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1. 发明申请

US20130245233A1 Multispecific Molecules 审中-公开
标题翻译：多特异性分子
公开(公告)号：US20130245233A1
公开(公告)日：2013-09-19
申请号：US13988802
申请日：2011-11-22
申请人： Ming Lei , Jing Li , Li Zhou , Zhenping Zhu
发明人： Ming Lei , Jing Li , Li Zhou , Zhenping Zhu
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/53 , C07K2317/60 , C07K2317/64
摘要： The present invention is directed to multi-specific/multivalent molecules of novel formats. The molecules with the formats of the present invention have desired yield and thermostability. The present invention also includes methods of producing and using the molecules described herein.
摘要翻译：本发明涉及新型的多特异性/多价分子。具有本发明形式的分子具有期望的产率和热稳定性。本发明还包括生产和使用本文所述分子的方法。

2. 发明申请

US20160362472A1 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR)- EXPRESSING CELL 审中-公开
标题翻译： CD20治疗方案，CD22治疗方案和与CD19基因抗体受体（CAR） - 表达细胞的联合治疗
公开(公告)号：US20160362472A1
公开(公告)日：2016-12-15
申请号：US15094674
申请日：2016-04-08
申请人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
发明人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
IPC分类号： C07K14/705 , A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/70 , C07K14/7051 , C07K16/2803 , C07K16/2866 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过与一种或多种B细胞抑制剂组合施用包含本文所述的CD19 CAR的重组T细胞，例如一种或多种 CD10，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a。本公开另外具有指向CD20和CD22的新型抗原结合结构域和CAR分子，并且例如用作单一疗法或联合治疗。本发明还提供了本文所述的试剂盒和组合物。

3. 发明授权

US09290573B2 Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies 有权
标题翻译：治疗性低密度脂蛋白相关蛋白6（LRP6）多价抗体
公开(公告)号：US09290573B2
公开(公告)日：2016-03-22
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译：本公开涉及具有至少两个LRP6的两个不同结合位点的受体结合结构域的抗体或抗原结合片段及其组合物及其使用方法。

4. 发明申请

US20130064823A1 COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES 有权
标题翻译：用于治疗性低密度脂蛋白相关蛋白6（LRP6）多种抗体的组合物和方法
公开(公告)号：US20130064823A1
公开(公告)日：2013-03-14
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
IPC分类号： C07K16/46 , A61P35/02 , A61K39/395 , A61P35/00 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译：本公开内容涉及具有至少两个受体结合的抗体或抗原结合片段，其用于LRP6的两个不同结合位点和组合物及其使用方法。

5. 发明授权

US09661412B2 Apparatus for providing passive stereo amplification for a portable device 有权
公开(公告)号：US09661412B2
公开(公告)日：2017-05-23
申请号：US14126314
申请日：2011-06-20
申请人： Qifeng Yan , Ming Lei , Zhichang Wang , Jyri Salomaa , Zhen Liu , Koray Ozcan
发明人： Qifeng Yan , Ming Lei , Zhichang Wang , Jyri Salomaa , Zhen Liu , Koray Ozcan
IPC分类号： H04R1/20 , H04R1/28 , H04R1/30 , H04R1/34
CPC分类号： H04R1/2861 , H04R1/30 , H04R1/345
摘要： An apparatus comprising: a first substantially horn shaped structure configured to couple and amplify sound from a first speaker of a further apparatus; and a second substantially horn shaped structure configured to couple and amplify sound from a second speaker of the further apparatus, wherein the first and second substantially horn shaped structure each comprise a mouth portion with a physical separation dimension greater than a physical separation dimension of the first and second speaker acoustic outlet of the further apparatus.

