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1. 发明申请

US20220331346A1 SUBSTITUTED BICYCLIC COMPOUNDS 有权
公开(公告)号：US20220331346A1
公开(公告)日：2022-10-20
申请号：US17307138
申请日：2021-05-04
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Alaric J. DYCKMAN , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

2. 发明申请

US20200281952A1 SUBSTITUTED BICYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20200281952A1
公开(公告)日：2020-09-10
申请号：US16879824
申请日：2020-05-21
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

3. 发明授权

US09522888B2 Substituted bicyclic compounds 有权
标题翻译：取代的双环化合物
公开(公告)号：US09522888B2
公开(公告)日：2016-12-20
申请号：US14831439
申请日：2015-08-20
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： C07F9/02 , C07C211/00 , C07D217/24 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：和/或其盐，其中R1是-OH或-OP（O）（OH）2，X1，X2，X3，R2，R2a，Ra，Rb和Rc在本文中定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

4. 发明申请

US20160052888A1 SUBSTITUTED BICYCLIC COMPOUNDS 有权
标题翻译：取代的双环化合物
公开(公告)号：US20160052888A1
公开(公告)日：2016-02-25
申请号：US14831439
申请日：2015-08-20
申请人： Bristol-Myers Squibb Company
发明人： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： C07D217/24 , C07C217/52 , C07D311/58 , C07D311/76 , C07D309/12 , C07D231/12 , C07D333/16 , C07D309/06 , C07D213/69 , C07C217/58 , C07C233/65 , C07D231/20 , C07C321/28 , C07C321/16 , C07D213/70 , C07F7/08 , C07D213/32 , C07D241/12 , C07C321/22 , C07D277/24 , C07D305/08 , C07D215/12 , C07D239/26 , C07C317/32 , C07C317/28 , C07C219/24 , C07C271/34 , C07C233/41 , C07F9/117 , C07C215/42 , C07C251/50 , C07C251/54 , C07C251/52 , C07F9/655 , C07F9/62 , C07F9/6503 , C07F9/6553 , C07F9/6509 , C07D319/20
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：公开了式（I），（II），（III），（IV）和（V）的化合物：和/或其盐，其中R 1是-OH或-OP（O）（OH）2， X1，X2，X3，R2，R2a，Ra，Rb和Rc在本文中定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫性疾病和血管疾病）中的疾病或病症的进展。

5. 发明申请

US20050070584A1 Substituted aryloximes 失效
标题翻译：取代的芳胂
公开(公告)号：US20050070584A1
公开(公告)日：2005-03-31
申请号：US10948611
申请日：2004-09-23
申请人： Lisa Havran , John Butera , Hassan Elokdah , Douglas Jenkins , Eric Gundersen
发明人： Lisa Havran , John Butera , Hassan Elokdah , Douglas Jenkins , Eric Gundersen
IPC分类号： A61K31/195 , A61K31/343 , A61K31/40 , A61K31/445 , A61P7/02 , C07C251/54 , C07C251/40 , C07D207/46
CPC分类号： C07D257/04 , A61K31/195 , A61K31/343 , A61K31/40 , A61K31/445 , C07C251/54
摘要： The present invention relates to substituted aryl oximes and methods of using them.
摘要翻译：本发明涉及取代的芳基肟及其使用方法。

