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91. 发明授权

US07906645B2 Heterocyclic compounds as ccr2b antagonists 失效
标题翻译：杂环化合物作为ccr2b拮抗剂
公开(公告)号：US07906645B2
公开(公告)日：2011-03-15
申请号：US11793606
申请日：2005-12-19
申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , David Waterson
发明人： Justin Fairfield Bower , Jeffrey Philip Poyser , David Waterson
IPC分类号： C07D241/02 , A61K31/495
CPC分类号： C07D295/195 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/60 , C07D265/30 , C07D295/02 , C07D295/215 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
摘要翻译：式（I）化合物Q-L-W-C（= X）-Z-P其中Q是式-N（R1）（R2）的胺; L是烷基或杂环基 - 烷基接头; W是分别连接到基团L和C（X）的环原子Y1和Y2的6或7元脂肪环，Y1和Y2独立地选自N和C; X是O，N，N-CN或S; Z为NR3; P是任选取代的单环或双环芳基或杂芳基; 和其药学上可接受的盐或溶剂化物，可用于治疗C-C趋化因子介导的病症。

92. 发明申请

US20100274009A1 METHOD FOR PRODUCING AN AMINE 审中-公开
标题翻译：生产氨的方法
公开(公告)号：US20100274009A1
公开(公告)日：2010-10-28
申请号：US12809665
申请日：2008-12-10
申请人： Petr Kubanek , Wolfgang Mägerlein , Ekkehard Schwab , Johann-Peter Melder , Manfred Julius
发明人： Petr Kubanek , Wolfgang Mägerlein , Ekkehard Schwab , Johann-Peter Melder , Manfred Julius
IPC分类号： C07D265/30 , C07D211/00 , C07C209/00 , B01J27/185 , B01J23/72
CPC分类号： B01J23/825 , B01J23/002 , B01J23/8474 , B01J23/888 , B01J37/03 , B01J37/18 , B01J2523/00 , C07C209/16 , C07C213/02 , C07C213/06 , C07D295/02 , C07D295/08 , B01J2523/17 , B01J2523/48 , B01J2523/51 , B01J2523/847 , B01J2523/69 , B01J2523/68 , B01J2523/32 , B01J2523/56 , C07C211/10 , C07C215/10 , C07C217/08 , C07C217/28
摘要： Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, nickel, no oxygen compounds of cobalt, and 0.2 to 5.0% by weight of at least one oxygen compound of phosphorus or gallium, calculated as H3PO4 and Ga2O3 respectively.
摘要翻译：用于制备胺的方法，所述方法包括：将选自伯醇，仲醇，醛，酮及其混合物的反应物与氢和选自以下的氮化合物反应：氨，伯胺，仲胺及其混合物，在二氧化锆，含铜和镍的催化剂存在下; 其中所述催化剂包含催化活性组合物，其在用氢还原之前包括锆，铜，镍的氧化合物，不含钴的氧化合物和0.2至5.0重量％的至少一种磷或镓的氧化合物，计算分别为H3PO4和Ga2O3。

93. 发明申请

US20100197671A1 PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF 有权
标题翻译：苯胺氨基吡啶化合物及其用途
公开(公告)号：US20100197671A1
公开(公告)日：2010-08-05
申请号：US12530610
申请日：2008-03-12
申请人： Christopher John Burns , Andrew Craig Donohue , John Thomas Feutrill , Thao Lien Thi Nguyen , Andrew Frederick Wilks , Jun Zeng
发明人： Christopher John Burns , Andrew Craig Donohue , John Thomas Feutrill , Thao Lien Thi Nguyen , Andrew Frederick Wilks , Jun Zeng
IPC分类号： A61K31/505 , C07D413/12 , A61K31/5377 , C07D417/14 , C07D239/42 , C07D417/12 , A61K31/541 , C07D403/12 , C07D401/12 , A61K31/506 , C07D401/14 , C07D413/14 , A61P37/02 , A61P35/00 , A61P29/00 , A61P31/12 , A61P3/00 , C12N9/99
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
摘要翻译：本发明涉及作为包括JAK激酶的蛋白激酶抑制剂的苯基氨基嘧啶化合物。特别地，这些化合物对JAK2激酶是选择性的。激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病代谢疾病; 和血管疾病。

