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1. 发明申请

US20130245233A1 Multispecific Molecules 审中-公开
标题翻译：多特异性分子
公开(公告)号：US20130245233A1
公开(公告)日：2013-09-19
申请号：US13988802
申请日：2011-11-22
申请人： Ming Lei , Jing Li , Li Zhou , Zhenping Zhu
发明人： Ming Lei , Jing Li , Li Zhou , Zhenping Zhu
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/53 , C07K2317/60 , C07K2317/64
摘要： The present invention is directed to multi-specific/multivalent molecules of novel formats. The molecules with the formats of the present invention have desired yield and thermostability. The present invention also includes methods of producing and using the molecules described herein.
摘要翻译：本发明涉及新型的多特异性/多价分子。具有本发明形式的分子具有期望的产率和热稳定性。本发明还包括生产和使用本文所述分子的方法。

2. 发明授权

US09290573B2 Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies 有权
标题翻译：治疗性低密度脂蛋白相关蛋白6（LRP6）多价抗体
公开(公告)号：US09290573B2
公开(公告)日：2016-03-22
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译：本公开涉及具有至少两个LRP6的两个不同结合位点的受体结合结构域的抗体或抗原结合片段及其组合物及其使用方法。

3. 发明申请

US20160362472A1 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR)- EXPRESSING CELL 审中-公开
标题翻译： CD20治疗方案，CD22治疗方案和与CD19基因抗体受体（CAR） - 表达细胞的联合治疗
公开(公告)号：US20160362472A1
公开(公告)日：2016-12-15
申请号：US15094674
申请日：2016-04-08
申请人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
发明人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
IPC分类号： C07K14/705 , A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/70 , C07K14/7051 , C07K16/2803 , C07K16/2866 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过与一种或多种B细胞抑制剂组合施用包含本文所述的CD19 CAR的重组T细胞，例如一种或多种 CD10，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a。本公开另外具有指向CD20和CD22的新型抗原结合结构域和CAR分子，并且例如用作单一疗法或联合治疗。本发明还提供了本文所述的试剂盒和组合物。

4. 发明申请

US20130064823A1 COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES 有权
标题翻译：用于治疗性低密度脂蛋白相关蛋白6（LRP6）多种抗体的组合物和方法
公开(公告)号：US20130064823A1
公开(公告)日：2013-03-14
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
IPC分类号： C07K16/46 , A61P35/02 , A61K39/395 , A61P35/00 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译：本公开内容涉及具有至少两个受体结合的抗体或抗原结合片段，其用于LRP6的两个不同结合位点和组合物及其使用方法。

5. 发明申请

US20130074202A1 GENE SEQUENCES AND USES THEREOF IN PLANTS 审中-公开
公开(公告)号：US20130074202A1
公开(公告)日：2013-03-21
申请号：US13470467
申请日：2012-05-14
申请人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K. R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
发明人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K. R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
IPC分类号： C12N15/82 , A01D45/00
CPC分类号： C12N15/8279 , A01D45/00 , A01N25/34 , A01N31/16 , A01N41/10 , A01N43/40 , A01N43/653 , A01N43/78 , A01N43/80 , A01N55/02 , C07K14/415 , C12N9/0071 , C12N15/8241 , C12N15/8243 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12Y114/12017 , A01N25/10 , A01N25/02 , A01N2300/00
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

6. 发明申请

US20120244583A1 Method for Preparing High Purity L-alpha Glycerylphosphorylcholine 有权
标题翻译：高纯度L-α甘油磷酰胆碱的制备方法
公开(公告)号：US20120244583A1
公开(公告)日：2012-09-27
申请号：US13071126
申请日：2011-03-24
申请人： Yuanfa Liu , Kangyi Zhang , Xingguo Wang , Xiangyun Qian , Li Zhou , Zhihua Song
发明人： Yuanfa Liu , Kangyi Zhang , Xingguo Wang , Xiangyun Qian , Li Zhou , Zhihua Song
IPC分类号： C12P13/00
CPC分类号： C12P9/00 , C12P13/001
摘要： Disclosed is a method for preparing L-α-Glycerylphosphorylcholine with high yields and purity. The method uses phospholipase A1-based enzymatic hydrolysis, ion-exchange resin purification and silica gel column chromatography to prepare L-α-glycerylphosphorylcholin with purity up to 99.8% and a final yield up to 78.4%. The method disclosed is simple, cost-effective, environmentally friendly, and adaptable to industrial applications.
摘要翻译：公开了以高产率和纯度制备L-α-甘油基磷酰胆碱的方法。该方法采用磷脂酶A1酶水解，离子交换树脂纯化和硅胶柱色谱法制备纯度高达99.8％的L-α-甘油基磷酰胆碱，最终产率高达78.4％。所公开的方法简单，成本效益高，环保，适用于工业应用。

7. 发明申请

US20110258734A1 GENE SEQUENCES AND USES THEREOF IN PLANTS 审中-公开
标题翻译：基因序列及其在植物中的应用
公开(公告)号：US20110258734A1
公开(公告)日：2011-10-20
申请号：US13046601
申请日：2011-03-11
申请人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
发明人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
IPC分类号： A01H1/02 , A01D45/00 , A01H5/10 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8279 , A01D45/00 , A01N25/34 , A01N31/16 , A01N41/10 , A01N43/40 , A01N43/653 , A01N43/78 , A01N43/80 , A01N55/02 , C07K14/415 , C12N9/0071 , C12N15/8241 , C12N15/8243 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12Y114/12017 , A01N25/10 , A01N25/02 , A01N2300/00
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

