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61. 发明授权

US4918170A Process for producing gangliosides 失效
标题翻译：神经节苷脂的制备方法
公开(公告)号：US4918170A
公开(公告)日：1990-04-17
申请号：US352595
申请日：1989-05-16
申请人： Akira Hasegawa , Makoto Kiso
发明人： Akira Hasegawa , Makoto Kiso
IPC分类号： A61K31/70 , A61K31/7028 , A61P25/28 , A61P35/00 , C07H15/04 , C07H15/10
CPC分类号： C07H15/10 , Y02P20/55
摘要： The present invention provides a novel process for producing gangliosides such as GM.sub.3 and GM.sub.4 and analogues thereof. This process has the excellent characteristics in that in introduction of ceramide into sialooligosaccharides, first an azidosphingosine derivative is introduced and then the azido portion is reduced to effect N-acylation. The present invention has a conspicuous effect in that the yield is markedly improved as compared with conventional processes.
摘要翻译：本发明提供了用于生产神经节苷脂如GM3和GM4及其类似物的新方法。该方法具有优异的特征，即将神经酰胺引入唾液寡糖中，首先引入叠氮鞘氨醇衍生物，然后还原叠氮部分进行N-酰化。与常规方法相比，本发明具有明显的效果。

62. 发明授权

US4766083A Method for the photometric determination of biological agglutination 失效
标题翻译：光度测定生物凝集的方法
公开(公告)号：US4766083A
公开(公告)日：1988-08-23
申请号：US481961
申请日：1983-04-04
申请人： Yoshinobu Miyashita , Haruki Oishi , Yasumichi Ueno , Hiromi Shiraishi , Kazuyuki Tubaki
发明人： Yoshinobu Miyashita , Haruki Oishi , Yasumichi Ueno , Hiromi Shiraishi , Kazuyuki Tubaki
IPC分类号： G01N21/47 , G01N33/53 , G01N21/82 , G01N33/557
CPC分类号： G01N33/53 , G01N21/47 , Y10S436/805 , Y10S436/909
摘要： A photometric method and apparatus for measuring agglutination in a biological agglutination reaction system test sample using a laser beam source and at least one photodetector for detecting light scattered by the test sample. The method includes the following steps: (1) arranging the at least one photodetector so as to be capable of detecting scattered light from the test sample at a scatter angle of 30 to 60 with respect to a laser beam directed at the test sample from the laser beam source; (2) irradiating the test sample with the laser beam from the laser beam source; (3) selectively detecting the intensity of scattered light from the test sample at the scatter angle of 30 to 60 using the at least one photodetector which provides an output indicative thereof; and (4) determining the first derivative of the output of the at least one photodetector with respect to time and obtaining the maximum value thereof. In addition to the laser beam source and the at least one photodetector, the apparatus also includes a reaction cuvette for containing the test sample.
摘要翻译：一种光度测定方法和装置，用于使用激光束源和至少一个光检测器测量生物凝集反应系统测试样品中的凝集，用于检测由测试样品散射的光。该方法包括以下步骤：（1）布置至少一个光电检测器，以便能够以相对于来自测试样品的激光束以30至60的散射角检测来自测试样品的散射光激光束源; （2）用来自激光束源的激光束照射测试样品; （3）使用提供其指示的输出的至少一个光电检测器来选择性地以30至60的散射角检测来自测试样品的散射光的强度; 以及（4）确定所述至少一个光电检测器的输出相对于时间的一阶导数并获得其最大值。除了激光束源和至少一个光电检测器之外，该装置还包括用于容纳测试样品的反应池。

63. 发明授权

US4762917A Oligosaccharide derivatives and their use as substrate for measuring .alpha . 失效
标题翻译：寡糖衍生物及其作为测定α-淀粉酶活性的底物的用途
公开(公告)号：US4762917A
公开(公告)日：1988-08-09
申请号：US765080
申请日：1985-08-13
申请人： Tokuji Ikenaka , Kaoru Omichi
发明人： Tokuji Ikenaka , Kaoru Omichi
IPC分类号： G01N33/50 , C07H3/06 , C07H15/20 , C07H15/203 , C07H17/02 , C07H17/075 , C08B37/00 , C12Q1/26 , C12Q1/40
CPC分类号： C12Q1/26 , C07H3/06 , C12Q1/40
摘要： An oligosaccharide derivative having 4 to 7 glucose units wherein a primary alcohol moiety positioned at the 6-position of the non-reducing end glucose unit is replaced by ##STR1## --CH.sub.2 OCH.sub.2 COOH, or the like group and the 1-position of the reducing end glucose unit is replaced by a phenoxy or substituted phenoxy group or an umbelliferyl group or an indoxyl group is particularly suitable as a substrate for measuring .alpha.-amylase activity.
摘要翻译：具有4至7个葡萄糖单元的寡糖衍生物，其中位于非还原性末端葡萄糖单元6位的伯醇部分被“IMA”> -CH 2 OCH 2 COOH等取代，还原末端的1-位置换葡萄糖单元被苯氧基或取代的苯氧基或伞形酮基取代，或吲哚基特别适合作为测定α-淀粉酶活性的底物。

