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    • 1. 发明申请
      US20140065608A1 METHOD FOR THE ENUMERATION OF MAMMALIAN MICRONUCLEATED ERYTHROCYTE POPULATIONS, WHILE DISTINGUISHING PLATELETS AND/OR PLATELET-ASSOCIATED AGGREGATES 有权
    • METHOD FOR THE ENUMERATION OF MAMMALIAN MICRONUCLEATED ERYTHROCYTE POPULATIONS, WHILE DISTINGUISHING PLATELETS AND/OR PLATELET-ASSOCIATED AGGREGATES
    • 用于产生马马利亚微球蛋白质人群的方法，在分解平板和/或平板相关聚集体
    • US20140065608A1
    • 2014-03-06
    • US14075082
    • 2013-11-08
    • Litron Laboratories, Ltd.
    • Stephen D. DERTINGER
    • G01N33/50
    • G01N33/56966 , G01N33/5094 , G01N33/80 , G01N2333/70582 , G01N2333/70596 , Y02A50/58 , Y10S435/968 , Y10S435/973 , Y10T436/101666
    • A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains DNA (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample. In particular, the use of the second antibody prevents interference by platelet-associated aggregates in the scoring procedures.
    • 用于计数微核红细胞群体同时区分血小板和血小板相关聚集体的方法涉及使用具有对网织红细胞表面标志物具有结合特异性的第一荧光标记抗体，对于血小板表面标志物具有结合特异性的第二荧光标记抗体 ，以及在红细胞群体中染色DNA（微核）的核酸染色染料。 因为第一和第二荧光标记的抗体的荧光发射光谱基本上彼此不重叠或者与核酸染色染料的发射光谱基本重叠，所以在标记和染料激发时，可以检测荧光发射和光散射 由红细胞群体和血小板产生，并计数所述样品中一种或多种红细胞群体的细胞数。 特别地，使用第二抗体可防止血小板相关聚集体在评分程序中的干扰。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 4. 发明授权
      US08153442B2 Stabilization of signal generation in particles used in assays 有权
    • Stabilization of signal generation in particles used in assays
    • 在测定中使用的颗粒中信号产生的稳定性
    • US08153442B2
    • 2012-04-10
    • US12603364
    • 2009-10-21
    • Alan R. Craig , Zhu Teng , Carsten Schelp , Jason Snyder , Christine Moran
    • Alan R. Craig , Zhu Teng , Carsten Schelp , Jason Snyder , Christine Moran
    • G01N1/00 , G01N21/76 , G01N33/546
    • G01N21/76 , G01N21/6428 , G01N33/54393 , Y10S435/968 , Y10T436/10 , Y10T436/2525
    • Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support includes a chemiluminescent composition that includes a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles including other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium that contains the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
    • 公开了用于进行测定的方法和试剂。 本发明的方法和试剂的实施方案涉及固体支持物，例如颗粒。 载体包括包含金属螯合物的化学发光组合物。 本发明人观察到，当将这种载体例如颗粒用于测定分析物时，与包含其它化学发光组合物的颗粒相比，由与颗粒相关的化学发光组合物输出的信号的稳定性不可接受地降低 。 根据本发明的实施方案，通过在含有颗粒的介质中包含足量的一种或多种稳定剂（其可以是螯合剂和/或金属螯合物）来增加来自这些颗粒的信号输出的稳定性 例如与颗粒相关的金属螯合物。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 5. 发明申请
      US20110014721A1 HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS 失效
    • HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS
    • 羟丙基纤维素标签试剂（HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS）
    • US20110014721A1
    • 2011-01-20
    • US12889277
    • 2010-09-23
    • Ramon Evangelista , Martha Garrity
    • Ramon Evangelista , Martha Garrity
    • G01N21/76 , C07D219/08 , C07K16/00 , C07D401/12
    • C07D401/12 , C07D219/04 , C09B15/00 , G01N33/533 , Y10S435/968 , Y10S436/80
    • In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.