94. 发明授权

US07696384B2 Process for producing ethyleneamines 有权
标题翻译：制备亚乙基胺的方法
公开(公告)号：US07696384B2
公开(公告)日：2010-04-13
申请号：US12088715
申请日：2006-09-25
申请人： Gunther Van Cauwenberge , Johann-Peter Melder , Holger Evers , Till Gerlach , Frank Kiesslich , Ekkehard Schwab , Bram Willem Hoffer
发明人： Gunther Van Cauwenberge , Johann-Peter Melder , Holger Evers , Till Gerlach , Frank Kiesslich , Ekkehard Schwab , Bram Willem Hoffer
IPC分类号： C07C211/00
CPC分类号： C07C209/16 , B01J21/04 , B01J23/755 , B01J35/023 , B01J37/0201 , B01J37/18 , C07D295/02 , C07D295/13 , C07C211/10 , C07C211/14
摘要： Processes comprising: providing a starting material comprising monoethanolamine; and reacting the starting material with ammonia in the presence of a heterogeneous transition metal catalyst to form a reaction product comprising one or more ethylene amines; wherein the catalyst comprises a catalytically active composition, which prior to treatment with hydrogen, comprises a mixture of oxygen-containing compounds of aluminum, copper, nickel and cobalt; and wherein the catalyst is present as one or more shaped catalyst particles selected from spheres, extrudates, pellets and other geometries, wherein the sphere or extrudate has a diameter of
摘要翻译：方法包括：提供包含单乙醇胺的原料; 并在非均相过渡金属催化剂的存在下使原料与氨反应形成包含一种或多种亚乙基胺的反应产物; 其中所述催化剂包含催化活性组合物，其在用氢处理之前包括铝，铜，镍和钴的含氧化合物的混合物; 并且其中所述催化剂作为选自球体，挤出物，丸粒和其它几何形状的一种或多种成型催化剂颗粒存在，其中所述球体或挤出物的直径<3mm，所述颗粒具有<3mm的高度，而另一种几何形状具有等效直径L = 1 / a'<0.70mm，其中a'是每单位体积的外表面积（mms2 / mmp3），由'= A p V p定义，其中Ap是外表面积的催化剂颗粒（mms2），Vp是催化剂颗粒的体积（mmp3）。

95. 发明授权

US06884803B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US06884803B2
公开(公告)日：2005-04-26
申请号：US10307870
申请日：2002-12-02
申请人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
发明人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号： C07D295/12 , A61K31/444 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/08 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/14 , A61P27/16 , A61P37/08 , A61P43/00 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/38 , C07D215/06 , C07D215/12 , C07D239/42 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10 , C07D491/113 , C07D403/06 , A61K31/495 , A61P25/24 , C07D295/04
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要： Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：公开了式（I）的取代的苯基炔，其中R 1，R 2，R 3，R 4， R 5和n如上所定义，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

