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1. 发明申请

WO2019110553A1 A PORTABLE DEVICE AND A SYSTEM FOR MONITORING VITAL SIGNS OF A PERSON 审中-公开
公开(公告)号：WO2019110553A1
公开(公告)日：2019-06-13
申请号：PCT/EP2018/083422
申请日：2018-12-04
申请人： IMEC VZW , KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： TORFS, Tom , BUNTINX, Frank , VAN HOOF, Christiaan , VAES, Bert
IPC分类号： A61B5/0205 , A61B5/024 , A61B5/0402 , A61B5/026 , A61B5/00 , A61B5/021 , A61B5/0404 , A61B5/01
CPC分类号： A61B5/0205 , A61B5/01 , A61B5/02125 , A61B5/02427 , A61B5/0261 , A61B5/0402 , A61B5/0404 , A61B5/6826 , A61B5/6828 , A61B2560/0462 , A61B2560/0468
摘要： A portable device for monitoring vital signs of a person, said device (102) comprising: a first wearable sensor unit (110) comprising a first electrode (114) arranged to be electrically coupled to a first limb; a second wearable sensor unit (120) comprising a second electrode (124) arranged to be electrically coupled to a second limb; wherein the first wearable sensor unit (110) and the second wearable sensor unit (120) are wiredly connected for allowing an electrocardiogram, ECG, of the person to be acquired; and wherein at least one of the first and the second wearable sensor unit (110; 120) further comprises an oximetry sensor (116; 126) arranged on the carrier (112; 122), said oximetry sensor (116; 126) including a light source (116a; 126a) for transmitting light towards the limb and a detector (116b; 126b) for detecting light being transmitted through or reflected by the limb.

2. 发明申请

WO2019010348A1 A MINIATURE MICROSCOPE FOR MULTI-CONTRAST OPTICAL IMAGING IN ANIMALS 审中-公开
公开(公告)号：WO2019010348A1
公开(公告)日：2019-01-10
申请号：PCT/US2018/040979
申请日：2018-07-06
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： PATHAK, Arvind , THAKOR, Nitish , SENARATHNA, Janaka , YU, Hang
IPC分类号： G02B21/14 , A61B5/00
CPC分类号： A61B1/00 , A61B5/0042 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0261 , A61B5/1455 , A61B5/489 , G02B21/0008 , G02B21/082 , G02B21/16
摘要： An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the present invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic/electrical/chemical stimulations, drug delivery, microdialysis, accompanied by electrical signal recording, wireless image transmission and charging.

3. 发明申请

WO2018072175A1 APPARATUS AND METHOD FOR DETERMINING A BLOOD PRESSURE OF A SUBJECT 审中-公开
标题翻译：用于确定受试者的血压的装置和方法
公开(公告)号：WO2018072175A1
公开(公告)日：2018-04-26
申请号：PCT/CN2016/102712
申请日：2016-10-20
申请人： BOE TECHNOLOGY GROUP CO., LTD.
发明人： LI, Hui
IPC分类号： A61B5/021
CPC分类号： A61B5/02125 , A61B5/02225 , A61B5/02416 , A61B5/0261 , A61B5/0295 , A61B5/0452 , A61B5/0456 , A61B5/1112 , A61B5/6824 , A61B5/6828 , A61B5/7257 , A61B5/7278 , A61B5/746 , A61B2560/0214 , A61B2560/0223 , A61B2562/043
摘要： An apparatus for determining a blood pressure of a subject is disclosed, the apparatus includes a sensor assembly (110) configured to measure a pulse wave signal (101a) of the subject; and a signal processor (100) configured to generate a metric of the pulse wave signal (101a) based on the pulse wave signal (101a), to select a blood pressure calculation algorithm base on the metric of the pulse wave signal (101a), and to determine the blood pressure of the subject using the blood pressure calculation algorithm.
摘要翻译：公开了一种用于确定对象的血压的设备，该设备包括：传感器组件（110），其被配置为测量对象的脉搏波信号（101a）和信号处理器（100），被配置为基于脉波信号（101a）生成脉波信号（101a）的度量，基于脉波信号（101a）的度量来选择血压计算算法，并使用血压计算算法确定受试者的血压。

