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1. 发明授权

US5403701A Method of forming small geometry patterns on piezoelectric membrane films 失效
标题翻译：在压电薄膜上形成小几何图案的方法
公开(公告)号：US5403701A
公开(公告)日：1995-04-04
申请号：US085848
申请日：1993-06-30
申请人： Paul Lum , Belinda J. Kendle , Michael Greenstein
发明人： Paul Lum , Belinda J. Kendle , Michael Greenstein
IPC分类号： G03F7/26 , G03F7/00 , G03F7/38 , H01L41/22 , H01L41/26 , H05K3/04
CPC分类号： G03F7/38 , G03F7/00 , H01L41/29 , H05K3/048
摘要： A method of patterning interconnect lines on a flexible membrane film of piezoelectric material includes securing the membrane film to a temporary support structure to allow direct patterning of the interconnect lines. A barrier plane is deposited onto the membrane film. A photoresist then coats the barrier plane. In a subsequent step of photolithographically exposing the photoresist, the barrier plane acts as a screen to prevent radiation from reaching the membrane film. The barrier film is also used as a focusing and alignment structure during photolithographic exposure. Optionally, the resulting structure is soaked in chlorobenzene, with the barrier plane functioning to prevent diffusion of the chlorobenzene through the back side of the porous membrane film to form undesired development-retarding regions of the photoresist. Openings are formed in the photoresist during a development step. A metallic interconnect layer is then deposited. A portion of the interconnect layer enters the openings in the photoresist for deposit onto the barrier plane. The barrier plane ensures proper adhesion of the interconnect layer. Lift-off techniques remove the photoresist and unwanted portions of the interconnect layer. The remaining portions of the interconnect layer provide an etch mask for patterning the barrier plane.
摘要翻译：在压电材料的柔性膜膜上构图互连线的方法包括将膜膜固定到临时支撑结构以允许互连线的直接图案化。屏障平面沉积在膜膜上。然后，光致抗蚀剂涂覆屏障平面。在光刻曝光光刻胶的后续步骤中，屏障平面用作屏幕以防止辐射到达膜膜。在光刻曝光期间，阻挡膜也用作聚焦和对准结构。任选地，将所得结构浸泡在氯苯中，其中屏障平面用于防止氯苯通过多孔膜膜的背面扩散以形成光致抗蚀剂的不期望的显影延迟区域。在显影步骤中在光致抗蚀剂中形成开口。然后沉积金属互连层。互连层的一部分进入光致抗蚀剂中的开口以沉积到屏障平面上。屏障平面确保互连层的适当粘附。剥离技术去除了光致抗蚀剂和互连层的不想要的部分。互连层的其余部分提供用于图案化屏障平面的蚀刻掩模。

2. 发明授权

US06364890B1 Extraction and transportation of blood for analysis 有权
标题翻译：提取和运输血液进行分析
公开(公告)号：US06364890B1
公开(公告)日：2002-04-02
申请号：US09614318
申请日：2000-07-12
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B1732
CPC分类号： A61B5/15144 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.
摘要翻译：一种用于通过穿刺从患者皮肤取样血液的装置。该装置包括用于切割皮肤的一个或多个刺血针和用于从穿刺伤口输送血液的导流板单元。板单元具有用于将流体传导到一个或多个目标位置的一个或多个通道。优选地，存在用于传导第一部分流体的第一通道，所述第一部分流体包含更多的来自穿刺伤口的最初发射的流体（初始流体）和用于传导含有较少初始流体的第二部分流体的第二通道从穿刺伤口。通过毛细血管力将血液吸入通道。该装置可用于以相对简单的程序来刺激皮肤并获得代表性的血液样品。

3. 发明授权

US06176865B1 Apparatus and method for incising 有权
标题翻译：切割装置及方法
公开(公告)号：US06176865B1
公开(公告)日：2001-01-23
申请号：US09429551
申请日：1999-10-28
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.
摘要翻译：一种用于切割诸如身体组织的软弹性材料的基底的多轴装置。切割装置包括两个或更多个切口轴，每个切口具有远端边缘。轴彼此不固定并且允许彼此滑动以将远端边缘交替地驱动抵靠基板以切割基板。在切割身体组织的情况下，这种交替运动将导致比通过与轴相似尺寸的尖锐的尖锐刺戳导致的穿刺更少的疼痛。

