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1. 发明申请

WO2019142006A1 A SENSOR FOR MEASURING A FLOW OF A FLUID 审中-公开
公开(公告)号：WO2019142006A1
公开(公告)日：2019-07-25
申请号：PCT/GB2019/050163
申请日：2019-01-22
申请人： UCL BUSINESS PLC
发明人： DESJARDINS, Adrien , FINLAY, Malcolm , PAPAKONSTANTINOU, Ioannis , MOSSE, Charles Alexander , COOTE, Joanne , NOIMARK, Sacha , ALLES, Erwin
IPC分类号： G01F1/688 , A61B5/0215 , A61B5/01
CPC分类号： A61B5/0215 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/01 , A61B5/021 , A61B5/02154 , A61B5/026 , A61B5/0261 , A61B5/028 , A61B5/061 , A61B5/14503 , A61B5/14546 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/205 , A61B5/208 , A61B5/6852 , A61B5/7228 , A61B5/7285 , A61B8/0841 , G01F1/661 , G01F1/662 , G01F1/6845 , G01F1/688 , G01F1/6884 , G01K11/3206 , G01L9/0079 , G01L19/04 , G01L19/149
摘要： A sensor is provided for measuring a flow of a fluid in a physiological environment, such as within a vessel of a human or animal subject. The sensor comprises an interrogation light guide extending from a proximal end to a distal end of the sensor. The interrogation light guide is configured to transmit interrogation light to, and receive reflected interrogation light from, the distal end of the sensor. The sensor further comprises an excitation light guide configured to transmit excitation light to the distal end of the sensor. The excitation light is provided for heating the fluid (directly or indirectly). The sensor further comprises a sensing element located at the distal end of the sensor. The sensing element comprises at least two etalons for reflecting interrogation light back along the interrogation light guide towards the proximal end of the sensor. Each etalon has a respective optical path length and further has at least one reflective surface external to the interrogation light guide. The sensing element is configured to be in thermal contact with the fluid such that the optical path length of at least one etalon is dependent on a temperature of the fluid. The reflected interrogation light forms an interferogram which is dependent on the optical path lengths of the respective etalons.

2. 发明申请

WO2019141869A1 OPTICAL RESPONSE MEASUREMENT FROM SKIN AND TISSUE USING SPECTROSCOPY. 审中-公开
公开(公告)号：WO2019141869A1
公开(公告)日：2019-07-25
申请号：PCT/EP2019/051494
申请日：2019-01-22
申请人： SPECTRICITY
发明人： BORREMANS, Jonathan , AGRAWAL, Prashant
IPC分类号： A61B5/00 , A61B5/024 , A61B5/1455
CPC分类号： A61B5/681 , A61B5/0002 , A61B5/0075 , A61B5/02405 , A61B5/02427 , A61B5/02438 , A61B5/14552 , A61B5/44
摘要： A device for measuring optical response from skin includes one or more illumination sources configured to irradiate light directly onto skin or tissue, where each illumination source is configured to provide light within a predetermined range of optical wavelengths. The device further includes one or more spectrometers, each including a plurality of interference filters overlaying one or more optical sensors, where each of spectrometers has a sensing range within a predetermined range of optical wavelengths and is configured to capture light emitted from the skin or tissue. Each of the one or more spectrometers included of the device is positioned a predetermined distance from at least one illumination source of the one or more illumination sources.