6. 发明授权

US09521677B2 Methods and apparatuses for allocation of resource blocks 有权
标题翻译：资源块分配方法和装置
公开(公告)号：US09521677B2
公开(公告)日：2016-12-13
申请号：US14345134
申请日：2012-03-29
申请人： Su Yi , Ming Lei , Shaoyi Xu
发明人： Su Yi , Ming Lei , Shaoyi Xu
IPC分类号： H04W36/00 , H04W72/04 , H04W28/26 , H04W72/08 , H04W84/00
CPC分类号： H04W72/048 , H04W28/26 , H04W72/082 , H04W84/005
摘要： Provided are methods and corresponding apparatuses for allocation of resource blocks. A method for allocation of resource blocks comprises receiving, from a base station, information regarding a measurement location at which at least one identified resource block has been measured; and using, based upon a current location of a mobile relay node and the measurement location, the at least one identified resource block for communication between the mobile relay node and at least one user equipment connected therewith, wherein the at least one identified resource block is not used for communication between the base station and at least one user equipment connected therewith at the measurement location and a measurement of the at least one identified resource block is below a predetermined threshold. With the claimed inventions, interference in the high speed railway communication could be ameliorated and the spectrum efficiency would be improved.
摘要翻译：提供了用于分配资源块的方法和相应的装置。一种用于分配资源块的方法包括从基站接收关于已经测量了至少一个所识别的资源块的测量位置的信息; 以及基于移动中继节点的当前位置和所述测量位置，使用所述至少一个识别的资源块来进行所述移动中继节点与至少一个与之相连的用户设备之间的通信，其中所述至少一个识别的资源块是不用于在测量位置处的基站与与其连接的至少一个用户设备之间的通信，并且至少一个识别的资源块的测量低于预定阈值。通过所要求的发明，可以改善高速铁路通信的干扰，提高频谱效率。

7. 发明授权

US09392606B2 Method and apparatus for dynamically adjusting uplink-downlink configuration 有权
标题翻译：动态调整上行链路 - 下行链路配置的方法和装置
公开(公告)号：US09392606B2
公开(公告)日：2016-07-12
申请号：US14345107
申请日：2012-03-30
申请人： Dalin Zhu , Zhennian Sun , Su Yi , Gang Wang , Ming Lei
发明人： Dalin Zhu , Zhennian Sun , Su Yi , Gang Wang , Ming Lei
IPC分类号： H04L1/00 , H04W72/04 , H04L5/14
CPC分类号： H04W72/0486 , H04L5/14 , H04W72/0446
摘要： Embodiments of the disclosure provide a method and apparatus for dynamically adjusting UL-DL configuration. In the method according to embodiments of the present invention, downlink traffic load and uplink traffic load for transmission between a BS and a UE in a TDD system may be obtained, a UL-DL traffic load relation may be determined based on the downlink traffic load and the uplink traffic load and a UL-DL configuration may be selected based on the UL-DL traffic load relation.
摘要翻译：本公开的实施例提供了用于动态调整UL-DL配置的方法和装置。在根据本发明的实施例的方法中，可以获得用于TDD系统中的BS与UE之间的传输的下行业务负载和上行流量负载，可以基于下行业务负载来确定UL-DL业务负载关系并且可以基于UL-DL业务负载关系来选择上行链路业务负载和UL-DL配置。

8. 发明授权

US09313746B2 Method and apparatus for determining transmission power of a secondary transmitter in a hierarchical spectrum sharing system 有权
标题翻译：用于确定分层频谱共享系统中的次发射机的发射功率的方法和装置
公开(公告)号：US09313746B2
公开(公告)日：2016-04-12
申请号：US13995845
申请日：2011-09-16
申请人： Chaofeng Li , Lei Jiang , Ming Lei
发明人： Chaofeng Li , Lei Jiang , Ming Lei
IPC分类号： H04B7/00 , H04W52/24 , H04W52/22 , H04W52/34
CPC分类号： H04W52/241 , H04W52/226 , H04W52/244 , H04W52/34
摘要： The present invention provides a method and apparatus for determining a transmission power of a secondary transmitter in a hierarchical spectrum sharing system. The method can comprise steps of obtaining channel quality information on a primary link from at least one primary receiver within a transmission range of the secondary transmitter; and determining the transmission power for the secondary transmitter based on the channel quality information, wherein the transmission power is matched with the channel quality indicated by the channel quality information. According to the embodiments of the present invention, a power control scheme is applied to the secondary transmitter based on the channel quality information on the primary link. In such a way, the secondary transmitter' throughput can be improved with controllable rate loss to the primary receiver and accordingly the spectrum efficiency for the whole system can be further upgraded.
摘要翻译：本发明提供一种用于确定分层频谱共享系统中的次发射机的发射功率的方法和装置。该方法可以包括以下步骤：从次发射机的传输范围内的至少一个主接收机获得主链路上的信道质量信息; 以及基于所述信道质量信息确定所述辅助发射机的发射功率，其中所述发射功率与由所述信道质量信息指示的信道质量匹配。根据本发明的实施例，基于主链路上的信道质量信息，将次级发射机应用功率控制方案。以这种方式，可以通过对主接收机的可控的速率损失来提高次级发射机的吞吐量，因此可以进一步升级整个系统的频谱效率。

