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1. 发明申请

WO2011041463A2 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译：经皮分析传感器
公开(公告)号：WO2011041463A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050788
申请日：2010-09-29
申请人： DEXCOM, INC. , NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
发明人： NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供经配置用于连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括被配置用于插入宿主的皮肤180下方的体内部分160和被配置为在传感器插入到主体的传感器之后保持在宿主的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括被配置用于刺穿主体的皮肤180的组织刺穿元件110和包括材料或支撑构件130的传感器主体120，该传感器主体120提供足够的柱强度以允许传感器主体可以在宿主组织中大量屈曲。离体部分170可以被配置成包括（或可操作地连接到）传感器电子单元并且可以包括安装单元150.这里还描述了传感器主体和组织穿透元件的各种配置，其可以用于保护传感器主体的膜。

2. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

3. 发明申请

WO2005019795A3 ELECTROCHEMICAL SENSORS INCLUDING ELECTRODE SYSTEMS WITH INCREASED OXYGEN GENERATION 审中-公开
标题翻译：包括电极系统在内的电化学传感器与增加的氧气发生
公开(公告)号：WO2005019795A3
公开(公告)日：2006-03-16
申请号：PCT/US2004023650
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , C12Q1/00 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
摘要翻译：本发明一般涉及用于增加电化学传感器（10）中的氧气产生的系统和方法，以克服氧的限制。优选实施例采用电极系统（16b），其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极中的催化剂，从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。电化学传感器（10）可以包括具有感测区域（14）的主体和设置在电极系统（16b）的电活性表面之上的膜系统（18）。

4. 发明申请

WO2005057173A2 SYSTEMS AND METHODS FOR IMPROVING ELECTROCHEMICAL ANALYTE SENSORS 审中-公开
标题翻译：改进电化学分析仪传感器的系统和方法
公开(公告)号：WO2005057173A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040913
申请日：2004-12-07
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
发明人： SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
IPC分类号： G01N
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译：提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本无干扰的分析物浓度测量。当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。

5. 发明申请

WO2011003039A2 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040842
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes 802', 802" formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层810，其将导电层820与细长主体分离;膜层，通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

6. 发明申请

WO2011003035A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040838
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

7. 发明申请

WO2009105337A3 CONTINUOUS MEDICAMENT SENSOR SYSTEM FOR IN VIVO USE 审中-公开
标题翻译：连续使用医疗传感器系统
公开(公告)号：WO2009105337A3
公开(公告)日：2010-12-16
申请号：PCT/US2009033096
申请日：2009-02-04
申请人： DEXCOM INC , SIMPSON PETER C , YANG RICHARD C , MATSUBARA BRADLEY SHIGETO , BOOCK ROBERT , MCCARTHY ELEANOR , BRISTER MARK
发明人： SIMPSON PETER C , YANG RICHARD C , MATSUBARA BRADLEY SHIGETO , BOOCK ROBERT , MCCARTHY ELEANOR , BRISTER MARK
IPC分类号： A61M31/00
CPC分类号： A61B5/14546 , A61B5/0002 , A61B5/064 , A61B5/14532 , A61B5/4094 , A61B5/411 , A61B5/4839 , A61B5/4848 , A61M5/1723 , A61M2005/14296 , A61M2230/201
摘要： Systems and methods for continuous measurement of a medicament In vivo are provided. In some embodiments, the system 10 is configured to provide information associated with medicament titration using continuous analyte sensor 100 and communication device 110. In some embodiments, the system Is configured for continuous ambulatory drug testing in a host ß, including a host monitor having a continuous sensor, location module, processor module and transmitter. In some embodiments, the system Is configured for continuously monitoring hormone levels and Includes a continuous hormone sensor and a communication device configured to output hormone information in real time. Another embodiment provides an analyte sensor for continuous monitoring of a host's nutritional status, and Is configured for both continuous glucose and albumin detection. The sensor system 10 is configured to interact with one or more secondary devices 120, which can be non-medical or medical devices, e.g., an infusion pump.
摘要翻译：用于连续测量药物的系统和方法提供体内。在一些实施例中，系统10被配置为使用连续分析物传感器100和通信设备110来提供与药物滴定相关联的信息。在一些实施例中，该系统被配置为用于主机ß中的连续动态药物测试，包括具有连续传感器，位置模块，处理器模块和变送器。在一些实施例中，系统被配置为连续监测激素水平，并且包括连续激素传感器和被配置为实时输出激素信息的通信装置。另一个实施方案提供了用于连续监测宿主营养状态的分析物传感器，并且被配置用于连续葡萄糖和白蛋白检测。传感器系统10被配置为与一个或多个辅助设备120相互作用，其可以是非医疗或医疗设备，例如输液泵。

