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91. 发明授权

US4507248A Preparation from hydroxylammonium sulfate of oximes and hydroxamic acids via alcoholic hydroxylamine solution 失效
标题翻译：通过醇羟胺溶液由肟和异羟肟酸的羟基硫酸铵制备
公开(公告)号：US4507248A
公开(公告)日：1985-03-26
申请号：US534291
申请日：1983-09-23
申请人： Chempolil T. Mathew , Harry E. Ulmer
发明人： Chempolil T. Mathew , Harry E. Ulmer
IPC分类号： C01B21/14 , C07C51/41 , C07C83/10 , C07C131/00
CPC分类号： C07C51/412 , C01B21/1445 , C01B21/1454
摘要： Solid hydroxylammonium sulfate is reacted with an alcohol solution of an alkali metal hydroxide or alkoxide to produce an alcoholic hydroxylamine liquid phase and a sulfate-containing solid phase. The liquid phase is used for further reactions such as oximations and hydroxamic acid production. The different bases behave differently with regard to suitable and preferable solvents and temperatures.
摘要翻译：将固体羟基硫酸铵与碱金属氢氧化物或醇盐的醇溶液反应以产生醇羟胺液相和含硫酸盐的固相。液相用于进一步的反应，例如肟化和异羟肟酸生产。不同的碱基在合适和优选的溶剂和温度方面表现不同。

92. 发明授权

US4504680A 4-Phenyl-1,3-benzodiazepines 失效
标题翻译： 4-苯基-1,3-苯并二氮杂卓
公开(公告)号：US4504680A
公开(公告)日：1985-03-12
申请号：US541363
申请日：1983-10-12
申请人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
发明人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
IPC分类号： C07D243/04 , C07C131/00
CPC分类号： C07D243/04 , C07C205/45 , C07C211/29 , C07C211/49 , C07C217/58 , C07C217/80 , C07C225/16 , C07C233/13 , C07C233/18 , C07C233/59 , C07C233/60 , C07C251/48 , C07C251/66 , C07C2101/14
摘要： Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
摘要翻译：描述了新的4-苯基-1,3-苯并二氮杂，其新颖的中间体及其制备方法。这些苯二氮卓类可用作抗抑郁药，止痛药和抗惊厥药。

93. 发明授权

US4456468A Aminoglyoxylonitrile oximiro carbamates for the protection of crops against injury by herbicides 失效
标题翻译：用于保护作物免受除草剂损伤的氨基乙二腈肟基氨基甲酸酯
公开(公告)号：US4456468A
公开(公告)日：1984-06-26
申请号：US425813
申请日：1982-09-28
申请人： Henry Martin
发明人： Henry Martin
IPC分类号： A01N25/32 , A01N43/84 , A01N37/52 , C07C131/00 , C07D223/06
CPC分类号： A01N25/32
摘要： Oxime carbamates and oxime carbonates of the formula ##STR1## in which Ar is optionally substituted phenyl, naphthyl, furan or thiophene,X is hydrogen, carboxylic acid, alkanoyl, halogen or alkyl, andR is mono- or disubstituted amine, an optionally substituted alkoxy or an optionally substituted alkylthio group, the substituents of which include optionally-substituted hydrocarbyl groups and heterocyclic groupsare suitable as antidotes for the protection of cultivated plants against harmful agricultural chemicals, in particular against herbicides which are insufficiently compatible with the cultivated plants. These compounds can be used either on their own or together with the agricultural chemicals. One of the possibilities offered is the dressing or immersion treatment of seed or of seedlings, of the crop to be protected with solutions or dispersions of said compounds.
摘要翻译：其中Ar是任选取代的苯基，萘基，呋喃或噻吩，X是氢，羧酸，烷酰基，卤素或烷基，R是单或二取代的胺，任选取代的，其中Ar是任选取代的苯基，萘基，呋喃或噻吩的肟基氨基甲酸酯和肟碳酸酯烷氧基或任选取代的烷硫基，其取代基包括任选取代的烃基和杂环基适合作为用于保护栽培植物免受有害农药，特别是与栽培植物不相容的除草剂的解毒剂。这些化合物可以单独使用或与农药一起使用。所提供的可能性之一是用所述化合物的溶液或分散体对待保护的作物的种子或幼苗进行敷料或浸渍处理。

