专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013009057A3 XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME 审中-公开
公开(公告)号：WO2013009057A3
公开(公告)日：2013-07-04
申请号：PCT/KR2012005423
申请日：2012-07-09
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
IPC分类号： A61F2/28 , A61L27/38 , A61L27/54 , C12N5/071
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/365 , A61L27/3687 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a bone grafting substitute and to a method for manufacturing same. The method for manufacturing the bone grafting substitute according to the present invention enables production of a bone grafting substitute which, compared with existing xenograft-derived bone grafting substitutes, has superior biocompatibility due to a lower protein content and which can fuse well in the tissues of a graft site without an inflammatory reaction, and furthermore, the method can provide increased osteoblast adhesion by treating surfaces of the bone grafting substitute with an acidic amino acid, and can provide improved conduction of newly-generated bone by introducing a bioactive factor.

2. 发明申请

WO2013009057A2 XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：异源衍生骨移植替代物及其制造方法
公开(公告)号：WO2013009057A2
公开(公告)日：2013-01-17
申请号：PCT/KR2012005423
申请日：2012-07-09
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
IPC分类号： A61F2/28 , A61L27/38 , A61L27/54 , C12N5/071
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/365 , A61L27/3687 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a bone grafting substitute and to a method for manufacturing same. The method for manufacturing the bone grafting substitute according to the present invention enables production of a bone grafting substitute which, compared with existing xenograft-derived bone grafting substitutes, has superior biocompatibility due to a lower protein content and which can fuse well in the tissues of a graft site without an inflammatory reaction, and furthermore, the method can provide increased osteoblast adhesion by treating surfaces of the bone grafting substitute with an acidic amino acid, and can provide improved conduction of newly-generated bone by introducing a bioactive factor.
摘要翻译：骨移植替代物及其制造方法技术领域本发明涉及一种骨移植替代物及其制造方法。根据本发明的用于制造骨移植替代物的方法能够生产骨移植替代物，与现有的异种移植物衍生的骨移植替代物相比，由于蛋白质含量较低且具有良好的生物相容性，没有炎症反应的移植部位，并且此方法通过用酸性氨基酸处理骨移植替代物的表面可以提供增加的成骨细胞粘附，并且通过引入生物活性因子可以改善新生骨的传导。

3. 发明申请

WO2012144778A3 SURFACE-ACTIVE COLLAGEN BARRIER MEMBRANE TO WHICH A PEPTIDE IS BOUND 审中-公开
标题翻译：表面活性胶原蛋白膜对于肽是有害的
公开(公告)号：WO2012144778A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012002895
申请日：2012-04-17
申请人： NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
IPC分类号： C07K19/00 , A61K38/39 , A61L27/24 , C07K14/78
CPC分类号： C07K14/51 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/412 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/78 , C07K2319/00
摘要： The present invention relates to a barrier membrane to which a peptide, which binds to collagen and which is capable of regenerating bone tissue, is bound. More particularly, the present invention relates to a collagen barrier membrane in which a fusion peptide consisting of a collagen-bound peptide and a functional bone-tissue-regenerating peptide is fixed to the surface of collagen. According to the present invention, the surface-active collagen barrier membrane, in which a fusion peptide is coupled to the surface of collagen, can stably bind to the body due to increased local retention, and promote the transport, proliferation, and differentiation of cells, to thereby ultimately maximize bone-tissue-regenerating capacity when implanted in the body. Therefore, the barrier membrane of the present invention is useful in the development of guided bone-regeneration technology. In addition, a fusion peptide can be applied to implants made of collagen having other shapes, and a collagen-bound peptide, which constitutes the fusion peptide, can be bound to and synthesized with a peptide having effects in regenerating other tissue, and therefore can be useful in tissue-regenerating biomaterials for other purposes, e.g. for regenerating skin.
摘要翻译：本发明涉及一种与胶原结合且能够再生骨组织的肽结合的阻隔膜。更具体地说，本发明涉及胶原屏障膜，其中由胶原结合肽和功能性骨组织再生肽组成的融合肽固定在胶原蛋白表面。根据本发明，融合肽与胶原表面偶联的表面活性胶原屏障膜可以由于局部保留的增加而稳定地结合身体，促进细胞的转运，增殖和分化，从而最终使植入体内的骨组织再生能力最大化。因此，本发明的阻隔膜可用于引导骨再生技术的开发。此外，融合肽可以应用于具有其他形状的胶原的植入物，并且构成融合肽的胶原结合肽可以与具有再生其他组织的作用的肽结合并合成，因此可以用于组织再生生物材料用于其他目的，例如用于再生皮肤。

