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1. 发明申请

WO2007050100A3 IMMOBILIZED ENZYMES AND PROCESSES FOR PREPARING AND USING SAME 审中-公开
标题翻译：固定化酶及其制备和使用方法
公开(公告)号：WO2007050100A3
公开(公告)日：2009-05-22
申请号：PCT/US2005042657
申请日：2005-11-23
申请人： IND SCIENCE & TECHNOLOGY NETWO , DAVID ALLAN , YANG ARTHUR
发明人： DAVID ALLAN , YANG ARTHUR
IPC分类号： C12N11/00 , C12N11/04 , C12N11/16 , C12Q1/00 , C12Q1/68 , G01N33/537
CPC分类号： C12N11/14 , C12N9/54 , C12P21/06
摘要： A highly loaded immobilized enzyme conjugate is prepared from a nanopore silica gel support. The enzyme may be immobilized in an amount, based on the silica gel support, of at least about 500 mg enzyme per gram of silica gel. The immobilized enzyme conjugate may be prepared by a method which includes the following steps: (a) surface modifying silicic acid by reacting the silicic acid with a basic aminoalkylsilane in solution in an alcoholic medium, wherein the amount of the basic aminoalkylsilane is sufficient to raise the pH of the solution to induce gelation and form a chemically surface-modified silica gel; (b) activating the chemically surface-modified silica gel by reaction with a cross-linking agent; and (c) contacting the activated chemically surface-modified silica gel with an enzyme. Immobilized thermolysin has been used to prepare a low molecular weight protamine with high efficiency.
摘要翻译：由纳米孔硅胶支持体制备高度负载的固定化酶缀合物。该酶可以以基于硅胶载体的量固定至少约500mg酶/克硅胶。固定化酶偶联物可以通过包括以下步骤的方法制备：（a）通过在醇介质中的溶液中使硅酸与碱性氨基烷基硅烷反应来表面改性硅酸，其中碱性氨基烷基硅烷的量足以提高溶液的pH以引起凝胶化并形成化学表面改性的硅胶; （b）通过与交联剂反应来活化化学表面改性的硅胶; 和（c）使活化的化学表面改性的硅胶与酶接触。已经使用固定的嗜热菌蛋白酶以高效率制备低分子量鱼精蛋白。

2. 发明申请

WO2009020577A3 INNOVATIVE FORMULATION FOR ORAL INSULIN DELIVERY 审中-公开
标题翻译：口服胰岛素分泌物的创新配方
公开(公告)号：WO2009020577A3
公开(公告)日：2009-05-28
申请号：PCT/US2008009365
申请日：2008-08-04
申请人： IND SCIENCE & TECHNOLOGY NETWO , DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
发明人： DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
IPC分类号： C12Q1/68
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention provides for an encapsulated, mucoadhesive oral formulation for hormones, such as insulin, and methods of using such formulations.
摘要翻译：本发明提供了用于激素（例如胰岛素）的包封的粘膜粘附性口服制剂，以及使用这些制剂的方法。

3. 发明申请

WO2004081188A3 NON-TOXIC MEMBRANE-TRANSLOCATING PEPTIDES 审中-公开
标题翻译：非毒性膜转录肽
公开(公告)号：WO2004081188A3
公开(公告)日：2008-01-24
申请号：PCT/US2004007145
申请日：2004-03-10
申请人： UNIV MICHIGAN , IND SCIENCE & TECHNOLOGY NETWO , PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
发明人： PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K14/46 , C12N20060101 , C12N15/87
CPC分类号： C12N15/87 , A61K38/168 , A61K47/64 , A61K47/645 , A61K48/0008 , A61K49/0041 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K14/461 , C07K2319/03
摘要： Compositions for transport across a biological membrane include a membrane-translocating LMWP peptide and a cargo molecule. Methods for transporting a cargo molecule across a biological membrane are also described.
摘要翻译：用于在生物膜上运输的组合物包括膜易位的LMWP肽和货物分子。还描述了将货物分子穿过生物膜运送的方法。

