专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08470408B2 Carbon nanotube synthesis for nanopore devices 有权
公开(公告)号：US08470408B2
公开(公告)日：2013-06-25
申请号：US12286849
申请日：2008-10-02
申请人： Daniel Branton , Jene A. Golovchenko , Slaven Garaj , Dimitar M. Vlassarev , El-Hadi S. Sadki
发明人： Daniel Branton , Jene A. Golovchenko , Slaven Garaj , Dimitar M. Vlassarev , El-Hadi S. Sadki
IPC分类号： D01F9/12 , C40B50/14 , C23C16/00 , B05D3/00
CPC分类号： B81C1/00182 , G01N33/48721
摘要： In a process for fabricating a nanopore device, at least one carbon nanotube catalyst region is formed on a structure. A plurality of nanopores is formed in the structure at a distance from the catalyst region that is no greater than about an expected length for a carbon nanotube synthesized from the catalyst region. Then at least one carbon nanotube is synthesized from the catalyst region. This fabrication sequence enables the in situ synthesis of carbon nanotubes at the site of nanopores, whereby one or more nanotubes articulate one or more nanopores without requiring manual positioning of the nanotubes.

2. 发明授权

US08273257B2 Nanotube processing employing solid-condensed-gas-layers 有权
标题翻译：采用固体冷凝气层的纳米管加工
公开(公告)号：US08273257B2
公开(公告)日：2012-09-25
申请号：US12409580
申请日：2009-03-24
申请人： Jene A Golovchenko , Gavin M King , Gregor M Schurmann , Daniel Branton
发明人： Jene A Golovchenko , Gavin M King , Gregor M Schurmann , Daniel Branton
IPC分类号： C23C14/34 , B82B3/00
CPC分类号： C23C14/06 , B82Y10/00 , C23C14/5873 , H01J37/3005 , H01J2237/31732 , H01J2237/3174 , H01L21/02238 , H01L21/0332 , H01L21/0337 , H01L21/30604 , H01L21/3065 , H01L21/31662 , H01L21/3185 , Y10S977/856 , Y10S977/857 , Y10S977/888 , Y10S977/89 , Y10S977/891
摘要： In a method for processing a nanotube, a vapor is condensed to a solid condensate layer on a surface of the nanotube and then at least one selected region of the condensate layer is locally removed by directing a beam of energy at the selected region. The nanotube can be processed with at least a portion of the solid condensate layer maintained on the nanotube surface and thereafter the solid condensate layer removed. Nanotube processing can include, e.g., depositing a material layer on an exposed nanotube surface region where the condensate layer was removed. After forming a solid condensate layer, an electron beam can be directed at a selected region along a nanotube length corresponding to a location for cutting the nanotube, to locally remove the condensate layer at the region, and an ion beam can be directed at the selected region to cut the nanotube at the selected region.
摘要翻译：在用于处理纳米管的方法中，蒸汽被冷凝到纳米管表面上的固体冷凝物层，然后通过在所选择的区域引导能量束来局部去除冷凝物层的至少一个选定区域。纳米管可以用保持在纳米管表面上的固体冷凝物层的至少一部分进行处理，然后除去固体冷凝物层。纳米管加工可以包括例如在去除冷凝物层的暴露的纳米管表面区域上沉积材料层。在形成固体冷凝物层之后，电子束可以沿着与用于切割纳米管的位置相对应的纳米管长度的选定区域被引导，以在该区域局部移除冷凝物层，并且离子束可以被引导到所选择的区域以在所选择的区域切割纳米管。

3. 发明申请

US20120094278A1 METHODS AND APPARATUS FOR CHARACTERIZING POLYNUCLEOTIDES 有权
标题翻译：用于表征多核苷酸的方法和装置
公开(公告)号：US20120094278A1
公开(公告)日：2012-04-19
申请号：US13110536
申请日：2011-05-18
申请人： Mark Akeson , Daniel Branton , David W. Deamer , Jeffrey R. Sampson
发明人： Mark Akeson , Daniel Branton , David W. Deamer , Jeffrey R. Sampson
IPC分类号： C12Q1/68 , C12M1/40 , B82Y15/00
CPC分类号： G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2300/0896 , B01L2400/0475 , B82Y5/00 , B82Y30/00 , C12Q1/6869 , C12Q2565/631 , C12Q2521/543
摘要： Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.
摘要翻译：提供了用于分析聚合物的系统和方法，例如多核苷酸。该系统能够以指定的速率分析聚合物。一个这样的分析系统包括具有纳米孔孔的结构和邻近纳米孔孔的分子马达，例如聚合酶。

