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1. 发明申请

US20050118591A1 Diagnosis kit, dna chip, and methods for diagnosing or supervising the treatment of testicular cancer 审中-公开
标题翻译：诊断试剂盒，dna芯片，诊断或监督睾丸癌治疗方法
公开(公告)号：US20050118591A1
公开(公告)日：2005-06-02
申请号：US10496410
申请日：2001-11-22
申请人： Cengiz Tamak , Alf-Andreas Krehan , Pia Steffens , Stefanie Waschuetza , Veit Zieglschmid
发明人： Cengiz Tamak , Alf-Andreas Krehan , Pia Steffens , Stefanie Waschuetza , Veit Zieglschmid
IPC分类号： C07K16/30 , G01N33/543 , G01N33/569 , G01N33/574 , C12Q1/68 , C12M1/34
CPC分类号： C07K16/30 , G01N33/54326 , G01N33/56966 , G01N33/57492
摘要： The invention relates to a diagnosis kit, a DNA chip, and to methods for diagnosing or supervising the treatment of testicular cancer, which are of greatest importance, in particular, within the scope of cancer prevention and post-treatment. The invention is essentially characterized in that the mRNA of testicular tumor markers is detected in a blood sample, whereby the tumor markers depict a tumor-associated gene expression. To this end, particularly β-hCG, AFP, PLAP or GCAP come into question. The detection of the mRNA is carried out by reverse transcription in cDNA and by subsequently amplifying selected segments of the cDNA by means of polymerase chain reaction.
摘要翻译：本发明涉及诊断试剂盒，DNA芯片，以及用于诊断或监督睾丸癌治疗的方法，其特别是在癌症预防和后处理的范围内是最重要的。本发明的基本特征在于，在血液样品中检测到睾丸肿瘤标志物的mRNA，由此肿瘤标志物描绘肿瘤相关基因表达。为此，特别是beta-hCG，AFP，PLAP或GCAP受到质疑。 mRNA的检测通过cDNA中的逆转录和随后通过聚合酶链反应扩增cDNA的选定区段来进行。

2. 发明申请

US20100285581A1 Solid Phase Cell Isolation and/or Enrichment Method 有权
标题翻译：固相细胞分离和/或富集方法
公开(公告)号：US20100285581A1
公开(公告)日：2010-11-11
申请号：US12678636
申请日：2008-09-17
申请人： Siegfried Hauch , Winfried Albert
发明人： Siegfried Hauch , Winfried Albert
IPC分类号： C12N5/071 , C12N5/078 , C12N5/09 , C12N5/073
CPC分类号： G01N33/574 , C12N2500/35 , G01N1/34 , G01N33/54393
摘要： The present invention concerns a solid phase method for isolating and/or enriching predetermined cells from a sample. Such methods are used e.g. to isolate and enrich predetermined cells like fetal cells from a sample of maternal peripheral blood, tumor cells from a sample of body fluid or stem cells from a fluid or fluidized sample of body tissue or body fluid. The solid phase isolation method of the present invention is used for isolating predetermined cells from a sample containing such predetermined cells by binding the predetermined cells to a solid surface. According to the invention the sample is contacted with the solid surface and then removed from the solid surface, wherein the sample or a washing buffer contains a polyol during or after contacting the sample with the solid surface.
摘要翻译：本发明涉及用于从样品中分离和/或富集预定细胞的固相方法。这样的方法例如使用。从母体外周血样品，体液样品或来自体液或体液流体样本的干细胞的肿瘤细胞中分离和富集预定细胞，如胎儿细胞。本发明的固相分离方法用于通过将预定细胞与固体表面结合来从含有这种预定细胞的样品中分离出预定的细胞。根据本发明，样品与固体表面接触，然后从固体表面除去，其中样品或洗涤缓冲液在与样品与固体表面接触期间或之后含有多元醇。

3. 发明申请

US20080305480A1 NOVEL TUMOR MARKER 审中-公开
标题翻译：新肿瘤标记
公开(公告)号：US20080305480A1
公开(公告)日：2008-12-11
申请号：US11952006
申请日：2007-12-06
申请人： Silke LANKIEWICZ
发明人： Silke LANKIEWICZ
IPC分类号： C12Q1/68 , C07K14/47 , C07K14/71 , C12N15/87 , C07H21/02
CPC分类号： C07K14/71 , A61K38/00 , G01N33/57484
摘要： The present invention concerns a gene product largely homologous to the epithelial growth factor receptor (EGFR). It further refers to mRNA coding for such epithelial growth factor receptor. The present invention provides such an epithelial growth factor receptor which is characterized in that either exons 12 to 14 or exons 12 to 15 are deleted. These novel variants of the epithelial growth factor receptor can be used for a diagnosis, stratification, therapy guidance of a tumor or therapy guidance of tumor surgery.
摘要翻译：本发明涉及与上皮生长因子受体（EGFR）大部分同源的基因产物。它进一步指的是编码这种上皮生长因子受体的mRNA。本发明提供了这样的上皮生长因子受体，其特征在于，外显子12〜14或外显子12〜15被缺失。上皮生长因子受体的这些新颖变体可用于肿瘤的诊断，分层，治疗指导或肿瘤手术的治疗指导。

