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1. 发明申请

WO2016070166A3 MESSENGER UNA MOLECULES AND USES THEREOF 审中-公开
标题翻译：信使UNA分子及其用途
公开(公告)号：WO2016070166A3
公开(公告)日：2016-08-18
申请号：PCT/US2015058534
申请日：2015-11-01
申请人： ARCTURUS THERAPEUTICS INC
发明人： CHIVUKULA PADMANABH , WARREN LUIGI , TACHIKAWA KIYOSHI , PAYNE JOSEPH E
IPC分类号： C12N15/11 , A61K48/00 , C12N15/85
CPC分类号： C12N9/1018 , A61K39/00 , A61K48/00 , C07K14/445 , C07K14/463 , C07K14/47 , C07K14/4712 , C07K14/4717 , C07K14/505 , C07K14/524 , C07K14/575 , C07K14/705 , C07K14/745 , C07K14/805 , C07K14/8125 , C12N9/0071 , C12N9/1051 , C12N9/1205 , C12N9/2451 , C12N9/644 , C12N9/88 , C12N2740/16222 , C12N2840/105 , C12N2840/60 , C12Y114/16001 , C12Y201/03003 , C12Y204/01025 , C12Y207/0104 , C12Y302/01033 , C12Y304/21022 , C12Y403/02001
摘要： This invention provides a range of translatable messenger UNA (mUNA) molecules. The mUNA molecules can be translated in vitro and in vivo to provide an active polypeptide or protein, or to provide an immunization agent or vaccine component. The mUNA molecules can be used as an active agent to express an active polypeptide or protein in cells or subjects. Among other things, the mUNA molecules are useful in methods for treating rare diseases.
摘要翻译：本发明提供了一系列可转译信使UNA（mUNA）分子。可以在体外和体内翻译mUNA分子以提供活性多肽或蛋白质，或提供免疫剂或疫苗组分。 mUNA分子可以用作活性剂以在细胞或受试者中表达活性多肽或蛋白质。除此之外，mUNA分子可用于治疗罕见疾病的方法。

2. 发明申请

WO2015031654A3 SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATION AND TREATING CONDITIONS 审中-公开
标题翻译：用于移植和处理条件的系统，组合物和方法
公开(公告)号：WO2015031654A3
公开(公告)日：2015-11-05
申请号：PCT/US2014053223
申请日：2014-08-28
申请人： CYTONICS CORP
发明人： HANNA LEWIS , LAUGHLIN JOHN DAVID , BROWNING SHAWN ROBERT
IPC分类号： A61K38/00
CPC分类号： A61M1/34 , A61K9/0014 , A61K35/16 , A61K35/19 , A61K35/28 , A61K38/1722 , A61K38/1841 , A61K38/19 , A61K38/191 , A61K38/4886 , A61K38/55 , A61L15/32 , A61L15/44 , A61L2300/252 , A61L2300/434 , A61M1/341 , A61M2205/3334 , B01D61/18 , B01D69/02 , B01D69/08 , B01D2313/10 , B01D2313/24 , B01D2317/02 , B01D2317/08 , B01D2325/02 , C07K14/4717 , C07K14/8107 , C12Y304/24 , C12Y304/24023 , C12Y304/24065 , C12Y304/24082 , A61K2300/00
摘要： Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.
摘要翻译：提供了用于从全血和/或重组A2M纯化和浓缩自体α-2巨球蛋白（A2M）的系统和方法。还提供了用A2M治疗伤口的方法。除了与外源性药物或载体的组合之外，还提供了与其他治疗（例如血小板和其他生长因子）组合使用A2M的方法。还提供了生产重组A2M野生型或其变体的方法，其中诱饵区被修饰以增强A2M的抑制特性和/或延长用于治疗伤口的蛋白质的半衰期。