4. 发明申请

WO0064969A9 NANOCOMPOSITE OF POLYMERIC MATERIALS WITH SURFACE MODIFIED CLAY AND SILICA XEROGEL 审中-公开
标题翻译：具有表面改性粘土和二氧化硅XEROGEL的聚合物材料的纳米复合材料
公开(公告)号：WO0064969A9
公开(公告)日：2002-02-21
申请号：PCT/US0010711
申请日：2000-04-21
申请人： IND SCIENCE & TECHNOLOGY NETWO , YANG ARTHUR JING MIN , ZHANG YUEHUA
发明人： YANG ARTHUR JING-MIN , ZHANG YUEHUA
IPC分类号： C08F283/12 , C08F289/00 , C08G18/48 , C08K9/08 , C08L51/10 , C08K3/22 , C08K3/34
CPC分类号： C08K9/08 , C08F283/12 , C08F289/00 , C08G18/4829 , C08G2101/0083 , C08G2101/0091 , C08L51/10 , C08L2666/02
摘要： A grafted silica or other metal oxide xerogel is interpenetrated or impregnated by a polymer and sandwiched between layered clay plate molecules. The grafted segments on the backbone of the xerogel provide phase compatibilization between the polymer and layered clay plate molecules. The grafted xerogel is produced by a gel precursor with a coupling reactant, under specified conditions, to cause the coupling reactant to condense and react with functional, e.g., hydroxyl (from silanol) groups on the gel precursor to form grafted sol. The grafted sol is mixed under stirring with clay to exfoliate the clay plate molecules. The exfoliated clay molecules may be mixed with oligomers or blended with a polymer to form the grafted xerogel as shown in Figure 1.
摘要翻译：接枝二氧化硅或其它金属氧化物干凝胶被聚合物互穿或浸渍并夹在层状粘土板分子之间。干凝胶骨架上的接枝部分提供聚合物和层状粘土板分子之间的相位相容性。接枝的干凝胶在特定条件下由具有偶联反应物的凝胶前体产生，以使偶联反应物冷凝并与功能性例如凝胶前体上的（由硅烷醇）基团反应形成接枝的溶胶。接枝溶胶在搅拌下与粘土混合以剥离粘土板分子。剥离的粘土分子可以与低聚物混合或与聚合物共混以形成接枝的干凝胶，如图1所示。

5. 发明申请

WO2008057382A3 NANOPORE REACTIVE ADSORBENTS FOR THE HIGH-EFFICIENCY REMOVAL OF WASTE SPECIES 审中-公开
标题翻译：纳米孔反应活性吸附剂，用于高效去除废物
公开(公告)号：WO2008057382A3
公开(公告)日：2008-08-14
申请号：PCT/US2007023069
申请日：2007-10-31
申请人： IND SCIENCE & TECHNOLOGY NETWO , DOMSZY ROMAN , LEE YUN HAN
发明人： DOMSZY ROMAN , LEE YUN HAN
IPC分类号： B01J20/00
CPC分类号： C22B3/24 , B01J20/048 , B01J20/103 , B01J20/26 , B01J20/262 , B01J20/28007 , B01J20/2808 , B01J39/09 , B01J39/12 , B01J41/10 , B01J47/018 , B01J2220/46 , B82Y30/00 , C02F1/288 , C02F2101/20 , C22B13/045 , Y02P10/234
摘要： A nanopore reactive adsorbent composite material, which may be a porous adsorbent comprising a chemically surface modified gel, has a composition and micro structure, which integrals ion exchange components such as hydroxy apatite.
摘要翻译：纳米孔反应性吸附剂复合材料可以是包含化学表面改性的凝胶的多孔吸附剂，其具有组成和微观结构，其整合离子交换组分如羟基磷灰石。

