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1. 发明申请

US20100324065A1 Compounds and methods for development of Ret Modulators 有权
标题翻译： Ret调制剂开发的化合物和方法
公开(公告)号：US20100324065A1
公开(公告)日：2010-12-23
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： A61K31/497 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

2. 发明申请

US20070049615A1 Compounds and methods for development of Ret modulators 有权
标题翻译： Ret调制剂的开发化合物和方法
公开(公告)号：US20070049615A1
公开(公告)日：2007-03-01
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

3. 发明申请

US20050170431A1 PYK2 crystal structure and uses 审中-公开
标题翻译： PYK2晶体结构及用途
公开(公告)号：US20050170431A1
公开(公告)日：2005-08-04
申请号：US10789818
申请日：2004-02-27
申请人： Prabha Ibrahim , Heike Krupka , Abhinav Kumar , Michael Milburn , Yoshihisa Suzuki
发明人： Prabha Ibrahim , Heike Krupka , Abhinav Kumar , Michael Milburn , Yoshihisa Suzuki
IPC分类号： C07K16/40 , C12N20060101 , C12N9/12 , G01N33/53 , G01N33/573
CPC分类号： G01N33/573 , C07K2299/00 , C12N9/1205 , G01N2333/9121 , G01N2500/00
摘要： A crystal structure of PYK2 is described that was determined by X-ray crystallography. The use of PYK2 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PYK2.
摘要翻译：描述了通过X射线晶体学确定的PYK2的晶体结构。例如，使用PYK2晶体和结构信息可以用于鉴定分子支架和开发结合和调节PYK2的配体。

4. 发明申请

US20220284643A1 METHODS OF ESTIMATION-BASED SEGMENTATION AND TRANSMISSION-LESS ATTENUATION AND SCATTER COMPENSATION IN NUCLEAR MEDICINE IMAGING 有权
公开(公告)号：US20220284643A1
公开(公告)日：2022-09-08
申请号：US17187727
申请日：2021-02-26
申请人： Abhinav Kumar Jha , Ziping Liu , Hae Sol Moon , Zitong Yu , Md Ashequr Rahman
发明人： Abhinav Kumar Jha , Ziping Liu , Hae Sol Moon , Zitong Yu , Md Ashequr Rahman
IPC分类号： G06T11/00 , G06K9/00 , G06T7/11 , G06T7/00 , A61B6/03 , A61B6/00
摘要： Among the various aspects of the present disclosure is the provision of methods for estimation-based segmentation of nuclear medicine images, as well as methods of transmission-less attenuation and scatter compensation of nuclear medicine images.

5. 发明申请

US20120254900A1 FLOW TRACING THOUGH DIVERSE LOGICAL AND PHYSICAL APPLICATION AND INFRASTRUCTURE LAYERS/DEPENDENCIES 有权
标题翻译：流动跟踪通过多元逻辑和物理应用和基础设施层/依赖
公开(公告)号：US20120254900A1
公开(公告)日：2012-10-04
申请号：US13078677
申请日：2011-04-01
申请人： Abhinav Kumar , Bhaven Avalani
发明人： Abhinav Kumar , Bhaven Avalani
IPC分类号： G06F9/46
CPC分类号： G06F11/3688 , G06F8/70 , G06F11/3419 , G06F11/3452 , G06F11/3466 , G06F11/3476 , G06F2201/865 , G06F2201/87
摘要： In various exemplary embodiments, a system and a related method and a related computer-readable medium to perform the method, for tracking numerous software calls in an enterprise environment is provided. The method includes tracking, during a runtime operation of the enterprise environment, layers through which each of the software calls passes. The tracking includes logging each of a multitude of physical components involved in each of the software calls, annotating each of the physical components with associated metadata, logging each of a multitude of logical components involved in the software calls, annotating each of the logical components with associated metadata, and logging a reliance of each of the physical components and the logical components on other physical and logical components. A dependency map is generated indicating the layers tracked in each of the software calls.
摘要翻译：在各种示例性实施例中，提供了一种用于执行该方法的系统和相关方法以及相关的计算机可读介质，用于跟踪企业环境中的许多软件调用。该方法包括在企业环境的运行时操作期间跟踪每个软件呼叫通过的层。跟踪包括记录每个软件调用中涉及的多个物理组件中的每一个，用关联的元数据注释每个物理组件，记录软件调用中涉及的大量逻辑组件中的每一个，用每个逻辑组件注释每个逻辑组件关联的元数据，并记录每个物理组件和逻辑组件对其他物理和逻辑组件的依赖。生成依赖关系图，指示在每个软件调用中跟踪的层。