3. 发明申请

WO2013014485A1 A2M FRAGMENTS AND APPLICATIONS THEREOF 审中-公开
标题翻译： A2M的片段及其应用
公开(公告)号：WO2013014485A1
公开(公告)日：2013-01-31
申请号：PCT/IB2011/002066
申请日：2011-07-27
申请人： BIO-RAD INNOVATIONS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BATXELLI, Isabelle, Catherine , WATELET, Bénédicte
发明人： BATXELLI, Isabelle, Catherine , WATELET, Bénédicte
IPC分类号： G01N33/576
CPC分类号： C07K14/4717 , C07K7/06 , C07K7/08 , C07K16/18 , G01N33/5767 , G01N2800/085
摘要： The application relates to a polypeptide, the amino acid sequence of which is the sequence of a sub-fragment of the C-terminal thioester-cleaved fragment of human alpha-2-macroglobulin (A2M), wherein the molecular weight of said polypeptide is of 36 to 44 kDa, and wherein the first N-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human A2M, is at a position 1,098 or 1,085 or 1,084 or 1,083, and the last C-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human A2M, is one of the last twenty C-terminal amino acids. This polypeptide is differently abundant depending on the stage of liver fibrosis. The application also relates to means deriving therefrom and to the application thereof, notably in the field of hepatitis.
摘要翻译：本申请涉及多肽，其氨基酸序列是人α-2-巨球蛋白（A2M）的C-末端硫酯切割的片段的亚片段的序列，其中所述多肽的分子量为 36至44kDa，并且其中所述多肽的第一N-末端氨基酸是氨基酸，其在所述人A2M的全长序列中位于1,098或1,085或1,084或1,083的位置，最后的C 所述多肽的末端氨基酸是氨基酸，其在所述人A2M的全长序列中是最后20个C末端氨基酸之一。这种多肽根据肝纤维化的阶段而不同。本申请还涉及从其衍生的方法及其应用，特别是在肝炎领域。

4. 发明申请

WO2012135981A1 利用锌指核酸酶敲除牛β-乳球蛋白基因的方法审中-公开
公开(公告)号：WO2012135981A1
公开(公告)日：2012-10-11
申请号：PCT/CN2011/000689
申请日：2011-04-20
申请人：北京济福霖生物技术有限公司 , 于胜利 , 罗俊杰 , 丁方荣 , 李松 , 汤波 , 李宁
发明人：于胜利 , 罗俊杰 , 丁方荣 , 李松 , 汤波 , 李宁
IPC分类号： C12N15/85 , C12N15/87 , C12N15/16 , A01K67/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/101 , C07K14/4717 , C12N9/22 , C12N15/8509

5. 发明申请

WO2012075570A1 BIOACTIVE PEPTIDES AND PROTEINS CONTAINING BIOACTIVE PEPTIDES, THEIR USES AND PROCESSES FOR MAKING THE SAME 审中-公开
标题翻译：含有生物活性肽的生物活性肽和蛋白质，其使用及其制备方法
公开(公告)号：WO2012075570A1
公开(公告)日：2012-06-14
申请号：PCT/CA2011/001346
申请日：2011-12-08
申请人： MCGILL UNIVERSITY , ISMAIL, Ashraf A. , GOMAA, Ahmed I. , SEDMAN, Jacqueline
发明人： ISMAIL, Ashraf A. , GOMAA, Ahmed I. , SEDMAN, Jacqueline
IPC分类号： C12P21/06 , A23C9/127 , A23J1/00 , A23L1/30 , A61K38/08 , A61P9/12 , C07K1/00 , C07K7/06 , C07K7/08
CPC分类号： C07K14/47 , A23J3/08 , A23J3/16 , A23L5/34 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/556 , C07K1/12 , C07K14/415 , C07K14/4717 , C12P21/06 , C12Y304/00 , A23V2200/322 , A23V2200/326 , A23V2250/54242 , A23V2250/54244 , A23V2250/5488
摘要： A process for treating a protein before hydrolytic digestion, the process comprising exposing the protein to at least one cycle of microwave irradiation to produce a microwave treated protein containing one or more bioactive peptides. Further hydrolyzing the microwave treated protein to release at least one of the one or more bioactive peptides. A pharmaceutical composition, supplement and food product including the microwave treated protein or the one or more released bioactive peptides.
摘要翻译：一种在水解消化之前处理蛋白质的方法，该方法包括将蛋白质暴露于至少一个微波照射循环，以产生含有一种或多种生物活性肽的微波处理的蛋白质。进一步水解微波处理的蛋白质以释放一种或多种生物活性肽中的至少一种。药物组合物，补充剂和食品，包括微波处理的蛋白质或一种或多种释放的生物活性肽。

