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    • 3. 发明申请
    • DIGITAL HISTOPATHOLOGY AND MICRODISSECTION
    • US20230129222A1
    • 2023-04-27
    • US18088487
    • 2022-12-23
    • NantOmics, LLC
    • Bing SongGregory Chu
    • G06V10/82G06T7/00G06N3/04G06T7/187G06T7/11G06V10/50G06V10/44G06V20/69G06F18/21G06F18/20G06F18/2411G06F18/23213G06F18/2413G06F18/2415G06N3/045G06N7/01G06V10/764G06V10/778
    • A computer implemented method of generating at least one shape of a region of interest in a digital image is provided. The method includes obtaining, by an image processing engine, access to a digital tissue image of a biological sample; tiling, by the image processing engine, the digital tissue image into a collection of image patches; identifying, by the image processing engine, a set of target tissue patches from the collection of image patches as a function of pixel content within the collection of image patches; assigning, by the image processing engine, each target tissue patch of the set of target tissue patches an initial class probability score indicating a probability that the target tissue patch falls within a class of interest, the initial class probability score generated by a trained classifier executed on each target tissue patch; generating, by the image processing engine, a first set of tissue region seed patches by identifying target tissue patches having initial class probability scores that satisfy a first seed region criteria, the first set of tissue region seed patches comprising a subset of the set of target tissue patches; generating, by the image processing engine, a second set of tissue region seed patches by identifying target tissue patches having initial class probability scores that satisfy a second seed region criteria, the second set of tissue region seed patches comprising a subset of the set of target tissue patches; calculating, by the image processing engine, a region of interest score for each patch in the second set of tissue region seed patches as a function of initial class probability scores of neighboring patches of the second set of tissue region seed patches and a distance to patches within the first set of issue region seed patches; and generating, by the image processing engine, one or more region of interest shapes by grouping neighboring patches based on their region of interest scores.