3. 发明申请

WO2019089655A1 SYSTEM FOR DISPLAYING OXYGEN STATE INDICATIONS 审中-公开
公开(公告)号：WO2019089655A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058294
申请日：2018-10-30
申请人： MASIMO CORPORATION
发明人： CHANDRAN, Prashanth Rengaswamy , SAMPATH, Anand , INDORF, Keith Ward , FREY, Sebastian T. , MUHSIN, Bilal
IPC分类号： A61B5/1455
CPC分类号： A61B5/7445 , A61B5/0082 , A61B5/14551 , A61B5/14552 , A61B5/6826 , A61B5/7435 , A61B5/746 , A61M2205/3306 , A61M2230/205
摘要： A patient monitoring system can have a display screen or potion thereof with graphic user interface for displaying indications of a patient's oxygen state. The indications can include the patient's SpO 2 , dissolved oxygen index, and/or an increasing or decreasing trend of dissolved oxygen index. The displays of oxygen state indications can be compact, and/or able to provide direct visual information to a user of various aspects of the patient's oxygen state. The display elements can be used to represent any other physiological parameters.

4. 发明申请

WO2019086364A1 DEVICE, SYSTEM AND METHOD FOR DETERMINING AT LEAST ONE VITAL SIGN OF A SUBJECT 审中-公开
公开(公告)号：WO2019086364A1
公开(公告)日：2019-05-09
申请号：PCT/EP2018/079525
申请日：2018-10-29
申请人： KONINKLIJKE PHILIPS N.V.
发明人： DE HAAN, Gerard
IPC分类号： A61B5/00 , A61B5/024 , A61B5/1455
CPC分类号： A61B5/02416 , A61B5/14552 , A61B5/7207 , A61B5/7221
摘要： The present invention relates to a device, system and method for determining at least one vital sign of a subject. The device (130) comprises an input interface (131) configured to obtain at least three detection signals (210) derived from detected electromagnetic radiation transmitted through or reflected from a skin region of a subject, wherein each detection signal comprises wavelength-dependent reflection or transmission information in a different wavelength channel, a vital sign extraction unit (132) configured to extract multiple candidate vital signs (232) of the same type of vital sign from said at least three detection signals, wherein each candidate vital sign is extracted from a different detection signal or a different combination of at least two detection signals, a vital sign determination unit (133) configured to determine a final vital sign (233) from said multiple candidate vital signs, and a reliability information unit (134) configured to provide reliability information (234a) indicating the reliability of said final vital sign and/or one or more of said candidate vital signs and to provide unreliability source information (234b) indicating the source of unreliability of said final vital sign and/or one or more of said candidate vital signs.

5. 发明申请

WO2019005577A1 PHYSIOLOGICAL MONITORING AND RELATED METHODS 审中-公开
公开(公告)号：WO2019005577A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/038764
申请日：2018-06-21
申请人： WELCH ALLYN, INC.
发明人： QUINN, David E.
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/7278 , A61B5/02125 , A61B5/02444 , A61B5/14552
摘要： A method of estimating oxygen saturation includes illuminating a target site with light of three different wavelengths, for example green, red and infrared, and detecting light returned from the site at each of the wavelengths. The method distinguishes between cardiac pulsatility and nonpulsatility based on a parameter of the return light of the shortest wavelength. The method formulates an estimate of oxygen saturation as a function of a parameter of the light of the two longer wavelengths taken at both a period of pulsatility and at a period of nonpulsatility. An oximeter adapted to carry out the method is also disclosed. Aspects of the method and oximeter may be used to estimate other physiological parameters.

6. 发明申请

WO2018194992A1 NOSE SENSOR 审中-公开
公开(公告)号：WO2018194992A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/027833
申请日：2018-04-16
申请人： MASIMO CORPORATION
发明人： SHREIM, Samir , SHARMA, Vikrant , PEREA, Philip , RINES, Jennifer , ROBINS, Clinton , EICHELE, Chad , ABDUL-HAFIZ, Yassir, Kamel , DEVLIN, Sean
IPC分类号： A61B5/00 , A61B5/145 , A61B5/083 , A61B5/087 , A61B5/1455 , A61M16/00
CPC分类号： A61B5/6819 , A61B5/0015 , A61B5/0205 , A61B5/02438 , A61B5/14552
摘要： A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a detector. The detector is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the detector. The nose sensor can include an inner prong and an outer prong to assist the nose sensor in securing to a patient's nose. The detector can be coupled to an inner post of the inner prong and can be configured to secure to an interior or exterior portion of the patient's nose.

