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31. 发明授权

US07271912B2 Method of determining analyte concentration in a sample using infrared transmission data 有权
标题翻译：使用红外线传输数据确定样品中分析物浓度的方法
公开(公告)号：US07271912B2
公开(公告)日：2007-09-18
申请号：US10825085
申请日：2004-04-15
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

32. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

33. 发明授权

US06989891B2 Device and method for in vitro determination of analyte concentrations within body fluids 失效
公开(公告)号：US06989891B2
公开(公告)日：2006-01-24
申请号：US10219625
申请日：2002-08-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein
发明人： James R. Braig , Peter Rule , Philip C. Hartstein
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

34. 发明授权

US06983177B2 Layered spectroscopic sample element with microporous membrane 失效
公开(公告)号：US06983177B2
公开(公告)日：2006-01-03
申请号：US10337226
申请日：2003-01-06
申请人： Peter Rule , James R. Braig , Philip C. Hartstein
发明人： Peter Rule , James R. Braig , Philip C. Hartstein
IPC分类号： A61B5/00
CPC分类号： B01L3/5023 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , B01L3/5027 , B01L3/508 , B01L2200/027 , B01L2300/0654 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/8483 , G01N2021/0346
摘要： A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.

35. 发明授权

US06884222B1 Method and apparatus for estimation of resting respiratory quotient 失效
公开(公告)号：US06884222B1
公开(公告)日：2005-04-26
申请号：US10718075
申请日：2003-11-20
申请人： James R. Braig
发明人： James R. Braig
IPC分类号： A61B5/083 , A61B5/08
CPC分类号： A61B5/083
摘要： A method and apparatus for determining a user's Respiratory Quotient (RQ) using just measured O2 and CO2 concentrations without use of a flow meter. The RQ is determined by measuring the user's real-time inspired O2 concentration (INS O2) and end tidal O2 concentration (ETO2) and measuring the user's real-time inspired CO2 concentration (INS CO2) and end tidal CO2 concentration (ETCO2), and then determining the user's RQ from the measured INS O2, ETO2, INS CO2, and ETCO2 values in accordance with the following equation: RQ=(ETCO2−INS CO2)/(INS O2−ETO2). In order to avoid error introduced by the flow rate, the measurement steps are preferably performed while the user is in a resting condition. Also, ETCO2 is preferably measured as the maximum CO2 value in a breath cycle of the user, while INS CO2 is preferably measured as the minimum CO2 value in a breath cycle of the user. Similarly, ETO2 is preferably measured as the minimum O2 value within a breath cycle of the user, while INS O2 is measured as the maximum O2 value within a breath cycle of the user. On the other hand, the values of INS CO2 and ETCO2 also may be determined in accordance with the invention by analysis of a CO2 waveform of a breath cycle of the user and the values of INS O2 and ETO2 determined by synchronizing timing of the O2 waveform of a breath cycle of the user with the CO2 waveform and sampling INS O2 and ETO2 values simultaneously with sampling of complementary CO2 values determined by analysis of the CO2 wavefomm. The RQ measuring device may include the oxygen and CO2 sensors in a mainstream or sidestream configuration.

36. 发明授权

US06862534B2 Method of determining an analyte concentration in a sample from an absorption spectrum 有权
公开(公告)号：US06862534B2
公开(公告)日：2005-03-01
申请号：US10366540
申请日：2003-02-12
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： A61B5/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N33/487 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

37. 发明授权

US06731961B2 Method for transforming phase spectra to absorption spectra 失效
公开(公告)号：US06731961B2
公开(公告)日：2004-05-04
申请号：US10291912
申请日：2002-11-08
申请人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
发明人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , G01N21/1717 , G01N21/35 , G01N21/3577 , G01N21/71
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