6. 发明授权

US6448444B2 Oxime compounds, their use, and intermediates for their production 失效
标题翻译：肟化合物，其用途和中间体用于生产
公开(公告)号：US6448444B2
公开(公告)日：2002-09-10
申请号：US83920101
申请日：2001-04-23
申请人： SUMITOMO CHEMICAL CO
发明人： IZUMI KEIICHI , SAITO SHIGERU
IPC分类号： A01N39/00 , C07C251/38 , C07C251/48 , C07C251/52 , C07C251/54 , C07D213/53 , C07D213/64 , C07D307/52 , C07C251/32 , A01N33/24 , A01N43/40
CPC分类号： C07D213/53 , A01N39/00 , C07C251/38 , C07C251/48 , C07C251/52 , C07C251/54 , C07D213/64 , C07D307/52
摘要： Oxime compounds of formula (1)wherein R1, R2, and R3 are independently halogen, C1-C3 alkyl, C1-C3 halolalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, nitro, or cyano; R4 is 3,3-dihalogeno-2-propenyl; a is an integer of 0 to 2; Y is oxygen, sulfur, or NH; Z is oxygen, sulfur, or NR5 wherein R5 is hydrogen, acetyl, or C1-C3 alkyl; and X is of formula (2)insecticidal/acaricidal agents containing them as active ingredients; and intermediates for their production.
摘要翻译：式（1）的肟化合物，其中R 1，R 2和R 3独立地是卤素，C 1 -C 3烷基，C 1 -C 3卤代烷基，C 1 -C 3烷氧基，C 1 -C 3卤代烷氧基，硝基或氰基; R4是3,3-二卤代-2-丙烯基; a为0〜2的整数; Y是氧，硫或NH; Z是氧，硫或NR 5，其中R5是氢，乙酰基或C1-C3烷基; X为式（2），含有它们作为活性成分的杀虫/杀螨剂; 和中间体用于生产。

7. 发明授权

US5990339A Phenylacetic acid derivatives, and use as fungicides 失效
标题翻译：苯乙酸衍生物，用作杀真菌剂
公开(公告)号：US5990339A
公开(公告)日：1999-11-23
申请号：US97862
申请日：1998-06-16
申请人： Herbert Bayer , Hubert Sauter , Ruth Muller , Wassilios Grammenos , Albrecht Harreus , Reinhard Kirstgen , Franz Rohl , Eberhard Ammermann , Gisela Lorenz
发明人： Herbert Bayer , Hubert Sauter , Ruth Muller , Wassilios Grammenos , Albrecht Harreus , Reinhard Kirstgen , Franz Rohl , Eberhard Ammermann , Gisela Lorenz
IPC分类号： C07D249/08 , A01N20060101 , A01N37/00 , A01N37/36 , A01N37/44 , A01N37/50 , A01N41/10 , A01N43/00 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/66 , A01N43/707 , A01N43/72 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/824 , A01N43/836 , A01N43/88 , A01N47/02 , A01P3/00 , A01P7/04 , C07C20060101 , C07C205/04 , C07C249/08 , C07C251/34 , C07C251/36 , C07C251/38 , C07C251/48 , C07C251/50 , C07C251/52 , C07C251/54 , C07C251/56 , C07C251/60 , C07C255/07 , C07C255/12 , C07C255/62 , C07C255/64 , C07C259/06 , C07C259/14 , C07C309/04 , C07C309/28 , C07C317/18 , C07C317/22 , C07C317/26 , C07C317/44 , C07C323/12 , C07C323/19 , C07C323/23 , C07C325/00 , C07C327/38 , C07C327/42 , C07C327/48 , C07C327/58 , C07D207/32 , C07D207/323 , C07D207/333 , C07D207/36 , C07D211/72 , C07D211/88 , C07D213/30 , C07D213/50 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/79 , C07D213/80 , C07D215/20 , C07D215/22 , C07D231/12 , C07D231/20 , C07D231/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/12 , C07D237/14 , C07D239/26 , C07D239/28 , C07D239/30 , C07D239/34 , C07D239/36 , C07D239/38 , C07D239/74 , C07D241/12 , C07D241/16 , C07D241/18 , C07D241/44 , C07D251/16 , C07D251/26 , C07D251/30 , C07D261/06 , C07D261/08 , C07D261/10 , C07D261/12 , C07D263/32 , C07D263/34 , C07D263/46 , C07D271/06 , C07D271/10 , C07D275/02 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/34 , C07D277/36 , C07D285/08 , C07D285/12 , C07D307/12 , C07D307/36 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/58 , C07D333/16 , C07D333/22 , C07D333/28 , C07D333/32 , C07C251/10
CPC分类号： C07D207/333 , A01N37/36 , A01N37/50 , A01N43/08 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/88 , C07C249/08 , C07C251/38 , C07C251/48 , C07C251/60 , C07C327/58 , C07D213/53 , C07D213/64 , C07D239/34 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D307/12 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： The present invention relates to phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is NOCH.sub.3, CHOCH.sub.3, CHCH.sub.3 and [sic] CHCH.sub.2 CH.sub.3 ;R.sup.1 is hydrogen and [sic] C.sub.1 -C.sub.4 -alkyl;R.sup.2 is cyano, nitro, trifluoromethyl, halogen, C.sub.1 -C.sub.4 -alkyl and [sic] C.sub.1 -C.sub.4 -alkoxy;m is 0, 1 or 2, it being possible for the R.sup.2 radicals to be different if m is 2;R.sup.3 is hydrogen, cyano, nitro, hydroxyl, amino, halogen, C.sub.1 -C.sub.1 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino;R.sup.4 is hydrogen, cyano, nitro, hydroxyl, amino, halogen,R.sup.5 is hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.2 -C.sub.10 -alkynyl, C.sub.1 -C.sub.10 -alkylcarbonyl, C.sub.2 -C.sub.10 -alkenylcarbonyl, C.sub.3 -C.sub.10 -alkynylcarbonyl or C.sub.1 -C.sub.10 -alkylsulfonyl, it being possible for these radicals to be partly or completely halogenated or to carry one to three of the following groups: cyano, nitro, hydroxyl, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl,
摘要翻译：本发明涉及式I的苯乙酸衍生物，其中取代基和指数具有以下含义：X为NOCH 3，CHOCH 3，CHCH 3和[sic] CHCH 2 CH 3; R 1是氢和[C 1-6] C 1 -C 4 - 烷基; R2是氰基，硝基，三氟甲基，卤素，C 1 -C 4 - 烷基和[C 1] C 1 -C 4 - 烷氧基; m为0,1或2，如果m为2，则R2基团可能不同; R3是氢，氰基，硝基，羟基，氨基，卤素，C1-C1烷基，C1-C4卤代烷基，C1-C4-烷氧基，C1-C4-卤代烷氧基，C1-C4-烷硫基，C1-C4烷基氨基或二-C 1 -C 4烷基氨基; R4是氢，氰基，硝基，羟基，氨基，卤素，R5是氢，C1-C10-烷基，C3-C6-环烷基，C2-C10-烯基，C2-C10-炔基，C1-C10-烷基羰基，C2- C 1 -C 10 - 烯基羰基，C 3 -C 10 - 炔基羰基或C 1 -C 10 - 烷基磺酰基，这些基团可能被部分或完全卤化或携带一至三个以下基团：氰基，硝基，羟基，巯基，氨基，羧基，氨基羰基，氨基硫代羰基，

