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1. 发明申请

WO2004081188A3 NON-TOXIC MEMBRANE-TRANSLOCATING PEPTIDES 审中-公开
标题翻译：非毒性膜转录肽
公开(公告)号：WO2004081188A3
公开(公告)日：2008-01-24
申请号：PCT/US2004007145
申请日：2004-03-10
申请人： UNIV MICHIGAN , IND SCIENCE & TECHNOLOGY NETWO , PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
发明人： PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K14/46 , C12N20060101 , C12N15/87
CPC分类号： C12N15/87 , A61K38/168 , A61K47/64 , A61K47/645 , A61K48/0008 , A61K49/0041 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K14/461 , C07K2319/03
摘要： Compositions for transport across a biological membrane include a membrane-translocating LMWP peptide and a cargo molecule. Methods for transporting a cargo molecule across a biological membrane are also described.
摘要翻译：用于在生物膜上运输的组合物包括膜易位的LMWP肽和货物分子。还描述了将货物分子穿过生物膜运送的方法。

2. 发明申请

WO2009020577A3 INNOVATIVE FORMULATION FOR ORAL INSULIN DELIVERY 审中-公开
标题翻译：口服胰岛素分泌物的创新配方
公开(公告)号：WO2009020577A3
公开(公告)日：2009-05-28
申请号：PCT/US2008009365
申请日：2008-08-04
申请人： IND SCIENCE & TECHNOLOGY NETWO , DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
发明人： DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
IPC分类号： C12Q1/68
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention provides for an encapsulated, mucoadhesive oral formulation for hormones, such as insulin, and methods of using such formulations.
摘要翻译：本发明提供了用于激素（例如胰岛素）的包封的粘膜粘附性口服制剂，以及使用这些制剂的方法。

3. 发明申请

WO2010095881A3 TARGET ACTIVATED CELL/TISSUE TRANSLOCATION PEPTIDE FOR IMPERMEABLE COMPOUND STRATEGY, AND USES THEREOF 审中-公开
标题翻译：目标活化细胞/组织转移肽用于不可复制的化合物战略及其用途
公开(公告)号：WO2010095881A3
公开(公告)日：2011-01-06
申请号：PCT/KR2010001033
申请日：2010-02-19
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C
发明人： PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C
IPC分类号： C07K19/00 , A61K38/17 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K47/645 , A61K47/65 , C07K2319/10
摘要： The present invention relates to a target activated cell/tissue translocation peptide for an impermeable compound strategy (TACTICS), and to uses thereof. More particularly, the present invention relates to a target activated cell/tissue translocation peptide for an impermeable compound strategy (TACTICS), which comprises (a) a protein transport domain (PTD), (B) a masking domain, and (C) a spacer having a target cell/tissue enzyme-specific cleavage, wherein the peptide is provided with selectivity to exhibit translocation performance specifically only in the target tissue. The present invention also relates to an image of the peptide, therapeutic drugs, or a complex of drug-containing grains. The target activated cell/tissue translocation peptide for an impermeable compound strategy-drug complex according to the present invention provides the peptide with target selectivity to obtain the highest quality images and excellent curative effects, and inhibits the unspecific distribution of the complex in the body to minimize side effects and maximize diagnosis effects. Thus, the peptide of the present invention can be valuably used in treating diseases.
摘要翻译：本发明涉及用于不可渗透化合物策略（TACTICS）的靶活化细胞/组织易位肽及其应用。更具体地，本发明涉及用于不可渗透化合物策略（TACTICS）的靶活化细胞/组织易位肽，其包含（a）蛋白质转运结构域（PTD），（B）掩蔽结构域，和（C）具有靶细胞/组织酶特异性切割的间隔物，其中所述肽具有仅在靶组织中显示易位性能的选择性。本发明还涉及肽，治疗药物或含药颗粒的复合物的图像。根据本发明的用于不可渗透化合物策略 - 药物复合物的靶活化细胞/组织易位肽提供具有靶选择性的肽以获得最高质量的图像和优异的疗效，并且抑制复合体在体内的非特异性分布尽量减少副作用并最大化诊断效果。因此，本发明的肽可以有价值地用于治疗疾病。

4. 发明申请

WO2009045063A3 COMPLEX OF CELL TRANSLOCATIONAL PEPTIDE AND MAGNETIC NANOPARTICLES AND USE THEREOF 审中-公开
标题翻译：细胞转移肽和磁性纳米颗粒的复合物及其用途
公开(公告)号：WO2009045063A3
公开(公告)日：2009-06-18
申请号：PCT/KR2008005815
申请日：2008-10-02
申请人： SEOUL NAT UNIV IND FOUNDATION , PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C , SUH JIN SOOK
发明人： PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C , SUH JIN SOOK
IPC分类号： B82B3/00
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： The present invention relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex and the use thereof. More specifically, relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex in which a cell-penetrating peptide is chemically linked to a fluorescence-labeled magnetic nanoparticle, such that fluorescence-labeled magnetic nanoparticle can be stably introduced directly into cells without endocytosis, and a composition for cell imaging containing the complex. The disclosed invention suggests an innovative therapeutic technology which shows high stability, maximizes the effect of imaging diagnosis through optimal targeting and minimizes side effects, unlike existing viral peptide transporters.
摘要翻译：本发明涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物及其用途。更具体地，涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物，其中细胞穿透肽与荧光标记的磁性纳米颗粒化学连接，使得荧光标记的磁性纳米颗粒可以直接引入细胞而不用内吞作用，以及含有该复合物的细胞成像用组合物。所公开的发明提出了一种创新的治疗技术，其显示出高稳定性，与现有的病毒肽转运蛋白不同，通过最佳靶向使得成像诊断的效果最大化并且最小化副作用。