4. 发明申请

WO2017173351A1 VASCULAR MONITORING SYSTEM 审中-公开
标题翻译：血管监测系统
公开(公告)号：WO2017173351A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025522
申请日：2017-03-31
申请人： DESIGNPLEX BIOMEDICAL, LLC
发明人： BENKOWSKI, Robert , MORELLO, Gino , SUKAVANESHVAR, Sivaprasad
IPC分类号： A61B5/02 , A61B5/00 , A61B5/026
CPC分类号： A61B5/02007 , A61B5/0031 , A61B5/0084 , A61B5/0086 , A61B5/0261 , A61B5/6852 , A61B5/686 , A61B2560/0204
摘要： A vascular sensor system includes a vascular sensor configured to monitor a blood vessel parameter and to output a signal representative of the measured parameter. A computing system is configured to receive the signal representative of the measured parameter. The computing system is programmed to process the received signal and evaluate a medical condition based on the processed signal.
摘要翻译：血管传感器系统包括血管传感器，血管传感器被配置成监测血管参数并输出代表测量参数的信号。计算系统被配置为接收代表测量参数的信号。计算系统被编程为处理接收到的信号并基于处理后的信号评估医疗状况。

5. 发明申请

WO2017144524A1 VORRICHTUNG UND VERFAHREN ZUR ERMITTLUNG DES HERZZEITVOLUMENINDEX EINER TESTPERSON 审中-公开
标题翻译：用于确定测试人员的心脏时间体积指数的装置和方法
公开(公告)号：WO2017144524A1
公开(公告)日：2017-08-31
申请号：PCT/EP2017/054044
申请日：2017-02-22
申请人： HUBER, Wolfgang
发明人： HUBER, Wolfgang
IPC分类号： A61B5/01 , A61B5/00 , A61B5/026 , A61B5/029 , A61B5/02 , A61B5/021 , A61B5/145 , A61B5/0452 , G06F19/00
CPC分类号： A61B5/01 , A61B5/0059 , A61B5/02 , A61B5/021 , A61B5/0261 , A61B5/029 , A61B5/0452 , A61B5/14535 , A61B5/14542 , A61B5/4866 , A61B5/7267 , A61B5/7275 , A61B2562/0271 , G16H50/30
摘要： Es wird eine Vorrichtung und ein Verfahren zur Ermittlung des Herzzeitvolumenindex einer Testperson bereitgestellt. Die Vorrichtung umfasst eine Auswerteeinheit, wobei die Auswerteeinheit umfasst: einen Dateneingang, der zum Empfang einer Körperoberflächentemperatur der Testperson eingerichtet ist, eine Recheneinheit, die den Herzzeitvolumenindex der Testperson durch Korrelation der empfangenen Körperoberflächentemperatur mit einer Referenzkörperoberflächentemperatur und einem Referenzherzzeitvolumenindex berechnet, wobei die Referenzkörperoberflächentemperatur und der Referenzherzzeitvolumenindex aus einer Messreihe entnommen sind, in der Körperoberflächentemperaturen einer Reihe von Personen in Abhängigkeit von deren jeweiligen dazugehörigen Herzzeitvolumenindizes erfasst sind, und einen Datenausgang, der den berechneten Herzzeitvolumenindex der Testperson bereitstellt. Das Verfahren umfasst die folgenden Schritte: Empfangen einer Körperoberflächentemperatur der Testperson an einem Dateneingang einer Auswerteeinheit, Berechnen des Herzzeitvolumenindex der Testperson durch eine Recheneinheit der Auswerteeinheit, indem die empfangene Körperoberflächentemperatur mit einer Referenzkörperoberflächentemperatur und einem Referenzherzzeitvolumenindex korreliert wird, wobei die Referenzkörperoberflächentemperatur und der Referenzherzzeitvolumenindex aus einer Messreihe entnommen werden, in der Körperoberflächentemperaturen einer Reihe von Personen in Abhängigkeit von deren jeweiligen dazugehörigen Herzzeitvolumenindizes erfasst sind, und Bereitstellen des berechneten Herzzeitvolumenindex der Testperson an einem Datenausgang der Auswerteeinheit.
摘要翻译：提供了用于确定受试者的心输出量指数的设备和方法。该装置包括：分析单元，其中，所述评估单元包括：数据输入端和用于接收A K ouml; rperoberfl BEAR适于受试者，计算单元包括由接收到的K＆ouml相关受试者的心脏指数的chentemperatur; rperoberfl BEAR chentemperatur与Referenzk＆OUML; rperoberfl＆AUML 计算chentemperatur和参考心输出量指数，其中所述Referenzk＆oUML; rperoberfl BEAR chentemperatur和参考心脏输出索引是从一系列测量所采取，在K＆ouml; rperoberfl BEAR chentemperaturen一些依赖BEAR者被检测元心输出量指数，和一个;在它们各自的dazugeh＆oUML依赖数据输出提供了受试者的计算心输出量指数。测试者在评估单元的数据输入的chentemperatur，由所接收的K＆ouml ;;接收计算所述对象的心指数由评估单元的计算单元中的K＆ouml; rperoberfl＆AUML rperoberfl BEAR chentemperatur与Referenzk＆OUML;一个chentemperatur和; rperoberfl＆AUML：该方法包括以下步骤是相关的参考心脏指数，其中所述Referenzk＆oUML; rperoberfl BEAR chentemperatur和参考心脏输出索引是从一系列测量所采取，在K＆ouml; rperoberfl BEAR chentemperaturen许多其各自的dazugeh＆oUML依赖BEAR依赖人;元中检测到的心输出量指数，以及提供所述计算出的心输出量指数测试人员在评估单元的数据输出处。