4. 发明授权

US5932315A Microfluidic structure assembly with mating microfeatures 失效
标题翻译：具有交配微特征的微流体结构组件
公开(公告)号：US5932315A
公开(公告)日：1999-08-03
申请号：US846570
申请日：1997-04-30
申请人： Paul Lum , Michael Greenstein
发明人： Paul Lum , Michael Greenstein
IPC分类号： B01L3/00 , B29C65/02 , B29C65/56 , B32B3/30 , G01N27/447 , G01N30/60 , B32B3/00 , B01D47/00 , B28B5/00
CPC分类号： B29C65/02 , B01L3/502707 , B29C65/56 , B29C65/7814 , B29C66/1122 , B29C66/54 , B32B3/30 , B81C3/005 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B29C2793/009 , B29C66/73921 , B29C66/73941 , B29C66/8322 , B29L2031/756 , B81B2201/058 , B81C2203/054 , G01N30/6095 , Y10T156/1089 , Y10T428/24479 , Y10T428/2457 , Y10T428/24612 , Y10T428/24661 , Y10T428/24744
摘要： A microfluidic structure assembly having a microchannel formed by bonding two plates together is disclosed. The microfluidic structure assembly includes a first plate and a second plate. At least one of these plates has one or more microgrooves. Microdepressions and microprojections are also present in the plates and they connect such that the microprojections of one plate fit into the microdepressions of the other plate. As a result, the two plates are proximate to each other to form an assembly in which the microgrooves to form microchannels. These microdepressions and microprojections securely lock the microchannels into desired positions. Preferably the plates are made by molding to form the microdepressions, microgrooves, and microchannels.
摘要翻译：公开了具有通过将两个板结合在一起形成的微通道的微流体结构组件。微流体结构组件包括第一板和第二板。这些板中的至少一个具有一个或多个微槽。微压缩和微喷射也存在于板中，并且它们连接，使得一个板的微突出物适合于另一个板的微挤压。结果，两个板彼此靠近以形成微槽形成微通道的组件。这些微压缩和微注射将微通道牢固地锁定到所需的位置。优选地，板通过模塑制成以形成微压缩物，微槽和微通道。

5. 发明授权

US06660018B2 Multiple lancet device 失效
标题翻译：多重刺血针装置
公开(公告)号：US06660018B2
公开(公告)日：2003-12-09
申请号：US09846139
申请日：2001-04-30
申请人： Paul Lum , Michael Greenstein , Leslie A. Leonard , Dominique M Freeman
发明人： Paul Lum , Michael Greenstein , Leslie A. Leonard , Dominique M Freeman
IPC分类号： A61B1714
CPC分类号： A61B5/150977 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150396 , A61B5/150427 , A61B5/15142 , A61B5/157 , A61B17/205
摘要： A device for puncturing the skin of a patient. The device includes first and second protrusions, each protrusion puncturing the skin when pressed against the skin. The first and second protrusions are arranged such that the first protrusion punctures the skin at a location less than a predetermined distance from the second protrusion. The distance is chosen to be less than the discriminatable distance between distinct pain perception points in the patient, such that the patient perceives a single puncture when the first and second protrusions puncture the skin. In one embodiment of the invention, the device includes a base lip that applies a lateral force to the skin when the base lip is pressed against the skin. In this embodiment, the protrusions are pressed into the skin as the base lip is pressed against the skin.
摘要翻译：一种用于刺穿患者皮肤的装置。该装置包括第一和第二突起，每个突出部在压靠皮肤时刺入皮肤。第一突起和第二突起被布置成使得第一突起在距离第二突起小于预定距离的位置刺穿皮肤。该距离选择为小于患者中不同疼痛感知点之间的可区分距离，使得当第一和第二突起刺穿皮肤时，患者感知到单次穿刺。在本发明的一个实施例中，所述装置包括基底唇部，当基底唇被压靠在皮肤上时，所述基部唇缘向皮肤施加横向力。在该实施例中，当基底唇被压在皮肤上时，突起被压入皮肤。

6. 发明授权

US06171325B2 Apparatus and method for incising 有权
公开(公告)号：US06171325B2
公开(公告)日：2001-01-09
申请号：US09420988
申请日：1999-10-20
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.

