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    • 61. 发明申请
    • A LASER AND A METHOD OF CONTROLLING THE GENERATION OF A LIGHT
    • 激光和控制光的产生的方法
    • US20150325976A1
    • 2015-11-12
    • US14412402
    • 2013-07-05
    • Macquarie University
    • David James SpenceHelen Margaret PaskAndrew Lee
    • H01S3/108H01S3/16H01S3/30H01S3/109
    • H01S3/30H01S3/08059H01S3/09415H01S3/1086H01S3/109H01S3/1611H01S3/1671
    • A laser configured to optimise output power at a desired wavelength, by suppression of unwanted Stokes orders in a Raman cascade, the laser comprising a resonating structure configured to resonate precursor light and Raman light frequencies, having a Raman medium configured to interact with the precursor resonating light to generate the Raman light; a control nonlinear medium configured to reduce an extraction of power from the precursor resonating light by the Raman process; and an output nonlinear medium configured to interact with the precursor resonating light to generate a desired output light thereby extracting power from the precursor resonating light; whereby the control nonlinear medium reduces the extraction of power from the precursor resonating light by the Raman process to enhance the extraction of power from the precursor resonating light by the output nonlinear medium interacting with the precursor resonating light thereby increasing the power of desired output the light.
    • 激光器,被配置为通过抑制拉曼级联中的不期望的斯托克斯次数来优化在期望波长处的输出功率,所述激光器包括被配置为共振前驱光和拉曼光频率的谐振结构,所述谐振结构被配置为与前体谐振相互作用 光产生拉曼光; 控制非线性介质,被配置为通过拉曼过程减少从所述前体谐振光的功率的提取; 以及输出非线性介质,其被配置为与前体谐振光相互作用以产生期望的输出光,从而从前体谐振光提取功率; 由此,控制非线性介质通过拉曼过程减少来自前体谐振光的功率的提取,以通过与前驱体谐振光相互作用的输出非线性介质增强从前体谐振光的功率提取,从而增加所需输出光的功率 。
    • 62. 发明申请
    • MULTIPLEX SUSPENSION ASSAY/ARRAY USING LIFETIME CODING
    • 多用途悬挂测定/使用寿命编码的阵列
    • US20150185149A1
    • 2015-07-02
    • US14410015
    • 2013-06-21
    • Macquarie University
    • Dayong JinYiqing LuJiangbo Zhao
    • G01N21/64
    • G01N21/6408B42D25/382B42D25/387C09D11/50C09K11/02C09K11/025C09K11/06C09K11/7773C09K2211/182C40B70/00G01N21/6428G01N33/542G01N33/582
    • A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilised for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct colour bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.
    • 用于多重测定的系统,装置和/或方法。 在特定但非限制性的示例中,提供了多路复用阵列,例如悬架阵列。 发光衰减寿命用于悬浮阵列中的探针,并对来自时间分辨光谱的代码进行编码/解码。 可以在不同的色带上生成终身人口。 一种新颖的时间技术或尺寸应用于常规光谱和强度组合,从而扩大了悬架阵列的复用能力。 在一个示例形式中,悬挂阵列的复用容量可以扩展到大约58个数量级。这提供了可靠的,高通量的和相对便宜的解决方案,用于在各种应用领域中的多重测定,诸如生命科学,数据存储和 安全。
    • 63. 发明申请
    • WAVELENGTH VERSATILE VECSEL RAMAN LASER
    • 波长VERSSTILE VECSEL拉曼激光
    • US20140269787A1
    • 2014-09-18
    • US14355734
    • 2012-11-09
    • Macquarie University
    • Jipeng LinHelen M. PaskDavid James SpenceCraig J. HamiltonGraeme P. Malcolm
    • H01S5/183H01S5/06H01S3/30
    • H01S5/0604H01S3/08027H01S3/082H01S3/1086H01S3/109H01S3/30H01S5/041H01S5/141H01S5/142H01S5/183
    • A tunable lasing device including a vertical external cavity surface emitting laser, adapted to generate a fundamental laser beam in response to pumping from a pump source, said fundamental laser beam having a fundamental wavelength and a fundamental linewidth; a fundamental resonator cavity adapted to resonate the fundamental beam therein; a first optical element located within the fundamental resonator cavity for control of the fundamental linewidth of the fundamental beam; a Raman resonator located at least partially in said fundamental resonator adapted to receive the fundamental beam and comprising therein, a solid state Raman active medium located therein for generating at least a first Stokes beam from the fundamental beam wherein said Raman resonator cavity is adapted to resonate said Stokes beam therein and further adapted to emit an output beam; and further comprising a nonlinear medium located within the Raman resonator cavity for nonlinear frequency conversion of at least one of the beams present in the fundamental or the Raman resonator cavity; said tunable lasing device further comprising an output coupler adapted to emit an output beam, said output beam comprising at least a portion of said frequency converted beam being derived from at least one of the resonating beams in said fundamental or said Raman resonator cavities.