64. 发明授权

US4536206A Miticidal composition and method for controlling spider mites 失效
标题翻译：杀虫剂组成及防治螨虫的方法
公开(公告)号：US4536206A
公开(公告)日：1985-08-20
申请号：US541841
申请日：1983-10-14
申请人： Yoshiaki Kubo , Kaoru Takemura , Shuichiro Kouno
发明人： Yoshiaki Kubo , Kaoru Takemura , Shuichiro Kouno
IPC分类号： A01N37/00 , A01N25/10 , A01N25/00
CPC分类号： A01N25/10
摘要： A miticidal composition comprising a water-soluble acidic high polymer electrolyte of branching crosslinked polymer having a plurality of carboxyl groups as active ingredient and an aqueous medium is effective for various spider mites without causing chemical injury.
摘要翻译：包含具有多个羧基作为活性成分的支化交联聚合物的水溶性酸性高分子电解质和水性介质的杀螨剂组合物对于各种蜘蛛螨而言不会引起化学损伤。

65. 发明授权

US4533652A Azo polymerization initiator composition 失效
标题翻译：偶氮聚合引发剂组合物
公开(公告)号：US4533652A
公开(公告)日：1985-08-06
申请号：US597893
申请日：1984-04-09
申请人： Motoaki Tanaka , Takanori Toyama , Hitoshi Oba , Osamu Yamaguchi
发明人： Motoaki Tanaka , Takanori Toyama , Hitoshi Oba , Osamu Yamaguchi
IPC分类号： C08F4/00 , C08F2/18 , C08F4/04 , C08K5/22 , C08K5/23 , C08F , C08F2/20
CPC分类号： C08F4/04
摘要： An azo polymerization initiator composition obtained by kneading an azo compound, a dispersing agent and a surface active agent at a temperature of 20.degree. C. or lower, while adjusting the water content of the composition to 0 to 50% by weight, has good storage stability for a long period of time and, at any time desired for polymerization, can give a uniform aqueous suspension of the azo compound for polymerization of unsaturated vinyl monomers with high polymerization initiator activity.
摘要翻译：通过在将组合物的含水量调节至0〜50重量％的同时，在20℃以下的温度下将偶氮化合物，分散剂和表面活性剂混合而获得的偶氮聚合引发剂组合物具有良好的储存长时间的稳定性，并且在任何需要聚合的时候，均可得到具有高聚合引发剂活性的用于聚合不饱和乙烯基单体的偶氮化合物的均匀水悬浮液。

66. 发明授权

US4260713A Process for producing water-soluble polymers 失效
标题翻译：生产水溶性聚合物的方法
公开(公告)号：US4260713A
公开(公告)日：1981-04-07
申请号：US28190
申请日：1979-04-09
申请人： Motoaki Tanaka , Tsutomu Miyagawa , Takashi Nakata
发明人： Motoaki Tanaka , Tsutomu Miyagawa , Takashi Nakata
IPC分类号： C08F4/00 , C08F4/04 , C08F120/56 , C08F120/54
CPC分类号： C08F4/04
摘要： Water-soluble polymers having high molecular weight with little branching and good water solubility, particularly acrylamide series polymers having excellent flocculation effect can be obtained when 2,2'-azobis-(N,N'-dimethyleneisobutylamidine) or an acid addition salt thereof or a mixture of 2,2'-azobis(N,N'-dimethyleneisobutylamidine) or an acid addition salt thereof and another azo compound is used as polymerization initiator.
摘要翻译：当2,2'-偶氮双（N，N'-二亚甲基异丁基脒）或其酸加成盐或其酸加成盐或其酸加成盐时，可获得具有极好的絮凝作用的丙烯酰胺系列聚合物使用2,2'-偶氮双（N，N'-二亚甲基异丁基脒）或其酸加成盐和另一种偶氮化合物的混合物作为聚合引发剂。

