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1. 发明授权

US06552024B1 Compositions and methods for mucosal delivery 失效
标题翻译：粘膜递送的组成和方法
公开(公告)号：US06552024B1
公开(公告)日：2003-04-22
申请号：US09434878
申请日：1999-11-05
申请人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
发明人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
IPC分类号： A61K31495
CPC分类号： A61K9/0007 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K9/006 , A61K9/145 , A61K9/1623 , A61K9/7007 , A61K9/7015 , A61K31/495 , A61K31/505
摘要： Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.
摘要翻译：含有水溶性水胶体的粘膜表面涂膜形成膜剂量单位，有效剂量的活性剂和粘膜粘附增强剂; 其中所述活性剂包封在化学或物理上不同于所述液体胶体的聚合物内; 其中粘膜粘附增强剂是淀粉接枝共聚物; 其中所述膜的干粘度值小于3.5g，湿粘性大于35g，对于2％聚合物溶液的凝胶化温度大于70℃，干膜厚度小于20密耳，水含量为0.5〜10％，拉伸强度大于1500psi，模量为35,000〜300,000psi，％伸长率小于20％，耐撕裂概率为0.001〜1N，施用于口腔粘膜表面后的溶出时间为1至600秒。

2. 发明授权

US07138135B2 Bioadhesive, closed-cell foam film, sustained release, delivery devices and methods of making and using same 失效
标题翻译：生物粘附剂，闭孔泡沫膜，持续释放，递送装置及其制造和使用方法
公开(公告)号：US07138135B2
公开(公告)日：2006-11-21
申请号：US10874223
申请日：2004-06-24
申请人： Li-Lan H. Chen , Li Tao , Alfred Liang , Xu Zheng
发明人： Li-Lan H. Chen , Li Tao , Alfred Liang , Xu Zheng
IPC分类号： A61F13/00 , A61F13/02 , A61F2/00 , A61F6/05 , A61L15/16
CPC分类号： A61K9/0034 , A61K9/006 , A61K9/7007
摘要： Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.
摘要翻译：提供生物粘附剂，闭孔泡沫膜，持续释放，用于给予受试者的活性剂或活性剂组合的递送装置。还提供了制备这种递送装置的方法和使用这样的递送装置的方法，其提供对受试者的活性剂或活性成分的组合的受控和持续释放，优选接近零级释放。

3. 发明授权

US06756051B1 Bioadhesive, closed-cell foam film, sustained release, delivery devices and methods of making and using same 失效
标题翻译：生物粘附剂，闭孔泡沫膜，持续释放，递送装置及其制造和使用方法
公开(公告)号：US06756051B1
公开(公告)日：2004-06-29
申请号：US09713548
申请日：2000-11-15
申请人： Li-Lan H. Chen , Li Tao , Alfred Liang , Xu Zheng
发明人： Li-Lan H. Chen , Li Tao , Alfred Liang , Xu Zheng
IPC分类号： A01N2534
CPC分类号： A61K9/0034 , A61K9/006 , A61K9/7007
摘要： Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and to methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.
摘要翻译：提供生物粘附剂，闭孔泡沫膜，持续释放，用于给予受试者的活性剂或活性剂组合的递送装置。还提供了制备这种递送装置的方法以及使用这样的递送装置的方法，其提供对受试者的活性剂或活性成分的组合的受控和持续释放，优选为零级释放。

4. 发明授权

US07125564B2 Water soluble and palatable complexes 失效
公开(公告)号：US07125564B2
公开(公告)日：2006-10-24
申请号：US10071380
申请日：2002-02-08
申请人： Li-Lan H. Chen , Li Tao , Alfred Liang
发明人： Li-Lan H. Chen , Li Tao , Alfred Liang
IPC分类号： A61K9/14
CPC分类号： A61K9/0056 , A61K9/0004 , A61K9/0007 , A61K9/006 , A61K9/0095 , A61K9/5084 , A61K36/484 , A61K47/554 , A61K47/69 , A61K2300/00
摘要： The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.

