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1. 发明授权

US10179242B2 Tissue oxygenation monitoring in heart failure 有权
公开(公告)号：US10179242B2
公开(公告)日：2019-01-15
申请号：US12797815
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61N1/36 , A61B5/145 , A61N1/365
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.

2. 发明授权

US09636059B2 Implantable tissue perfusion sensing system and method 有权
公开(公告)号：US09636059B2
公开(公告)日：2017-05-02
申请号：US13612967
申请日：2012-09-13
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： G01N33/46 , G01N31/00 , C12M1/00 , A61B5/1459 , A61B5/00 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/145 , A61N1/39
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

3. 发明授权

US08983619B2 Testing communication during implantation 有权
标题翻译：测量植入过程中的沟通
公开(公告)号：US08983619B2
公开(公告)日：2015-03-17
申请号：US12732403
申请日：2010-03-26
申请人： Can Cinbis , H. Toby Markowitz
发明人： Can Cinbis , H. Toby Markowitz
IPC分类号： A61N1/08 , A61B5/00 , A61N1/372 , A61B19/00 , A61N1/375
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for testing communication through a patient during implantation using telemetry coupling electrodes on a delivery catheter. In one example, at least two telemetry coupling electrodes may be placed on or within a delivery catheter to test conductive communication with external body electrodes during implantation. In some instances, the telemetry coupling electrodes of the delivery catheter may approximate the spacing of telemetry electrodes on an IMD. In this manner, testing conductively coupled communication with telemetry coupling electrodes of the catheter may be used to mimic the telemetry electrodes on the IMD and determine a target position and/or orientation of an electrode or electrodes of the IMD for successful conductive communication through the body.
摘要翻译：描述了一种系统和方法，用于在植入期间通过患者使用传送导管上的遥测耦合电极来测试通信。在一个示例中，至少两个遥测耦合电极可以放置在输送导管上或内部，以在植入期间测试与外部身体电极的导电连通。在一些情况下，输送导管的遥测耦合电极可以接近IMD上遥测电极的间距。以这种方式，测试与导管的遥测耦合电极的导电耦合通信可以用于模拟IMD上的遥测电极，并且确定IMD的电极或电极的目标位置和/或取向以便通过身体成功地导电连通。

4. 发明授权

US08942818B2 Communication with an implantable medical device during implantation 有权
标题翻译：植入期间与可植入医疗器械的通讯
公开(公告)号：US08942818B2
公开(公告)日：2015-01-27
申请号：US12732433
申请日：2010-03-26
申请人： H. Toby Markowitz , Can Cinbis
发明人： H. Toby Markowitz , Can Cinbis
IPC分类号： A61N1/08 , A61B5/00 , A61N1/372 , A61B19/00 , A61N1/375
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for delivering an implantable medical device in a patient and through a catheter. The delivery catheter comprises telemetry means for communicatively coupling the implantable medical device with an external instrumentation during implantation.
摘要翻译：描述了用于将可植入医疗装置递送到患者体内并通过导管的系统和方法。递送导管包括用于在植入期间将可植入医疗装置与外部装置通信地连接的遥测装置。

5. 发明授权

US08571620B2 Tissue oxygenation monitoring in heart failure 有权
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US08571620B2
公开(公告)日：2013-10-29
申请号：US12797816
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

6. 发明授权

US08244339B2 Wireless cardiac pulsatility sensing 有权
标题翻译：无线心脏搏动检测
公开(公告)号：US08244339B2
公开(公告)日：2012-08-14
申请号：US12852740
申请日：2010-08-09
申请人： Xiaonan Shen , Can Cinbis
发明人： Xiaonan Shen , Can Cinbis
IPC分类号： A61B5/04
CPC分类号： A61B5/6846 , A61B5/0245 , A61B5/0538 , A61N1/3937 , A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and associated method monitor changes in transimpedance in a body tissue due to changes in cardiac pulsatility. A first dipole is used to deliver a non-stimulating electrical current. The first dipole includes a first electrode and a second electrode adapted to be deployed along a first body location. A second dipole is used to measure a voltage resulting from the non-stimulating electrical current being conducted through a portion of a patient's body. The second dipole includes a third electrode and a fourth electrode different than the first electrode and the second electrode and adapted to be deployed along a second body location spaced apart from the first body location.
摘要翻译：可植入医疗装置系统和相关方法监测由于心脏搏动的变化而导致的身体组织中的跨阻抗变化。第一偶极子用于传递非刺激电流。第一偶极子包括适于沿着第一身体位置展开的第一电极和第二电极。使用第二偶极子来测量通过患者身体的一部分传导的非刺激性电流产生的电压。第二偶极子包括不同于第一电极和第二电极的第三电极和第四电极，并且适于沿着与第一主体位置间隔开的第二主体位置展开。

7. 发明授权

US07912537B2 Telemetry-synchronized physiological monitoring and therapy delivery systems 有权
标题翻译：遥测同步生理监测和治疗传播系统
公开(公告)号：US07912537B2
公开(公告)日：2011-03-22
申请号：US11380435
申请日：2006-04-27
申请人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
发明人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
IPC分类号： A61N1/06
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

8. 发明申请

US20100318146A1 Tissue Oxygenation Monitoring in Heart Failure 审中-公开
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US20100318146A1
公开(公告)日：2010-12-16
申请号：US12797815
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

9. 发明申请

US20100317942A1 Tissue Oxygenation Monitoring in Heart Failure 有权
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US20100317942A1
公开(公告)日：2010-12-16
申请号：US12797816
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

10. 发明申请

US20100317939A1 Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权
标题翻译：用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法
公开(公告)号：US20100317939A1
公开(公告)日：2010-12-16
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译：一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光，确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。

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