有蹄类动物相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
81	System and method for measuring relative leg positions of an ungulate	US13824745	2011-09-29	US09363983B2	2016-06-14	John Conan Doyle
A system (20) for measuring relative front (12, 13) and hind leg (16, 17) positions of a standing ungulate, the system including a sensing area within which an ungulate to be measured stands and which comprises a plurality of discrete linear sensor regions (30) spaced a known distance apart within the sensing area, each sensing region having a sensor operatively associated therewith, which sensor is responsive to the presence of the lower part of a leg within a sensing region and; a processor for receiving data from each sensor, identifying those sensor regions within which a lower part of a leg is present and based upon the distance between the identified sensor regions, determining the relative front and hind leg positions.
82	GENE EXPRESSION PROFILES THAT IDENTIFY GENETICALLY ELITE UNGULATE MAMMALS	EP04753647.9	2004-05-27	EP1633889B1	2010-09-01	LEWIN, Harris, A.; LIU, Zongling, Lewis; RODRIGUEZ-ZAS, Sandra; EVERTS, Robin, E.
Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.
83	Unactivated oocytes in nuclear transfer to produce ungulates	US09650194	2000-08-29	US07361804B1	2008-04-22	Keith Henry Stockman Campbell; Ian Wilmut
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.
84	Laufbandvorrichtung zur Laufbewegung von Lebewesen, insbesondere von Huftieren, hierbei insbesondere von Pferden	EP07021857.3	2007-11-10	EP1925340B1	2011-07-27	Lanny, Michael

85	TRANSGENIC UNGULATES CAPABLE OF HUMAN ANTIBODY PRODUCTION	EP03738939.2	2003-05-19	EP1513397A2	2005-03-16	Robl, James M.; Collas, Philippe; Sullivan, Eddie; Kasinathan, P.; Goldsby, Richard A.; Kuroiwa, Yoshimi; Tomizuka, Kazuma; Ishida, Isao
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
86	Gene expression profiles that identify genetically elite ungulate mammals	US10857294	2004-05-27	US20050137805A1	2005-06-23	Harris Lewin; Zonglin Liu; Sandra Rodriguez-Zas; Robin Everts
Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.
87	GENE EXPRESSION PROFILES THAT IDENTIFY GENETICALLY ELITE UNGULATE MAMMALS	EP04753647.9	2004-05-27	EP1633889A2	2006-03-15	LEWIN, Harris, A.; LIU, Zongling, Lewis; RODRIGUEZ-ZAS, Sandra; EVERTS, Robin, E.
Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.
88	Sole support pad for hoofed animals and process for producing the same	EP14180080.5	2014-08-06	EP2835049A3	2015-05-06	Mangan, David J.
The present invention relates to sole support pad (10) for hoofed animals but more particularly to sole support pad for horses with laminitis or other foot problems. Said sole support pad comprises a curable resin-coating tiny expandable polystyrene balls (12) which can be placed directly to the foot with or without shoes in a matter of seconds. It further relates to a process of producing said sole support pad comprising the steps of; coating polystyrene balls with poly-isocyanate prepolymer under dry atmosphere; allowing isocyanate and polyol to react; hardening the resin upon wetting with tertiary amine or organic peroxide solutions, and packaging coated balls in impervious package to prevent contact with atmospheric pressure.
89	TRANSGENIC UNGULATES CAPABLE OF HUMAN ANTIBODY PRODUCTION	EP03738939.2	2003-05-19	EP1513397B1	2010-04-14	Robl, James M.; Collas, Philippe; Sullivan, Eddie; Kasinathan, P.; Goldsby, Richard A.; Kuroiwa, Yoshimi; Tomizuka, Kazuma; Ishida, Isao; Osborne, Barbara
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
90	Sole support pad for hoofed animals and process for producing the same	EP14180080.5	2014-08-06	EP2835049B1	2016-12-07	Mangan, David J.