94. 发明授权

US4453974A Phenyl- and naphthyl-glyoxylonitrile oximino carbamates for the protection of crops against injury by herbicides 失效
标题翻译：用于保护作物免受除草剂损伤的苯基和萘基 - 乙醛腈肟基氨基甲酸酯
公开(公告)号：US4453974A
公开(公告)日：1984-06-12
申请号：US425815
申请日：1982-09-28
申请人： Henry Martin
发明人： Henry Martin
IPC分类号： A01N25/32 , A01N37/34 , C07C131/00
CPC分类号： A01N25/32
摘要： Oxime carbamates and oxime carbonates of the formula ##STR1## in which Ar is optionally substituted phenyl, naphthyl, furan or thiophene,X is hydrogen, carboxylic acid, alkanoyl, halogen or alkyl, andR is a mono- or di-substituted amine, an optionally substituted alkoxy or an optionally substituted alkylthio group, the substituents of which include optionally-substituted hydrocarbyl groups and heterocyclic groups,are suitable as antidotes for the protection of cultivated plants against harmful agricultural chemicals, in particular against herbicides which are insufficiently compatible with the cultivated plants. These compounds can be used either on their own or together with the agricultural chemicals. One of the possibilities offered is the dressing or immersion treatment of seed or of seedlings, of the crop to be protected, with solutions or dispersions of said compounds.
摘要翻译：其中Ar为任选取代的苯基，萘基，呋喃或噻吩，X为氢，羧酸，烷酰基，卤素或烷基，R为单取代或二取代的胺，任选取代的烷氧基或任选取代的烷硫基，其取代基包括任选取代的烃基和杂环基，适用于保护栽培植物免受有害农药，特别是与不兼容的除草剂的解毒剂栽培植物。这些化合物可以单独使用或与农药一起使用。所提供的一种可能性是用所述化合物的溶液或分散体对种子或幼苗，待保护的作物进行敷料或浸渍处理。

95. 发明授权

US4440964A Substituted 2-alkylsulfonylalkyl nitrobenzenes and process for their preparation 失效
标题翻译：取代的2-烷基磺酰基烷基硝基苯及其制备方法
公开(公告)号：US4440964A
公开(公告)日：1984-04-03
申请号：US358774
申请日：1982-03-17
申请人： John P. Chupp , Gerhard H. Alt , Terry M. Balthazor
发明人： John P. Chupp , Gerhard H. Alt , Terry M. Balthazor
IPC分类号： A01N20060101 , C07C20060101 , C07C311/00 , C07C131/00
CPC分类号： C07C317/00
摘要： The disclosure herein relates to substituted 2-alkylsulfonylalkyl nitrobenzenes and a process for the preparation thereof. The compounds herein are useful as intermediates in the preparation of certain substituted anilines used as reactants in the preparation of 2-haloacetanilide herbicides.
摘要翻译：本文的公开涉及取代的2-烷基磺酰基烷基硝基苯及其制备方法。本文中的化合物可用作制备在制备2-卤代乙酰苯胺除草剂中用作反应物的某些取代的苯胺的中间体。