96. 发明授权

US06613458B2 Organic electroluminescent elements 有权
标题翻译：有机电致发光元件
公开(公告)号：US06613458B2
公开(公告)日：2003-09-02
申请号：US09952215
申请日：2001-09-13
申请人： Shuit-Tong Lee , Chun-Sing Lee , Liang-Sun Hung , Bao-Xiu Mi , Zhi-Qiang Gao
发明人： Shuit-Tong Lee , Chun-Sing Lee , Liang-Sun Hung , Bao-Xiu Mi , Zhi-Qiang Gao
IPC分类号： H05B3314
CPC分类号： C09K11/06 , C07C15/20 , C07C15/56 , C07C25/22 , C07C211/61 , C07C255/52 , C07C265/12 , C07C2601/14 , C07C2602/10 , C07C2603/54 , C07D295/02 , H01L51/0056 , H01L51/0058 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/50 , Y10S428/917
摘要： An electroluminescent element has an anode, a cathode, and an organic layer structure between the two electrodes. The layer structure has a luminescent zone containing 1,9-perinaphtylene-10-1′-naphthylanthracene or derivatives as dopant. The luminescent material utilized as dopant has the following structure called pNNA or pNNA derivatives: Wherein: R1, R2, R3, R4 are individual substituents or a group of substituents, and they may be identical or different. Each substituent is individually selected from the following groups consisting of: H, alkyl (—R), halogen (—X), aryl (—Ar), alkenyl (RCH═CH—), allyl(CH2═CHCH2—), cyano (NC—), isocyano (CN—), amino (H2N—), tertiary amino (R2N—or Ar1Ar2N—), amide (RCONR—), nitro (N2O—), acyl (RCO—), carboxyl (—CO2H), alkoxyl (RO—), alkylsulfonyl (RSO2—), hydroxy (HO—) and single or fused aromatic heterocyclic rings.
摘要翻译：电致发光元件在两个电极之间具有阳极，阴极和有机层结构。该层结构具有包含1,9-围烷基-10-1'-萘基蒽或其衍生物作为掺杂剂的发光区。用作掺杂剂的发光材料具有称为pNNA或pNNA衍生物的以下结构：其中：R1，R2，R3，R4是各自的取代基或一组取代基，它们可以相同或不同。每个取代基分别选自：H，烷基（-R），卤素（-X），芳基（-Ar），烯基（RCH = CH-），烯丙基（CH 2 = CHCH 2 - ），氰基（ NC-），异氰基（CN-），氨基（H2N-），叔氨基（R2N-或Ar1Ar2N-），酰胺（RCONR-），硝基（N2O-），酰基（RCO-），羧基（-CO2H）烷氧基（RO-），烷基磺酰基（RSO2-），羟基（HO-）和单或稠合芳族杂环。

97. 发明授权

US6133265A Certain amido- and amino- substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands 失效
标题翻译：某些酰氨基和氨基取代的苄胺衍生物; 一类新的神经肽Y1特异性配体
公开(公告)号：US6133265A
公开(公告)日：2000-10-17
申请号：US897046
申请日：1997-07-18
申请人： Charles A. Blum , Robert DeSimone , Alan Hutchison , John M. Peterson
发明人： Charles A. Blum , Robert DeSimone , Alan Hutchison , John M. Peterson
IPC分类号： C07D295/12 , A61K31/415 , A61K31/416 , A61K31/42 , A61K31/444 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/502 , A61P3/00 , A61P9/04 , A61P9/12 , A61P43/00 , C07D209/42 , C07D211/76 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D295/02 , C07D295/135 , C07D295/14 , C07D295/155 , C07D333/24 , C07D333/40 , A61K31/5355 , C07D487/04
CPC分类号： C07D231/56 , C07D237/28 , C07D295/02 , C07D295/135 , C07D295/155
摘要： Amido, amino and sulfonamide substituted benzylamine derivatives useful in treating eating disorders have the formula ##STR1## where X.sub.1, X.sub.2, and X.sub.3, independently represent substituents of formula ##STR2## D=H, lower straight or branched chain alkyl having 1-6 carbon atoms, a methylene unit incorporated into a ring connected with G as in the cases of pyrrolidine, pyrrolidone, piperidine, and piperidone;E=O or H.sub.2 ;O=0 or 1;G=straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, aryl substituted with halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, heteroaryl--selected from the group consisting of 2-, 3-, or 4-pyridyl, 2-pyrazyl, 2-, or 3-thienyl, 2-pyrazinyl, 2-, 3-, or 4-quinolyl, 1-, 3-, or 4-isoquinolyl, 2-quinoxalyl, 3-, or 4-cinnolyl, said heteroaryl substituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms;and A, T and R.sub.1 -R.sub.4 are hydrogen or organic substituents.
摘要翻译：可用于治疗进食障碍的酰氨基，氨基和磺酰胺取代的苄基胺衍生物具有下式，其中X1，X2和X3独立地表示式D = H的取代基，具有1-6个碳原子的低级直链或支链烷基，如吡咯烷，吡咯烷酮，哌啶和哌啶酮的情况下与G连接的环; E = O或H2; O = 0或1; G =具有1-6个碳原子的直链或支链低级烷基，芳基，被卤素取代的芳基，具有1-6个碳原子的直链或支链低级烷基，杂芳基 - 选自2-，3-或 4-吡啶基，2-吡嗪基，2-或3-噻吩基，2-吡嗪基，2-，3-或4-喹啉基，1-，3-或4-异喹啉基，2-喹喔啉基，3-或所述杂芳基被卤素取代，羟基，具有1-6个碳原子的直链或支链低级烷基，具有1-6个碳原子的直链或支链低级烷氧基; 并且A，T和R 1 -R 4是氢或有机取代基。