4. 发明申请

WO2009151268A3 ORAL RETRACTOR FOR DENTAL USE 审中-公开
标题翻译：口腔使用的口腔返流器
公开(公告)号：WO2009151268A3
公开(公告)日：2010-03-11
申请号：PCT/KR2009003100
申请日：2009-06-10
申请人： SEOUL NAT UNIV IND FOUNDATION , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , PARK HYUN JUNG , KIM JUNG BIN
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , PARK HYUN JUNG , KIM JUNG BIN
IPC分类号： A61C19/00
CPC分类号： A61B1/24 , A61C5/90
摘要： The present invention relates to an oral retractor for dental use, and more particularly, to an oral retractor which has a pair of holders for supporting the lips that are connected to and formed integrally with a support to enable the oral retractor to be easily installed inside a mouth and enable a dentist to diagnose and treat the dental condition of the patient without causing discomfort and damage to the gums and teeth of the patient when installed. The oral retractor for dental use according to the present invention provides convenience for both the patient and the dentist as it is simple to install and further enables the patient to open his/her mouth to an appropriate degree without discomfort, thus ensuring sufficient space for diagnosis and treatment. The oral retractor for dental use according to the present invention can be applied to a variety of oral-related fields as it can be used also for injection of drugs with oral applications.
摘要翻译：本发明涉及一种用于牙科用途的口腔牵开器，更具体地说，涉及一种口腔牵开器，其具有一对用于支撑嘴唇的保持器，所述保持器连接并与支撑件一体地形成，从而能够将口腔牵开器容易地安装在内部口腔，使得牙科诊断和治疗患者的牙齿状况，而不会在安装时引起不适和对患者牙龈的损伤。根据本发明的用于牙科用途的口腔牵开器为患者和牙医提供了方便，因为其易于安装，并且进一步使得患者能够在适当的程度上打开他/她的口腔而不受到不适，从而确保足够的诊断空间和治疗。根据本发明的用于牙科用途的口腔牵开器可以应用于各种口腔相关领域，因为它也可以用于口服应用的药物的注射。

5. 发明申请

WO2009020577A3 INNOVATIVE FORMULATION FOR ORAL INSULIN DELIVERY 审中-公开
标题翻译：口服胰岛素分泌物的创新配方
公开(公告)号：WO2009020577A3
公开(公告)日：2009-05-28
申请号：PCT/US2008009365
申请日：2008-08-04
申请人： IND SCIENCE & TECHNOLOGY NETWO , DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
发明人： DAVID ALLAN E , YANG ARTHUR J , PARK YOON JEONG , CHANG LI-CHIEN , YANG VICTOR C
IPC分类号： C12Q1/68
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention provides for an encapsulated, mucoadhesive oral formulation for hormones, such as insulin, and methods of using such formulations.
摘要翻译：本发明提供了用于激素（例如胰岛素）的包封的粘膜粘附性口服制剂，以及使用这些制剂的方法。