9. 发明申请

US20150193811A1 SYSTEM AND METHOD FOR ESTIMATING POTENTIAL UNIQUE ONLINE USERS AN ADVERTISEMENT CAN REACH 有权
标题翻译：用于估计潜在的在线用户的广告系统和方法
公开(公告)号：US20150193811A1
公开(公告)日：2015-07-09
申请号：US13246609
申请日：2011-09-27
申请人： Ming Lei , Renjie Jiang , Kenneth R. Alton , Varun Chirravuri , Russell W. Quong , Abhinay Sharma , Oren E. Zamir , Xing Yu , Zhengzhu Feng
发明人： Ming Lei , Renjie Jiang , Kenneth R. Alton , Varun Chirravuri , Russell W. Quong , Abhinay Sharma , Oren E. Zamir , Xing Yu , Zhengzhu Feng
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0242 , G06Q30/0249 , G06Q30/0275
摘要： Methods, systems, and computer programs encoded on a computer storage medium include receiving, from an advertiser, advertisement criteria associated with an advertisement, the advertisement criteria comprising a first set of criteria and a budget and/or a bid, the advertisement criteria to be used in advertisement auctions for which the advertisement is to be considered for display to users performing online actions; determining a number of users for whom the advertisement was a candidate to be shown based on the first set of criteria associated with the advertisement, but to whom the advertisement was not shown based on the budget and/or bid of the advertisement during a particular period of time; and providing, in a report, information relating to the number of users.
摘要翻译：在计算机存储介质上编码的方法，系统和计算机程序包括从广告商接收与广告相关联的广告标准，所述广告标准包括第一组标准和预算和/或投标，所述广告标准为用于广告拍卖的广告拍卖，广告被考虑用于显示给执行在线动作的用户; 基于与广告相关联的第一组标准来确定广告是候选人的广告的用户数量，但是在特定时段期间基于广告的预算和/或投标而不向广告者显示广告的用户数量的时间并且在报告中提供与用户数量有关的信息。

10. 发明申请

US20150105025A1 METHOD AND APPARATUS FOR THREE-DIMENSIONAL BEAMFORMING 有权
标题翻译：三维波束形成的方法和装置
公开(公告)号：US20150105025A1
公开(公告)日：2015-04-16
申请号：US14384449
申请日：2012-06-08
申请人： Yu Zhang , Ming Lei
发明人： Yu Zhang , Ming Lei
IPC分类号： H04W16/28 , H04B15/00 , H04B7/04
CPC分类号： H04W16/28 , H01Q1/246 , H01Q3/26 , H04B7/0408 , H04B7/0413 , H04B7/0426 , H04B7/0447 , H04B7/0456 , H04B7/0465 , H04B7/0617 , H04B7/0626 , H04B7/063 , H04B7/0632 , H04B7/0639 , H04B15/00 , H04L1/0003 , H04L1/0009 , H04L1/06
摘要： Embodiments of the disclosure provide methods and apparatuses for three-dimensional beamforming. The method may comprise: mapping vertical virtual antenna ports to physical antenna ports based on vertical reference signals to obtain mapped vertical reference signals; transmitting the mapped vertical reference signals to a user equipment; receiving a tilting indicator from the user equipment, wherein the tilting indicator is obtained based on the mapped vertical reference signals at the user equipment; determining a tilting vector based on the received tilting indicator, wherein the tilting vector indicates adjustment for traffic data in antenna vertical tilting; and adjusting traffic data with the tilting vector.
摘要翻译：本公开的实施例提供了用于三维波束成形的方法和装置。该方法可以包括：基于垂直参考信号将垂直虚拟天线端口映射到物理天线端口以获得映射的垂直参考信号; 将映射的垂直参考信号发送到用户设备; 从所述用户设备接收倾斜指示符，其中所述倾斜指示符是基于所述用户设备处的映射的垂直参考信号获得的; 基于所接收的倾斜指示器确定倾斜向量，其中所述倾斜矢量指示天线垂直倾斜中的交通数据的调整; 并用倾斜向量调整交通数据。

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