91	USE OF FRUCTANASES IN FEED OF HOOFED ANIMALS TO TREAT AND PREVENT LAMINITIS	EP06806357.7	2006-10-18	EP1937084A2	2008-07-02	WEGENER TAMS, Jeppe; PHILIPPS, Petra
Laminitis is defined as an inflammation of the sensitive laminae of the hoof, especially in horses. It has been surprisingly found that fructanases such as 2,1-β-D-fructan hydrolase are highly effective as therapeutic and prophylactic agents against laminitis in horses. The fructanases may be used as enzyme compositions in horse feed, as additives for horse feed or as oral preparations for the therapy and prophylaxis of laminitis. Because of its effectiveness in hydrolyzing fructans, which seem to play an important role in the aetiology of laminitis, the administration of fructanases in combination with an increased intake of fructans or with an increased availability of fructans is particularly advantageous.
92	TRANSGENIC UNGULATES CAPABLE OF HUMAN ANTIBODY PRODUCTION	EP03738939	2003-05-19	EP1513397A4	2007-10-24	ROBL JAMES M; COLLAS PHILIPPE; SULLIVAN EDDIE; KASINATHAN P; GOLDSBY RICHARD A; KUROIWA YOSHIMI; TOMIZUKA KAZUMA; ISHIDA ISAO; OSBORNE BARBARA
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
93	TRANSGENIC UNGULATES EXPRESSING CTLA4-IG AND USES THEREOF	EP06824805.3	2006-08-09	EP1924686A2	2008-05-28	AYARES, David, Lee
The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein.
94	Vorrichtung zur Behandlung von Hornspalten oder -rissen am Huf von Pferden oder anderen Huftieren	EP06400034.2	2006-11-03	EP1792539A1	2007-06-06	Puhl, Michael
Die Erfindung betrifft eine Vorrichtung zur Behandlung von Hornspalten oder -rissen am Huf von Pferden oder anderen Huftieren. Die Vorrichtung nach der Erfindung ist gekennzeichnet durch Halteteile (1,1'), die an den Längsseiten eines Hornspalts oder -risses einander gegenüberliegend am Huf zu befestigen sind, sowie die Halteteile (1,1') verbindende Einrichtungen (3-14) durch die der Abstand zwischen den Halteteilen (1,1') unter Aufweitung oder Verengung des Hornspalts oder-risses verstellbar ist.
95	Machine for separating the bone and the flesh from the feet of slaughtered ungulates	US102994	1979-12-12	US4299009A	1981-11-10	Claude Tournier
A machine for boning feet comprises on a frame, fixed immobilization means and a movable extraction member constituted by at least one set of jaws. In order to bone the feet of hoofed animals, said immobilization means are constituted by at least one set of jaws designed to hold the foot to be boned, the movable means gripping at least the skin of the foot.
96	Enriched Pag-55 Fraction and Methods for Early Detection of Preganancy in Ungulate Animals	US11587391	2005-04-27	US20080003695A1	2008-01-03	Nagappan Mathialagan; Michael Mcgrath; Robert Schenkel
Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immulogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with few1 false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.
97	Mittel zur äusserlichen Behandlung von Hufpilz bei Unpaarhufern, insbes.bei Pferden	EP96250044.3	1996-02-20	EP0728485A2	1996-08-28	Sell, Hartmut
Die Erfindung lehrt als Mittel zur äußerlichen Behandlung von Hufpilz von Unpaarhufern, insbes. bei Pferden, sowie als Hufpflegemittel eine Emulsion aus Huföl und einer wäßrigen Wasserstoffperoxyd-Lösung mit zumindest einem oxydationsbeständigen Emulgator.
98	Expression of Xenogenous (Human) Immunoglobulins in cloned, transgenic ungulates	US12378061	2009-02-09	US20110067122A1	2011-03-17	James M. Robl; Richard A. Goldsby; Stacy E. Ferguson; Yoshimi Kuroiwa; Kazuma Tomizuka; Isao Ishida; Barbara A. Osborne
The present invention relates to the production of a transgenic ungulate which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
99	Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates	US11291668	2005-12-01	US07491867B2	2009-02-17	James M. Robl; Richard A. Goldsby; Stacy E. Ferguson; Yoshimi Kuroiwa; Kazuma Tomizuka; Isao Ishida; Barbara A. Osborne
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
100	Expression of xenogenous (human) imunoglobulins in cloned, transgenic ungulates	US11291668	2005-12-01	US20060117394A1	2006-06-01	James Robl; Richard Goldsby; Stacy Ferguson; Yoshimi Kuroiwa; Kazuma Tomizuka; Isao Ishida; Barbara Osborne
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.

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