6. 发明申请

WO2009045063A2 COMPLEX OF CELL TRANSLOCATIONAL PEPTIDE AND MAGNETIC NANOPARTICLES AND USE THEREOF 审中-公开
标题翻译：细胞跨定位肽和磁性纳米颗粒的复合物及其用途
公开(公告)号：WO2009045063A2
公开(公告)日：2009-04-09
申请号：PCT/KR2008/005815
申请日：2008-10-02
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , PARK, Yoon-Jeong , CHUNG, Chong-Pyoung , YANG, Victor, C. , SUH, Jin Sook
发明人： PARK, Yoon-Jeong , CHUNG, Chong-Pyoung , YANG, Victor, C. , SUH, Jin Sook
IPC分类号： B82B3/00
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： The present invention relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex and the use thereof. More specifically, relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex in which a cell-penetrating peptide is chemically linked to a fluorescence-labeled magnetic nanoparticle, such that fluorescence-labeled magnetic nanoparticle can be stably introduced directly into cells without endocytosis, and a composition for cell imaging containing the complex. The disclosed invention suggests an innovative therapeutic technology which shows high stability, maximizes the effect of imaging diagnosis through optimal targeting and minimizes side effects, unlike existing viral peptide transporters.
摘要翻译：本发明涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物及其用途。更具体地说，涉及一种细胞穿透肽/荧光标记磁性纳米颗粒复合物，其中细胞穿透肽与荧光标记磁性纳米颗粒化学连接，使得荧光标记磁性纳米颗粒可以稳定地直接引入细胞中而无需内吞作用和含有该复合物的细胞成像组合物。所公开的发明提出了一种创新的治疗技术，该技术与现有的病毒肽转运蛋白不同，显示出高稳定性，通过最佳靶向最大化了成像诊断的效果并使副作用最小化。

7. 发明申请

WO2008150119A1 INJECTABLE BONE REGENERATION GEL CONTAINING BONE FORMATION ENHANCING PEPTIDE 审中-公开
标题翻译：骨髓再生凝胶含有骨形成增强肽
公开(公告)号：WO2008150119A1
公开(公告)日：2008-12-11
申请号：PCT/KR2008/003165
申请日：2008-06-05
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD , CHUNG, Chong-Pyoung , PARK, Yoon-Jeong , LEE, Jue-Yeon
发明人： CHUNG, Chong-Pyoung , PARK, Yoon-Jeong , LEE, Jue-Yeon
IPC分类号： A61L27/56
CPC分类号： A61L27/52 , A61L27/227 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
摘要翻译：本发明涉及包含骨形成增强肽的可注射骨再生材料，更具体地，涉及可注射骨再生材料，其中，基本上含有SEQ ID NO：1至 SEQ ID NO：28被结合或混合到选自壳聚糖，藻酸，丝素蛋白，丙二醇，丙二醇藻酸，泊洛沙姆，硫酸软骨素及其组合中的凝胶形成基材。根据本发明的可注射骨再生材料可以增加骨髓基质细胞和成骨细胞分化成骨组织，从而通过能够促进骨组织分化和牙周组织再生的肽最大化组织再生。可注射骨再生材料为凝胶形式，因此可以应用于诸如植入物等各种医疗装置的表面，并且可以与骨移植物颗粒混合使用，从而可以增加治疗效果的现有医疗装置以最大化组织再生效果。

8. 发明申请

WO2004081188A3 NON-TOXIC MEMBRANE-TRANSLOCATING PEPTIDES 审中-公开
标题翻译：非毒性膜转录肽
公开(公告)号：WO2004081188A3
公开(公告)日：2008-01-24
申请号：PCT/US2004007145
申请日：2004-03-10
申请人： UNIV MICHIGAN , IND SCIENCE & TECHNOLOGY NETWO , PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
发明人： PARK YOON JEONG , LIANG JUN FENG , YANG VICTOR C , CHANG LI-CHIEN
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K14/46 , C12N20060101 , C12N15/87
CPC分类号： C12N15/87 , A61K38/168 , A61K47/64 , A61K47/645 , A61K48/0008 , A61K49/0041 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K14/461 , C07K2319/03
摘要： Compositions for transport across a biological membrane include a membrane-translocating LMWP peptide and a cargo molecule. Methods for transporting a cargo molecule across a biological membrane are also described.
摘要翻译：用于在生物膜上运输的组合物包括膜易位的LMWP肽和货物分子。还描述了将货物分子穿过生物膜运送的方法。

