有蹄类动物相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
161	Transgenic animals and uses thereof	US12215085	2008-06-25	US20090222935A1	2009-09-03	James M. Robl; Yoshimi Kuroiwa; Poothappillai Kasinathan; Isao Ishida; Kazuma Tomizuka
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
162	Transgenic porcines lacking endogenous immunoglobulin light chain	EP12161321.0	2005-10-24	EP2527456A1	2012-11-28	Wells, Kevin; Ayares, David
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.
163	SHOE AND SHOEING METHOD	EP01948918.6	2001-02-01	EP1251733B1	2004-04-14	Poynton, Andrew Paul
A shoe for a hoofed animal, e.g. a horseshoe, is described which comprises a body made from a thermoplastic composition which comprises a matrix of a thermoplastic material which has a softening point of less than 100 DEG C, such as a polycaprolactone. A method of shoeing a hoofed animal, such as a horse, is also described.
164	AQUAPORIN 2 PROTECTS CATTLE FROM TICKS AND TICK-BORNE PARASITES	US15177865	2016-06-09	US20160361396A1	2016-12-15	Glen A. Scoles; Felicito Guerrero; Reginaldo Bastos
A novel method of using an aquaporin protein from Rhipicephalus microplus (RmAQP2), fragments of RmAQP2, and/or the cDNA encoding RmAQP2 and/or the fragments are described. Immunogenic composition containing recombinant RmAQP2 and/or fragments of RmAQP2 are produced and administered to an ungulate which generates an immune response to RmAQP2. After feeding female ticks on the ungulate injected with RmAQP2 and/or fragments of RmAQP2, the female ticks have lower reproductive viability because of a reduced egg mass, reduced hatching percentage, and reduced survival of larvae. Thus, administering RmAQP2 and/or RmAQP2 fragments to an ungulate can reduce the incidence of R. microplus and also reduce the incidence of tick-borne pathogens in ungulates because of the lower number of R. microplus.
165	卵胞同期化後の単回リコンビナントウシＦＳＨ	JP2015542272	2013-11-15	JP2016502523A	2016-01-28	ソウザ，アレクサンドル; イサカ，ナオミ; キャリー，オード; ティボー，ドミニク
本発明は、生物学的に活性なリコンビナント卵胞刺激ホルモン(rFSH)を使用して、非ヒト哺乳動物において繁殖成績を向上させるための方法及び組成物に関する。本発明はまた、rFSHを使用して、非ヒト哺乳動物において排卵又は胚生産又は妊娠を向上させるための方法に関する。本発明は、特にウシ又はウマなどの有蹄動物で使用され得る。
166	DETERMINING IMMUNOGLOBULINS IN NON-BLOOD BODY FLUIDS OF NEONATAL UNGULATES	PCT/US2009/062931	2009-11-02	WO2010062711A1	2010-06-03	SMITH, Nathan, L.
Provided is a method for determining immunoglobulins in a neonatal ungulate. The method entails obtaining a sample of oral secretions from the neonatal ungulate and measuring an amount of immunoglobulins in the sample of oral secretions. The method is faster and more convenient than previously available methods for determining immunglobulins in neonatal ungulates, such as neonatal horses and cattle.
167	Vaccines comprising acapsular P. multocida hyaE deletion mutants	US10882666	2004-07-02	US20050106185A1	2005-05-19	Robert Briggs; Fred Tatum
Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.
168	LYSOZYME TRANSGENIC UNGULATES	PCT/US2004/000606	2004-01-08	WO2004063349A2	2004-07-29	MURRAY, James, D.; ANDERSON, Gary, B.; MAGA, Elizabeth, A.
The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and further has an attenuated or non-functional β-lactoglobulin allele. The invention further provides methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
169	TRANSGENIC ANIMALS AND USES THEREOF	PCT/US2005013618	2005-04-21	WO2005104835A3	2006-09-28	ROBL JAMES; KUROIWA YOSHIMI; KASINATHAN POOTHAPPILLAI; ISHIDA ISAO; TOMIZUKA KAZUMA
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and method of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
170	Reducing ungulate pressure on post-burn areas in mosaic burns	US11126376	2003-07-25	US20050193955A1	2005-09-08	Mark Robbins
The present invention, in one embodiment, is a method of reducing ungulate pressure on burned sub-areas within a mosaic burn area. The method comprises identifying an unburned sub-area within the mosaic burn area and providing at least one highly palatable, portable, self-limiting, animal feed supplement in the first unburned sub-area. The highly palatable, portable, self-limiting, animal feed supplement attracts the ungulates to the first unburned sub-area and increases the length of the ungulates' stay in the first unburned sub-area. The ungulates are attracted to the first unburned sub-area by the supplement in preference to the burned sub-area with new growth.