4. 发明授权

US07582490B2 Controlled fabrication of gaps in electrically conducting structures 有权
标题翻译：控制导电结构间隙的制造
公开(公告)号：US07582490B2
公开(公告)日：2009-09-01
申请号：US10767102
申请日：2004-01-29
申请人： Jene A. Golovchenko , Gregor M. Schürmann , Gavin M. King , Daniel Branton
发明人： Jene A. Golovchenko , Gregor M. Schürmann , Gavin M. King , Daniel Branton
IPC分类号： H01L21/00 , C23C14/00 , G01N35/08 , G01N35/00 , H01L29/78
CPC分类号： G01N33/48721 , Y10T436/11 , Y10T436/12
摘要： A method for controlling a gap in an electrically conducting solid state structure provided with a gap. The structure is exposed to a fabrication process environment conditions of which are selected to alter an extent of the gap. During exposure of the structure to the process environment, a voltage bias is applied across the gap. Electron tunneling current across the gap is measured during the process environment exposure and the process environment is controlled during process environment exposure based on tunneling current measurement. A method for controlling the gap between electrically conducting electrodes provided on a support structure. Each electrode has an electrode tip separated from other electrode tips by a gap. The electrodes are exposed to a flux of ions causing transport of material of the electrodes to corresponding electrode tips, locally adding material of the electrodes to electrode tips in the gap.
摘要翻译：一种用于控制具有间隙的导电固态结构中的间隙的方法。该结构暴露于制造工艺环境条件，其条件被选择以改变间隙的程度。在将结构暴露于工艺环境中时，跨越间隙施加电压偏置。在工艺环境暴露期间测量跨越间隙的电子隧道电流，并且基于隧道电流测量在工艺环境暴露期间控制工艺环境。一种用于控制设置在支撑结构上的导电电极之间的间隙的方法。每个电极具有通过间隙与其它电极尖端分离的电极头。电极暴露于离子通量，导致电极的材料传输到相应的电极尖端，将电极的材料局部地添加到间隙中的电极尖端。

5. 发明授权

US07258838B2 Solid state molecular probe device 有权
标题翻译：固态分子探针装置
公开(公告)号：US07258838B2
公开(公告)日：2007-08-21
申请号：US10367075
申请日：2003-02-14
申请人： Jiali Li , Derek M. Stein , Gregor M. Schurmann , Gavin M. King , Jene Golovchenko , Daniel Branton , Michael Aziz
发明人： Jiali Li , Derek M. Stein , Gregor M. Schurmann , Gavin M. King , Jene Golovchenko , Daniel Branton , Michael Aziz
IPC分类号： H01L29/00 , H01L47/00 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N33/48721 , Y10S977/70 , Y10S977/701 , Y10S977/712 , Y10S977/72 , Y10S977/762 , Y10S977/84 , Y10S977/902 , Y10S977/92 , Y10S977/953 , Y10S977/957
摘要： A solid state nanopore device including two or more materials and a method for fabricating the same. The device includes a solid state insulating membrane having an exposed surface, a conductive material disposed on at least a portion of the exposed surface of the solid state membrane, and a nanopore penetrating an area of the conductive material and at least a portion of the solid state membrane. During fabrication a conductive material is applied on a portion of a solid state membrane surface, and a nanopore of a first diameter is formed. When the surface is exposed to an ion beam, material from the membrane and conductive material flows to reduce the diameter of the nanopore. A method for evaluating a polymer molecule using the solid state nanopore device is also described. The device is contacted with the polymer molecule and the molecule is passed through the nanopore, allowing each monomer of the polymer molecule to be monitored.
摘要翻译：包括两种或多种材料的固体纳米孔装置及其制造方法。该装置包括具有暴露表面的固态绝缘膜，设置在固态膜的暴露表面的至少一部分上的导电材料，以及穿透导电材料区域的纳米孔和固体的至少一部分状态膜。在制造期间，将导电材料施加在固态膜表面的一部分上，并且形成第一直径的纳米孔。当表面暴露于离子束时，来自膜的材料和导电材料流动以减小纳米孔的直径。还描述了使用固态纳米孔装置评估聚合物分子的方法。该装置与聚合物分子接触，分子通过纳米孔，允许监测聚合物分子的每个单体。

6. 发明申请

US20060063171A1 Methods and apparatus for characterizing polynucleotides 有权
公开(公告)号：US20060063171A1
公开(公告)日：2006-03-23
申请号：US11088140
申请日：2005-03-23
申请人： Mark Akeson , Daniel Branton , David Deamer , Jeffrey Sampson
发明人： Mark Akeson , Daniel Branton , David Deamer , Jeffrey Sampson
IPC分类号： C12Q1/68
CPC分类号： G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2300/0896 , B01L2400/0475 , B82Y5/00 , B82Y30/00 , C12Q1/6869 , C12Q2565/631 , C12Q2521/543
摘要： Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.