67. 发明授权

US4197410A N-[(N-Nitrosoalkylamino)methyl]carbamic acid esters for generating diazoalkanes 失效
标题翻译：用于产生重氮烷烃的N - [（N-亚硝基烷基氨基）甲基]氨基甲酸酯
公开(公告)号：US4197410A
公开(公告)日：1980-04-08
申请号：US8160
申请日：1979-01-31
申请人： Minoru Sekiya , Keiichi Ito , Yoshiyasu Terao
发明人： Minoru Sekiya , Keiichi Ito , Yoshiyasu Terao
IPC分类号： C07C271/20 , C07C67/00 , C07C239/00 , C07C241/00 , C07C245/14 , C07C245/16 , C07C271/06 , C07C125/06
CPC分类号： C07C271/06
摘要： An N-[(N-nitrosoalkylamino)methyl]carbamic acid ester of the formula: ##STR1## wherein R.sup.1 is lower alkyl or aryl-substituted lower alkyl; and R.sup.2 is lower alkyl, which is an excellent diazoalkane generating agent, can be produced by reacting a carbamic acid ester with formaldehyde and a hydrohalide of alkylamine followed by the reaction with nitrous acid, an alkali nitrite or an alkyl nitrite.
摘要翻译：具有下式的N - [（N-亚硝基烷基氨基）甲基]氨基甲酸酯，其中R 1是低级烷基或芳基取代的低级烷基; R2是作为优异的重氮烷产生剂的低级烷基，可以通过使氨基甲酸酯与甲醛和烷基胺的氢卤酸反应，然后与亚硝酸，亚硝酸碱金属或亚硝酸烷基酯反应来制备。

68. 发明授权

US3959343A Process for producing hydrazonitriles 失效
标题翻译：制备hydraz腈的方法
公开(公告)号：US3959343A
公开(公告)日：1976-05-25
申请号：US518202
申请日：1974-10-25
申请人： Masanori Arashi , Hisahiko Shimada , Shigeyuki Fujituka , Kimio Kamiya , Tomoyuki Miyazaki
发明人： Masanori Arashi , Hisahiko Shimada , Shigeyuki Fujituka , Kimio Kamiya , Tomoyuki Miyazaki
IPC分类号： C07C255/66 , C07C120/00
CPC分类号： C07C255/66
摘要： A ketazine is reacted with hydrogen cyanide in the presence of at least one salt of a metal selected from the group consisting of zinc, tin, iron, copper, aluminum, antimony, tellurium and bismuth, whereby a hydrazo compound is formed. This hydrazo compound is oxidized with a halogen or the like to obtain an azonitrile. The thus obtained azonitrile is useful as a radical polymerization initiator, photo-polymerization initiator, blowing agent or the like.
摘要翻译：在选自锌，锡，铁，铜，铝，锑，碲和铋的金属的至少一种盐的存在下，将酮连同氰化氢反应，由此形成氢化物。该卤代化合物被卤素等氧化，得到偶氮腈。由此得到的氮腈可用作自由基聚合引发剂，光聚合引发剂，发泡剂等。

69. 发明授权

US2704422A Machine for thinning the lands of oil piston rings 失效
标题翻译：用于减薄油活塞环的地面的机器
公开(公告)号：US2704422A
公开(公告)日：1955-03-22
申请号：US30080852
申请日：1952-07-25
申请人： THOMPSON PROD INC
发明人： NORTON SAMUEL H
IPC分类号： B24B9/00 , B24B19/11
CPC分类号： B24B19/11 , B24B9/007 , Y10T29/49282 , Y10T409/300672

70. 发明授权

US09932625B2 Method for identification and detection of mutant gene using intercalator 有权
公开(公告)号：US09932625B2
公开(公告)日：2018-04-03
申请号：US14387150
申请日：2013-03-22
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD. , KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION
发明人： Shoichi Matsukuma , Tomokazu Ishikawa , Tatsuo Kurosawa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/6827 , G01N2458/30 , C12Q2563/173 , C12Q2565/125 , C12Q2565/131 , C12Q2565/133
摘要： The invention provides a method for detection of mutant-type DNA or/and wild-type DNA by contacting at least one of a single-stranded DNA having a substituted nucleotide, a deficient nucleotide region, or an inserted nucleotide region (mutant-type DNA), or/and a wild-type single-stranded DNA corresponding to the mutant-type DNA (wild-type DNA) with a probe hybridizing with both single-stranded DNAs, to form a hybrid with the mutant-type DNA (mutant-type hybrid) or/and a hybrid with the wild-type DNA (wild-type hybrid) (at least one of the obtained mutant-type hybrid and wild-type hybrid has a loop structure), (2) contacting the obtained mutant-type hybrid or/and wild-type hybrid with an intercalator, and (3) detecting the presence or absence of the mutant-type DNA or/and the wild-type DNA by separating the conjugate of mutant-type hybrid and intercalator or/and the conjugate of wild-type hybrid and intercalator.

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