7. 发明申请

WO2017127669A1 METHOD, SYSTEM AND APPARATUS FOR MEASURING MULTIPLE SIGNALS IN A BODY 审中-公开
标题翻译：用于测量身体中的多个信号的方法，系统和设备
公开(公告)号：WO2017127669A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014319
申请日：2017-01-20
申请人： MICROCHIP TECHNOLOGY INCORPORATED
发明人： BARTLING, D. Ryan
IPC分类号： A61B5/024 , A61B5/1455 , A61B5/00 , H04B10/116
CPC分类号： A61B5/02427 , A61B5/02416 , A61B5/02433 , A61B5/14551 , A61B5/14552 , A61B5/7203 , A61B5/7225 , A61B5/7228 , A61B5/7246 , A61B5/725 , A61B2560/0252 , A61B2562/0233 , G01J1/08 , G01J1/44 , G01J2001/4413 , G01J2001/444 , H04B10/116
摘要： A pulse oximetry measurement system uses a pseudo-random noise generator to stimulate one or more light emitting diodes (LEDs). The light amplitudes from these LEDs, after passing through a part of a body, are detected by a phototransistor or photodiode and digitized with an analog-to-digital converter (ADC). The digitized ADC light amplitude values are re-correlated with the outgoing pseudo-random noise stimulus. Spread spectrum techniques are known for their noise mitigation properties, and ability to pass multiple signals through the same medium without interference. Thus, these measurements can be performed substantially simultaneously with minimal interference from each other. The pulse oximetry measurement system correlates the measured light intensities using pseudo-random noise generation and phase division multiplexing, and computes the measured and correlated peak- to-peak detected light amplitudes to obtain a ratio between these light amplitudes for determining oxygen saturation in the blood, and may also be used for heart rate monitoring.
摘要翻译：脉搏血氧饱和度测量系统使用伪随机噪声发生器来刺激一个或多个发光二极管（LED）。来自这些LED的光振幅在穿过身体的一部分之后，被光电晶体管或光电二极管检测到，并通过模数转换器（ADC）进行数字化。数字化的ADC光振幅值与输出的伪随机噪声刺激重新相关。扩频技术因其噪声抑制特性而闻名，并且能够在不受干扰的情况下通过同一介质传送多个信号。因此，这些测量可以在彼此的干扰最小的情况下基本上同时进行。脉搏血氧饱和度测量系统使用伪随机噪声生成和相位分割多路复用来关联测量的光强度，并且计算测量的和相关的峰值到峰值检测光振幅以获得这些光振幅之间的比率以确定血液中的氧饱和度，也可用于心率监测。

8. 发明申请

WO2017124069A1 SHIELDED, FOLDED CONNECTOR FOR A SENSOR 审中-公开
标题翻译：用于传感器的屏蔽折叠式连接器
公开(公告)号：WO2017124069A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013654
申请日：2017-01-16
申请人： CAS MEDICAL SYSTEMS, INC.
发明人： DALENE, Matthew
IPC分类号： A61B5/1455 , H05K1/02
CPC分类号： A61B5/14552 , A61B2562/12 , A61B2562/222 , A61B2562/227 , H01R12/77 , H01R13/658 , H01R13/665 , H01R13/70 , H05K1/0216 , H05K1/0219 , H05K1/0274 , H05K1/028 , H05K2201/056 , H05K2201/0723 , H05K2201/09727
摘要： An oximetry sensor assembly connector, and a method for making the same, is provided that includes a flexible circuit and a stiffener panel. The flexible circuit has a plurality of layers including at least one electrical trace layer and at least one electromagnetic interference (EMI) shield layer. The stiffener panel has a first side surface and a second side surface, which second side surface is opposite the first side surface. The flexible circuit includes a first segment and a second segment, and one or more of the plurality of layers are disposed within the first segment and the second segment. The flexible circuit is folded such that the first segment is contiguous with the first side surface of the stiffener panel, and the second segment is contiguous with the second side surface of the stiffener panel
摘要翻译：提供了一种血氧饱和度传感器组件连接器及其制造方法，其包括柔性电路和加强板。柔性电路具有包括至少一个电迹线层和至少一个电磁干扰（EMI）屏蔽层的多个层。加强板具有第一侧表面和第二侧表面，该第二侧表面与第一侧表面相对。柔性电路包括第一部分和第二部分，并且多个层中的一个或多个布置在第一部分和第二部分内。柔性电路被折叠，使得第一部分与加强板的第一侧表面邻接，并且第二部分与加强板的第二侧表面邻接，

