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1. 发明申请

US20060154354A1 HIGH YIELD PERTUSSIS VACCINE PRODUCTION STRAIN AND METHOD FOR MAKING SAME 有权
标题翻译：高产量PERTUSSIS VACCINE生产菌株及其制备方法
公开(公告)号：US20060154354A1
公开(公告)日：2006-07-13
申请号：US10312272
申请日：2001-06-26
申请人： Tod Merkel , Jerry Keith , Xiaoming Yang
发明人： Tod Merkel , Jerry Keith , Xiaoming Yang
IPC分类号： C12N1/21
CPC分类号： C12N1/20 , C07K14/235 , C12N15/74
摘要： The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin. The present invention further provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin and does not express filamentous hemagglutinin.
摘要翻译：本发明提供了以高产率产生百日咳毒素的支气管炎博德特氏菌疫苗生产菌株。本发明提供了一种产生博德特氏菌百日咳杆菌毒素的博德特氏菌细胞系的方法，包括将含有编码抗生素抗性的DNA的质粒导入支气管炎博德特氏菌菌株，选择其中编码抗生素抗性的DNA重组的分离株引入染色体以代替支气管炎博德特氏菌毒素基因，将含有编码百日咳杆菌毒素的亚基的DNA的质粒引入支气管炎博德特菌分离株; 并且选择其中编码百日咳博德特氏菌毒素亚基的DNA重组并入染色体的分离物，所得细胞产生百日咳博德特氏菌毒素。本发明还提供一种产生支气管炎博德特氏菌细胞系的方法，其产生百日咳杆菌毒素并且不表达丝状血凝素。

2. 发明授权

US08444996B2 Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia 有权
公开(公告)号：US08444996B2
公开(公告)日：2013-05-21
申请号：US13121574
申请日：2009-10-01
申请人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
发明人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
IPC分类号： A61K39/015 , A61K39/385
CPC分类号： C07K14/00 , A61K39/015 , A61K47/646 , Y02A50/412
摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.

3. 发明申请

US20110182929A1 MULTICOMPONENT VACCINE FOR MALARIA PROVIDING LONG-LASTING IMMUNE RESPONSES AGAINST PLASMODIA 有权
标题翻译：用于疟疾的多用途疫苗提供针对血浆的长期免疫应答
公开(公告)号：US20110182929A1
公开(公告)日：2011-07-28
申请号：US13121574
申请日：2009-10-01
申请人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
发明人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
IPC分类号： A61K39/015 , C07K14/445 , G01N33/566 , A61P37/04 , A61P33/06
CPC分类号： C07K14/00 , A61K39/015 , A61K47/646 , Y02A50/412
摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.
摘要翻译：公开了引起对疟原虫蛋白质的免疫应答的免疫原性缀合物。在具体实例中，疟原虫蛋白质包括性阶段表面蛋白质，环子孢子蛋白（CSP）或CSP的免疫原性部分。本文还提供了包含一种或多种所公开的免疫原性缀合物和药学上可接受的载体的免疫原性组合物。还提供了一种在受试者中引发对疟原虫的免疫应答的方法，包括向受试者施用本文公开的免疫原性组合物。

4. 发明授权

US08658180B2 Vaccines against influenza virus 失效
标题翻译：针对流感病毒的疫苗
公开(公告)号：US08658180B2
公开(公告)日：2014-02-25
申请号：US12541804
申请日：2009-08-14
申请人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
发明人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
IPC分类号： A61K39/00 , A61K39/38 , A61K39/12 , A61K39/385
CPC分类号： C07K17/06 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/6037 , C07K14/005 , C07K14/34 , C12N2760/16122 , C12N2760/16134
摘要： Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
摘要翻译：公开了具有以下通式的免疫原性缀合物：M2e-Cys-S-CH2-C（O）-NH-CH2-CH2-C（O-NH-Lys-Pr），M2e是流感M2胞外域（M2e）肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基，Pr是载体蛋白。还公开了分离的免疫原，其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段，其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域。还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。

5. 发明申请

US20060027726A1 Bracket and method for supporting a platform from concrete form tabs 审中-公开
标题翻译：用于从混凝土板上支撑平台的支架和方法
公开(公告)号：US20060027726A1
公开(公告)日：2006-02-09
申请号：US11183550
申请日：2005-07-18
申请人： Jerry Keith
发明人： Jerry Keith
IPC分类号： E04G9/10
CPC分类号： E04G5/06 , E04G5/04 , E04G5/046
摘要： A support or jack that hangs from the tabs of a poured concrete wall. The support may include a hook that engages in an opening in the tab, to connect the support to the wall. The support may include a slot in which the tab is received, to connect the support to the wall.
摘要翻译：从浇筑的混凝土墙壁的悬挂物上悬挂的支架或千斤顶。支撑件可以包括接合在突片中的开口中的钩，以将支撑件连接到壁。支撑件可以包括其中接收突片的槽，以将支撑件连接到墙壁。

6. 发明授权

US10145400B1 Clip 有权
公开(公告)号：US10145400B1
公开(公告)日：2018-12-04
申请号：US15166074
申请日：2016-05-26
申请人： Jerry Keith
发明人： Jerry Keith
IPC分类号： F16B5/06 , F16B2/12 , H04W88/08
摘要： A clip configured to releasably secure opposing halves of a fiberglass shroud surroundably mounted to a cellular tower. The clip includes a first tube member and a second tube member wherein the second tube member has a diameter that is less than that of the first tube member. The second tube member is slidably coupled with the first tube member wherein the second tube member is partially disposed within the interior volume of the first tuber member. A first post and a second post are distally mounted and each have a portion extending into the first tube member and second tube member respectively. A spring is present within the interior volume of the first tube member and second tube member and is operably coupled to the first post and second post. The first post and second post have angular portions configured to help maintenance of the clip's position.

7. 发明申请

US20100150954A1 VACCINES AGAINST INFLUENZA VIRUS 失效
标题翻译：疫苗对流感病毒
公开(公告)号：US20100150954A1
公开(公告)日：2010-06-17
申请号：US12541804
申请日：2009-08-14
申请人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
发明人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
IPC分类号： A61K39/385 , A61P31/16 , C07K17/06
CPC分类号： C07K17/06 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/6037 , C07K14/005 , C07K14/34 , C12N2760/16122 , C12N2760/16134
摘要： Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
摘要翻译：公开了具有以下通式的免疫原性缀合物：M2e-Cys-S-CH2-C（O）-NH-CH2-CH2-C（O-NH-Lys-Pr），M2e是流感M2胞外域（M2e）肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基，Pr是载体蛋白。还公开了分离的免疫原，其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段，其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域。还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。

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