4. 发明授权

US07858757B2 Monoclonal antibodies with specificity for fetal erythroid cells 有权
标题翻译：具有胎儿红细胞特异性的单克隆抗体
公开(公告)号：US07858757B2
公开(公告)日：2010-12-28
申请号：US10599512
申请日：2005-03-31
申请人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C12P21/08 , G01N33/53 , C12M3/00
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。单克隆抗体与存在于胎儿红细胞上的表面抗原（包括它们的有核前体细胞）反应，而不与成体红细胞上的表面抗原反应。

5. 发明授权

US07507528B2 Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells 有权
标题翻译：用于选择和/或定性和/或定量检测细胞的方法和诊断试剂盒
公开(公告)号：US07507528B2
公开(公告)日：2009-03-24
申请号：US10488729
申请日：2002-05-17
申请人： Winfried Albert , Pia Steffens , Alf-Andreas Krehan , Stefanie Waschuetza
发明人： Winfried Albert , Pia Steffens , Alf-Andreas Krehan , Stefanie Waschuetza
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/30 , G01N33/54326 , G01N33/56966
摘要： This invention relates to a method for selecting and/or for qualitative and/or quantitative detection of predetermined biological cells from or in a sample containing biological cells, the sample being mixed with a predetermined combination of at least two antibodies and/or antibody derivatives, which bind preferentially with their binding sites to different epitopes of the cells to be selected or detected, and/or with at least one biospecific antibody and/or antibody derivative, which binds preferentially with its two binding sites to different epitopes of the cells to be selected or detected, which are separated from the sample with cells marked with at least one of the antibodies and/or antibody derivatives, and the separated cells being tested with a predetermined combination of at least two molecular-biological detection reagents, the at least two detection reagents reacting preferentially with at least one component of the cells to be selected or detected.
摘要翻译：本发明涉及用于从含有生物细胞的样品中或在含有生物细胞的样品中选择和/或定性和/或定量检测预定生物细胞的方法，所述样品与至少两种抗体和/或抗体衍生物的预定组合混合，其优先与其结合位点结合至待选择或检测的细胞的不同表位，和/或与至少一种生物特异性抗体和/或抗体衍生物结合，所述生物特异性抗体和/或抗体衍生物优先与其两个结合位点结合至细胞的不同表位，选择或检测，其与标记有至少一种抗体和/或抗体衍生物的细胞与样品分离，并且分离的细胞用至少两种分子生物检测试剂的预定组合进行测试，所述至少两种检测试剂优选与待选择或检测的细胞的至少一种成分反应。

6. 发明申请

US20070275418A1 Monoclonal Antibodies With Specificity For Fetal Erythroid Cells 有权
标题翻译：胎儿红细胞特异性单克隆抗体
公开(公告)号：US20070275418A1
公开(公告)日：2007-11-29
申请号：US10599512
申请日：2005-03-31
申请人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C07K16/18 , C07K14/00 , C12N5/06 , G01N33/567
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。单克隆抗体与存在于胎儿红细胞上的表面抗原（包括它们的有核前体细胞）反应，而不与成体红细胞上的表面抗原反应。

7. 发明申请

US20140154704A1 Monoclonal Antibodies with Specficity for Fetal Erythroid Cells 有权
标题翻译：胎儿红细胞特异性单克隆抗体
公开(公告)号：US20140154704A1
公开(公告)日：2014-06-05
申请号：US14028027
申请日：2013-09-16
申请人： Adnagen AG
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： G01N33/569
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。本发明的单克隆抗体与存在于胎儿红细胞上的表面抗原（包括其有核的前体细胞）反应，但与成体红细胞上的表面抗原不反应。