    • 根据本发明，已经发现，衍生自同型半胱磺酸，半胱氨酸，甘氨酸肽，四环氧乙烷等的亲水性磺基烷基取代基和/或亲水接头的引入抵消了吖啶环体系的疏水性以产生 在遇到沉淀和聚集问题之前可以以更高的负载连接到抗体上的更可溶性标记。 本文所述的其它化合物含有源自短肽和四氧化二环的连接体，其由于与水分子的氢键而增加水溶性。 本发明还包括用于多个吖啶标记用于信号放大的试剂，其由具有几个具有磺酸盐基团的吖啶酯的肽以规则间隔的间隔组成，以增加溶解度。 本发明还包括使用上述化合物的测定。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明申请
      US20100105095A1 Optical Molecular Sensors for Cytochrome P450 Activity 有权
    • Optical Molecular Sensors for Cytochrome P450 Activity
    • 光学分子传感器用于细胞色素P450活性
    • US20100105095A1
    • 2010-04-29
    • US12499047
    • 2009-07-07
    • Lewis R. Makings , Gregor Zlokarnik
    • Lewis R. Makings , Gregor Zlokarnik
    • C12Q1/26 , C07D311/02 , C07D265/38
    • C07D493/10 , C07D219/06 , C07D265/38 , C07D311/16 , C07D311/82 , C12Q1/26 , G01N2333/90245 , G01N2500/02 , Y10S435/968
    • The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C1-C20 alkyl, unsaturated C1-C20 alkenyl, unsaturated C1-C20 alkynyl, substituted saturated C1-C20 alkyl, substituted unsaturated C1-C20 alkenyl, substituted unsaturated C1-C20 alkynyl, C1-C20 cycloalkyl, C1-C20 cycloalkenyl, substituted saturated C1-C20 cycloalkyl, substituted unsaturated C1-C20 cycloalkenyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; L is selected from the group of (—OCR2H)p—, wherein for each p, all R2 are separately selected from the group consisting of a hydrogen atom, saturated C1-C20 alkyl, unsaturated C1-C20 alkenyl, unsaturated C1-C20 alkynyl, substituted saturated C1-C20 alkyl, substituted unsaturated C1-C20 alkenyl, substituted unsaturated C1-C20 alkynyl, C1-C20 cycloalkyl, C1-C20 cycloalkenyl, substituted saturated C1-C20 cycloalkyl, substituted unsaturated C1-C20 cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and p is a positive integer no greater than twelve; and Q is a chemical moiety that gives rise to optical properties in its hydroxy or hydroxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form. Most preferably, p is one, R2 is hydrogen, and Q is the ether form of a phenoxide fluorophore.
    • 本发明提供了可用作至少一种细胞色素P450酶的活性的光学探针或传感器的化合物，以及使用该化合物筛选候选药物的方法以及通过这些方法鉴定的候选药物。 本发明的光学探针是具有一般结构YLQ的化合物，其中Y选自本文定义的Q，饱和C 1 -C 20烷基，不饱和C 1 -C 20烯基，不饱和C 1 -C 20炔基，取代的饱和C 1 -C 20烷基，取代的不饱和C 1 -C 20烯基，取代的不饱和C 1 -C 20炔基，C 1 -C 20环烷基，C 1 -C 20环烯基，取代的饱和C 1 -C 20环烷基，取代的不饱和C 1 -C 20环烯基，芳基，取代的芳基， 杂芳基; L选自（-OCR 2 H）p - ，其中对于每个p，所有的R 2分别选自氢原子，饱和C 1 -C 20烷基，不饱和C 1 -C 20烯基，不饱和C 1 -C 20炔基 取代的饱和C 1 -C 20烷基，取代的不饱和C 1 -C 20烯基，取代的不饱和C 1 -C 20炔基，C 1 -C 20环烷基，C 1 -C 20环烯基，取代的饱和C 1 -C 20环烷基，取代的不饱和C 1 -C 20环烯基，芳基， 杂芳基，取代的杂芳基，p是不大于12的正整数; 并且Q是一种化学部分，其在其羟基或羟基化物，苯酚或酚盐形式中产生与由其醚形式产生的光学性质不同的光学性质。 最优选地，p是1，R2是氢，Q是醚形式的苯氧基荧光团。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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