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1. 发明授权

US10179242B2 Tissue oxygenation monitoring in heart failure 有权
公开(公告)号：US10179242B2
公开(公告)日：2019-01-15
申请号：US12797815
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61N1/36 , A61B5/145 , A61N1/365
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.

2. 发明授权

US08571620B2 Tissue oxygenation monitoring in heart failure 有权
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US08571620B2
公开(公告)日：2013-10-29
申请号：US12797816
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

3. 发明授权

US08521245B2 Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权
标题翻译：使用组织氧合测量进行休克后评估的方法和装置
公开(公告)号：US08521245B2
公开(公告)日：2013-08-27
申请号：US12609538
申请日：2009-10-30
申请人： Jonathan L. Kuhn
发明人： Jonathan L. Kuhn
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and apparatus for controlling delivery of therapy that includes an emitting portion emitting light at a predetermined emitted light intensity to a volume of tissue at a plurality of wavelengths, and a detecting portion detecting the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals. A control module adjusts the detected light intensity output signals for shifts in intensity corresponding to the emitted light intensity, and determines a tissue oxygenation index in response to only the adjusted detected light intensity output signals, and a therapy delivery module controlling therapy in response to the determined tissue oxygenation index.
摘要翻译：一种用于控制治疗递送的方法和装置，其包括以预定的发射光强度发射多个波长的组织体积的发射部分，以及检测部分，其检测由组织体积散射的发射光，以产生相应的检测到光强输出信号。控制模块调整检测到的光强度输出信号，用于与发射的光强度相对应的强度偏移，并且仅响应于经调整的检测到的光强度输出信号确定组织氧合指数，以及治疗递送模块，确定组织氧合指数。

4. 发明申请

US20130109938A1 METHOD AND APPARATUS FOR CALIBRATING AN ABSOLUTE OXYGEN SATURATION SENSOR 有权
标题翻译：用于校准绝对氧气饱和传感器的方法和装置
公开(公告)号：US20130109938A1
公开(公告)日：2013-05-02
申请号：US13283930
申请日：2011-10-28
申请人： Jonathan L. Kuhn
发明人： Jonathan L. Kuhn
IPC分类号： A61B5/1495 , A61B5/1455
CPC分类号： A61B5/14551 , A61B5/1495
摘要： A method for using a medical device comprising an optical sensor to measure calibrated oxygen saturation in a body tissue uses a standard spectral response of blood established for multiple of oxygen saturations and a standard spectral response of a reference material. The standard responses are established using a spectrometer. The spectral power output of the optical sensor is measured using a spectrometer. The optical sensor output signal response to the reference material is obtained. A processor computes a device-specific calibration curve for the medical device using the measured spectral power output and the standard spectral response of blood and computes an optical gain using the standard spectral response of the reference material and the measured spectral power output of the optical sensor. The device-specific calibration curve and optical gain of the optical sensor are stored in a memory of the medical device.
摘要翻译：使用包括光学传感器来测量身体组织中的校准氧饱和度的医疗装置的方法使用针对多个氧饱和度建立的血液的标准光谱响应和参考材料的标准光谱响应。使用光谱仪建立标准响应。使用光谱仪测量光学传感器的光谱功率输出。获得对参考材料的光学传感器输出信号响应。处理器使用测量的光谱功率输出和血液的标准光谱响应来计算医疗设备的设备特定校准曲线，并使用参考材料的标准光谱响应和光学传感器的测量光谱功率输出来计算光学增益。光学传感器的器件专用校准曲线和光学增益被存储在医疗设备的存储器中。

5. 发明申请

US20100318146A1 Tissue Oxygenation Monitoring in Heart Failure 审中-公开
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US20100318146A1
公开(公告)日：2010-12-16
申请号：US12797815
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

6. 发明申请

US20100317942A1 Tissue Oxygenation Monitoring in Heart Failure 有权
标题翻译：心力衰竭组织氧合监测
公开(公告)号：US20100317942A1
公开(公告)日：2010-12-16
申请号：US12797816
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

7. 发明申请

US20100317939A1 Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权
标题翻译：用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法
公开(公告)号：US20100317939A1
公开(公告)日：2010-12-16
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译：一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光，确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。

8. 发明申请

US20100185262A1 CO-LOCATION OF EMITTERS AND DETECTORS AND METHOD OF OPERATION 有权
标题翻译：发射器和探测器的合作位置及其操作方法
公开(公告)号：US20100185262A1
公开(公告)日：2010-07-22
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61N1/08 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少另一个作为光检测组件进行操作

9. 发明申请

US20090270953A1 Optical Device 有权
标题翻译：光学设备
公开(公告)号：US20090270953A1
公开(公告)日：2009-10-29
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
IPC分类号： A61N5/06 , H01L31/12
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

10. 发明授权

US09958351B2 Strain compensation for pressure sensors 有权
公开(公告)号：US09958351B2
公开(公告)日：2018-05-01
申请号：US13428108
申请日：2012-03-23
申请人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
发明人： Jonathan L. Kuhn , Richard J. O'Brien , Jonathan P. Roberts , James D. Reinke , Michael B. Terry , Kamal Deep Mothilal
IPC分类号： G01L9/12 , G01L19/02 , A61B5/00 , A61B5/03 , G01L19/14 , G01L15/00 , A61B5/0215 , A61B5/20
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.

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