7. 发明申请

US20050241933A1 Material deposition techniques for control of solid state aperture surface properties 有权
标题翻译：用于控制固态孔径表面性质的材料沉积技术
公开(公告)号：US20050241933A1
公开(公告)日：2005-11-03
申请号：US11015349
申请日：2004-12-17
申请人： Daniel Branton , Roy Gordon , Peng Chen , Toshiyuki Mitsui , Damon Farmer , Jene Golovchenko
发明人： Daniel Branton , Roy Gordon , Peng Chen , Toshiyuki Mitsui , Damon Farmer , Jene Golovchenko
IPC分类号： C23C14/32
CPC分类号： G01N33/48721 , B82Y15/00
摘要： The invention provides a method for molecular analysis. In the method, sidewalls are formed extending through a structure between two structure surfaces, to define an aperture. A layer of material is deposited on the aperture sidewalls and the two structure surfaces. The aperture with the deposited material layer is then configured in a liquid solution with a gradient in a chemical potential, between the two structure surfaces defining the aperture, that is sufficient to cause molecular translocation through the aperture.
摘要翻译：本发明提供了一种分子分析方法。在该方法中，形成延伸穿过两个结构表面之间的结构的侧壁，以限定孔。一层材料沉积在孔侧壁和两个结构表面上。然后将具有沉积材料层的孔配置在具有化学势的梯度的液体溶液中，限定孔的两个结构表面之间，足以使分子易位穿过孔。

8. 发明授权

US6015714A Characterization of individual polymer molecules based on monomer-interface interactions 失效
标题翻译：基于单体界面相互作用的单个聚合物分子的表征
公开(公告)号：US6015714A
公开(公告)日：2000-01-18
申请号：US98142
申请日：1998-06-16
申请人： Richard Baldarelli , Daniel Branton , George Church , David W. Deamer , Mark Akeson , John Kasianowicz
发明人： Richard Baldarelli , Daniel Branton , George Church , David W. Deamer , Mark Akeson , John Kasianowicz
IPC分类号： C07K14/705 , C12N9/12 , C12Q1/68 , G01N27/04 , G01N33/68 , G01N33/483
CPC分类号： G01N33/68 , C07K14/705 , C12N9/1241 , C12Q1/6869 , G01N33/48721 , B82Y30/00 , Y10S977/781 , Y10S977/788 , Y10S977/84 , Y10S977/88 , Y10S977/924 , Y10S977/953
摘要： A method for sequencing a nucleic acid polymer by (1) providing two separate, adjacent pools of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage from one pool to the other pool of only one nucleic acid polymer at a time; (2) placing the nucleic acid polymer to be sequenced in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the nucleic acid polymer passes through the channel so as to sequence the nucleic acid polymer.
摘要翻译：一种用于通过（1）提供两个分离的相邻的培养基池和两个池之间的界面来测序核酸聚合物的方法，所述界面具有通道，其尺寸被设计成允许顺序的单体单体从一个池传递到一次只有一个核酸聚合物的另一个池; （2）将待测序的核酸聚合物置于两个池中的一个中; 和（3）作为核酸聚合物的每个核苷酸单体通过通道进行测量，以便对核酸聚合物进行排序。

9. 发明授权

US10564144B2 Nanometric material having a nanopore enabling high-sensitivity molecular detection and analysis 有权
公开(公告)号：US10564144B2
公开(公告)日：2020-02-18
申请号：US13419383
申请日：2012-03-13
申请人： Slaven Garaj , Jene A. Golovchenko , Daniel Branton
发明人： Slaven Garaj , Jene A. Golovchenko , Daniel Branton
IPC分类号： G01N33/487
摘要： There is provided a substantially bare, self-supported single-layer graphene membrane including a nanopore extending through a thickness of the graphene membrane from a first to a second membrane surface opposite the first graphene membrane surface. A connection from the first graphene membrane surface to a first reservoir provides, at the first graphene membrane surface, a species in an ionic solution to the nanopore, and a connection from the second graphene membrane surface to a second reservoir is provided to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first graphene membrane surface to the second graphene membrane surface. An electrical circuit is connected on opposite sides of the nanopore to measure flow of ionic current through the nanopore in the graphene membrane.

10. 发明授权

US09611140B2 Controlled fabrication of nanopores in nanometric solid state materials 有权
公开(公告)号：US09611140B2
公开(公告)日：2017-04-04
申请号：US14004743
申请日：2012-03-14
申请人： Christopher John Russo , Jene Golovchenko , Daniel Branton
发明人： Christopher John Russo , Jene Golovchenko , Daniel Branton
IPC分类号： G01L21/30 , B81C1/00 , G01N33/487
CPC分类号： B81B1/002 , B81B2201/0214 , B81B2203/0127 , B81B2207/056 , B81C1/00087 , G01N33/48721
摘要： In a method of forming a nanopore in a nanometric material, a nanopore nucleation site is formed at a location that is interior to lateral edges of the nanometric material by directing a first energetic beam, selected from the group of ion beam and neutral atom beam, at the interior location for a first time duration that imposes a first beam dose which causes removal of no more than five interior atoms from the interior location to produce at the interior location a nanopore nucleation site having a plurality of edge atoms. A nanopore is then formed at the nanopore nucleation site by directing a second energetic beam, selected from the group consisting of electron beam, ion beam, and neutral atom beam, at the nanopore nucleation site with a beam energy that removes edge atoms at the nanopore nucleation site but does not remove bulk atoms from the nanometric material.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式