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1. 发明申请

US20180200786A1 NANOPARTICLE STRUCTURE AND PROCESS FOR MANUFACTURE 审中-公开
公开(公告)号：US20180200786A1
公开(公告)日：2018-07-19
申请号：US15801987
申请日：2017-11-02
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION
发明人： Qing Cao , Kangguo Cheng , Juntao Li
IPC分类号： B22F1/00
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y15/00 , B82Y20/00 , C09K11/66 , H01L29/0665 , H01L29/66227 , H01L29/66439 , H01L29/66977 , Y10S977/773 , Y10S977/888 , Y10S977/92 , Y10S977/932
摘要： A method for forming nanoparticles includes forming a stack of alternating layers including a first material disposed between a second material. The stack of alternating layers is patterned to form pillars. A dielectric layer is conformally deposited over the pillars. The pillars are annealed in an oxygen environment to modify a shape of the first material of the alternating layers. The dielectric layer and the second material are etched selectively to the first material to form nanoparticles from the first material.

2. 发明申请

US20170151350A1 PHOSPHORESCENT NANOPARTICLES AND THEIR USES IN BIOSENSING AND BIOIMAGING 审中-公开
公开(公告)号：US20170151350A1
公开(公告)日：2017-06-01
申请号：US15365031
申请日：2016-11-30
申请人： University of North Texas
发明人： Mohammad A. Omary , Sreekar Marpu
IPC分类号： A61K49/00 , C08J3/075 , C09K11/70 , C09K11/08 , C09K11/02 , C09K11/87
CPC分类号： C09K11/0883 , B82Y5/00 , B82Y15/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C08J2305/08 , C09K11/025 , C09K11/06 , C09K11/70 , C09K11/87 , C09K2211/188 , Y10S977/774 , Y10S977/896 , Y10S977/92
摘要： Size-tunable phosphorescent particles may be formed through self-assembly of biocompatible linear polymers, such as chitosan and other linear polymers, that bear positive surface charges, through polyelectrolytic complexation to a polyanionic metal phosphor, such as polyanionic gold(I) phosphor (AuP). The phosphorescent hydrogel nanoparticles and thin films thereof are useful for imaging, sensing of biological molecules, detection of hypoxia, and light-emitting devices. The phosphorescent hydrogel particles can be formed from a variety of linear polymers by physical cross-linking using polyelectrolytic light-emitting species, without the need for the phosphorescent complex to be entrapped in an existing microsphere or nanosphere polymer particle.

3. 发明授权

US09442110B2 Magnetic resonance system and method to detect and confirm analytes 有权
公开(公告)号：US09442110B2
公开(公告)日：2016-09-13
申请号：US12837308
申请日：2010-07-15
申请人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
发明人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
IPC分类号： G01N33/543 , G01N24/08 , G01R33/28 , G01R33/34 , G01R33/38 , G01R33/383 , G01R33/56
CPC分类号： G01N33/54333 , G01N24/08 , G01N24/084 , G01N33/54373 , G01R33/281 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/5601 , Y10S977/702 , Y10S977/773 , Y10S977/81 , Y10S977/92
摘要： A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.

4. 发明授权

US09415442B2 Stable oxide encapsulated metal clusters and nanoparticles 有权
标题翻译：稳定的氧化物包封的金属簇和纳米颗粒
公开(公告)号：US09415442B2
公开(公告)日：2016-08-16
申请号：US14110804
申请日：2012-04-11
申请人： Nandini R. Devi , Anupam Samanta
发明人： Nandini R. Devi , Anupam Samanta
IPC分类号： B22F1/02 , B22F9/24 , B22F1/00 , B82Y30/00 , C22C5/02 , C22C5/04 , C22C5/06 , B01J23/42 , B01J23/44 , B01J23/52 , C09K11/02 , G01N33/58 , B82Y5/00
CPC分类号： B22F1/02 , B01J23/42 , B01J23/44 , B01J23/52 , B22F1/0018 , B22F9/24 , B82Y5/00 , B82Y30/00 , C09K11/025 , C09K11/58 , C09K11/87 , C22C5/02 , C22C5/04 , C22C5/06 , G01N33/587 , Y10S977/81 , Y10S977/89 , Y10S977/92
摘要： The present invention discloses stable, non-agglomerated, ultra-small metal/alloy clusters encapsulated in silica with the metal/alloy cluster size of less than 5 nm. The invention further discloses a simple, cost effective process for the preparation of metal/alloy clusters encapsulated in silica which is thermally stable and without agglomeration.
摘要翻译：本发明公开了一种包封在二氧化硅中的金属/合金簇尺寸小于5nm的稳定，非附聚的超小金属/合金团簇。本发明进一步公开了一种用于制备包封在二氧化硅中的金属/合金团簇的简单，成本有效的方法，其是热稳定的且没有附聚的。