7. 发明授权

US06472220B1 Method of using cassette of lancet cartridges for sampling blood 有权
标题翻译：使用刺血针盒式磁带取样血液的方法
公开(公告)号：US06472220B1
公开(公告)日：2002-10-29
申请号：US09417276
申请日：1999-10-13
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： G01N3349
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/15113 , A61B5/15153 , A61B5/15159 , A61B5/15165 , A61B5/15174 , A61B2562/0295 , Y10S436/808
摘要： A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.
摘要翻译：包含用于从患者取血的药筒的药盒。盒式磁带包括用于存储多个盒的容器和容器中的至少一个盒。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动柳叶刀将尖端延伸到药筒壳体外部，以便撕裂患者的皮肤以产生血液。容器具有包含至少一个盒的隔间。来自隔室的药筒可以被装载到驱动药筒中的刺血针的血糖仪上以刺激患者的皮肤。

8. 发明授权

US06276196B1 Thermometric vapor sensor with evaporation surface having micropores 有权
公开(公告)号：US06276196B1
公开(公告)日：2001-08-21
申请号：US09733511
申请日：2000-12-07
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N700
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.

9. 发明授权

US06231531B1 Apparatus and method for minimizing pain perception 有权
标题翻译：用于最小化疼痛感知的装置和方法
公开(公告)号：US06231531B1
公开(公告)日：2001-05-15
申请号：US09289884
申请日：1999-04-09
申请人： Paul Lum , Michael Greenstein , Edward Dennis Verdonk , Tad Decatur Simons , Dominique Freeman , Ganapati Ramnath Mauze , David King , Jerry Zawadzki
发明人： Paul Lum , Michael Greenstein , Edward Dennis Verdonk , Tad Decatur Simons , Dominique Freeman , Ganapati Ramnath Mauze , David King , Jerry Zawadzki
IPC分类号： A61H100
CPC分类号： A61H23/0263 , A61B5/150022 , A61B5/150076 , A61B5/150137 , A61B5/150435 , A61B5/15087 , A61B5/150893 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61H23/0218 , A61H2201/105 , A61M5/422
摘要： An apparatus and method for minimizing a subject's pain perception during an invasive medical procedure, such as blood sampling and the like. The apparatus can include a receiving surface constructed to contact a portion of the subject's skin and a vibratory mechanism associated with the receiving surface such that the vibratory mechanism transmits vibrations through the receiving surface and to the subject's skin. An invasive sharp can be substantially permanently supported and moveably disposed with respect to the receiving surface such that the invasive sharp reciprocates between a first position in which the sharp is spaced from the receiving surface, away from the subject's skin, and a second position in which at least a portion of the sharp protrudes through an opening in the receiving surface.
摘要翻译：一种用于在侵入性医疗过程（例如血液取样等）期间使受试者的疼痛感觉最小化的装置和方法。该装置可以包括构造成接触受试者皮肤的一部分的接收表面和与接收表面相关联的振动机构，使得振动机构通过接收表面和对象的皮肤传递振动。侵入性锋利物可以基本上永久地支撑并相对于接收表面可移动地设置，使得侵入性尖锐物在第一位置与第二位置之间往复运动，在第一位置中，尖锐部与受体表面间隔开远离被检者的皮肤，第二位置锋利的至少一部分突出穿过接收表面中的开口。

10. 发明授权

US06202480B1 Thermometric vapor sensor with evaporation surface having micropores 失效
标题翻译：具有蒸发表面的微孔蒸气传感器具有微孔
公开(公告)号：US06202480B1
公开(公告)日：2001-03-20
申请号：US09054852
申请日：1998-04-02
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N2562
CPC分类号： G01N25/64
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.
摘要翻译：一种传感器，用于在气流中检测液体的蒸汽。该传感器包括微孔和湿温度传感器。微孔具有蒸发端，并且具有内腔以在蒸发端从用于蒸发的液体供应源输送液体。湿式温度传感器具有与微孔中的液体接触的热敏部分。热敏部分围绕微孔并形成管腔的一部分。将潮湿的温度传感器用液体湿润时液体的蒸发导致的热损失被放置在气流中将导致由湿式温度传感器感测到的温度低于气流的非蒸发温度。可以测量这种温度降低以确定气流中的蒸气的浓度。这种传感器的示例具有热电偶结，其具有穿过热电偶结的微孔。

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