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1. 发明授权

US06552024B1 Compositions and methods for mucosal delivery 失效
标题翻译：粘膜递送的组成和方法
公开(公告)号：US06552024B1
公开(公告)日：2003-04-22
申请号：US09434878
申请日：1999-11-05
申请人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
发明人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
IPC分类号： A61K31495
CPC分类号： A61K9/0007 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K9/006 , A61K9/145 , A61K9/1623 , A61K9/7007 , A61K9/7015 , A61K31/495 , A61K31/505
摘要： Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.
摘要翻译：含有水溶性水胶体的粘膜表面涂膜形成膜剂量单位，有效剂量的活性剂和粘膜粘附增强剂; 其中所述活性剂包封在化学或物理上不同于所述液体胶体的聚合物内; 其中粘膜粘附增强剂是淀粉接枝共聚物; 其中所述膜的干粘度值小于3.5g，湿粘性大于35g，对于2％聚合物溶液的凝胶化温度大于70℃，干膜厚度小于20密耳，水含量为0.5〜10％，拉伸强度大于1500psi，模量为35,000〜300,000psi，％伸长率小于20％，耐撕裂概率为0.001〜1N，施用于口腔粘膜表面后的溶出时间为1至600秒。

2. 发明授权

US07163223B2 Lockout mechanism for a suspension system 有权
标题翻译：悬挂系统的锁定机构
公开(公告)号：US07163223B2
公开(公告)日：2007-01-16
申请号：US10707079
申请日：2003-11-19
申请人： Kevin F. Wesling , Brian T. Jordan , Christopher A. Shipman , John D. Cheever , Edward Herrington , James Osborne
发明人： Kevin F. Wesling , Brian T. Jordan , Christopher A. Shipman , John D. Cheever , Edward Herrington , James Osborne
IPC分类号： B62K21/00 , F16K17/26 , F16F9/34
CPC分类号： F16F9/446 , B62K25/08 , F16F9/003 , F16F9/516 , F16F9/56 , Y10T137/7775
摘要： A suspension system that includes a simplified lockout mechanism and an adjustable blow-off mechanism. The system includes a valve mechanism and a valve actuating assembly, a valve mechanism housing and a resilient member disposed between the valve mechanism and the valve mechanism housing. The valve mechanism is slidably mounted along the valve mechanism housing and it separates a first chamber from a second chamber. The valve actuating assembly operates the valve mechanism between open and closed positions. The resilient member is configured to be deformable by the valve mechanism as the valve mechanism is slidably displaced by an increasing pressure in the first fluid chamber. The sliding valve mechanism is configured to collide against the valve actuating assembly when a blow-off pressure is reached in the first fluid chamber switching the valve mechanism from the closed position to the open position.
摘要翻译：一种悬架系统，其包括简化的锁定机构和可调节的排放机构。该系统包括阀机构和阀致动组件，阀机构壳体和设置在阀机构和阀机构壳体之间的弹性构件。阀机构沿着阀机构壳体可滑动地安装，并且将第一室与第二室分离。阀致动组件在打开位置和关闭位置之间操作阀机构。弹性构件被构造成当阀机构通过第一流体室中的增加的压力可滑动地移位时由阀机构变形。当在第一流体室中达到泄放压力以将阀机构从关闭位置切换到打开位置时，滑动阀机构构造成与阀致动组件碰撞。

3. 发明申请

US20050186262A1 Transdermal delivery device for dihydropyridine type calcium antagonists 审中-公开
标题翻译：二氢吡啶型钙拮抗剂的透皮递送装置
公开(公告)号：US20050186262A1
公开(公告)日：2005-08-25
申请号：US11034857
申请日：2005-01-14
申请人： James Osborne , Meenal Chavan
发明人： James Osborne , Meenal Chavan
IPC分类号： A61K9/70 , A61K31/00 , A61K31/455 , A61K47/12
CPC分类号： A61K9/7061 , A61K31/00 , A61K31/455 , A61K47/12
摘要： A transdermal delivery device for delivering dihydropyridine-type calcium antagonists through the skin for treatment of hypertension. The device may comprise a backing layer and an adhesive matrix reservoir. The adhesive matrix reservoir is affixed to a side of the backing layer and may comprise at least one fatty acid permeation enhancer as well as the dihydropyridine-type calcium antagonists.
摘要翻译：用于通过皮肤递送二氢吡啶型钙拮抗剂以治疗高血压的透皮递送装置。该装置可以包括背衬层和粘合剂基质储存器。粘合剂基质储存器固定在背衬层的一侧，并且可以包含至少一种脂肪酸渗透增强剂以及二氢吡啶型钙拮抗剂。

