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1. 发明授权

US06552024B1 Compositions and methods for mucosal delivery 失效
标题翻译：粘膜递送的组成和方法
公开(公告)号：US06552024B1
公开(公告)日：2003-04-22
申请号：US09434878
申请日：1999-11-05
申请人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
发明人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
IPC分类号： A61K31495
CPC分类号： A61K9/0007 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K9/006 , A61K9/145 , A61K9/1623 , A61K9/7007 , A61K9/7015 , A61K31/495 , A61K31/505
摘要： Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.
摘要翻译：含有水溶性水胶体的粘膜表面涂膜形成膜剂量单位，有效剂量的活性剂和粘膜粘附增强剂; 其中所述活性剂包封在化学或物理上不同于所述液体胶体的聚合物内; 其中粘膜粘附增强剂是淀粉接枝共聚物; 其中所述膜的干粘度值小于3.5g，湿粘性大于35g，对于2％聚合物溶液的凝胶化温度大于70℃，干膜厚度小于20密耳，水含量为0.5〜10％，拉伸强度大于1500psi，模量为35,000〜300,000psi，％伸长率小于20％，耐撕裂概率为0.001〜1N，施用于口腔粘膜表面后的溶出时间为1至600秒。

2. 发明授权

US4951657A Heat sealable membrane for transdermal drug release 失效
标题翻译：用于透皮药物释放的可热封膜
公开(公告)号：US4951657A
公开(公告)日：1990-08-28
申请号：US184750
申请日：1988-04-22
申请人： William R. Pfister , Chi-Long Lee , Gerald A. Gornowicz
发明人： William R. Pfister , Chi-Long Lee , Gerald A. Gornowicz
IPC分类号： A61K9/70 , A61M35/00 , C08G18/61 , C08G77/42 , C08G77/458 , C09J7/02
CPC分类号： A61K9/7084 , A61M35/00 , C08G18/61
摘要： A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50.degree. C. and 200.degree. C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

3. 发明授权

US07462362B2 Antifungal nail coat and method of use 失效
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US07462362B2
公开(公告)日：2008-12-09
申请号：US10514190
申请日：2004-03-22
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译：公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。

4. 发明授权

US5613958A Transdermal delivery systems for the modulated administration of drugs 失效
标题翻译：用于调节药物给药的透皮递送系统
公开(公告)号：US5613958A
公开(公告)日：1997-03-25
申请号：US469178
申请日：1995-06-06
申请人： Frank Kochinke , William R. Pfister , Jenny Louie , Dan Arenson
发明人： Frank Kochinke , William R. Pfister , Jenny Louie , Dan Arenson
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7084 , Y10S514/947
摘要： A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.
摘要翻译：描述了用于调节药物给药的透皮递送系统。药物递送装置包括背衬; 含有药物的药物储存器，增塑剂型增强剂，溶剂型增强剂和任选的胶凝剂; 非速率控制膜; 和含有增塑剂型增强剂的粘合剂层。该药物递送系统特别可用于施用耐受诱导药物，例如血管扩张剂，例如硝酸异山梨酯。

5. 发明申请

US20120021111A1 Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture 审中-公开
标题翻译：用于饮料，食品和药物的天然低热量甜味剂组合物及其制造方法
公开(公告)号：US20120021111A1
公开(公告)日：2012-01-26
申请号：US13189501
申请日：2011-07-23
申请人： William R. Pfister , Sanjay Sehgal
发明人： William R. Pfister , Sanjay Sehgal
IPC分类号： A23L1/236
CPC分类号： A23L2/60 , A23L27/33 , A23L27/34 , A23L27/36
摘要： Natural sweetener compositions, comprising a highly purified steviol extract of rebaudioside A (Reb A) of about 80 to 99% purity, other steviol glycosides of about 3% or less, and sterebins of 1% or less, and one or more bulking agents, where the natural sweetener compositions are suitable for use as an ingredient in orally administered pharmaceuticals, foods, beverages, and other orally administered products, for humans and animals. A method of preparing naturally sweetened orally administered products, comprising the step of mixing natural sweetener compositions, having a highly purified steviol extract and one or more bulking agents, with other ingredients commonly used in manufacturing orally administered products. A process to prepare natural sweetener compositions, comprising the steps of combining a highly purified Stevia extract, having a pure primary steviol glycoside, and one or more bulking agents, with optional additives, and mixing, dissolving, drying, granulating and sieving the resulting composition.
摘要翻译：天然甜味剂组合物，其包含纯度为约80-99％的莱鲍迪甙A（Reb A）的高度纯化的甜菊醇提取物，约3％或更少的其它甜菊糖苷和1％或更少的立体异构体，以及一种或多种填充剂，其中天然甜味剂组合物适合用作人和动物的口服药物，食品，饮料和其它口服制剂中的成分。一种制备天然甜味口服产品的方法，包括将具有高度纯化的甜菊醇提取物和一种或多种填充剂的天然甜味剂组合物与通常用于制备口服产品的其它成分混合的步骤。一种制备天然甜味剂组合物的方法，包括以下步骤：将具有纯的初级甜菊醇糖苷的高度纯化的甜叶菊提取物与一种或多种填充剂与任选的添加剂混合，混合，溶解，干燥，造粒和筛分所得组合物。