38. 发明授权

US06196046B1 Devices and methods for calibration of a thermal gradient spectrometer 失效
标题翻译：用于校准热梯度光谱仪的设备和方法
公开(公告)号：US06196046B1
公开(公告)日：2001-03-06
申请号：US09382273
申请日：1999-08-25
申请人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
发明人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
IPC分类号： G01N100
CPC分类号： A61B5/1495 , A61B5/14532 , A61B2560/0233 , A61B2560/0271
摘要： A calibration standard for calibrating a thermal gradient spectrometer. The calibration standard is a structure having a particular glucose concentration which a thermal gradient spectrometer reads for determining whether the spectrometer is in calibration. The structure of the calibration standard properly mimics the physiology of human tissue. A number of such standards, each containing a different concentration of glucose are provided in kit form with a thermal gradient spectrometer for use in calibrating the spectrometer. The spectrometer is provided with a display and internal circuitry for performing self-calibrating adjustments and a communications port for electronically coupling to a remote computer and database for supplying external calibration commands to said spectrometer.
摘要翻译：用于校准热梯度光谱仪的校准标准。校准标准是具有特定葡萄糖浓度的结构，热梯度光谱仪读取以确定光谱仪是否在校准中。校准标准的结构恰当地模拟了人体组织的生理。提供了许多这样的标准，每种含有不同浓度的葡萄糖的试剂盒形式与用于校准光谱仪的热梯度光谱仪一起提供。光谱仪具有用于执行自校准调节的显示器和内部电路，以及用于电子耦合到远程计算机和数据库的通信端口，用于向所述光谱仪提供外部校准命令。

39. 发明授权

US06095986A Disposable anti-fog airway adapter 失效
标题翻译：一次性防雾气道适配器
公开(公告)号：US06095986A
公开(公告)日：2000-08-01
申请号：US123232
申请日：1998-07-28
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
IPC分类号： A61B5/097 , A61B5/08
CPC分类号： A61B5/097
摘要： A disposable anti-fog airway adapter for use with a mainstream respiratory gas analyzer which provides a measurement of a patient's inhaled and exhaled gases. The airway adapter includes windows that are constructed of a thin, low heat capacity plastic that rapidly equilibrates to the temperature of the warm moist gases in the patient breathing circuit. In addition, the inside of the windows is also coated with an anti-fog surfactant either by laminating an anti-fog film with the window plastic prior to attaching the window to the airway adapter body or by first attaching the window to the airway adapter body and then applying the surfactant to the airway adapter after the window film is bonded in place so that the surfactant coats the entire inside of the adapter. The surfactant functions to increase the critical wetting tension of the surface it covers so that water on the window spreads into a uniform thin layer which does not absorb very much infrared energy and thus does not significantly reduce the signal strength. "Instant on" operation is accomplished because no heater and the like is necessary to warm up the windows to maintain them at an elevated temperature to prevent fogging. Numerous techniques are also provided for adhering the windows to the airway adapter body so that a substantially airtight seal may be obtained.
摘要翻译：用于主流呼吸气体分析仪的一次性防雾气道适配器，其提供对患者的吸入和呼出气体的测量。气道适配器包括由能够快速平衡到患者呼吸回路中的温湿润气体的温度的薄的低热容塑料构成的窗户。此外，窗户的内部还通过在将窗口附接到气道适配器主体之前层叠防雾膜与窗户塑料，或者通过首先将窗口附接到气道适配器本体上来涂覆防雾表面活性剂然后在将窗膜粘合就位后将表面活性剂施用于气道适配器，使得表面活性剂涂覆在适配器的整个内部。表面活性剂用于增加其覆盖的表面的临界润湿张力，使得窗户上的水扩散到不吸收非常多的红外能量的均匀薄层，因此不显着降低信号强度。实现“即时打开”操作，因为不需要加热器等来预热窗户以将其保持在高温以防止起雾。还提供了许多技术用于将窗口粘附到气道适配器主体，使得可以获得基本上气密的密封。

40. 发明授权

US5515847A Self-emission noninvasive infrared spectrophotometer 失效
标题翻译：自发式无创红外分光光度计
公开(公告)号：US5515847A
公开(公告)日：1996-05-14
申请号：US247311
申请日：1994-05-23
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/6826 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled when a ratio of the detected signals is taken. The concentration of the blood constituents are then determined in accordance with a polynomial equation.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。监测由人发射的长波长红外能量作为热，并且对于那些成分在特征红外吸收波长处测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。所述测量优选与心动周期的收缩和心律舒张同步，使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献（其不脉冲）。然后根据多项式方程确定血液成分的浓度。

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