98. 发明授权

US5849912A Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US5849912A
公开(公告)日：1998-12-15
申请号：US855790
申请日：1997-05-12
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： C07D295/03 , A61K31/495 , A61P25/18 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/04 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/18 , C07D401/06
CPC分类号： C07D213/30 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1856 , C07C2101/02
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译：由下式（I）表示的联苯衍生物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4和R 5在本说明书中定义，其在临床上可用于治疗和改善精神障碍脑血管障碍，老年性痴呆，精神激动，心脏虚弱，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁，神经症，心理生理障碍和焦虑神经症引起的侵略行为。该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。

99. 发明授权

US5268470A Diamine compounds, method of making same, method of use of same and intermediates 失效
标题翻译：二胺化合物，其制备方法，使用方法和中间体
公开(公告)号：US5268470A
公开(公告)日：1993-12-07
申请号：US728688
申请日：1991-07-12
申请人： Wallace E. Puckett , Mark L. Zollinger
发明人： Wallace E. Puckett , Mark L. Zollinger
IPC分类号： C07D295/08 , A01N43/90 , C07D211/14 , C07D265/30 , C07D295/02 , C07D295/088 , C07D295/13 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/10 , C07D498/10 , C07D513/10 , C08G18/18 , C08G18/20 , C07D337/02 , C07D247/00 , C07D267/08 , C07D281/02
CPC分类号： C07D295/02 , C07D295/088 , C07D295/13 , C07D471/10 , C07D513/10 , C08G18/2018 , C08G18/2027 , C08G18/2081
摘要： A diamine useful as a catalyst for the polymerization of urethane. A method of making the catalyst comprises reacting a spiro quaternary amine with a secondary amine. The spiro quaternary amine is also useful as an antimicrobial agent.
摘要翻译：可用作聚氨酯聚合催化剂的二胺。制备催化剂的方法包括使螺季铵与仲胺反应。螺季胺也可用作抗微生物剂。

100. 发明授权

US4567257A Amidinium salts 失效
标题翻译：脒盐
公开(公告)号：US4567257A
公开(公告)日：1986-01-28
申请号：US571391
申请日：1984-01-16
申请人： Dale F. Regelman
发明人： Dale F. Regelman
IPC分类号： C07D295/02 , C08G18/02 , C07C123/00 , C07D295/12
CPC分类号： C07D295/02 , C08G18/025
摘要： Disclosed is a novel class of amidinium salts having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 when taken individually are independently selected from lower-alkyl, aralkyl and cycloalkyl, and, when taken together with the respective nitrogen atoms to which they are attached, R.sub.1 together with R.sub.2, and R.sub.3 together with R.sub.4 independently represent heterocyclic groups having 5 to 7 ring atoms, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are independently selected from hydrogen, lower-alkyl, aryl, aralkyl, and cycloalkyl.The amidinium salts are very active catalysts for converting organic isocyanates to products containing isocyanurate and carbodiimide linkages.
摘要翻译：公开了一类新的具有下式的脒鎓盐：其中R 1，R 2，R 3和R 4分别独立地选自低级烷基，芳烷基和环烷基，并且当与各自的氮原子一起 R 1和R 2一起连接，R 3与R 4一起独立地表示具有5至7个环原子的杂环基，R 5，R 6，R 7和R 8独立地选自氢，低级烷基，芳基，芳烷基和环烷基。脒鎓盐是将有机异氰酸酯转化为含有异氰脲酸酯和碳二亚胺键的产物的非常活泼的催化剂。

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