6. 发明申请

WO2007050100A9 IMMOBILIZED ENZYMES AND PROCESSES FOR PREPARING AND USING SAME 审中-公开
标题翻译：固定化酶及其制备和使用方法
公开(公告)号：WO2007050100A9
公开(公告)日：2007-06-14
申请号：PCT/US2005042657
申请日：2005-11-23
申请人： IND SCIENCE & TECHNOLOGY NETWO , DAVID ALLAN , YANG ARTHUR
发明人： DAVID ALLAN , YANG ARTHUR
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , C12N9/54 , C12P21/06
摘要： A highly loaded immobilized enzyme conjugate is prepared from a nanopore silica gel support. The enzyme may be immobilized in an amount, based on the silica gel support, of at least about 500 mg enzyme per gram of silica gel. The immobilized enzyme conjugate may be prepared by a method which includes the following steps: (a) surface modifying silicic acid by reacting the silicic acid with a basic aminoalkylsilane in solution in an alcoholic medium, wherein the amount of the basic aminoalkylsilane is sufficient to raise the pH of the solution to induce gelation and form a chemically surface-modified silica gel; (b) activating the chemically surface-modified silica gel by reaction with a cross-linking agent; and (c) contacting the activated chemically surface-modified silica gel with an enzyme. Immobilized thermolysin has been used to prepare a low molecular weight protamine with high efficiency.
摘要翻译：由纳米孔硅胶支持体制备高度负载的固定化酶缀合物。该酶可以以基于硅胶载体的量固定至少约500mg酶/克硅胶。固定化酶偶联物可以通过包括以下步骤的方法制备：（a）通过在醇介质中的溶液中使硅酸与碱性氨基烷基硅烷反应来表面改性硅酸，其中碱性氨基烷基硅烷的量足以提高溶液的pH以引起凝胶化并形成化学表面改性的硅胶; （b）通过与交联剂反应来活化化学表面改性的硅胶; 和（c）使活化的化学表面改性的硅胶与酶接触。已经使用固定的嗜热菌蛋白酶以高效率制备低分子量鱼精蛋白。

7. 发明申请

WO2005117844A2 MUCOADHESIVE NANOCOMPOSITE DELIVERY SYSTEM 审中-公开
标题翻译： MUCOADHESIVE NANOCOMPOSITE交货系统
公开(公告)号：WO2005117844A2
公开(公告)日：2005-12-15
申请号：PCT/US2005017638
申请日：2005-05-20
申请人： IND SCIENCE & TECHNOLOGY NETWO , PARK YOON JEONG , YANG ARTHUR JIN-MING , DAVID ALLAN EMERSON , ZHANG RUIYUN
发明人： PARK YOON JEONG , YANG ARTHUR JIN-MING , DAVID ALLAN EMERSON , ZHANG RUIYUN
IPC分类号： A61K9/14 , A61K9/51 , A61K9/52
CPC分类号： A61K9/143 , A61K9/146 , A61K9/5115 , A61K9/5161 , A61K9/5192
摘要： A nanocomposite delivery system uses chitosan as a mucoadhesive material encapsulated in a surface modified network of colloidal nanoporous nanoparticles, such as silica, or other colloid-forming materials, especially metal oxides. Drug delivery systems may be provided by binding a drug to the chitosan/silica nanocomposite, typically by adding a drug or other active agent during in-situ gellation of colloidal silica. When the active agent is, for example, amoxicillin or other antiobiotic agent, the drug delivery system may be used in the treatment of stomach ulcers, for example.
摘要翻译：纳米复合物递送系统使用壳聚糖作为胶体纳米多孔纳米颗粒（如二氧化硅）或其他形成胶体的材料，特别是金属氧化物的表面改性网络中的粘膜粘附材料。药物递送系统可以通过将药物与壳聚糖/二氧化硅纳米复合物结合来提供，通常通过在胶体二氧化硅的原位凝胶化过程中加入药物或其它活性剂。当活性剂为例如阿莫西林或其他抗生素时，药物递送系统可用于例如胃溃疡的治疗。