4. 发明授权

US07090308B2 Axle assembly for mounting a wheel to a vehicle 有权
标题翻译：用于将车轮安装到车辆上的车轮组件
公开(公告)号：US07090308B2
公开(公告)日：2006-08-15
申请号：US10707157
申请日：2003-11-24
申请人： Russell Rose , Edward Herrington , John Reid , James Osborne
发明人： Russell Rose , Edward Herrington , John Reid , James Osborne
IPC分类号： B60B27/06 , B62K25/02
CPC分类号： B62K25/02
摘要： An axle assembly connecting a wheel assembly to a vehicle frame. The axle assembly includes a tubular body having first and seconds connectable to the vehicle frame and open-ended slots disposed proximate at least one of the first and second ends of the tubular body. An expansion element is engageable with the tubular body to radially deform the tubular body at a mounting point to the vehicle frame. This configuration provides a rigid connection between the axle assembly and the vehicle frame in both the linear and radial directions.
摘要翻译：将车轮组件连接到车架的车轴组件。轴组件包括具有可连接到车辆框架的第一和第二秒的管状体，以及邻近管状体的第一和第二端中的至少一个设置的开口狭槽。膨胀元件可与管状体接合，以在安装点处将车体框架径向变形。这种构造提供在轴组件和车架之间在线性和径向方向上的刚性连接。

5. 发明申请

US20050269333A1 Fuel tank and method for reducing vapor permeation through a fuel tank 有权
标题翻译：燃料箱和通过燃料箱减少蒸汽渗透的方法
公开(公告)号：US20050269333A1
公开(公告)日：2005-12-08
申请号：US11134486
申请日：2005-05-20
申请人： Win Burrington , James Osborne , Steve Toth
发明人： Win Burrington , James Osborne , Steve Toth
IPC分类号： B01D24/00 , B32B1/02 , B60K15/03 , B60K15/035
CPC分类号： B60K15/03177 , Y10T156/10 , Y10T428/1383 , Y10T428/2826
摘要： A method of reducing fuel vapor permeation through a multi-layer tank includes providing a multi-layer overlay onto at least a portion of a structural layer of the multi-layer tank. The multi-layer overlay preferably comprises at least one structural layer composed of a polymeric material that is compatible with one or more of the polymeric structural layer(s) of the multi-layer tank. The multi-layer overlay further comprises at least one barrier layer composed of a vapor barrier material resistant to hydrocarbon permeation therethrough. The multi-layer overlay may be secured to the multi-layer tank by, for example, applying a suitable amount of heat and pressure thereto or by molding the multi-layer overlay to the tank body during a tank forming process.
摘要翻译：减少通过多层罐的燃料蒸汽渗透的方法包括在多层罐的结构层的至少一部分上提供多层覆盖层。多层覆盖物优选地包括至少一个结构层，其由与多层槽的一个或多个聚合物结构层相容的聚合物材料组成。多层覆层进一步包括至少一个阻挡层，该隔离层由耐烃渗透的蒸气阻隔材料组成。多层覆盖层可以通过例如在罐形成过程中向其施加合适量的热和压力或者通过将多层覆盖层模制到罐体而固定到多层罐。