6. 发明申请

US20110289092A1 METHOD AND SYSTEM TO MONITOR A DIVERSE HETEROGENEOUS APPLICATION ENVIRONMENT 有权
标题翻译：监测多元异构应用环境的方法和系统
公开(公告)号：US20110289092A1
公开(公告)日：2011-11-24
申请号：US13196516
申请日：2011-08-02
申请人： Abhinav Kumar , Ravinder Purumala , Premendra Singh
发明人： Abhinav Kumar , Ravinder Purumala , Premendra Singh
IPC分类号： G06F17/30
CPC分类号： G06F17/30321 , G06F11/3409 , G06F11/3452 , G06F11/3476 , G06F11/3495 , G06F17/30091 , G06F2201/805 , G06F2201/87 , G06F2201/875
摘要： In various embodiments, a system and related method for organizing transactional data from a diverse and heterogeneous application environment is disclosed. In an example embodiment, a system includes a file system and one or more daemon indexers in electrical communication with the file system. The file system is arranged as a non-relational and serverless file system to allow for cost-effectiveness with ready scalability. The file system is to receive, in substantially real-time, unsorted transactional data from a publishing module. The one or more daemon indexers are arranged to receive the unsorted transactional data from the file system, organize the unsorted transactional data by operational characteristics, and store the organized transactional data on the file system.
摘要翻译：在各种实施例中，公开了一种用于从多样化和异构应用环境组织事务数据的系统和相关方法。在示例实施例中，系统包括与文件系统电通信的文件系统和一个或多个守护进程索引器。文件系统被布置为非关系和无服务器的文件系统，以便具有成本效益并具有可扩展性。文件系统基本上实时地从发布模块接收未排序的事务数据。一个或多个守护进程索引器被安排为从文件系统接收未排序的事务数据，通过操作特征组织未排序的事务数据，并将有组织的事务数据存储在文件系统上。

7. 发明申请

US20110254599A1 Method and Apparatus for MEMS Phase Locked Loop 有权
标题翻译： MEMS锁相环的方法和装置
公开(公告)号：US20110254599A1
公开(公告)日：2011-10-20
申请号：US13086746
申请日：2011-04-14
申请人： Abhinav Kumar Dikshit , Gadam Chetty Deva Phanindra Kumar , Anjan Kumar Krishnaswamy
发明人： Abhinav Kumar Dikshit , Gadam Chetty Deva Phanindra Kumar , Anjan Kumar Krishnaswamy
IPC分类号： H03L7/08
CPC分类号： H03L7/02 , H03L3/00
摘要： The proper operation of a phase locked loop is determined by monitoring certain signals within the loop for their phase relationship or duty cycle. If a malfunction of the loop is detected, proper operation may be imposed or restored by resetting a phase-frequency detector, or by flipping the output of the phase-frequency detector.
摘要翻译：通过监测回路内的某些信号来确定锁相环的相位关系或占空比来确定锁相环的正确运行。如果检测到环路故障，可以通过复位相位频率检测器或翻转相位频率检测器的输出来施加或恢复适当的操作。