5. 发明申请

US20150141299A1 FABRICATING SELF-FORMED NANOMETER PORE ARRAY AT WAFER SCALE FOR DNA SEQUENCING 有权
标题翻译：用于DNA测序的WAFER SCALE自动形成纳米圆柱阵列
公开(公告)号：US20150141299A1
公开(公告)日：2015-05-21
申请号：US14608675
申请日：2015-01-29
申请人： International Business Machines Corporation
发明人： Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B81C1/00087 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/723 , Y10S977/74 , Y10S977/742 , Y10S977/781 , Y10S977/904 , Y10S977/92 , Y10S977/953 , Y10S977/958 , C12Q2565/631
摘要： A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.
摘要翻译：为结构提供了一种技术。衬底具有垂直定位在衬底上的纳米柱。在基底下方形成底层。在衬底的顶部和纳米柱的顶部上形成顶层，并且覆盖层覆盖顶层和纳米柱。通过底层形成窗口并形成穿过基底，并且窗口在顶层结束。通过去除覆盖层和纳米柱，通过顶层形成纳米孔。

6. 发明申请

US20150132785A1 PROTEASE ASSAY 有权
标题翻译： PROTEASE测定
公开(公告)号：US20150132785A1
公开(公告)日：2015-05-14
申请号：US14605039
申请日：2015-01-26
申请人： Kansas State University Research Foundation
发明人： Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel
IPC分类号： C12Q1/37 , G01N33/58
CPC分类号： A61K49/0067 , A61K49/0036 , A61K49/0056 , A61K49/0065 , A61K49/0093 , B82Y15/00 , C07K5/1021 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/588 , G01N2800/7028 , Y10S977/773 , Y10S977/774 , Y10S977/92
摘要： The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
摘要翻译：本发明提供用于评估蛋白酶在体内或体外的活性的诊断试剂或测定法，以及检测癌性或癌前细胞的存在的方法。测定由通过寡肽连接的两个颗粒组成，其包含对靶蛋白酶特异性的共有序列。可以目测或使用各种传感器检测靶蛋白酶序列的切割，诊断结果可与癌症预后相关。

7. 发明授权

US09029132B2 Sensor for biomolecules 有权
标题翻译：生物分子传感器
公开(公告)号：US09029132B2
公开(公告)日：2015-05-12
申请号：US12537063
申请日：2009-08-06
申请人： Marwan H. Khater , Tak H. Ning , Lidija Sekaric , Sufi Zafar
发明人： Marwan H. Khater , Tak H. Ning , Lidija Sekaric , Sufi Zafar
IPC分类号： C12M1/34 , G01N33/551 , G01N33/543 , B82Y10/00 , G01N27/327 , H01L29/78
CPC分类号： G01N33/54373 , B82Y10/00 , G01N27/3276 , G01N27/4145 , G01N33/543 , H01L29/785 , Y10S977/721 , Y10S977/92 , Y10S977/953
摘要： A sensor for biomolecules includes a silicon fin comprising undoped silicon; a source region adjacent to the silicon fin, the source region comprising heavily doped silicon; a drain region adjacent to the silicon fin, the drain region comprising heavily doped silicon of a doping type that is the same doping type as that of the source region; and a layer of a gate dielectric covering an exterior portion of the silicon fin between the source region and the drain region, the gate dielectric comprising a plurality of antibodies, the plurality of antibodies configured to bind with the biomolecules, such that a drain current flowing between the source region and the drain region varies when the biomolecules bind with the antibodies.
摘要翻译：用于生物分子的传感器包括包含未掺杂硅的硅片; 与硅鳍片相邻的源极区域，源极区域包括重掺杂的硅; 与所述硅鳍片相邻的漏极区域，所述漏极区域包括掺杂类型的与所述源极区域相同的掺杂类型的重掺杂硅; 以及覆盖源极区域和漏极区域之间的硅鳍片的外部部分的栅极电介质层，所述栅极电介质包括多个抗体，所述多个抗体被配置为与所述生物分子结合，使得漏极电流流动当生物分子与抗体结合时，在源区和漏区之间变化。