8. 发明申请

WO2009120239A1 INTEGRATED DEVICE FOR CONTINUOUS IN VIVO ANALYTE DETECTION AND SIMULTANEOUS CONTROL OF AN INFUSION DEVICE 审中-公开
标题翻译：集成设备连续
公开(公告)号：WO2009120239A1
公开(公告)日：2009-10-01
申请号：PCT/US2008/082870
申请日：2008-11-07
申请人： DEXCOM, INC. , LEACH, Jacob, S. , SIMPSON, Peter, C.
发明人： LEACH, Jacob, S. , SIMPSON, Peter, C.
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14865 , A61B5/15003 , A61B5/150229 , A61B5/150389 , A61B5/150503 , A61B5/150862 , A61B5/153 , A61B5/155 , A61M5/16804 , A61M5/1723 , A61M2230/201
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system and the simultaneous control of a flow control device are provided. In some embodiments, an integrated system includes a a vascular access device, such as a catheter 12 and/or a fluid coupler 20 connected to an implanted catheter 12 via the catheter's hub 18, a continuous analyte sensor 14, system electronics 110 and an electronic cable 120 for communication with a third-party infusion device, such as a flow control device 130 connected to a fluid reservoir 132, such as an IV bag containing an infusion fluid 132a, via tubing 134, the system being configured for insertion into fluid communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法以及流量控制装置的同时控制。在一些实施例中，集成系统包括血管通路装置，例如导管12和/或流体耦合器20，其经由导管的毂18连接到植入的导管12，连续的分析物传感器14，系统电子装置110和电子电缆 120，用于与第三方输液装置（例如连接到流体储存器132的流量控制装置130，例如包含输注流体132a的IV袋）经由管道134进行通信，该系统被配置为插入与主机的循环系统。

9. 发明申请

WO2007120442A3 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007612
申请日：2007-03-27
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
发明人： SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

10. 发明申请

WO2007002189A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007002189A3
公开(公告)日：2007-09-07
申请号：PCT/US2006024132
申请日：2006-06-20
申请人： DEXCOM INC , DOBBLES J MICHAEL , BRISTER MARK , BRAUKER JAMES H , KAMATH APURV ULLAS , KLINE DANIEL S , MASTERSON STEVE , MENSINGER MICHAEL ROBERT , SAINT SEAN , SIMPSON PETER C
发明人： DOBBLES J MICHAEL , BRISTER MARK , BRAUKER JAMES H , KAMATH APURV ULLAS , KLINE DANIEL S , MASTERSON STEVE , MENSINGER MICHAEL ROBERT , SAINT SEAN , SIMPSON PETER C
IPC分类号： A61B5/05
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/7264 , A61B5/742 , A61B2560/0223 , A61B2560/0276 , A61B2560/028 , A61L2/12 , A61L2/206 , Y02A90/22 , Y02A90/26 , Y10T29/49004
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. The system can include an applicator 12, a mounting unit 14, and an electronics unit 16.
摘要翻译：本发明总体上涉及用于测量宿主中的分析物的系统和方法。更具体地说，本发明涉及用于经皮测量宿主中的葡萄糖的系统和方法。该系统可以包括施加器12，安装单元14和电子单元16。

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