6. 发明申请

WO2004011676A3 MULTI-REPORTER GENE MODEL FOR TOXICOLOGICAL SCREENING 审中-公开
标题翻译：多媒体基因组毒理学筛选模型
公开(公告)号：WO2004011676A3
公开(公告)日：2004-05-06
申请号：PCT/GB0303192
申请日：2003-07-25
申请人： ROSLIN INST EDINBURGH , CXR BIOSCIENCES LTD , WHITELAW CHRISTOPHER BRUCE ALE , CLARK ANTHONY JOHN , WOLF CHARLES ROLAND
发明人： WHITELAW CHRISTOPHER BRUCE ALE , CLARK ANTHONY JOHN , WOLF CHARLES ROLAND
IPC分类号： A01K67/027 , C07K14/47 , C12N15/62 , C12N15/85 , G01N33/50 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/0393 , C07K14/4717 , C07K2319/00 , C07K2319/23 , C07K2319/41 , C07K2319/61 , C12N15/62 , C12N2800/30 , G01N33/5014 , G01N2500/10
摘要： A system for the detection of gene activation events is provided which comprises a nucleic acid construct encoding a protein of the lipocalin protein family and a peptide tag in which the expression of the construct in a cell or in the cells of a transgenic animal demonstrates the activation of a gene or genes of interest, in which the protein expressed is secreted from the cell and in which detection of the peptide tag indicates expression of the construct.
摘要翻译：提供了用于检测基因激活事件的系统，其包含编码脂质运载蛋白家族蛋白质的核酸构建体和肽标签，其中构建体在细胞中或转基因动物细胞中的表达表现出激活其中表达的蛋白质从细胞分泌并且其中肽标签的检测指示构建体的表达。

7. 发明申请

WO01044299A2 ANTIBODIES AND A METHOD FOR PRODUCING SAME, THE USE THEREOF AND IMMUNISATION COCKTAILS, IMMUNOASSAY-SETS AND PEPTIDES 审中-公开
标题翻译：抗体及其生产使用和免疫鸡尾酒，免疫测定SETS和肽的方法
公开(公告)号：WO01044299A2
公开(公告)日：2001-06-21
申请号：PCT/EP2000/012798
申请日：2000-12-15
IPC分类号： C07K14/47 , C07K16/00 , C07K16/18 , C12P21/08
CPC分类号： C07K16/18 , C07K14/4717 , C07K16/00
摘要： The present invention relates to a method for producing protein-specific antibodies and to protein-specific antibodies that can be obtained therewith, i.e. polyclonal, cross-reactive antiserums having a specificity for haptoglobin of at least two working and domestic animal species. The invention also relates to the use thereof for detecting haptoglobin in samples of working and domestic animals. The invention further relates to corresponding immunisation cocktails, peptides which are useful for producing antiserums and immunoassay sets which are based upon the antiserums. Protein and protein fragments are used for immunisation.
摘要翻译：本发明涉及一种用于蛋白特异性抗体，与其获得蛋白特异性抗体，多克隆抗体，交叉反应具有特异性的用于从至少两个家畜和宠物的物种触珠蛋白的抗血清，和他们的牲畜和伴侣动物的样品中对触珠蛋白测定使用的制备方法。此外，本发明的相应免疫鸡尾酒，肽，其是用于制备抗血清，以及免疫测定试剂盒，其基于所述抗血清涉及有用的。免疫蛋白质和使用蛋白质片段。