96. 发明授权

US4425360A Pharmacologically active novel O-substituted pyruvic acid oximes 失效
标题翻译：药理活性新型O-取代丙酮酸肟
公开(公告)号：US4425360A
公开(公告)日：1984-01-10
申请号：US300076
申请日：1981-09-08
申请人： Hans P. Wolff , Ruth Heerdt , Manfred Hubner, deceased , Hans Kuhnle , Felix H. Schmidt
发明人： Hans P. Wolff , Ruth Heerdt , Manfred Hubner, deceased , Hans Kuhnle , Felix H. Schmidt
IPC分类号： A61K31/15 , A61K31/19 , A61K31/195 , A61P3/06 , A61P3/08 , A61P3/10 , C07C249/08 , C07C251/32 , C07C251/36 , C07C251/50 , C07C251/52 , C07C251/54 , C07C251/60 , C07C253/30 , C07C255/50 , C07D295/185 , C07C131/00
CPC分类号： C07D295/185 , Y10S514/866
摘要： The present invention provides pyruvic acid oximes of the general formula: ##STR1## wherein R is a hydrogen atom, a C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, cinnamyloxy, phenylamino, phenyl-N-alkylamino or phenylthio radical or an aryl or aryloxy radical, the aryl moiety of which can be substituted one or more times by C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, hydroxyl, trifluoromethyl, amino, acetylamino, nitrile, nitro or methylenedioxy, A is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon chain containing up to 10 carbon atoms, which can be substituted one or more times by halogen or hydroxyl, and R.sub.1 is a C.sub.1 -C.sub.8 alkyl radical, which can be substituted one or more times by halogen, hydroxyl, nitrile, phenyl or carboxyl, or is a nitrile or formyl group, with the proviso that when R--A-- is a methyl or ethyl radical, R.sub.1 is not a methyl radical or a nitrile group and when R--A-- is a benzyl radical, R.sub.1 is not a methyl or benzyl radical; and the physiologically acceptable salts, carboxylic acid esters and amides thereof. The invention also provides processes for the preparation of these compounds pharmaceutical compositions containing them, and their use in combating hypoglycaemia.
摘要翻译：本发明提供以下通式的丙酮酸肟：其中R为氢原子，C 3 -C 8环烷基，C 1 -C 6烷氧基，肉桂氧基，苯基氨基，苯基-N-烷基氨基或苯硫基或芳基或芳氧基，其芳基部分可以被C 1 -C 6烷基，C 1 -C 6烷氧基，卤素，羟基，三氟甲基，氨基，乙酰氨基，腈，硝基或亚甲二氧基取代一次或多次，A是直链或含有至多10个碳原子的支链，饱和或不饱和脂族烃链，其可以被卤素或羟基取代一次或多次，并且R 1是可被卤素取代一次或多次的C 1 -C 8烷基，羟基，腈，苯基或羧基，或者是腈或甲酰基，条件是当RA-是甲基或乙基时，R 1不是甲基或腈基，当RA-是苄基时，R 1 不是甲基或苄基; 和其生理上可接受的盐，羧酸酯和酰胺。本发明还提供了制备这些化合物的方法，含有它们的药物组合物及其在抗低血糖中的应用。

97. 发明授权

US4409242A 4-Phenoxy-3-hydroxy-butyramidoxime derivatives 失效
标题翻译： 4-苯氧基-3-羟基 - 丁酰胺肟衍生物
公开(公告)号：US4409242A
公开(公告)日：1983-10-11
申请号：US360057
申请日：1982-03-19
申请人： Louis Lafon
发明人： Louis Lafon
IPC分类号： A61K31/15 , A61K31/155 , A61P9/06 , C07C43/23 , C07C67/00 , C07C239/00 , C07C255/53 , C07C257/14 , C07C259/14 , C07C131/00
CPC分类号： C07C255/00 , C07C259/14 , C07C43/23
摘要： The present invention relates as new industrial products to 4-phenoxy-3-butyramidoxime derivatives, characterized in that they are selected from the group consisting of 4-(allylphenoxy)-3-hydroxy-butyramidoximes of formula: ##STR1## and addition salts thereof. These products are useful in therapeutics, particularly as antiarrythmic agents. The compounds of formula I are prepared by reacting the corresponding butyronitrile with hydroxylamine.
摘要翻译：本发明涉及作为4-苯氧基-3-丁酰胺肟衍生物的新工业产品，其特征在于它们选自下式的4-（烯丙基苯氧基）-3-羟基 - 丁酰氨基肟：（I）和其加成盐。这些产品可用于治疗，特别是抗焦虑剂。通过使相应的丁腈与羟胺反应来制备式I化合物。

98. 发明授权

US4323706A Production of acetaldehyde oxime 失效
标题翻译：生产乙醛肟
公开(公告)号：US4323706A
公开(公告)日：1982-04-06
申请号：US217938
申请日：1980-12-18
申请人： John H. Bonfield , Stephen E. Belsky , Donald Pickens
发明人： John H. Bonfield , Stephen E. Belsky , Donald Pickens
IPC分类号： C07C131/00
摘要： Acetaldehyde oxime, a commercially useful intermediate in the production of pesticides, is prepared by oximating acetaldehyde with an aqueous hydroxylamine-containing solution to form an aqueous oximation reaction mixture and recovering acetaldehyde oxime from the aqueous oximation reaction mixture by distilling a mixture of acetaldehyde oxime and water directly from the aqueous oximation reaction mixture.
摘要翻译：乙醛肟是生产农药的商业上有用的中间体，通过用含羟胺溶液肟化乙醛以形成水性肟化反应混合物并通过蒸馏乙醛肟混合物和肟化反应混合物回收乙醛肟来制备，水直接从水性肟化反应混合物中。