5. 发明专利

CA2153627A1 PROTAMINE-RESPONSIVE POLYMERIC MEMBRANE ELECTRODE 未知
公开(公告)号：CA2153627A1
公开(公告)日：1996-12-08
申请号：CA2153627
申请日：1995-07-11
申请人： YUN JONG HOON , MEYERHOFF MARK E , YANG VICTOR C
发明人： YUN JONG HOON , MEYERHOFF MARK E , YANG VICTOR C
IPC分类号： C12M1/40 , C12Q1/37 , G01N27/333
摘要： A polymeric membrane electrode gives potentiometric responses to macromolecules, such as protamine, in solution or biological specimens. A protamine-responsive membrane includes a lipophilic cation-exchange material for ionic macromolecules in a specially formulated plasticized, polymeric matrix material. Potentiometric response to protamine has been observed in membranes comprising 30-70 wt.% polymeric matrix material, such as polyvinyl chloride; 1-3 wt.% salt of a tetraphenylborate, such as potassium tetrakis(4-chlorophenyl) borate or salt of an organophosph(on)ate, such as calcium bis-¢4-(1,1,3,3-tetramethylbutyl)phenyl! phosphate; and 30-70 wt.% of a plasti-cizer, such as 2-nitrophenyl octyl ether or tris (2-ethylhexyl) phosphate. The potentio-metric response of these membranes to protamine can be used to study the binding interaction of protamine with heparin (both native and low molecular fractions) or to monitor protease activity, for example, by following the rate of degradation of intact protamine or a synthetic substrate by trypsin, as well as to measure protamine concentration in biological fluids, such as blood or plasma.

6. 发明公开

EP0630472A4 HEPARIN-SELECTIVE POLYMERIC MEMBRANE ELECTRODE. 失效
标题翻译：肝素选择性聚合膜电极。
公开(公告)号：EP0630472A4
公开(公告)日：1995-08-23
申请号：EP93907373
申请日：1993-03-10
申请人： UNIV MICHIGAN
发明人： MA SHU-CHING , MEYERHOFF MARK E , YANG VICTOR C
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1473 , G01N27/333 , G01N27/26
CPC分类号： G01N27/3335 , Y10S435/817

7. 发明专利

CA2169652A1 HEPARIN-SELECTIVE POLYMERIC MEMBRANE 未知
公开(公告)号：CA2169652A1
公开(公告)日：1995-02-23
申请号：CA2169652
申请日：1994-08-16
申请人： UNIV MICHIGAN
发明人： MA SHU-CHING , MEYERHOFF MARK E , YANG VICTOR C
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1473 , G01N27/333 , G01N27/26 , G01N33/49
摘要： An anion exchange membrane (15) for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material and an anion exchange material suitable for heparin detection can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in blood or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt. % polymeric matrix material, such as polyvinyl chloride, 0.1-12 wt. % quaternary ammonium salt, such as tridodecyl methyl ammonium chloride (TDMAC), and 30-70 wt. % of a plasticizer, such as dioctyl sebacate. A solid state sensor (200) employs TDMAC dissolved in a polymeric compound, such as silicone rubber, to form a membrane (270) which is responsive to heparin concentration.

8. 发明公开

EP0714507A4 HEPARIN-SELECTIVE POLYMERIC MEMBRANE 失效
标题翻译：肝素选择性的聚合物膜
公开(公告)号：EP0714507A4
公开(公告)日：1996-07-31
申请号：EP94927170
申请日：1994-08-16
申请人： UNIV MICHIGAN
发明人： MA SHU-CHING , MEYERHOFF MARK E , YANG VICTOR C
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1473 , G01N27/333 , G01N27/26
CPC分类号： G01N27/3335 , Y10S435/817
摘要： An anion exchange membrane (15) for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material and an anion exchange material suitable for heparin detection can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in blood or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt. % polymeric matrix material, such as polyvinyl chloride, 0.1-12 wt. % quaternary ammonium salt, such as tridodecyl methyl ammonium chloride (TDMAC), and 30-70 wt. % of a plasticizer, such as dioctyl sebacate. A solid state sensor (200) employs TDMAC dissolved in a polymeric compound, such as silicone rubber, to form a membrane (270) which is responsive to heparin concentration.

9. 发明专利

CA2117692A1 HEPARIN-SELECTIVE POLYMERIC MEMBRANE ELECTRODE 未知
公开(公告)号：CA2117692A1
公开(公告)日：1993-09-16
申请号：CA2117692
申请日：1993-03-10
申请人： UNIV MICHIGAN
发明人： MA SHU-CHING , MEYERHOFF MARK E , YANG VICTOR C
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1473 , G01N27/333 , G01N27/40
摘要： (see fig. 1) An anion exchange membrane (15) for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material, an anion exchange material suitable for heparin detection, and a plast icizer can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in bloo d or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt.% polymeric matrix material , such as polyvinyl chloride, 0.1-12 wt.% quaternary ammonium salt, such as tridodecyl methyl ammonium chloride, and 30-70 wt.% of a plasticizer, such as dioctyl sebacate.

10. 发明专利

AU8193391A PHOTOBIOREACTORS AND CLOSED ECOLOGICAL LIFE SUPPORT SYSTEMS AND ARTIFICIAL LUNGS CONTAINING THE SAME 未知
公开(公告)号：AU8193391A
公开(公告)日：1992-01-23
申请号：AU8193391
申请日：1991-06-28
申请人： UNIV MICHIGAN
发明人： YANG VICTOR C , BARTLETT ROBERT H , PALSSON BERNHARD O , JAVANMARDIAN MINOO
IPC分类号： C12M1/00 , C12P3/00 , C12M1/42

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