted in the presence of: (a) a buffer providing for a pH of about 8.5 to about 9; and optionally (b) one or more additional solutes; the total concentration of components (a) and (b), when present, being from about 0.02M to about 0.4M.
摘要翻译：提供了一种方法，试剂混合物和测试试剂盒，用于通过使尿液样品与无过氧化氢酶的碱性蛋白酶和与之相容的洗涤剂反应来测试尿液样品中细菌或体细胞的存在，以便破坏任何这样的细胞存在于样品中并从其中释放活性过氧化氢酶。过氧化氢酶的存在通过在加入H 2 O 2后形成泡沫来检测。样品与蛋白酶和洗涤剂的反应在以下条件下进行：（a）提供约8.5至约9的pH的缓冲液; 和任选地（b）一种或多种另外的溶质; 组分（a）和（b）当存在时的总浓度为约0.02M至约0.4M。

9. 发明授权

US5081014A Method of measuring a co-enzyme 失效
标题翻译：测定CO酶的方法
公开(公告)号：US5081014A
公开(公告)日：1992-01-14
申请号：US587480
申请日：1990-09-19
申请人： Jean Brochot , Iqbal Siddiqi
发明人： Jean Brochot , Iqbal Siddiqi
IPC分类号： C12Q1/26 , C12Q1/00 , C12Q1/28 , C12Q1/52 , C12Q1/54 , C12Q1/58 , C12Q1/62 , G01N33/50
CPC分类号： C12Q1/008 , C12Q1/28 , C12Q1/52 , C12Q1/54 , C12Q1/58 , C12Q1/62
摘要： The method makes use of the action of the co-enzyme in the production of H.sub.2 O.sub.2 associated with the reaction of a hydroxylase with a decoupling agent in the presence of air or oxygen, the H.sub.2 O.sub.2 being subsequently determined by quantitative breaking of the C--F bond of a fluorinated compound in the presence of peroxidase, followed by electrometric titration of the resulting ions.
摘要翻译：该方法利用辅酶在空气或氧气存在下与羟化酶与脱钩剂反应相关的H 2 O 2的生成的作用，随后通过定量地破坏氟化化合物在过氧化物酶的存在下，然后电渗滴定所得离子。

10. 发明授权

US4933277A Method of quantitative analysis of hydrogen peroxide and reagent therefor 失效
标题翻译：过氧化氢及其试剂的定量分析方法
公开(公告)号：US4933277A
公开(公告)日：1990-06-12
申请号：US262720
申请日：1988-10-26
申请人： Toshikatsu Abe , Mitsuhisa Manabe , Masayuki Nozawa , Atsushi Izumi , Fumio Masumi , Akemichi Maki
发明人： Toshikatsu Abe , Mitsuhisa Manabe , Masayuki Nozawa , Atsushi Izumi , Fumio Masumi , Akemichi Maki
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/54 , C12Q1/62 , G01N33/50
CPC分类号： C12Q1/28 , C12Q1/54 , C12Q1/62 , C12Q2326/00 , Y10S435/81 , Y10T436/206664
摘要： A method for quantitative analysis of hydrogen peroxide at a high precision is disclosed. The method comprises reacting a divalent cobalt compound with hydrogen peroxide in the presence of peroxidase or a substance similar to peroxidase to produce a trivalent cobalt compound, reacting the trivalent cobalt compound thus produced with a trivalent cobalt indicator to produced a colored complex, and subjecting the colored complex to colorimetric quantitative analysis. The method enables various enzymatic activities producing hydrogen peroxide by the reaction with substrates as well as the amount or activity of substances involving the known enzymatic reactions linked with such enzymatic reactions, of enzymes and coenzymes, to be quantitatively determined very easily at a high sensitivity at a wavelength of above 600 nm without the interference of hemoglobin, bilirubin, or turbidity.

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