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    • 51. 发明授权
    • Distributed control system with global contraints for controlling object motion with smart matter
    • 具有全局控制的分布式控制系统,用智能物体控制物体运动
    • US07269475B1
    • 2007-09-11
    • US09033222
    • 1998-03-02
    • Tad H. HoggBjorn R. CarlsonVineet GuptaAndrew A. Berlin
    • Tad H. HoggBjorn R. CarlsonVineet GuptaAndrew A. Berlin
    • G06F7/00
    • B65H5/228B65H7/02B65H2406/113B65H2511/20B65H2511/51B65H2513/40B65H2553/41Y10S414/101B65H2220/01B65H2220/03B65H2220/02
    • Embedded in a transport assembly are arrays of microelectromechanical sensors and actuators for detecting and propelling an object. A controller having defined therein local computational agents and a global controller controls the array of sensors and actuators. The global controller provides global operating constraints to the local computational agents. The global operating constraints are developed using an approximate specification of system behavior based on simplified assumptions of an idealized system as well as limited sensor information aggregated from the array of sensors. The local computational agents compute a desired local actuator response using sensor information from a localized grouping of sensor units. To improve the accuracy of the global operating constraints, the local computational agents reduce differences between a global actuator response, computed using the global operating constraints, and the desired local actuator response. In addition, the local computational agents reduce the correlation among different parts of the transport assembly by reducing differences between actuator responses of neighborhoods of local computational agents.
    • 嵌入在运输组件中的是用于检测和推进物体的微机电传感器和致动器的阵列。 其中定义有局部计算代理和全局控制器的控制器控制传感器和致动器阵列。 全局控制器为本地计算代理提供全局操作约束。 基于理想系统的简化假设以及从传感器阵列聚合的有限传感器信息,使用系统行为的近似规范来开发全局操作约束。 本地计算代理使用来自传感器单元的局部分组的传感器信息来计算期望的本地致动器响应。 为了提高全局操作约束的准确性,本地计算代理减少使用全局操作约束计算的全局执行器响应与所需局部执行器响应之间的差异。 此外,本地计算代理通过减少本地计算代理邻域的执行器响应之间的差异来减少运输组件的不同部分之间的相关性。
    • 54. 发明申请
    • BIOMATERIALS WITH MICROSPHERE GRADIENTS AND CORE AND SHELL MICROSPHERES
    • 具有微球梯度和芯和壳微生物的生物材料
    • US20140200678A1
    • 2014-07-17
    • US14202379
    • 2014-03-10
    • Michael DetamoreVineet GuptaNeethu MohanCory Berkland
    • Michael DetamoreVineet GuptaNeethu MohanCory Berkland
    • A61L27/56A61L27/38
    • A61L27/56A61L27/10A61L27/14A61L27/38A61L27/40A61L27/54C12N5/0075C12N2533/10C12N2533/40
    • Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
    • 方法可以制备组织工程支架,其包括连接在一起的多个生物相容性核/壳微球形成三维基质。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性,并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性,以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物,聚合物,粒度,粒度分布,生物活性剂的类型,生物活性剂组合的类型,生物活性剂浓度,生物活性剂的量,生物活性剂释放速率,机械强度,柔韧性, 刚度,颜色,辐射透明度,无线电等等。