99. 发明授权

US4304938A Process for the preparation of 3-phenoxybenzenes 失效
标题翻译： 3-苯氧基苯的制备方法
公开(公告)号：US4304938A
公开(公告)日：1981-12-08
申请号：US106102
申请日：1979-12-21
申请人： Endre Palosi , Gergely Heja , Dezso Korbonits , Pal Kiss , Csaba Gonczi , Judit Cser nee Kun , Ida Szvoboda nee Kauzel , Gabor Kovacs , Gabor Szabo , Tamas Kallay , Laszlo Ledniczky
发明人： Endre Palosi , Gergely Heja , Dezso Korbonits , Pal Kiss , Csaba Gonczi , Judit Cser nee Kun , Ida Szvoboda nee Kauzel , Gabor Kovacs , Gabor Szabo , Tamas Kallay , Laszlo Ledniczky
IPC分类号： C07C43/295 , B01J23/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C29/14 , C07C41/00 , C07C41/26 , C07C43/23 , C07C43/263 , C07C45/00 , C07C47/575 , C07C67/00 , C07C239/00 , C07C251/48 , C07C253/00 , C07C255/37 , C07C255/53 , C07C301/00 , C07C303/32 , C07C309/24 , C07D317/14 , C07D317/16 , C07D317/22 , C07C131/00
CPC分类号： C07D317/22 , C07C255/00 , C07C309/00 , C07C41/26 , C07D317/16
摘要： 3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.
摘要翻译： 3-苯氧苯衍生物通过包括以下步骤的方法制备：（a）在烃和路易斯酸催化剂的存在下用氯气氯化苯甲醛，得到3-氯苯甲醛; （b）使3-氯苯甲醛与乙二醇反应得到2-（3-氯苯基）-1,3-二氧戊环; （c）用碱性酚盐醚化所述二氧戊环，得到中间体2-（3-苯氧基苯基）-1,3-二氧戊环，并将该中间体转化成相应的醛，氰醇，磺酸盐或肟衍生物。

100. 发明授权

US4256668A Removing aqueous ammonium sulfate from oxime product 失效
标题翻译：从肟产物中除去硫酸铵
公开(公告)号：US4256668A
公开(公告)日：1981-03-17
申请号：US50356
申请日：1979-06-20
申请人： Chempolil T. Mathew , Donald Pickens
发明人： Chempolil T. Mathew , Donald Pickens
IPC分类号： C07C131/00 , C07C131/04
CPC分类号： C07C323/47 , C07C249/14 , C07C2101/14
摘要： An organic, substantially water-insoluble oxime product is recovered from the liquid reaction mixture of water, ammonium sulfate and the oxime product. First the reaction mixture is separated into a first liquid layer containing an aqueous ammonium sulfate solution and a second liquid layer containing an emulsion of the oxime product as the continuous phase and aqueous ammonium sulfate as the discontinuous phase. These layers are separated and the second liquid layer is contacted with solid ammonium sulfate for a time sufficient to agglomerate the discontinuous phase. The agglomerated discontinuous phase is then removed from the continuous phase. Thereafter, either a lites fraction can be distilled from the continuous phase or the oxime product can be distilled from the continuous phase, or both. The process is particularly applicable to the production of oximes such as Aldicarb oxime, cyclohexanone oxime and methylethylketoxime from aqueous reaction mixtures in which by-product ammonium sulfate is formed.
摘要翻译：从水，硫酸铵和肟产物的液体反应混合物中回收有机的，基本上不溶于水的肟产物。首先，将反应混合物分离成含有硫酸铵水溶液的第一液体层和含有作为连续相的肟产物的乳液的第二液体层和作为不连续相的硫酸铵水溶液。分离这些层，第二液层与固体硫酸铵接触一段足以使不连续相结块的时间。然后从连续相中除去聚集的不连续相。此后，可以从连续相中蒸馏出lites馏分，或者可以从连续相或两者中蒸馏出肟产物。该方法特别适用于由其中形成副产物硫酸铵的水性反应混合物生产肟类，如涕灭威肟，环己酮肟和甲基乙基酮肟。

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