5. 发明申请

US20110064801A1 Pharmaceutical Formulations Containing an SGLT2 Inhibitor 有权
标题翻译：含有SGLT2抑制剂的药物制剂
公开(公告)号：US20110064801A1
公开(公告)日：2011-03-17
申请号：US12949473
申请日：2010-11-18
申请人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
发明人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
IPC分类号： A61K9/48 , A61K31/70 , A61K9/30 , A61P3/00 , A61P9/00
CPC分类号： A61K31/7034 , A61K9/0095 , A61K9/08 , A61K9/16 , A61K9/1652 , A61K9/20 , A61K9/2054 , A61K31/155 , A61K31/403 , A61K31/70 , A61K45/06
摘要： Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical acceptable carrier therefor, which formulation is designed for immediate release.
摘要翻译：提供药物制剂，其为口服使用的胶囊或片剂的形式，其包括药物达帕格列锌或其丙二醇水合物及其药学上可接受的载体，该制剂被设计用于立即释放。

6. 发明授权

US07851502B2 Pharmaceutical formulations containing an SGLT2 inhibitor 有权
标题翻译：含有SGLT2抑制剂的药物制剂
公开(公告)号：US07851502B2
公开(公告)日：2010-12-14
申请号：US12053442
申请日：2008-03-21
申请人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
发明人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
IPC分类号： A61K31/351 , A61P3/10
CPC分类号： A61K31/7034 , A61K9/0095 , A61K9/08 , A61K9/16 , A61K9/1652 , A61K9/20 , A61K9/2054 , A61K31/155 , A61K31/403 , A61K31/70 , A61K45/06
摘要： Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical acceptable carrier therefor, which formulation is designed for immediate release.
摘要翻译：提供药物制剂，其为口服使用的胶囊或片剂的形式，其包括药物达帕格列锌或其丙二醇水合物及其药学上可接受的载体，该制剂被设计用于立即释放。

7. 发明申请

US20090225329A1 Phase-Shift Analysis System and Method 有权
标题翻译：相移分析系统与方法
公开(公告)号：US20090225329A1
公开(公告)日：2009-09-10
申请号：US12042800
申请日：2008-03-05
申请人： Clark Alexander Bendall , Kevin George Harding , Guiju Song , Li Tao
发明人： Clark Alexander Bendall , Kevin George Harding , Guiju Song , Li Tao
IPC分类号： G01B11/00
CPC分类号： G01B11/25 , G02B23/2407
摘要： A system for determining an object distance z includes a plurality of light emitters. A group of at least one of the plurality of light emitters includes an emitter group, and the pattern projected when one emitter group is emitting includes a fringe set. The light pattern of one fringe set exhibits a phase-shift relative to the light patterns of the other fringe sets, and the phase-shift varies as the distance from the origin of the plurality of fringe sets varies. The system further includes a processing unit that is configured to compute a ripple metric value associated with each of a plurality of possible z values. The processing unit is further configured to determine an approximated z value using the computed ripple metric values. A probe system is also provided. The probe system is configured to project a plurality of fringe sets from the probe onto an object. The light pattern of one fringe set exhibits a phase-shift relative to the light patterns of the other fringe sets, and the phase-shift varies as the distance from the origin of the plurality of fringe sets varies. The probe system is further configured to compute a ripple metric value associated with each of a plurality of possible z values, where z is an object distance. The probe system is also configured to determine an approximated z value using the computed ripple metric values. A method for determining an object distance z is also provided.
摘要翻译：用于确定对象距离z的系统包括多个发光器。多个发光体中的至少一个的一组包括发射体组，并且当一个发射体组发射时投射的图案包括边缘组。一个条纹集合的光图案相对于其他条纹集合的光图案显示相移，并且相移随着多个条纹集合的原点的距离变化而变化。该系统还包括处理单元，其被配置为计算与多个可能z值中的每一个相关联的纹波度量值。处理单元还被配置为使用所计算的纹波度量值来确定近似的z值。还提供探针系统。探针系统被配置为将多个边缘组从探针投影到物体上。一个条纹集合的光图案相对于其他条纹集合的光图案显示相移，并且相移随着多个条纹集合的原点的距离变化而变化。探针系统还被配置为计算与多个可能z值中的每一个相关联的波纹度量值，其中z是对象距离。探针系统还被配置为使用计算的纹波度量值来确定近似的z值。还提供了一种用于确定对象距离z的方法。