8. 发明授权

US5877190A Substituted biphenyl compounds 失效
标题翻译：取代的联苯化合物
公开(公告)号：US5877190A
公开(公告)日：1999-03-02
申请号：US943562
申请日：1997-10-03
申请人： Alain Dhainaut , Guillaume Poissonnet , Emmanuel Canft , Michel Lonchampt
发明人： Alain Dhainaut , Guillaume Poissonnet , Emmanuel Canft , Michel Lonchampt
IPC分类号： C07D233/64 , A61K31/05 , A61K31/11 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/275 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/495 , A61P11/00 , A61P11/08 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C43/20 , C07C45/71 , C07C47/546 , C07C47/57 , C07C47/575 , C07C49/798 , C07C49/84 , C07C49/86 , C07C65/21 , C07C67/14 , C07C69/157 , C07C69/24 , C07C69/28 , C07C69/75 , C07C201/12 , C07C205/20 , C07C205/44 , C07C205/60 , C07C217/82 , C07C235/44 , C07C235/60 , C07C251/48 , C07C251/54 , C07C251/86 , C07C255/53 , C07C255/54 , C07C255/58 , C07C257/18 , C07C259/10 , C07C323/31 , C07D209/08 , C07D213/06 , C07D213/50 , C07D215/12 , C07D231/12 , C07D307/79 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D401/02
CPC分类号： C07D307/79 , C07C205/20 , C07C205/44 , C07C205/60 , C07C235/60 , C07C251/48 , C07C251/86 , C07C255/53 , C07C259/10 , C07C45/71 , C07C47/57 , C07C47/575 , C07D209/08 , C07D213/50 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06
摘要： A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,A represents a bond, oxygen, sulphur, a group ##STR2## a group ##STR3## or a group ##STR4## wherein Rc represents hydrogen, alkyl or cycloalkyl, R.sub.2 represents halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, formyl, carboxy, alkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkyloxycarbonyl, optionally substituted carbamoyl, optionally substituted amino, formylamino, cyano, optionally substituted amidino, hydroxyaminomethyl, amide oxime, hydrazono, or a group selected from: ##STR5## wherein R.sub.21, R.sub.22 and R.sub.23 are as defined in the description, R.sub.3 represents hydrogen or alkyl, cycloalkyl or acyl,or ##STR6## together form the ring ##STR7## X is oxygen, sulphur, or NR", B is phenyl, Ra and Rb, which may be identical or different, each represents hydrogen, halogen, or alkyl, hydroxy, alkoxy, carboxy, polyhalogenoalkyl, cyano, nitro, alkoxycarbonyl, cycloalkyloxycarbonyl, amino, carbamoyl, sulfo, alkylsulfonyl, cycloalkylsulfonyl or aminosulfonyl, their isomers, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as PDE IV inhibitors.
摘要翻译：式（I）化合物：其中：R 1表示未取代或取代的环烷基，苯基，萘基，杂环基，烷基或烯基，A表示键，氧，硫，取代或未取代的烷基，取代或未取代的链烯基，取代或未取代的炔基，环烷基，甲酰基，羧基，烷基羰基，环烷基羰基，烷氧基羰基，环烷氧基羰基，任选取代的氨基甲酰基，任选取代的氨基，甲酰氨基，氰基，任选取代的脒基，羟基氨基甲基，酰胺肟，亚氨基或选自以下的基团：其中R 21，R 22和R 23如说明书中所定义，R 3表示氢或烷基，环烷基或酰基，或一起形成环，X是氧，硫或NR“，B是苯基，R a和R b可以相同或不同，各自表示氢，卤素或烷基，羟基，烷氧基，羧基，多卤代烷基，氰基，硝基，烷氧基羰基，环烷氧基羰基，氨基，氨基甲酰基，磺基，烷基磺酰基，环烷基磺酰基或氨基磺酰基，它们的异构体及其与药学上可接受的酸或碱的加成盐，含有该药物的药物可用作PDE IV抑制剂。