171	TISSUE PRODUCT DERIVED FROM ANIMAL LACKING FUNCTIONAL α 1,3 GALACTOSYLTRANSFERASE	JP2013147567	2013-07-16	JP2013215615A	2013-10-24	AYARES DAVID; ROHRICHT PAUL
PROBLEM TO BE SOLVED: To provide tissue products derived from animals lacking functional α 1,3 galactosyltransferase.SOLUTION: The present invention provides tissues derived from animals, which lack any expression of functional α 1,3 galactosyltransferase (α-1,3.GT). Such tissue can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices. The animal can be a ruminant or an ungulate, such as a bovine, porcine, or ovine. The tissues from animals lacking any functional expression of the α-1,3-GT gene can be obtained from a prenatal, neonatal, immature, or mature animal, such as a porcine, bovine or ovine.
172	Vaccines comprising acapsular P. multocida hyaE deletion mutants	US10882666	2004-07-02	US07351416B2	2008-04-01	Robert E. Briggs; Fred M. Tatum
Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.
173	ANIMAL REPELLING DEICER	US13275892	2011-10-18	US20120121680A1	2012-05-17	Neil Alexander Rosenburgh; Michelle Lee Daum; Jason Louis Bagley; Dan Pannell; Kristopher Shelite
Deicing products designed to deter ungulates are provided, along with methods of using those products to treat iced surfaces. The deicing product comprises a mixture of a deicer along with an ungulate repellent. The repellent can repel based on conditioned avoidance, fear, chemical irritation, and/or bad taste. The deicer can be a salt or a deicer solution. The invention is useful for deterring any ungulate that might be attracted to a component of the deicing product (e.g., the salt), but it is particularly useful for deterring deer.
174	UNGULATES WITH GENETICALLY MODIFIED IMMUNE SYSTEMS	PCT/US2005038582	2005-10-24	WO2006047603A2	2006-05-04	WELLS KEVIN; AYARES DAVID
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.
175	EMBRYONIC STEM CELLS FOR MAKING CHIMERIC AND TRANSGENIC UNGULATES	PCT/US1994005529	1994-05-16	WO1994026884A1	1994-11-24	BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION; WHEELER, Matthew, B.
Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.
176	SHOE AND SHOEING METHOD	EP01948918.6	2001-02-01	EP1251733A1	2002-10-30	Poynton, Andrew Paul
A shoe for a hoofed animal, e.g. a horseshoe, is described which comprises a body made from a thermoplastic composition which comprises a matrix of a thermoplastic material which has a softening point of less than 100 °C, such as a polycaprolactone. A method of shoeing a hoofed animal, such as a horse, is also described.
177	Reducing ungulate pressure on post-burn areas in mosaic burns	US11126376	2003-07-25	US07143721B2	2006-12-05	Mark A. Robbins
The present invention, in one embodiment, is a method of reducing ungulate pressure on burned sub-areas within a mosaic burn area. The method comprises identifying an unburned sub-area within the mosaic burn area and providing at least one highly palatable, portable, self-limiting, animal feed supplement in the first unburned sub-area. The highly palatable, portable, self-limiting, animal feed supplement attracts the ungulates to the first unburned sub-area and increases the length of the ungulates' stay in the first unburned sub-area. The ungulates are attracted to the first unburned sub-area by the supplement in preference to the burned sub-area with new growth.
178	UNGULATE PREBLASTOCYST DERIVED EMBRYONIC STEM CELLS AND USE THEREOF TO PRODUCE CLONED TRANSGENIC AND CHIMERIC UNGULATES	PCT/US1994014587	1994-12-16	WO1995016770A1	1995-06-22	ABS GLOBAL, INC.; STRELCHENKO, Nick; STICE, Steven, L.
Totipotent ungulate embryonic stem cell lines, e.g., of bovine origin, derived from preblastocyst precursor cells are taught. These cell lines are used for cloning of ungulates, for the production of transgenic cell lines, and for the production of transgenic and chimeric ungulates.
179	Method of producing products for use in the treatment of bacterial and/or virus infections	US108937	1987-10-13	US4843065A	1989-06-27	Robert A. Collins; Philip F. Weighner
A method of preparing remedies for the treatment of bacterial and viral infections which involves introduction into the udder of an ungulate during lactation, a specific vaccine comprising bacterial and/or viral organisms in an inactive state, and the preparation of small dosages of the secretary fluid subsequently withdrawn during lactation from the ungulate thus treated.
180	LYSOZYME TRANSGENIC UNGULATES	PCT/US2004000606	2004-01-08	WO2004063349A3	2004-11-11	MURRAY JAMES D; ANDERSON GARY B; MAGA ELIZABETH A
The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and further has an attenuated or non-functional beta-lactoglobulin allele. The invention further provides methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.

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