6. 发明申请

WO2017142980A1 SYSTEMS AND METHODS FOR OBTAINING CARDIOVASCULAR PARAMETERS 审中-公开
标题翻译：用于获得心血管参数的系统和方法
公开(公告)号：WO2017142980A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018036
申请日：2017-02-16
申请人： ECOM MEDICAL, INC.
发明人： LOWERY, Guy Russell
IPC分类号： A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/0295 , A61B5/053 , A61B5/1455
CPC分类号： A61B5/6853 , A61B5/0205 , A61B5/02427 , A61B5/0261 , A61B5/029 , A61B5/0295 , A61B5/042 , A61B5/08 , A61B5/14552 , A61B5/1459 , A61B5/4839 , A61B5/6886 , A61B5/7225 , A61B2562/0209 , A61B2562/0233 , A61B2562/06 , A61J15/00 , A61J15/0084 , A61M16/0069 , A61M16/021 , A61M16/0409 , A61M16/0434 , A61M16/044 , A61M16/0447 , A61M16/0461 , A61M2202/0208 , A61M2205/0266 , A61M2205/3303 , A61M2205/3306 , A61M2205/3317 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/50 , A61M2230/65 , A61M2202/0007
摘要： A system for measuring cardiovascular data includes an elongate member, a first expandable member carried by the elongate member, a first sensor disposed on a surface of the elongate member, second and third sensors disposed on a surface of the first expandable member and configured to contact a wall of the body lumen of the subject when the first expandable member is in its expanded state, a first optical sensor located at a first location in relation to the distal end of the elongate member and configured for obtaining photoplethsmographic data, and a processor configured to calculate a stroke volume variation (SVV) of the subject based at least in part on data obtained by the second and third sensors and the first optical sensor, and without the use of any data derived from intra-arterial blood pressure measurement.
摘要翻译：用于测量心血管数据的系统包括细长构件，由细长构件承载的第一可膨胀构件，设置在细长构件的表面上的第一传感器，设置在细长构件的表面上的第二传感器和第三传感器，所述第一可扩张构件并且构造成当所述第一可扩张构件处于其扩张状态时接触所述对象的所述体腔的壁;第一光学传感器，所述第一光学传感器位于相对于所述细长构件的所述远端的第一位置并且被配置用于获得光泳描计数据;以及处理器，被配置为至少部分基于由第二传感器和第三传感器和第一光传感器获得的数据来计算对象的每搏输出量变化（SVV），并且不使用从内部动脉血压测量。

