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1. 发明授权

US10648970B2 Method for evaluation of target in histological sample 有权
公开(公告)号：US10648970B2
公开(公告)日：2020-05-12
申请号：US14356735
申请日：2012-11-08
申请人： DAKO DENMARK A/S
发明人： Jesper Lohse , Kristian Jensen , Rikke Malene Krusenst Jerna-Hafstrom , Kirsten Damgaard Hoff , Lars Christian Jacobsen
IPC分类号： G01N33/53 , G01N33/68 , G01N33/58
摘要： The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

2. 发明申请

US20180306686A1 TISSUE PROCESSING APPARATUS 审中-公开
公开(公告)号：US20180306686A1
公开(公告)日：2018-10-25
申请号：US16007756
申请日：2018-06-13
申请人： Dako Denmark A/S
发明人： Tim Svenstrup Poulsen , Steen Hauge Matthiesen
IPC分类号： G01N1/28 , G01N1/31 , G01N1/30
CPC分类号： G01N1/2813 , G01N1/30 , G01N1/312
摘要： An apparatus (100) for processing a biological sample (101). The biological sample being arranged on a first planar surface (102) of a carrier (103). The apparatus comprises a second planar surface (104) arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said first planar surface and said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP); supply means (126, 131, 230) for supplying an amount (105) of a liquid that is to be applied to said biological sample. The first planar surface and second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said suppled amount of liquid is distributed ever said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.

3. 发明申请

US20180080936A1 METHOD FOR DETECTION OF L523S EXPRESSION IN BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20180080936A1
公开(公告)日：2018-03-22
申请号：US15828017
申请日：2017-11-30
申请人： Dako Denmark A/S
发明人： Katherine Marks SOJKA , Elizabeth Oliver SPAULDING
IPC分类号： G01N33/574
CPC分类号： G01N33/57476 , G01N33/5743
摘要： The present invention discloses methods, for differentiating between normal or reactive cells and malignant cells biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells. In embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular cell lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.

4. 发明授权

US09767425B2 Systems and methods for tracking and providing workflow information 有权
公开(公告)号：US09767425B2
公开(公告)日：2017-09-19
申请号：US14143274
申请日：2013-12-30
申请人： Dako Denmark A/S
发明人： Laura Chirica , Mats Grahn , Stephen Jones
IPC分类号： G06Q10/06
CPC分类号： G06Q10/0633 , G06F19/00 , G06Q10/06 , G16H10/40 , G16H40/20 , G16H40/67
摘要： A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may be configured to perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen, wherein the tissue specimen is processed by the one or more laboratory stations according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow. The method may further include enabling a first active component associated with the virtual laboratory component, wherein the first active component is configured to receive a user selection of a laboratory station and generating a supplemental view component of the selected laboratory station in response to the user selection, wherein the supplemental view provides supplemental information on processing by the selected laboratory station of the tissue specimen.

5. 发明申请

US20170220775A1 SYSTEM FOR TRACKING BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20170220775A1
公开(公告)日：2017-08-03
申请号：US15491849
申请日：2017-04-19
申请人： Dako Denmark A/S
发明人： Jose De La Torre-Bueno
IPC分类号： G06F19/00 , G01N35/00
CPC分类号： G16H10/40 , B01L3/545 , G01N35/00029 , G01N35/00732 , G01N35/00871 , G01N2035/00138 , G01N2035/00742 , G01N2035/00752 , G01N2035/00831 , G01N2035/00841 , G01N2035/00881 , G01N2035/0091 , G06F19/32 , G06F19/324 , G06Q50/24 , G16B40/00 , G16B50/00 , G16H10/60
摘要： Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection to processing to analyzing to storage.

6. 发明授权

US09599630B2 Method and apparatus for automatic staining of tissue samples 有权
公开(公告)号：US09599630B2
公开(公告)日：2017-03-21
申请号：US14151130
申请日：2014-01-09
申请人： Dako Denmark A/S
发明人： Doug Sweet , Marc Key , Gordon Feingold , Kristopher Buchanan , Bob Lathrop , John Favuzzi
IPC分类号： G01N1/31 , G01N35/00 , G01N1/30
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

