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1. 发明申请

WO2004063346A2 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063346A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000501
申请日：2004-01-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
发明人： MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
IPC分类号： C12N
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2267/02 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了包含编码溶菌酶的转基因的转基因有蹄类动物，以及用于生产这种动物的方法。本发明还提供了使用受试者转基因有蹄类动物以及从受试者转基因有蹄类型收获的食品来生产食品如牛奶或奶制品的方法。

2. 发明申请

WO2004063349A2 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063349A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000606
申请日：2004-01-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
发明人： MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
IPC分类号： C12N
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2227/102 , A01K2267/02 , C07K14/4717 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and further has an attenuated or non-functional β-lactoglobulin allele. The invention further provides methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了转基因有蹄类动物，其包括编码溶菌酶的转基因，并且还具有减毒或无功能的β-乳球蛋白等位基因。本发明还提供了用于生产这种动物的方法。本发明进一步提供了使用主题转基因有蹄类动物以及从主题转基因有蹄类动物收获的食物产品生产食物产品例如牛奶或奶产品的方法。

3. 发明申请

WO2003022220A2 METHOD OF GENERATING A TRANSGENIC LIVESTOCK ANIMAL 审中-公开
标题翻译：产生转基因动物的方法
公开(公告)号：WO2003022220A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028763
申请日：2002-09-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MAGA, Elizabeth, A. , ANDERSON, Gary, B. , MURRAY, James, D. , OPPENHEIM, Stefanie, M.
发明人： MAGA, Elizabeth, A. , ANDERSON, Gary, B. , MURRAY, James, D. , OPPENHEIM, Stefanie, M.
IPC分类号： A61K
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2227/108 , C12N15/8509 , C12N15/87 , C12N15/873
摘要： The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or pluripotent cell and then growing the recombinant totipotent or pluripotent cell to produce the transgenic livestock animal. The invention further provides kits for use in generating transgenic non-human animals of the invention.
摘要翻译：本发明提供了生产转基因家畜的方法。方法通常包括首先将由核酸和重组酶组成的核蛋白引入全能或多能细胞以产生重组全能或多能细胞，然后生长重组全能或多能细胞以产生转基因家畜。本发明还提供用于产生本发明的转基因非人动物的试剂盒。

4. 发明申请

WO1997025413A1 UNGULATE EMBRYONIC STEM-LIKE CELLS, MAKING AND USING THE CELLS TO PRODUCE A TRANSGENIC UNGULATE 审中-公开
标题翻译：分离胚胎干细胞，制备和使用细胞生产转基因细胞
公开(公告)号：WO1997025413A1
公开(公告)日：1997-07-17
申请号：PCT/IB1996000016
申请日：1996-01-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ANDERSON, Gary, B. , SHIM, Hosup
IPC分类号： C12N05/06
CPC分类号： C12N15/8778 , A01K67/0271 , C12N5/0611
摘要： Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine embryos. The primordial germ cells are cultured in long term culture (over 30 days) resulting in cells which resemble embryonic stem cells in morphology and with respect to maintaining pluripotency. The cells obtained can be maintained for several months in culture and can be genetically manipulated using homologous recombination technology in order to insert desired genetic material into the genetic compliment of the cell at a desired location. The genetically manipulated cell can be inserted into a blastocyst obtained from the same species of animal as the cell was derived in order to produce a chimeric ungulate which ungulate may, via its genetic engineering, produce desired pharmaceutical products.
摘要翻译：原始生殖细胞从有蹄类动物的胚泡胚胎中提取，如从25天猪胚胎或34-40天牛胚胎的性腺中提取原始生殖细胞。原始生殖细胞在长期培养（30天以上）中培养，导致类似胚胎干细胞形态学和保持多能性的细胞。所获得的细胞可以在培养物中保持数月，并且可以使用同源重组技术进行遗传操作，以便将期望的遗传物质插入到所需位置的细胞遗传补体中。遗传操纵的细胞可以插入到从与衍生细胞相同的动物种类获得的胚泡中，以便产生嵌合的有蹄类动物，其可以通过其遗传工程产生所需的药物产品。

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