6. 发明申请

US20090099266A1 Antifungal nail coat and method of use 审中-公开
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US20090099266A1
公开(公告)日：2009-04-16
申请号：US12316009
申请日：2008-12-09
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A01N33/04 , A01P3/00
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
摘要翻译：含有烯丙胺，N，N-二（C1-C8）烷基氨基取代的（C4-C18）烷基（C2-C18）羧酸酯或其药学上可接受的酸加成盐的抗真菌指甲油组合物，亲水性聚合物和公开了药学上可接受的挥发性有机载体。当与真菌感染或感染的指甲接触时，组合物提供基本上水溶性的杀真菌涂层。

7. 发明授权

US4874129A Multi-laminate fragrance release device 失效
标题翻译：多层次的香水释放装置
公开(公告)号：US4874129A
公开(公告)日：1989-10-17
申请号：US213738
申请日：1988-06-30
申请人： Alfred J. DiSapio , William R. Pfister , Mary A. Sheeran
发明人： Alfred J. DiSapio , William R. Pfister , Mary A. Sheeran
IPC分类号： A45D40/00 , A61L9/12 , B32B25/20
CPC分类号： A45D40/0087 , A61L9/12
摘要： A multi-layered multi-laminate sustained release device capable of releasing fragrances, colognes, and perfumes, at a controlled rate for a prolonged period of time and having a first layer of a pressure sensitive adhesive release liner for providing a protective peel strip for the device, a second layer of a silicone pressure sensitive adhesive for adhering the device to a substrate to which it is applied including human skin, a third layer of a fragrance oil impregnated matrix of a silicone material selected from the group consisting of silicone elastomers, silicone elastomers having adhesive characteristics, and elastomeric silicone pressure sensitive adhesives, and a fourth layer of a permeable facestock backing member on the surface of the device for controlling the rate of release of the fragrance oil from the impregnated matrix.

8. 发明授权

US5798786A Electro-optical imaging detector array for a moving vehicle which includes two axis image motion compensation and transfers pixels in row directions and column directions 失效
标题翻译：用于移动车辆的电光成像检测器阵列，其包括两轴图像运动补偿并且在行方向和列方向上传送像素
公开(公告)号：US5798786A
公开(公告)日：1998-08-25
申请号：US646509
申请日：1996-05-07
申请人： Andre G. Lareau , Brian James , William R. Pfister , Kenneth J. Jerkatis , Stephen R. Beran , Russell A. Bennett
发明人： Andre G. Lareau , Brian James , William R. Pfister , Kenneth J. Jerkatis , Stephen R. Beran , Russell A. Bennett
IPC分类号： H01L27/146 , G01C11/02 , H04N5/232 , H04N5/335 , H04N7/18 , H04N9/47 , H04N5/228
CPC分类号： H04N5/23274 , G01C11/02 , G03B15/006 , H04N3/155 , H04N5/23248 , H04N5/335
摘要： An electro-optical imaging array having pixels arranged in rows and columns electronically compensates for image motion in the plane of the array regardless of whether the motion vector is in the row direction, the column direction, or in a diagonal direction, i.e., in some vector combination of row and column directions. In an aerial reconnaissance application, the image motion may be due to rotation of the aircraft about roll, pitch and/or yaw angles in addition to forward velocity of the aircraft. The image motion compensation is achieved with no moving parts and does not require a stabilized platform. A camera control computer determines the magnitude and direction of the image motion from inertial navigation system inputs, including velocity, flight, and aircraft rotation information, and calculates pixel information transfer rates in the row and column directions. The pixel information transfer rates are supplied to a counter and clock driver circuit for the array. The pixel information in the array is transferred in the row and column direction in a step-wise fashion in the row and column directions at a rate and direction substantially matching the image motion. The array itself is provided with a gate and control line design to enable charge representing pixel information to be transferred in both the row and column directions.
摘要翻译：具有排列成行和列的像素的电光学成像阵列电子地补偿阵列的平面中的图像运动，而不管运动矢量是在行方向，列方向还是在对角线方向上，即在某些方面行和列方向的向量组合。在空中侦察应用中，图像运动可能是由于除了飞行器的向前速度之外，飞机关于滚动，俯仰和/或偏航角度的旋转。图像运动补偿无需移动部件即可实现，不需要稳定的平台。相机控制计算机确定惯性导航系统输入的图像运动的大小和方向，包括速度，飞行和飞行器旋转信息，并计算行和列方向上的像素信息传输速率。像素信息传送速率被提供给阵列的计数器和时钟驱动器电路。阵列中的像素信息在行和列方向上以逐行方式以基本上与图像运动匹配的速率和方向在行和列方向上传送。阵列本身设置有栅极和控制线设计，以使得能够在行和列方向上传送代表像素信息的电荷。