9. 发明授权

US5739085A O-(oximino)ethylcyclohexenone oxime ethers and their use as herbicides 失效
标题翻译： O-（肟基）乙基环己烯酮肟醚及其作为除草剂的用途
公开(公告)号：US5739085A
公开(公告)日：1998-04-14
申请号：US435450
申请日：1995-05-05
申请人： Ulf Misslitz , Albrecht Harreus , Hartmann Konig , Helmut Walter , Karl-Otto Westphalen , Matthias Gerber
发明人： Ulf Misslitz , Albrecht Harreus , Hartmann Konig , Helmut Walter , Karl-Otto Westphalen , Matthias Gerber
IPC分类号： A01N35/10 , A01N41/06 , A01N43/16 , A01N43/18 , A01N43/56 , A01N43/80 , C07C251/38 , C07C251/52 , C07C251/54 , C07C251/58 , C07C311/05 , C07C323/19 , C07C323/47 , C07D231/12 , C07D261/08 , C07D309/06 , C07D335/02 , A01N33/24
CPC分类号： A01N35/10 , A01N43/16 , A01N43/18 , C07C251/38 , C07C251/52 , C07C251/58 , C07C323/19 , C07C323/47 , C07D309/06 , C07D335/02 , C07C2101/02 , C07C2101/16
摘要： O-(Oximino)ethylcyclohexenone oxime ethers I ##STR1## (R.sup.1 and R.sup.2 =C.sub.1 -C.sub.6 -alkyl; R.sup.3 =unsubstituted or substituted phenyl, C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.4 -alkenyl or C.sub.3 -C.sub.4 -alkynyl, which in each case can be substituted by halogen, C.sub.1 -C.sub.3 -alkyl, unsubstituted or substituted phenyl or unsubstituted or substituted phenoxy; R.sup.4 =C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.4 -alkylthio-C.sub.1 -C.sub.6 -alkyl, unsubstituted or substituted phenylthio-C.sub.1 -C.sub.6 -alkyl, N-(C.sub.1 -C.sub.4 -alkylsulfonyl)-N-(C.sub.1 -C.sub.4 -alkyl)aminomethyl, unsubstituted or substituted C.sub.3 -C.sub.7 -cycloalkyl or C.sub.5 -C.sub.7 -cycloalkenyl, 5-membered saturated heterocyclyl having one or two oxygen and/or sulfur atoms, which can carry one to three substituents, saturated or unsaturated 6-/7-membered heterocyclyl having 1 or 2 non-adjacent oxygen and/or sulfur atoms, which can carry 1 to 3 substituents, 5-membered heteroaryl, containing 1 to 2 nitrogen atoms and an oxygen or sulfur atom, where the heteroaromatic can carry 1 to 3 substituents, phenyl or pyridyl, which can carry 1 to 3 of the following substituents: halogen, nitro, cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy and --NR.sup.a R.sup.b ; R.sup.a =H, C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.6 -alkenyl or C.sub.3 -C.sub.6 -alkynyl; R.sup.b =H, C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -acyl or unsubstituted or substituted benzoyl) and their agriculturally utilizable salts and esters are described.
摘要翻译： O-（肟基）乙基环己烯酮肟醚I（R1和R2 = C1-C6-烷基; R3 =未取代或取代的苯基，C1-C4-烷基，C3-C4-烯基或C3-C4-炔基，其中在每种情况下可以被卤素，C 1 -C 3 - 烷基，未取代或取代的苯基或未取代或取代的苯氧基取代; R 4 = C 1 -C 4 - 烷氧基-C 1 -C 6烷基或C 1 -C 4 - 烷硫基-C 1 -C 6烷基，未取代或取代的苯硫基-C 1 -C 6烷基，N-（C 1 -C 4 - 烷基磺酰基）-N-（C 1 -C 4 - 烷基）氨基甲基，未取代或取代的C 3 -C 7 - 环烷基或C 5 -C 7 - 环烯基，具有一个或两个氧和/或硫原子的五元饱和杂环基，其可以携带一至三个取代基，具有1或2个不相邻的氧和/或硫原子的饱和或不饱和的6-元/ 7元杂环基，其可携带1 包含1至2个氮原子和氧或硫原子的3个取代基，5元杂芳基，其中杂芳族可以带有1-3个取代基，苯基或吡啶基，其可以携带1至3个 C 1 -C 4烷氧基，C 1 -C 4 - 烷硫基，C 1 -C 4卤代烷基，C 3 -C 6 - 烯氧基，C 3 -C 6 - 炔氧基和-NR a R b;取代基：卤素，硝基，氰基， R a = H，C 1 -C 4 - 烷基，C 3 -C 6 - 烯基或C 3 -C 6炔基; 描述了Rb = H，C 1 -C 4 - 烷基，C 3 -C 6 - 烯基，C 3 -C 6炔基，C 1 -C 6酰基或未取代或取代的苯甲酰基）和它们的农业可利用的盐和酯。