9. 发明申请

WO2007132952A1 METHOD FOR PREPARING A PRION-FREE BONE GRAFTING SUBSTITUTE 审中-公开
标题翻译：用于制备无创骨髓移植替代物的方法
公开(公告)号：WO2007132952A1
公开(公告)日：2007-11-22
申请号：PCT/KR2006/001773
申请日：2006-05-12
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , RHEE, Sang-Hoon , CHUNG, Chong-Pyoung , PARK, Yoon-Jeong
发明人： RHEE, Sang-Hoon , CHUNG, Chong-Pyoung , PARK, Yoon-Jeong
IPC分类号： A61F2/28
CPC分类号： A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61F2002/4645 , A61F2002/4649 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L2430/02
摘要： The present invention relates to a method for preparing a hone graft substitute using bovine bone, and more particularly to a method for preparing a safe bone graft substitute which does not have the risk of infection with bovine spongiform encephalopathy, the method comprising treating bovine bone with sodium hypochlorite and treating the treated bone at a high temperature of more than 600 °C. The bone graft substitute does not cause an immune response, because it is prepared by effectively removing lipids and organic substances from bovine bone having a structure very similar to that of the human bone. Also, it has excellent osteoconductivity, and is free of prion, and thus it does not have the risk of infection with bovine spongiform encephalopathy. According to the disclosed invention, the bone graft substitute having such advantages can be prepared in a simple manner.
摘要翻译：本发明涉及一种使用牛骨制备骨髓接枝替代物的方法，更具体地涉及一种不具有牛海绵状脑病感染风险的安全骨移植物替代物的制备方法，所述方法包括用牛骨治疗牛骨次氯酸钠，并在高于600℃的高温下处理骨。骨移植物替代物不会引起免疫应答，因为它通过有效地从具有与人骨的结构非常相似的牛骨中除去脂质和有机物质来制备。此外，它具有优异的骨传导性，没有朊病毒，因此不具有感染牛海绵状脑病的风险。根据所公开的发明，可以以简单的方式制备具有这些优点的骨移植物替代物。

10. 发明申请

WO2007089084A1 BONE GRAFT AND SCAFFOLDING MATERIALS IMMOBILIZED WITH TYPE I COLLAGEN BINDING PEPTIDES 审中-公开
标题翻译：用I型胶原蛋白结合肽固定的骨髓和切割材料
公开(公告)号：WO2007089084A1
公开(公告)日：2007-08-09
申请号：PCT/KR2007/000335
申请日：2007-01-19
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , PARK, Yoon-Jeong , CHUNG, Chong-Pyoung , LEE, Seung-Jin , LEE, Jue-Yeon
发明人： PARK, Yoon-Jeong , CHUNG, Chong-Pyoung , LEE, Seung-Jin , LEE, Jue-Yeon
IPC分类号： A61L27/10
CPC分类号： A61L27/10 , A61L27/34 , A61L27/54 , A61L2430/02
摘要： The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.
摘要翻译：本发明涉及一种药物组合物，其包含骨移植材料，用于组织工程应用的支架和具有固定在表面上的骨钙化促进肽的I型胶原结合肽，更具体地涉及骨移植材料和支架对于具有与固定在表面上的I型胶原特异性结合的肽的组织工程应用（以下称为支架），以及用于回收含有I型胶原结合诱导肽的组织再生的药物组合物。在用于组织工程应用的本发明的骨移植材料和支架中，与胶原结合诱导肽再生相关的细胞粘附在表面上，促进I型胶原结合诱导肽（细胞外基质的主要成分）的粘附以增加分化速率进入骨组织，并促进钙化，这是骨再生的最后一步，最终最大限度地发挥组织再生。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式