7. 发明申请

US20160274122A1 NEW METHOD FOR ENZYME-MEDIATED SIGNAL AMPLIFICATION 有权
标题翻译：用于酶介导信号放大的新方法
公开(公告)号：US20160274122A1
公开(公告)日：2016-09-22
申请号：US15166133
申请日：2016-05-26
申请人： Dako Denmark A/S
发明人： Jesper Lohse , Galina Skladchikova
IPC分类号： G01N33/58 , C12Q1/26
CPC分类号： G01N33/581 , C12Q1/26 , C12Q1/28 , G01N33/57492
摘要： The present invention relates to methods and compounds for enzyme-mediated amplification of target-associated signals for visualization of biological or chemical targets in samples, wherein the targets are immobilized, in particular the invention relates to the oxidoreductase-mediated signal amplification for visualization of targets in samples comprising cells. The methods of the invention are particular useful for qualitative and quantitative evaluation of biological markers relating to medical diagnostic and therapy.
摘要翻译：本发明涉及用于酶介导扩增靶标相关信号的方法和化合物，用于在样品中生物或化学靶标的可视化，其中靶标被固定，特别是本发明涉及用于目标可视化的氧化还原酶介导的信号放大在包含细胞的样品中。本发明的方法对于与医学诊断和治疗有关的生物学标记的定性和定量评估特别有用。

8. 发明申请

US20160033372A1 TISSUE PROCESSING APPARATUS 审中-公开
标题翻译：组织加工设备
公开(公告)号：US20160033372A1
公开(公告)日：2016-02-04
申请号：US14883257
申请日：2015-10-14
申请人： DAKO DENMARK A/S
发明人： Tim Svenstrup Poulsen , Steen Hauge Matthiesen
IPC分类号： G01N1/28 , G01N1/31
CPC分类号： G01N1/2813 , G01N1/30 , G01N1/312
摘要： An apparatus (100) for processing a biological sample (101). The biological sample being arranged on a first planar surface (102) of a carrier (103). The apparatus comprises a second planar surface (104) arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP); supply means (126, 131, 220) for supplying an amount (105) of a liquid that is to be applied to said biological sample. The first planar surface and the second planar surface are configured to be arranged in a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and second planar surface are brought to said second distance from each other.
摘要翻译：一种用于处理生物样品（101）的装置（100）。生物样品被布置在载体（103）的第一平坦表面（102）上。该装置包括基本上平行于所述第一平面表面并且距离所述第一平面的第一距离设置的第二平表面（104），所述第二平表面以与水平面大于零度的角度（A）生命值）; 供应装置（126,131,220），用于供应要施加到所述生物样品的液体的量（105）。第一平坦表面和第二平坦表面被配置为彼此相距第二距离，所述第二距离使得当所述第一平面和第二平面被带入时，所述供应量的液体分布在所述生物样品上到彼此的第二距离。

9. 发明授权

US09164013B2 Reagent delivery system, dispensing device and container for a biological staining apparatus 有权
标题翻译：用于生物染色设备的试剂递送系统，分配装置和容器
公开(公告)号：US09164013B2
公开(公告)日：2015-10-20
申请号：US13919959
申请日：2013-06-17
申请人： DAKO Denmark A/S
发明人： John Favuzzi , Jonathan Sweda , Loren Bland , Merrit Martin , Robert Lathrop , John Van Bosch , Kristopher Buchanan
IPC分类号： G01N1/10 , G01N1/30 , G01N35/10 , B01L3/00 , G01N1/31
CPC分类号： G01N1/30 , B01L3/508 , G01N1/312 , G01N35/1002 , G01N35/109 , Y10T436/2575
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
摘要翻译：本发明涉及用于处理布置在显微镜载片上的生物样品的装置的试剂递送系统，包括具有一个或多个试剂容器的试剂部分; 其中布置有至少一个显微镜载玻片的滑动部分; 用于将一部分试剂分配到预定显微镜载玻片上的探针和用于处理探针的装置。探针包括连续证明管道元件，其延伸穿过刚性探针构件并将探针尖端连接到气动调压装置。试剂容器适于与探针尖端配合。以这种方式，由于没有组成部件构成探针的内部体积，其中可以保留流体，所以实现了高的保留和非常低的流体残余的携带。

10. 发明授权

US09040284B2 Systems and methods of sample processing and temperature control 有权
标题翻译：样品处理和温度控制的系统和方法
公开(公告)号：US09040284B2
公开(公告)日：2015-05-26
申请号：US13625115
申请日：2012-09-24
申请人： DAKO Denmark A/S
发明人： Kristopher Buchanan , Marc Key , John Favuzzi , Rosanne Welcher , Benno Guggenheimer , Robert Clark , Michael Barber , Bob Lathrop
IPC分类号： G01N35/00 , G01N1/30 , G01N1/31
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.
摘要翻译：公开了样品处理和温度控制的系统和方法。本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。本发明可能具有特定适用性的科学领域包括免疫组织化学，杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和生物应用。

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