8. 发明申请

US20110236904A1 DETECTION OF TUMOR STEM CELLS AND TUMOR CELLS IN EPITHELIAL-MESENCHYMAL TRANSITION IN BODY FLUIDS OF CANCER PATIENTS 有权
标题翻译：肿瘤患者体液转移中肿瘤干细胞和肿瘤细胞的检测
公开(公告)号：US20110236904A1
公开(公告)日：2011-09-29
申请号：US12678712
申请日：2007-09-17
申请人： Siegfried Hauch , Albert Winfried
发明人： Siegfried Hauch , Albert Winfried
IPC分类号： G01N33/574 , C12N5/095 , C12N5/09
CPC分类号： G01N33/574 , C12N2500/35 , G01N1/34 , G01N33/54393
摘要： The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods.According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed from the solid surface in a washing step. The inventive method is characterized in that the sample contains a polyol at least during one of contacting the sample with the solid surface and the washing step and in a detection step detecting in said cells, preferentially selected or enriched by said selecting step, the presence or absence of expression of at least one marker associated with at least one of the group comprising tumor stem cells and tumor cells in epithelial-mesenchymal transition.
摘要翻译：本发明涉及上皮 - 间质转化中肿瘤干细胞和肿瘤细胞的检测及其应用。根据本发明，所述方法包括用于从样品中选择或富集所述预定细胞的选择步骤，其中样品与固体表面接触，以将所述预定细胞优先结合到固体表面，然后将样品从洗涤步骤中的固体表面。本发明的方法的特征在于，至少在使样品与固体表面和洗涤步骤接触的过程中，样品含有多元醇，并且在所述细胞中检测优选由所述选择步骤选择或富集的检测步骤中，存在或在上皮 - 间质转化中不存在与至少一个包含肿瘤干细胞和肿瘤细胞的组相关的标记物的表达。

9. 发明申请

US20100159445A1 METHOD FOR THE INDIVIDUAL STAGING OF TUMOR DISEASES 审中-公开
标题翻译：肿瘤疾病个体分型方法
公开(公告)号：US20100159445A1
公开(公告)日：2010-06-24
申请号：US11816159
申请日：2007-03-01
申请人： Michael Lustig , Oliver Böcher , Winfried Albert
发明人： Michael Lustig , Oliver Böcher , Winfried Albert
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , G01N33/57484
摘要： The present invention concerns a method for the individual staging of the tumor disease of an individual cancer patient, a method for the individual decision on the method of treatment as well as a method for treating a cancer patient as well as their use in the treatment of various cancer diseases like colorectal tumor, prostate tumor, breast tumor, lung tumor, as primary tumors, tumor relapse and/or metastases. The present invention further provides a new prognosis factor in cancer treatment. This inventive method includes the step of analyzing at least one disseminated tumor cell present in a sample taken from a patient for the expression of at least one mRNA of at least one of growth factors, growth factor receptors and tumor associated transcripts.
摘要翻译：本发明涉及个体癌症患者肿瘤疾病个体分期的方法，个体决定治疗方法的方法以及治疗癌症患者的方法及其在治疗中的用途各种癌症如结肠直肠肿瘤，前列腺肿瘤，乳腺肿瘤，肺肿瘤，原发性肿瘤，肿瘤复发和/或转移。本发明进一步提供了癌症治疗中的新的预后因子。本发明的方法包括分析存在于患者中的样品中至少一种弥散性肿瘤细胞以表达至少一种生长因子，生长因子受体和肿瘤相关转录物的mRNA的步骤。

10. 发明申请

US20060246430A1 Method and kit for the diagnosis or treatment control of intestinal carcinoma 审中-公开
标题翻译：肠癌诊断或治疗控制的方法和试剂盒
公开(公告)号：US20060246430A1
公开(公告)日：2006-11-02
申请号：US10488728
申请日：2002-09-06
申请人： Winfried Albert , Pia Steffens , Alf-Andreas Krehan , Monica Stefan , Stefanie Waschuetza
发明人： Winfried Albert , Pia Steffens , Alf-Andreas Krehan , Monica Stefan , Stefanie Waschuetza
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K16/30 , G01N33/54326 , G01N33/56966 , G01N33/57492
摘要： The invention relates to a diagnosis kit and to a method for the diagnosis or treatment control of intestinal carcinoma in a human being. According to the invention, the presence or absence of at least two different messenger-RNAs coding for several of the tumor marker proteins CK20, EGF-R, CEA, GA733.2, PDGF-β and/or stanniocalcin is detected in a human blood sample. The presence of intestinal tumor cells in the blood sample is then deduced therefrom, as is possible metastatic spread.
摘要翻译：本发明涉及诊断试剂盒和用于人类肠癌诊断或治疗控制的方法。根据本发明，在人血液中检测到编码几种肿瘤标志物蛋白CK20，EGF-R，CEA，GA733.2，PDGF-β和/或铁蓝蛋白的至少两种不同信使RNA的存在或不存在样品。然后从血液样本中推断出肠肿瘤细胞的存在，如可能的转移扩散。

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