8. 发明申请

WO9939816A9 ION SEPARATION USING A SURFACE-TREATED XEROGEL 审中-公开
标题翻译：使用表面处理XEROGEL进行离子分离
公开(公告)号：WO9939816A9
公开(公告)日：2000-04-27
申请号：PCT/US9902181
申请日：1999-02-03
申请人： IND SCIENCE & TECHNOLOGY NETWO , YANG ARTHUR JING MIN
发明人： YANG ARTHUR JING-MIN
IPC分类号： B01J20/10 , B01D15/00 , B01J20/32 , B01J39/14 , C09K3/32 , B01J13/00
CPC分类号： C09K3/32 , B01D15/00 , B01J20/103 , B01J20/2808 , B01J20/3092 , B01J20/3204 , B01J20/3257 , B01J20/3425 , B01J20/3433 , B01J20/3475 , B01J2220/58 , C02F1/288 , C02F1/681
摘要： Silica gel is formed, then aged at 40-80 degrees celcius. It is then surface-modified at this temperature and the resulting material is used to remove metal ion from solution.
摘要翻译：形成硅胶，然后在40-80摄氏度下老化。然后在该温度下对其进行表面改性，所得材料用于从溶液中除去金属离子。

9. 发明专利

AU753228B2 Ion separation using a surface-treated xerogel 未知
公开(公告)号：AU753228B2
公开(公告)日：2002-10-10
申请号：AU2573799
申请日：1999-02-03
申请人： IND SCIENCE & TECHNOLOGY NETWO
发明人： YANG ARTHUR JING-MIN
IPC分类号： B01J20/10 , B01D15/00 , B01J20/32 , B01J39/14 , C09K3/32 , B01J13/00
摘要： Amorphous, nanoporous silica gel having an open channel structure may be surface modified at higher loading of surface modifying ligands, e.g., 7.5 mmole per gram, than known nanoporous silica gels. In one embodiment, an amorphous silica gel has a bimodal pore size distribution of pores at about 10 nanometers and at about 10 microns, and a bulk density of about 0.2 to about 0.25 g/ml. Surface modification with functionalized ligand groups, effective for selective adsorption or reaction catalysis, is achieved by gelling silica sol solution to form a wet silica gel, maintaining the gel at a relatively low elevated temperature in a moist state to obtain a wet nanoporous silica gel having a plurality of open channels within the gel structure and silanol groups on the surface and reacting the surface silanol groups with the ligand group to introduce the functionalized group. The surface modifying reaction may be carried out concurrently with the gelling of a silica precursor in an aqueous alcoholic medium. 3-mercaptopropyltrialkoxysilane is an exemplary ligand introducing compound. The chemically surface modified gel may be used, for example, to remove or concentrate metallic substances in a liquid, or to separate two or more metallic impurities from a mixture thereof, or for cleanup of oil or chemical contaminants from the surface of a body of water.

10. 发明专利

AU4365500A Nanocomposite of polymeric materials with surface modified clay and silica xerogel 未知
公开(公告)号：AU4365500A
公开(公告)日：2000-11-10
申请号：AU4365500
申请日：2000-04-21
申请人： IND SCIENCE & TECHNOLOGY NETWO
发明人： YANG ARTHUR JING-MIN , ZHANG YUEHUA
IPC分类号： C08F283/12 , C08F289/00 , C08G18/48 , C08K9/08 , C08L51/10 , C08K3/22 , C08K3/34
摘要： A grafted silica or other metal oxide xerogel is interpenetrated or impregnated by a polymer and sandwiched between layered clay plate molecules. The grafted segments on the backbone of the xerogel provide phase compatibilization between the polymer and layered clay plate molecules. The grafted xerogel is produced by a gel precursor with a coupling reactant, under specified conditions, to cause the coupling reactant to condense and react with functional, e.g., hydroxyl (from silanol) groups on the gel precursor to form grafted sol. The grafted sol is mixed under stirring with clay to exfoliate the clay plate molecules. The exfoliated clay molecules may be mixed with oligomers or blended with a polymer to form the grafted xerogel as shown in Figure 1.

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