8. 发明授权

US08643849B2 Measurement systems and methods 失效
标题翻译：测量系统和方法
公开(公告)号：US08643849B2
公开(公告)日：2014-02-04
申请号：US13312423
申请日：2011-12-06
申请人： Li Tao , Guiju Song , Xinjun Wan , Kevin George Harding , Steven Robert Hayashi , James Joseph Hoffman , Charles Walter Muekmore , Yana Zhang Williams , Shukuan Xu
发明人： Li Tao , Guiju Song , Xinjun Wan , Kevin George Harding , Steven Robert Hayashi , James Joseph Hoffman , Charles Walter Muekmore , Yana Zhang Williams , Shukuan Xu
IPC分类号： G02B11/24
CPC分类号： G01B11/2513 , G01B11/2527 , G01S17/36 , G01S17/89
摘要： A measurement system comprising a light source unit, a projection unit and an optics unit is disclosed. The light source unit is configured to generate a plurality of modulated phase shifted light beams. The projection unit is configured to reflect the modulated phase shifted light beams onto an object surface. The optics unit is configured to capture the modulated phase shifted light beams from the object surface. The measurement system further comprises a photodetector and a processor. The photodetector is configured to receive the modulated phase shifted light beams from the optics unit to generate electrical signals. The processor is configured to retrieve position information of the object surface based on the electrical signals from the photodetector. A measurement method is also presented.
摘要翻译：公开了一种包括光源单元，投影单元和光学单元的测量系统。光源单元被配置为产生多个调制相移光束。投影单元被配置为将调制的相移光束反射到物体表面上。光学单元被配置为捕获来自物体表面的经调制的相移光束。测量系统还包括光电检测器和处理器。光电检测器被配置为从光学单元接收经调制的相移光束以产生电信号。处理器被配置为基于来自光电检测器的电信号来检索物体表面的位置信息。还提出了一种测量方法。

9. 发明申请

US20130057650A1 OPTICAL GAGE AND THREE-DIMENSIONAL SURFACE PROFILE MEASUREMENT METHOD 审中-公开
标题翻译：光栅和三维表面轮廓测量方法
公开(公告)号：US20130057650A1
公开(公告)日：2013-03-07
申请号：US13257268
申请日：2009-03-19
申请人： Guiju Song , Kevin George Harding , Ming Jia , Bo Yang , Qingying Hu , Jianming Zheng , Li Tao
发明人： Guiju Song , Kevin George Harding , Ming Jia , Bo Yang , Qingying Hu , Jianming Zheng , Li Tao
IPC分类号： H04N13/02 , G06K9/00
CPC分类号： G01B11/2527
摘要： An optical gage (10) with a small field of view for three-dimensional surface profile measurement includes a projector (20) having a light source (22) and projection optics (28, 30, 42) that guide light along a projection light path. An optical grating device (34) is arranged in the projection light path and modifies the projection light distribution to project a structured light pattern (46). A phase shifting apparatus (47) shifts the structured light pattern to at least three positions with desired phase shift on said surface (80) to be measured. A viewer (50) includes viewing optics with a viewing light path that is non-parallel to the projection light path, a light sensing array (58) for sensing images of diffuse reflections of the structured light patterns from said surface, and a camera (57) for recording the images. The optical gage further includes a computer (61) which comprises data input communication with the camera and a processor for modeling the surface being profiled based on surface contour information provided by the images.
摘要翻译：具有用于三维表面轮廓测量的小视野的光学计（10）包括具有光源（22）和投影光学器件（28,30,42）的投影仪（20），其沿着投影光路。光栅装置（34）布置在投影光路中并修改投影光分布以投影结构光图案（46）。相移装置（47）将结构化光图案移动到要测量的所述表面（80）上期望的相移的至少三个位置。观察器（50）包括具有不平行于投影光路的观察光路的观察光学器件，用于感测来自所述表面的结构化光图案的漫反射的图像的光感测阵列（58）和相机 57）用于记录图像。光学计进一步包括计算机（61），其包括与相机的数据输入通信，以及处理器，用于基于由图像提供的表面轮廓信息来对正在被轮廓的表面进行建模。

10. 发明授权

US08361972B2 Pharmaceutical formulations containing an SGLT2 inhibitor 有权
公开(公告)号：US08361972B2
公开(公告)日：2013-01-29
申请号：US13529463
申请日：2012-06-21
申请人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
发明人： Dilbir S. Bindra , Mandar V. Dali , Prakash V. Parab , Jatin M. Patel , Li Tao , Ravindra W. Tejwani , Nipa Vatsaraj , Yongmei Wu
IPC分类号： A61K9/48 , A61K31/70 , A61K9/30 , A61P3/00 , A61P9/00
CPC分类号： A61K31/7034 , A61K9/0095 , A61K9/08 , A61K9/16 , A61K9/1652 , A61K9/20 , A61K9/2054 , A61K31/155 , A61K31/403 , A61K31/70 , A61K45/06
摘要： Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical acceptable carrier therefor, which formulation is designed for immediate release.

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