9. 发明申请

WO2017123764A1 PERIPHERAL FIBEROPTIC INTRAVASCULAR BLOOD METRIC PROBE MODULAR DEVICE AND METHOD 审中-公开
标题翻译：外周血管血管内血液计量探针模块装置及方法
公开(公告)号：WO2017123764A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013199
申请日：2017-01-12
申请人： BLOODWORKS, LLC
发明人： ANDERSON, Robert J.
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0215 , A61B5/14539 , A61B5/14552 , A61B5/14556 , A61B2562/0233 , A61B2562/223 , A61M25/003 , A61M39/105 , A61M2025/0004
摘要： The invention is a device and method for measuring, inter alia, blood oxygenation, arterial/venous blood gas, and/or hemoglobin values in an already-inserted arterial or venous catheter in a patient. It allows the measurement of a meaningful and commonly understood metrics of blood oxygenation and gas exchange in hypo-perfused patients while avoiding the additional discomfort and risk of infection posed by inserting a standalone device with its own catheter. Analogous uses of the apparatus for other measurements is possible.
摘要翻译：
本发明是用于测量，除其他外，血氧，动脉/静脉的血液气体，和/或血红蛋白的值在患者中的已插入动脉或静脉导管的设备和方法。它允许测量低灌注患者血氧和气体交换的有意义和通常理解的指标，同时避免由于使用自己的导管插入独立装置而造成的额外不适和感染风险。该设备可用于其他测量的类似用途。

10. 发明申请

WO2017100685A1 METHODS AND APPARATUS FOR MEASURING BLOOD OXYGENATION OF TISSUE 审中-公开
标题翻译：用于测量组织血液氧化的方法和设备
公开(公告)号：WO2017100685A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065990
申请日：2016-12-09
申请人： BIOXYTECH RETINA, INC.
发明人： BASIRI, Ali
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/7257 , A61B5/14552 , A61B5/14555
摘要： An apparatus and method of measuring oxygenation of tissue in a non-invasive manner are provided. The apparatus comprises a light source configured to emit a light pattern to be projected onto the tissue, in which the light pattern comprises superimposed patterns having different patterns. A detector captures an image of a reflected light pattern which is reflected from the tissue as a result of the projected light pattern. A processor coupled to the detector can be configured to perform a transform on the image of the reflected light pattern and determine oxygenation of each of a plurality of layers of the tissue in response to the transform of the image. Polarimetry can be used in determining a change in polarization angle of light beam. Tissue oxygenation can be determined at a plurality of layers from one snapshot, for example oxygenation of retinal layers.
摘要翻译：提供了一种以非侵入方式测量组织氧合的装置和方法。该装置包括光源，该光源配置成发射待投影到组织上的光图案，其中光图案包括具有不同图案的叠加图案。作为投影光图案的结果，检测器捕获从组织反射的反射光图案的图像。耦合到检测器的处理器可以被配置为对反射光图案的图像执行变换并且响应于图像的变换来确定组织的多个层中的每个层的充氧。偏振测定可用于确定光束偏振角的变化。组织氧合可以在一次快照的多个层处确定，例如视网膜层的氧合。

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