10. 发明授权

US5563114A Cyclohexenone oxime ethers, their preparation, intermediates for their preparation and their use as herbicides 失效
标题翻译：环己烯酮肟醚，它们的制备，其制备中间体及其作为除草剂的用途
公开(公告)号：US5563114A
公开(公告)日：1996-10-08
申请号：US409969
申请日：1995-03-24
申请人： Norbert Meyer , Juergen Kast , Ulf Misslitz , Albrecht Harreus , Norbert Goetz , Bruno Wuerzer , Helmut Walter , Karl-Otto Westphalen , Matthias Gerber
发明人： Norbert Meyer , Juergen Kast , Ulf Misslitz , Albrecht Harreus , Norbert Goetz , Bruno Wuerzer , Helmut Walter , Karl-Otto Westphalen , Matthias Gerber
IPC分类号： A01N35/10 , A01N43/08 , A01N43/10 , A01N43/14 , A01N43/16 , A01N43/18 , A01N43/30 , A01N43/32 , A01N43/36 , A01N43/80 , A01P13/00 , C07C239/20 , C07C251/36 , C07C251/42 , C07C251/50 , C07C251/52 , C07C251/54 , C07C251/60 , C07C255/62 , C07C323/47 , C07D207/32 , C07D207/335 , C07D261/02 , C07D261/04 , C07D261/08 , C07D275/02 , C07D307/14 , C07D309/06 , C07D317/26 , C07D319/06 , C07D333/16 , C07D333/22 , C07D333/58 , C07D335/02 , C07D339/06 , A01N43/28 , A01N43/78
CPC分类号： C07D207/335 , A01N35/10 , A01N43/14 , C07C239/20 , C07C251/42 , C07C251/52 , C07D261/08 , C07D275/02 , C07D309/06 , C07D319/06 , C07D333/22 , C07D335/02 , C07C2101/12 , C07C2101/14
摘要： Cyclohexenone oxime ethers of the general formula I ##STR1## where R.sup.1 is alkyl,A is unsubstituted or substituted C.sub.3 -, C.sub.5 - or C.sub.6 -alkylene or C.sub.3 -, C.sub.5 - or C.sub.6 -alkenylene,X is NO.sub.2, CN, halogen, alkyl, alkoxy, phenoxy, alkylthio, haloalkyl, haloalkoxy, carboxyl, alkoxycarbonyl, unsubstituted or substituted benzyloxycarbonyl and/or unsubstituted or substituted phenyl,n is 0-3 or 1-5 where X is halogen,R.sup.2 is alkoxy-alkyl or alkylthio-alkyl, unsubstituted or substituted cycloalkyl or cycloalkenyl, an unsubstituted or substituted 5-membered saturated heterocyclic structure having one or two oxygen and/or sulfur atoms as hetero atoms, an unsubstituted or substituted 6-membered or 7-membered heterocyclic structure having up to two oxygen and/or sulfur atoms and up to two double bonds, an unsubstituted or substituted 5-membered heteroaromatic having up to two nitrogen atoms and one oxygen atom or one sulfur atom, or unsubstituted or substituted phenyl or pyridyl, and their agriculturally useful salts and esters of C.sub.1 -C.sub.10 -carboxylic acids and inorganic acids, processes and intermediates for their preparation, and their use as herbicides.
摘要翻译：通式I的环己烯酮肟醚其中R 1为烷基，A为未取代或取代的C3-，C5-或C6-亚烷基或C3-，C5-或C6-亚烯基，X为NO2，CN，卤素，烷基，烷氧基，苯氧基，烷硫基，卤代烷基，卤代烷氧基，羧基，烷氧基羰基，未取代或取代的苄氧羰基和/或未取代或取代的苯基，n为0-3或1-5，其中X为卤素，R2为烷氧基 - 烷硫基 - 烷基，未取代或取代的环烷基或环烯基，具有一个或两个氧和/或硫原子作为杂原子的未取代或取代的5元饱和杂环结构，未取代或取代的6元或7元杂环结构，至多两个氧原子和/或硫原子和至多两个双键，未取代或取代的具有至多两个氮原子和一个氧原子或一个硫原子的5元杂芳族化合物，或未取代或取代的苯基或吡啶基，以及它们的农业用途 C1-C10羧酸和无机酸的富盐和酯，其制备方法和中间体，以及它们作为除草剂的用途。

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