8. 发明授权

US07526670B2 Method and system to monitor a diverse heterogeneous application environment 失效
标题翻译：监控各种不同应用环境的方法和系统
公开(公告)号：US07526670B2
公开(公告)日：2009-04-28
申请号：US11057702
申请日：2005-02-14
申请人： James Lloyd , Faye Dai Hall , Michael Eynon , Abhinav Kumar
发明人： James Lloyd , Faye Dai Hall , Michael Eynon , Abhinav Kumar
IPC分类号： G06F11/00
CPC分类号： G06F11/3495 , G06F11/3447 , G06F11/3476 , G06F2201/87
摘要： A method to detect potential problems within a heterogeneous and diverse application environment. Operations data is received from a plurality of application servers within the application environment. The operations data pertains to operations performed at the plurality of application servers over a predetermined time interval. The operations data is aggregated. The aggregated data is compared to reference data, and a potential problem within the application environment is detected if the aggregated data deviates from the reference data in a predetermined manner.
摘要翻译：一种检测异构和多样化应用环境中的潜在问题的方法。从应用环境中的多个应用服务器接收操作数据。操作数据涉及在多个应用服务器上在预定时间间隔内执行的操作。操作数据被聚合。将聚合数据与参考数据进行比较，如果聚合数据以预定方式偏离参考数据，则检测应用环境内的潜在问题。

9. 发明申请

US20060181034A1 Vehicle ride control system 失效
标题翻译：车辆行驶控制系统
公开(公告)号：US20060181034A1
公开(公告)日：2006-08-17
申请号：US11060055
申请日：2005-02-17
申请人： Michael Wilde , John Hart , Abhinav Kumar
发明人： Michael Wilde , John Hart , Abhinav Kumar
IPC分类号： B60G17/02 , B60G11/26
CPC分类号： B60G17/08 , B60G15/12 , B60G17/0152 , B60G17/0165 , B60G2202/154 , B60G2202/24 , B60G2400/102 , B60G2400/104 , B60G2400/204 , B60G2400/252 , B60G2400/39 , B60G2400/41 , B60G2500/10 , B60G2500/106 , B60G2600/08 , B60G2800/80
摘要： A ride control suspension control system having suspension control units with a damper and a single pressure regulator that controls dampening in both the compression and rebound chambers of the damper. The fluid control circuit may include a plurality of check valves that coordinate the flow of fluid to and from both chambers through the pressure regulator. In one embodiment, the system includes a central controller that receives input from a variety of sensors and directly controls operation the pressure regulators in each of the suspension control units without the need for any remote processors. The ride control suspension system may also include wheel position sensors that are external to the accumulator.
摘要翻译：具有悬挂控制单元的行驶控制悬架控制系统具有阻尼器和单个压力调节器，其控制阻尼器的压缩室和回弹室中的润湿。流体控制电路可以包括多个止回阀，其协调流体流过和通过压力调节器的两个腔室的流动。在一个实施例中，该系统包括中央控制器，其接收来自各种传感器的输入并且直接控制每个悬架控制单元中的压力调节器的操作，而不需要任何远程处理器。行驶控制悬架系统还可以包括在蓄能器外部的轮位置传感器。

10. 发明申请

US20050262136A1 Method and system to monitor a diverse heterogeneous application environment 失效
标题翻译：监控各种不同应用环境的方法和系统
公开(公告)号：US20050262136A1
公开(公告)日：2005-11-24
申请号：US11057702
申请日：2005-02-14
申请人： James Lloyd , Faye Hall , Michael Eynon , Abhinav Kumar
发明人： James Lloyd , Faye Hall , Michael Eynon , Abhinav Kumar
IPC分类号： G06F17/00 , G06F17/30
CPC分类号： G06F11/3495 , G06F11/3447 , G06F11/3476 , G06F2201/87
摘要： A method to detect potential problems within a heterogeneous and diverse application environment. Operations data is received from a plurality of application servers within the application environment. The operations data pertains to operations performed at the plurality of application servers over a predetermined time interval. The operations data is aggregated. The aggregated data is compared to reference data, and a potential problem within the application environment is detected if the aggregated data deviates from the reference data in a predetermined manner.
摘要翻译：一种检测异构和多样化应用环境中的潜在问题的方法。从应用环境中的多个应用服务器接收操作数据。操作数据涉及在多个应用服务器上在预定时间间隔内执行的操作。操作数据被聚合。将聚合数据与参考数据进行比较，如果聚合数据以预定方式偏离参考数据，则检测应用环境内的潜在问题。

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