9. 发明授权

US5348429A Tapping apparatus with rapid tap advance/retraction 失效
标题翻译：具有快速抽头进给/缩回的攻丝装置
公开(公告)号：US5348429A
公开(公告)日：1994-09-20
申请号：US142720
申请日：1993-10-25
申请人： William R. Pfister
发明人： William R. Pfister
IPC分类号： B23B47/18 , B23G3/00
CPC分类号： B23G3/005 , Y10T408/675 , Y10T408/6757 , Y10T408/6793
摘要： Tapping apparatus for tapping holes in workpieces is provided with a tap assembly that includes a tap fitted to a lower tip end of a vertical lead screw, there being means including a bushing for rotating the lead screw thereby to vertically advance and retract the tap relative to the a workpiece hole. Power operating means are provided to rapidly advance and retract the lead screw independently of rotating advance/retraction of the lead screw so as to more quickly locate the tap proximal the workpiece hole allowing that tapping commences with lessened need for lead screw rotation as a means of effecting lineal advance of the lead screw. This lessens the tapping cycle time and results in increased production rate with the apparatus as well as lengthening tap life. The power operating means also functions to rapidly retract the lead screw and tap upwardly from the workpiece on completion of the tapping which also increases production particularly where the workpiece includes heightened structure adjacent the hole location so that more rapid tool clearance is achieved permitting quicker workpiece indexing to present a next to be tapped hole at a tapping station.
摘要翻译：具有用于工件中的攻丝孔的攻丝装置设置有龙头组件，其包括装配到垂直导螺杆的下尖端的龙头，其中包括用于旋转导螺杆的衬套，从而相对于竖直方向前进和后退，一个工件孔。提供动力操作装置以独立于导螺杆的旋转提前/缩回来快速前进和缩回导螺杆，以便更加快速地将挖掘头定位在靠近工件孔的位置，从而可以减少丝杠旋转的需要，作为一种手段实现丝杠的直线前进。这减少了攻丝周期时间，并且使设备的生产率提高并且延长了龙头寿命。动力操作装置还起到快速缩回导螺杆的作用，并在攻丝完成时从工件上向上挖掘，这也提高了生产，特别是在工件包括靠近孔位置的加高结构的地方，从而实现更快速的刀具间隙，从而可以更快的工件分度提出一个旁边是一个攻丝台的攻丝孔。

10. 发明授权

US5232702A Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices 失效
标题翻译：用于超导药物递送装置和相关医疗装置的硅胶压敏胶粘剂
公开(公告)号：US5232702A
公开(公告)日：1993-08-03
申请号：US733497
申请日：1991-07-22
申请人： William R. Pfister , Jeniffer M. Wilson
发明人： William R. Pfister , Jeniffer M. Wilson
IPC分类号： A61K9/70 , A61L15/10 , A61L15/58 , C08L83/00 , C08L83/02 , C09J183/00 , C09J183/04
CPC分类号： A61K9/7069 , A61L15/10 , A61L15/585 , C09J183/04
摘要： A silicone pressure sensitive adhesive composition which is compatible with drugs, excipients, co-solvents and skin penetration enhancers is disclosed which includes a cohesive strengthening agent in combination with a silicone fluid and a silicate resin. The addition of the cohesive strengthening agent helps to maintain the adhesive on the substrate, while reducing cold flow. The adhesive is useful as an improved component in transdermal drug delivery devices and related medical devices.

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