7. 发明申请

WO2017142240A1 METHOD AND ELECTRONIC DEVICE FOR CUFF-LESS BLOOD PRESSURE(BP) MEASUREMENT 审中-公开
标题翻译：用于无袖血压（BP）测量的方法和电子设备
公开(公告)号：WO2017142240A1
公开(公告)日：2017-08-24
申请号：PCT/KR2017/001230
申请日：2017-02-03
申请人： SAMSUNG ELECTRONICS CO., LTD.
发明人： GAURAV, Aman , MAHEEDHAR, Maram , TIWARI, Vijay Narayan , NARAYANAN, Rangavittal
IPC分类号： A61B5/026 , A61B5/024 , A61B5/00
CPC分类号： A61B5/02125 , A61B5/02405 , A61B5/02416 , A61B5/0261 , A61B5/0295 , A61B5/486 , A61B5/7264
摘要： A method and an electronic device for measuring blood pressure are provided. The method includes illuminating, by a PPG sensor included in the electronic device, skin of a user and measuring a PPG signal based on an illumination absorption by the skin. Further, the method also includes extracting, by the electronic device, a plurality of parameters from the PPG signal, wherein the parameters comprises PPG features, Heart Rate Variability (HRV) features, Acceleration Plethysmograph (APG) features, and non-linear features. The method also includes estimating, by the electronic device, the BP based on the extracted plurality of parameters.
摘要翻译：提供了一种用于测量血压的方法和电子设备。该方法包括通过包括在电子设备中的PPG传感器照亮用户的皮肤并且基于皮肤的照明吸收来测量PPG信号。此外，该方法还包括由电子设备从PPG信号提取多个参数，其中参数包括PPG特征，心率变异性（HRV）特征，加速度体积描记器（APG）特征和非线性特征。该方法还包括由电子设备基于提取的多个参数估计BP。

8. 发明申请

WO2017136772A1 NON-INVASIVE AND NON-OCCLUSIVE BLOOD PRESSURE MONITORING DEVICES AND METHODS 审中-公开
标题翻译：非侵入性和非闭合性血压监测装置和方法
公开(公告)号：WO2017136772A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016580
申请日：2017-02-03
申请人： ANGILYTICS INC.
发明人： ZHUO, Xiaoding , PRZYBYSZEWSKI, Piotr
IPC分类号： A61B5/021 , A61B5/024 , A61B5/053 , A61B5/0402 , A61B5/01 , A61B5/00
CPC分类号： A61B5/02141 , A61B5/002 , A61B5/02055 , A61B5/02116 , A61B5/02225 , A61B5/02241 , A61B5/0261 , A61B5/0402 , A61B5/0533 , A61B5/0816 , A61B5/7278 , A61B2560/0214 , A61B2560/0223
摘要： A blood pressure monitoring device includes a body portion having a size and structure to extend around an appendage of a user during use, a fluid bladder at least one of attached to or integral with the body portion and arranged to be able to apply pressure to an adjacent artery or vein of the user during use, a pressure actuator fluidly connected to the fluid bladder, a controller configured to provide control signals to the pressure actuator to fill the fluid bladder to selected pressures, a signal processor configured to communicate with the controller to receive signals indicating the selected pressures to which the fluid bladder is filled, and a pressure sensor arranged in operative contact with the fluid bladder to measure blood pressure waveforms plus bladder fluid pressure to provide a pressure waveform signal containing information regarding a relationship between vessel distention and transmural pressure. The pressure sensor is further configured to communicate with the signal processor to provide the pressure waveform signal to the signal processor. The controller is configured to provide a plurality of selected pressures that are less than a mean arterial pressure of the user, and the signal processor is configured to calculate blood pressure parameters using pressure waveform signals produced during application of the plurality of selected pressures that are less than the mean arterial pressure of the user.
摘要翻译：血压监测装置包括具有在使用期间围绕使用者的附肢延伸的尺寸和结构的主体部分，连接到主体部分或与主体部分成一体的至少一个流体囊，能够在使用期间向使用者的邻近动脉或静脉施加压力，流体连接至流体囊的压力致动器，配置成向压力致动器提供控制信号以将流体囊填充至选定压力的控制器，处理器，其被配置为与控制器通信以接收指示流体囊被填充到的选定压力的信号;压力传感器，其被布置为与流体囊操作性接触以测量血压波形加上囊流体压力以提供压力波形信号，有关船只膨胀与跨壁压力之间关系的信息。压力传感器还被配置为与信号处理器通信以将压力波形信号提供给信号处理器。控制器被配置为提供小于用户的平均动脉压的多个选择的压力，并且信号处理器被配置为使用在施加多个选择的压力期间产生的压力波形信号来计算血压参数比使用者的平均动脉压高。