6. 发明申请

US20070067934A1 Multi-Use and Decorative Bathing Implement 审中-公开
标题翻译：多用途和装饰洗澡器具
公开(公告)号：US20070067934A1
公开(公告)日：2007-03-29
申请号：US11561711
申请日：2006-11-20
申请人： James Osborne
发明人： James Osborne
IPC分类号： A47K7/02
CPC分类号： A47K7/02 , Y10S248/915
摘要： A multi-use bathing implement for use in cleansing and exfoliating skin and as a toy, a holder of soap or like products, and a decoration. The bathing implement includes a toroidal sponge component and can also have a removable attachment component. The donut-shaped sponge component is preferably made of mesh sponge material and is concentrically disposed about an inner ring-shaped component defining a central opening in which the attachment component can be removably secured. The inner ring-shaped component provides a ready gripping area which can be held for manipulating the bathing implement. The attachment component can be, for instance, a toy, a solid soap product, a container of a bath/cosmetic product or the like, a mesh netting pocket, or a knob-shaped hanging device having a suction cup. In addition, the implement can have a drawstring for converting the toroid shape sponge into a ball shaped sponge.
摘要翻译：用于清洁和去角质皮肤以及作为玩具，肥皂或类似产品的保持器和装饰的多用途洗澡器具。洗澡器具包括环形海绵组件，并且也可以具有可拆卸的附接部件。环形海绵部件优选由网状海绵材料制成，并且围绕限定中心开口的内环形部件同心地设置，其中附接部件可拆卸地固定在该中心开口中。内环形部件提供可以保持用于操纵洗澡器具的准备好的抓握区域。附着部件可以是例如玩具，固体肥皂产品，浴/化妆品等的容器，网眼袋或具有吸盘的旋钮形悬挂装置。此外，该工具可以具有用于将环形海绵转换成球形海绵的束带。

7. 发明申请

US20050171977A1 Methods, systems and products for data preservation 审中-公开
标题翻译：用于数据保存的方法，系统和产品
公开(公告)号：US20050171977A1
公开(公告)日：2005-08-04
申请号：US10895612
申请日：2004-07-20
申请人： James Osborne , Hong Bui , L. Brosnahan , Michael McDaniel , Philip Winant
发明人： James Osborne , Hong Bui , L. Brosnahan , Michael McDaniel , Philip Winant
IPC分类号： G06F17/30
CPC分类号： G06F11/3476 , G06F11/1451 , G06F11/3447 , G06F2201/86
摘要： A method implementable by an electronic system comprises identifying an event corresponding to a data set, the data set being of a type of a plurality of data-set types; identifying the type of the data set; identifying an association between the type of the data set and an entity of a plurality of entities; and instructing the entity to perform an action with respect to the data set.
摘要翻译：一种可由电子系统实现的方法包括：识别与数据集相对应的事件，所述数据集是多种数据集类型的类型; 识别数据集的类型; 识别数据集的类型和多个实体的实体之间的关联; 并指示该实体对数据集执行动作。

8. 发明申请

US20050115054A1 Fuel system component and method of manufacture 有权
公开(公告)号：US20050115054A1
公开(公告)日：2005-06-02
申请号：US10999455
申请日：2004-11-30
申请人： Brian Brandner , Vladimir Franjo , Keith Kersey , Harald Knueppel , Ted Latouf , James Osborne
发明人： Brian Brandner , Vladimir Franjo , Keith Kersey , Harald Knueppel , Ted Latouf , James Osborne
IPC分类号： B60K15/04 , B23P17/04 , B29C49/04 , B29C49/22 , B29C49/48 , B29C49/54 , B29C51/06 , B29C51/08 , B29C51/10 , B29C51/14 , B29D23/00 , B29L9/00 , B29L23/00 , B32B1/08 , B60K15/00 , B60K15/03 , B60P3/00
CPC分类号： B29C49/22 , B29C49/04 , B29C49/4802 , B29C51/06 , B29C51/08 , B29C51/082 , B29C51/10 , B29C51/14 , B29C2049/4807 , B29C2791/001 , B29C2791/006 , B29K2023/065 , B29K2023/086 , B29K2025/00 , B29K2995/0067 , B29L2031/24 , B29L2031/7172 , B60K15/04 , Y10T29/49
摘要： A fuel tank that is substantially impermeable to fuel vapor has a shell with an interior for holding fuel, an opening for receiving fuel into the interior, and a fill nipple with a barrier layer. The fill nipple has an outer surface and an inner surface defining a passage extending between a pair of generally opposed ends of the fill nipple. One of the ends is attached to the shell such that the passage is aligned with the opening to allow fuel to flow through the passage and into the interior of the fuel tank. The fill nipple has an inner layer of material forming the inner surface, and an outer layer of material forming the outer surface, and has at least one intermediate layer of material forming the barrier layer. The intermediate layer is formed from a material that is different in composition from the inner and outer layers.