8. 发明申请

WO1996000237A1 FILTRATION 审中-公开
标题翻译：过滤
公开(公告)号：WO1996000237A1
公开(公告)日：1996-01-04
申请号：PCT/SE1995000777
申请日：1995-06-22
申请人： PHARMACIA AB , WINGE, Stefan
发明人： PHARMACIA AB
IPC分类号： C07K01/34
CPC分类号： C12N9/644 , C07K1/34 , C07K14/4717 , C07K14/755 , C07K14/76 , C07K14/8128 , C12Y304/21022
摘要： The present invention relates to a method of virus-filtering a solution that contains at least one macromolecule, by virtue of the total salt content of the solution lying in the range of from about 0.2 M up to saturation of the solution with the salt concerned. The inventive method reduces the residence time and the extent to which the solution need to be diluted, and optimizes the yield when virus-filtering primarily proteins, polysaccharides and polypeptides. The reduction in virus content is at least as good as with conventional techniques where the total salt content is low. The present invention facilitates virus filtration with the aid of the so-called "dead-end" technique, which affords several process and economic advantages in comparison with the tangential virus-filtering technique normally used. When virus-filtering the plasma protein factor IX, the yield obtained in the virus-filtering stage is increased from about 70 % to above 95 %, by raising the salt content of the solution in accordance with the present invention.
摘要翻译：本发明涉及一种通过溶液的总盐含量在约0.2M至相对于所述盐的溶液饱和度范围内的方法来对包含至少一个大分子的溶液进行病毒过滤。本发明的方法减少了停留时间以及溶液需要稀释的程度，并且在病毒主要过滤蛋白质，多糖和多肽时优化产率。病毒含量的降低至少与总盐含量低的常规技术一样好。本发明借助于所谓的“死端”技术便于病毒过滤，与通常使用的切向病毒过滤技术相比，其提供了几个过程和经济优点。当对血浆蛋白因子IX进行病毒过滤时，通过提高根据本发明的溶液的盐含量，病毒过滤阶段中获得的产量从约70％提高到95％以上。

9. 发明申请

WO1992011358A1 INCREASED EXPRESSION BY A SECOND TRANSFERRED SEQUENCE IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：通过转基因有序转录序列增加表达
公开(公告)号：WO1992011358A1
公开(公告)日：1992-07-09
申请号：PCT/GB1991002318
申请日：1991-12-24
申请人： THE AGRICULTURAL AND FOOD RESEARCH COUNCIL , CLARK, Anthony, John
发明人： THE AGRICULTURAL AND FOOD RESEARCH COUNCIL
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A61K38/00 , C07K14/4717 , C07K14/745 , C07K14/76 , C07K14/8125 , C12N9/6464 , C12N15/8216 , C12N15/85 , C12N2830/008 , C12N2830/85 , C12Y304/21069
摘要： Transgenic animals and plants capable of expressing a desired protein can be prepared by co-introducing into an egg or embryo cell of an animal, or into suitable recipient cells of a plant, a first sequence, which encodes the desired protein, and a second, more efficiently expressed, DNA sequence. Expression efficiency is thereby conferred on the first sequence, leading to improved yield or targeting, or both. Co-introduction may be achieved by co-injecting a mixture of the two DNA sequences into a fertilised egg, in the case of an animal. The invention can be used to enhance the efficiency of expression of desired proteins, such as those having pharmaceutical activity in the mammary gland of a female transgenic animal.
摘要翻译：能够表达所需蛋白质的转基因动物和植物可以通过共同引入到动物的卵或胚胎细胞中，或者合成植物的合适的受体细胞，编码所需蛋白质的第一序列，更有效地表达DNA序列。因此，表达效率被赋予第一序列，导致提高的产量或靶向，或两者。在动物的情况下，可以通过将两个DNA序列的混合物共注入受精卵来实现共引入。本发明可用于增强所需蛋白质（例如在雌性转基因动物的乳腺中具有药物活性的蛋白质）的表达效率。

10. 发明申请

WO2016029193A9 COMPOSITIONS COMPRISING A CASEIN AND METHODS OF PRODUCING THE SAME 审中-公开
标题翻译：包含酪蛋白的组合物及其制备方法
公开(公告)号：WO2016029193A9
公开(公告)日：2017-06-15
申请号：PCT/US2015046428
申请日：2015-08-21
申请人： PERFECT DAY INC
发明人： PANDYA RYAN , GANDHI PERUMAL , JI SHAOWEN , BEAUCHAMP DEREK , HOM LOUIS
IPC分类号： A23J3/10
CPC分类号： A23C19/053 , A23C9/123 , A23C9/1307 , A23C9/1315 , A23C9/1512 , A23C11/04 , A23C11/08 , A23C15/12 , A23C19/055 , A23J3/10 , A23L9/22 , A23V2002/00 , C07K14/00 , C07K14/4717 , C07K14/4732 , C07K14/76 , A23V2200/264 , A23V2250/54246
摘要： Disclosed herein are methods and compositions including casein, and methods for making these compositions.
摘要翻译：本文公开了包含酪蛋白的方法和组合物，以及制备这些组合物的方法。

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