9. 发明申请

WO2017096365A1 SYSTEM AND METHOD FOR MEASURING HEMOGLOBIN LEVEL 审中-公开
标题翻译：用于测量血红蛋白水平的系统和方法
公开(公告)号：WO2017096365A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064952
申请日：2016-12-05
申请人： MODI, Harsh
发明人： MODI, Harsh , MODI, Jay
IPC分类号： A61B5/083 , A61B5/087 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/14546 , A61B5/0205 , A61B5/02416 , A61B5/0261 , A61B5/0295 , A61B5/0816 , A61B5/0833 , A61B5/0836 , A61B5/087 , A61B5/091 , A61B5/14535 , A61B5/14551 , A61B5/14552 , A61B5/4836 , A61B5/7282 , A61B5/746 , A61M16/0051 , A61M16/024 , A61M2016/0039 , A61M2016/0042 , A61M2016/1025 , A61M2205/18 , A61M2205/502 , A61M2230/205 , A61M2230/432 , A61M2230/435 , A61M2230/005
摘要： A hemoglobin measuring device comprising a controller, a first oxygen sensor, a second oxygen sensor, a first volume flow meter, and a second volume flow meter. The controller is operable to receive data from each of the first and second oxygen sensors, the first and second volume flow meters, and a pulse oximeter associated with a patient. The controller is also operable to determine a hemoglobin level of the patient, defined as a determined hemoglobin level, based on the data received from the first and second oxygen sensors, the first and second volume flow meters, and the pulse oximeter.
摘要翻译：包括控制器，第一氧气传感器，第二氧气传感器，第一体积流量计和第二体积流量计的血红蛋白测量装置。控制器可操作以接收来自第一和第二氧传感器，第一和第二体积流量计以及与患者相关联的脉搏血氧计中的每一个的数据。控制器还可操作以基于从第一和第二氧传感器，第一和第二体积流量计以及脉搏血氧计接收的数据确定被定义为确定的血红蛋白水平的患者的血红蛋白水平。

10. 发明申请

WO2017095330A1 WEARABLE NON-INVASIVE APPARATUS FOR AND METHOD OF ENHANCING LOWER LIMBS VENOUS RETURN OF A SUBJECT 审中-公开
标题翻译：用于增强受试者下肢静脉回流的可穿刺无刺激装置和方法
公开(公告)号：WO2017095330A1
公开(公告)日：2017-06-08
申请号：PCT/SG2016/050580
申请日：2016-11-24
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： NG, Xu Wen , MOK, Wan Loong James , KAN, Enci Mary , CHEE, Ka Mung
IPC分类号： A61N1/36 , A61N1/04 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/0261 , A61B5/1118 , A61B5/4836 , A61B5/6828 , A61B2560/0412 , A61N1/0452 , A61N1/0484 , A61N1/0492 , A61N1/36003 , A61N1/36031 , A61N1/36034
摘要： In various embodiments, a wearable non -invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.
摘要翻译：在各种实施例中，可以提供用于增强对象的下肢静脉回流的可佩戴式非侵入性装置。该设备可以包括被配置为确定诸如光电容积描记（PPG）传感器的对象的静脉状态的监视设备。该装置还可以包括神经肌肉电刺激（NMES）装置，该神经肌肉电刺激（NMES）装置被配置成响应于所确定的状态而生成电刺激并且同时刺激具有所生成的电刺激的受试者的小腿三头肌和深小腿后肌以增强下肢静脉返回。在另一个实施方案中，电刺激可以在受试者的胫神经逆行靶向受试者的三头肌和深部小腿肌肉。

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