9. 发明申请

US20050110335A1 Axle assembly for mounting a wheel to a vehicle 有权
标题翻译：用于将车轮安装到车辆上的车轮组件
公开(公告)号：US20050110335A1
公开(公告)日：2005-05-26
申请号：US10707157
申请日：2003-11-24
申请人： Russell Rose , Edward Herrington , John Reid , James Osborne
发明人： Russell Rose , Edward Herrington , John Reid , James Osborne
IPC分类号： B62K25/02 , B60B35/00
CPC分类号： B62K25/02
摘要： An axle assembly connecting a wheel assembly to a vehicle frame. The axle assembly includes a tubular body having first and seconds connectable to the vehicle frame and open-ended slots disposed proximate at least one of the first and second ends of the tubular body. An expansion element is engageable with the tubular body to radially deform the tubular body at a mounting point to the vehicle frame. This configuration provides a rigid connection between the axle assembly and the vehicle frame in both the linear and radial directions.
摘要翻译：将车轮组件连接到车架的车轴组件。轴组件包括具有可连接到车辆框架的第一和第二秒的管状体，以及邻近管状体的第一和第二端中的至少一个设置的开口狭槽。膨胀元件可与管状体接合，以在安装点处将车体框架径向变形。这种构造提供在轴组件和车架之间在线性和径向方向上的刚性连接。

10. 发明申请

US20070186976A1 Fuel storage system for a vehicle 失效
标题翻译：车辆燃油储存系统
公开(公告)号：US20070186976A1
公开(公告)日：2007-08-16
申请号：US11355391
申请日：2006-02-16
申请人： Steven Hilderley , James Osborne
发明人： Steven Hilderley , James Osborne
IPC分类号： F16K24/04
CPC分类号： B60K15/035 , B60K15/03504 , B60K2015/03533 , B60K2015/0772 , Y10T137/3099 , Y10T137/86252
摘要： A fuel storage system for a transportation or recreational vehicle has a fuel tank that carries a vapor assembly that seeks out vapor pockets and controllably removes fuel vapor from the tank without releasing hydrocarbons to the surrounding environment. Preferably, a vent manifold attaches to a flange that sealably covers an access hole of the tank. At least one flexible tentacle extends from the manifold in the tank to a respective vapor vent valve that floats upon the surface of fuel at a vapor dome. When freely floating, the vent valve is open thus communicates the vapor dome through the tentacle and preferably with a filtering carbon canister. As fuel surface levels change or the vehicle tilts, changing the vapor dome size or location in the tank, the floating vapor vent valve is free to move generally with the vapor dome and as permitted by the flexibility of the trailing tentacle. With tank orientations where the vapor vent valve falls below the surface of fuel, the vent valve automatically closes to prevent flooding of the respective tentacle and remote vapor canister.
摘要翻译：用于运输或休闲车辆的燃料储存系统具有一个燃料箱，该燃料箱携带一个蒸气组件，该蒸气组件可以从罐中排出蒸汽袋并可控地从罐中除去燃料蒸气，而不向周围环境释放碳氢化合物。优选地，排气歧管连接到可密封地覆盖罐的进入孔的凸缘。至少一个柔性触手从罐中的歧管延伸到相应的蒸汽排气阀，其在蒸汽圆顶处漂浮在燃料的表面上。当自由浮动时，排气阀打开，从而使蒸气穹顶通过触手连接，优选地与过滤碳罐连通。随着燃料表面水平变化或车辆倾斜，改变蒸汽穹顶尺寸或罐中的位置，浮动蒸气排放阀通常随蒸汽穹顶自由移动，并且随着后触手的灵活性允许。随着蒸汽排气阀落在燃料表面下方的罐方向，排气阀自动关闭，以防止各个触手和远端蒸气罐的溢流。

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