    • 一种可调谐激光装置,包括垂直外腔表面发射激光器,适于响应于泵浦源的泵浦产生基本激光束,所述基本激光束具有基本波长和基本线宽; 基本谐振腔,其适于在其中谐振基波束; 位于基本谐振腔内的第一光学元件,用于控制基波束的基线宽度; 至少部分地位于所述基本谐振器中的拉曼谐振器,其适于接收基波束并且在其中包括位于其中的固态拉曼有源介质,用于从基波束产生至少第一斯托克斯波束,其中所述拉曼谐振腔适于谐振 所述斯托克斯光束在其中并进一步适于发射输出光束; 并且还包括位于拉曼谐振腔内的非线性介质,用于对存在于基波或拉曼谐振腔中的至少一个波束进行非线性频率转换; 所述可调谐激光装置还包括适于发射输出光束的输出耦合器,所述输出光束包括所述频率转换光束的至少一部分从所述基波或所述拉曼谐振腔中的至少一个谐振光束导出。
    • 64. 发明授权
    • Auto-synchronous fluorescence detection method and apparatus
    • 自动同步荧光检测方法及装置
    • US08779390B2
    • 2014-07-15
    • US12991474
    • 2009-05-13
    • Russell Connally
    • Russell Connally
    • G01N21/64G02B21/16G02B26/04
    • G01N21/6458G01N21/6408G01N2021/6463G02B21/16G02B26/04
    • An apparatus for time-gated fluorescence or luminescence detection includes gating means (206) arranged to alternately permit light from an excitation source (242) to be directed to a sample (235) along a first communication path (231, 232), and then permit light emitted from the sample to be directed to a detector (246) along a second communication path (237, 238) while blocking the first communication path (231, 232): The gating means (206) may comprise a single chopper wheel or apertured disc, or a rotating or oscillating arm, and may further comprise one or more reflective facets (207). The gating means (206) may be driven via a magnetic rotor, with a ferrite bead placed to offset rotor magnets with respect to drive coils, when at rest, so as to assist with self starting.
    • 用于时间门控荧光或发光检测的装置包括门控装置(206),其布置成交替地允许来自激发源(242)的光沿着第一通信路径(231,232)被引导到样本(235),然后 允许从样品发射的光沿着第二连通路径(237,238)引导到检测器(246),同时阻挡第一连通路径(231,232):门控装置(206)可以包括单个切碎机轮或 多孔圆盘或旋转或摆动臂,并且还可以包括一个或多个反射小平面(207)。 选通装置(206)可以经由磁性转子驱动,铁氧体磁珠被放置成相对于驱动线圈偏置转子磁体,当静止时,以帮助自启动。
    • 66. 发明授权
    • Fluorescence detection
    • 荧光检测
    • US07812324B2
    • 2010-10-12
    • US11577216
    • 2005-10-17
    • Russell ConnallyJames Austin Piper
    • Russell ConnallyJames Austin Piper
    • C12M1/34G01N21/64
    • G01N21/6458G01N21/6408
    • A fluorescence detection system comprises a light source (22), dichroic mirror (32), excitation port (16), emission port (14), and a detector. The light source (22) is, for example, a pulsed ultraviolet LED, with a light emission that decays sufficiently rapidly to permit gated detection of fluorescence from a fluorescently-labelled species, at a time when it is distinguishable from autofluorescence. The detector is, for example, an electron multiplying CCD, with high gain on-chip amplification. A circuit (26) may be used to control a repeating cycle of (i) generation of a 20-200 microsecond UV. pulse; (ii) a gate delay of 1-5 microseconds; and (iii) a 10-800 microsecond detection period. This allows time-resolved-fluorescence-microscopy with real time or near real time operation.
    • 荧光检测系统包括光源(22),分色镜(32),激发端口(16),发射端口(14)和检测器。 光源(22)例如是脉冲紫外LED,具有足够快速衰减的光发射,以允许在与自发荧光区分时从荧光标记物质进行门控检测。 检测器是例如具有高增益片上放大的电子倍增CCD。 电路(26)可用于控制(i)产生20-200微秒UV的重复循环。 脉冲; (ii)1-5微秒的门延迟; 和(iii)10-800微秒的检测周期。 这允许实时或接近实时操作的时间分辨荧光显微镜。