8. 发明申请

US20150119263A1 CARBON NANOTUBE BIOSENSORS AND RELATED METHODS 审中-公开
标题翻译：碳纳米管生物传感器及相关方法
公开(公告)号：US20150119263A1
公开(公告)日：2015-04-30
申请号：US14241671
申请日：2012-08-30
申请人： Alan T. Johnson, JR. , Mitchell Lerner , Matthew K. Robinson , Tatiana Pazina , Dustin Brisson , Jennifer Dailey
发明人： Alan T. Johnson, JR. , Mitchell Lerner , Matthew K. Robinson , Tatiana Pazina , Dustin Brisson , Jennifer Dailey
IPC分类号： G01N33/543 , G01N33/574 , G01N33/569
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/56911 , G01N33/57415 , Y02A50/57 , Y10S977/746 , Y10S977/92
摘要： Disclosed are devices that comprise a protein, such as an antibody, placed into electronic communication with a semiconductor material, such as a carbon nanotube. The devices are useful in assessing the presence or concentration of analytes contacted to the devices, including the presence of markers for prostate cancer and Lyme disease.
摘要翻译：公开了包含与诸如碳纳米管的半导体材料电子连通的蛋白质（例如抗体）的装置。该装置可用于评估与装置接触的分析物的存在或浓度，包括前列腺癌和莱姆病的标志物的存在。

9. 发明授权

US08940521B2 Composite detection devices having in-line desalting and methods of making the same 有权
标题翻译：具有在线脱盐的复合检测装置及其制造方法
公开(公告)号：US08940521B2
公开(公告)日：2015-01-27
申请号：US11947224
申请日：2007-11-29
申请人： Anthony John Murray , Anping Zhang , Rui Chen
发明人： Anthony John Murray , Anping Zhang , Rui Chen
IPC分类号： B01D63/08 , B01D69/10 , B01D71/02 , B01D71/04 , B01D71/06 , B82Y5/00 , G01N33/543 , B01L3/00
CPC分类号： G01N33/54373 , B01L3/5027 , B01L3/502753 , Y10S977/904 , Y10S977/92 , Y10S977/958
摘要： A composite detection device having in-line desalting is provided. The composite detection device comprises a membrane configured for desalting at least a portion of an analyte stream, and a nanostructure for detecting a bio-molecule or a bio-molecule interaction, wherein the nanostructure and the membrane are arranged such that an analyte stream desalted at least in part by the membrane is detected by the nanostructure. A bio-sending detection system having the composite detection device and method of fabrication of the composite detection device are also provided.
摘要翻译：提供具有直列脱盐的复合检测装置。复合检测装置包括被配置用于对分析物流的至少一部分进行脱盐的膜和用于检测生物分子或生物分子相互作用的纳米结构，其中纳米结构和膜被布置成使得分析物流在至少部分由膜被纳米结构检测。还提供了具有复合检测装置和复合检测装置的制造方法的生物发送检测系统。

10. 发明申请

US20130334578A1 MOLECULE SENSOR DEVICE 审中-公开
标题翻译：分子传感器设备
公开(公告)号：US20130334578A1
公开(公告)日：2013-12-19
申请号：US13870009
申请日：2013-04-25
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHE-WEI HUANG , YU-JIE HUANG , PEI-WEN YEN , HSIAO-TING HSUEH , SHEY-SHI LU , CHIH-TING LIN
IPC分类号： G01N27/414
CPC分类号： G01N27/4145 , B82Y15/00 , Y10S977/762 , Y10S977/92
摘要： A molecule sensor included in a molecule sensor device has a semiconductor substrate, a bottom gate, a source portion, a drain portion, and a nano-scale semiconductor wire. The bottom gate is for example a poly-silicon layer formed on the semiconductor substrate and electrically insulated from the semiconductor substrate. The source portion is formed on the semiconductor substrate and insulated from the semiconductor substrate. The drain portion is formed on the semiconductor substrate and insulated from the semiconductor substrate. The nano-scale semiconductor wire is connected between the source portion and the drain portion, formed on the bottom gate, insulated from the bottom gate, and has a decoration layer thereon for capturing a molecular. The source portion, drain portion, and nano-wire semiconductor wire are for example another poly-silicon layer. The bottom gate receives a specified voltage to change an amount of surface charge carriers of the nano-scale semiconductor wire.
摘要翻译：包含在分子传感器装置中的分子传感器具有半导体衬底，底栅，源极部，漏极部和纳米级半导体线。底栅是例如形成在半导体衬底上并与半导体衬底电绝缘的多晶硅层。源极部分形成在半导体衬底上并与半导体衬底绝缘。漏极部分形成在半导体衬底上并与半导体衬底绝缘。纳米级半导体线连接在源极部分和漏极部分之间，形成在底部栅极上，与底部栅极绝缘，并且在其上具有用于捕获分子的装饰层。源极部分，漏极部分和纳米线半导体导线例如是另一个多晶硅层。底栅接收指定电压以改变纳米级半导体线的表面电荷载流子的量。

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