8. 发明授权

US07939703B2 Method for photocatalytic isomerization of 1,2-diphenylethylene analogues 有权
标题翻译： 1,2-二苯基乙烯类似物的光催化异构化方法
公开(公告)号：US07939703B2
公开(公告)日：2011-05-10
申请号：US12327596
申请日：2008-12-03
申请人： Li-Zhu Wu , Ming-Li Peng , Li Zhou , Deng-Hui Wang
发明人： Li-Zhu Wu , Ming-Li Peng , Li Zhou , Deng-Hui Wang
IPC分类号： C07C5/23
CPC分类号： B01J31/1815 , B01J31/183 , B01J35/004 , B01J2231/52 , B01J2531/0241 , B01J2531/0244 , B01J2531/828 , C07C5/2286 , C07C2531/22 , C07C15/52
摘要： The present invention relates to methods for accelerating the trans-cis isomerization of 1,2-diphenylethylene analogues by using photocatalyst. According to this invention, in the presence of polypyridyl platinum(II) complex with catalytic dosage, a solution containing trans-1,2-diphenylethylene analogues or mixture of cis- and trans-1,2-diphenylethylene analogues is irradiated by visible light to prepare product of cis-1,2-diphenylethylene analogues or product predominantly being cis-1,2-diphenylethylene analogues under inert gas atmosphere. This method has the advantages of fast reaction, high performance, easy separation of reaction system and recycle of the polypyridyl platinum (II) complexes.
摘要翻译：本发明涉及通过使用光催化剂加速1,2-二苯基乙烯类似物的反式顺式异构化的方法。根据本发明，在催化剂量的聚吡啶基铂（II）络合物的存在下，含有反式1,2-二苯基乙烯类似物或顺式 - 和反式-1,2-二苯基乙烯类似物的混合物的溶液被可见光照射到在惰性气体气氛下制备顺式-1,2-二苯基乙烯类似物或主要为顺式1,2-二苯基乙烯类似物的产物。该方法具有反应快，性能好，反应体系分离容易，聚吡啶铂（II）配合物循环利用等优点。

9. 发明申请

US20070032890A1 Method and apparatus for robust vibration suppression 审中-公开
标题翻译：鲁棒振动抑制方法和装置
公开(公告)号：US20070032890A1
公开(公告)日：2007-02-08
申请号：US11385065
申请日：2006-03-21
申请人： Li Zhou , Eduardo Misawa
发明人： Li Zhou , Eduardo Misawa
IPC分类号： G05B19/04
CPC分类号： G05B19/416 , G05B2219/41144 , G05B2219/41337 , G11B5/5582 , G11B5/596 , G11B19/042
摘要： According to a preferred aspect of the instant invention, there is provided a system and method of robust vibration suppression which might be used in many subject matters, but which is preferably used in connection with computer controlled electromechanical devices such as disk drive arms. In a first preferred embodiment, a Gaussian waveform is selected as a velocity profile, with its integral and derivatives providing position and acceleration/jerk profiles respectively. According to another preferred embodiment, the movement velocity profile will be selected to be a member of the prolate spheroid family of waveforms. This family of functions has certain optimal properties with respect to the frequency domain concentration of energy for a given time-domain length time series. The movement of a flexible arm that is performed according to the invention will be one that has minimal or reduced residual vibration after it has reached its destination.
摘要翻译：根据本发明的优选方面，提供了可用于许多主题的鲁棒振动抑制系统和方法，但是优选地与计算机控制的机电装置如磁盘驱动臂结合使用。在第一优选实施例中，选择高斯波形作为速度分布，其积分和导数分别提供位置和加速度/加加曲线。根据另一个优选实施例，移动速度分布将被选择为波形的长椭球系列的成员。对于给定的时域长度时间序列，这个函数族对于能量的频域浓度具有一定的最佳性质。根据本发明执行的柔性臂的运动将是在到达目的地之后具有最小或减小的残余振动的运动。

10. 发明申请

US20200234244A1 PROVIDING LIMITED PERMISSION LEVEL FUNCTIONALITY FOR LISTINGS IN A NETWORK 审中-公开
公开(公告)号：US20200234244A1
公开(公告)日：2020-07-23
申请号：US16255195
申请日：2019-01-23
申请人： Li Zhou , Chong Zhang , Andrew Walter Chimka , Kevin Chuang , Kumaresh Pattabiraman , Yixiao Lu , Chen Qian , George Pearman
发明人： Li Zhou , Chong Zhang , Andrew Walter Chimka , Kevin Chuang , Kumaresh Pattabiraman , Yixiao Lu , Chen Qian , George Pearman
IPC分类号： G06Q10/10
摘要： Disclosed are systems, methods, and non-transitory computer-readable media for providing profiles with limited permission level functionality in the network. In response to receiving a request to post the new employment listing, a collaboration system updates a permission list of the employment listing to provide a first user account with an administrator permission level in relation to the employment listing. The administrator permission level provides a first function and a second function in relation to the employment listing. The collaboration system receives a request to tag a second user account to the employment listing and updates the permission list to provide the second user account with a limited permission level in relation to the employment listing. The limited permission level provides the second user account with permission to perform the first function in relation to the employment listing but does not provide permission to perform the second function.

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