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1. 发明授权

US10111613B2 Methods for data retention in an implantable medical device 有权
公开(公告)号：US10111613B2
公开(公告)日：2018-10-30
申请号：US11264846
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/00 , A61B5/04 , A61N1/372 , G06F19/00 , G06F17/30 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/16 , G16H10/60 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/021 , A61B5/024 , A61B5/03 , A61B5/08 , G16H40/63
摘要： Methods for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

2. 发明授权

US09888861B2 Method and apparatus for detecting a biomarker in the presence of electrical stimulation 有权
公开(公告)号：US09888861B2
公开(公告)日：2018-02-13
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/0488 , A61B5/0496
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

3. 发明授权

US08428733B2 Stimulation electrode selection 有权
标题翻译：刺激电极选择
公开(公告)号：US08428733B2
公开(公告)日：2013-04-23
申请号：US12563845
申请日：2009-09-21
申请人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
发明人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

4. 发明授权

US07976465B2 Phase shifting of neurological signals in a medical device system 有权
标题翻译：医疗器械系统中的神经信号相移
公开(公告)号：US07976465B2
公开(公告)日：2011-07-12
申请号：US11550294
申请日：2006-10-17
申请人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/048 , A61B5/4094 , A61M5/14276 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N2/006 , G06F19/00
摘要： Method and apparatus for phase shifting neurological signals received from monitoring elements of a medical device. The medical device comprises a plurality of monitoring elements each receiving a neurological signal. The device processes the neurological signals and identifies a time shift of the neurological signal relative to each other. The neurological signals are then time shifted according to the time shift upon which the signals are utilized to provide closed-loop feedback control of a treatment therapy.
摘要翻译：用于从医疗装置的监视元件接收的相移神经信号的方法和装置。医疗装置包括多个监测元件，每个监测元件接收神经信号。该装置处理神经信号并识别神经信号相对于彼此的时间偏移。神经信号然后根据信号被用于提供治疗治疗的闭环反馈控制的时间偏移而被时移。

5. 发明授权

US07933646B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07933646B2
公开(公告)日：2011-04-26
申请号：US11837987
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

6. 发明授权

US07764989B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US07764989B2
公开(公告)日：2010-07-27
申请号：US11609485
申请日：2006-12-12
申请人： David L. Carlson , Eric J. Panken
发明人： David L. Carlson , Eric J. Panken
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/04015 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36064 , A61N1/36082 , A61N1/37252 , G06F19/00 , G06K9/00496
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

7. 发明申请

US20080269835A1 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US20080269835A1
公开(公告)日：2008-10-30
申请号：US11609446
申请日：2006-12-12
申请人： David L. Carlson , Eric J. Panken , Jonathon E. Giftakis
发明人： David L. Carlson , Eric J. Panken , Jonathon E. Giftakis
IPC分类号： A61N1/36 , A61B5/0484
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/4094 , A61B5/7275 , A61N1/36082 , G16H40/63
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

8. 发明申请

US20070250133A1 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US20070250133A1
公开(公告)日：2007-10-25
申请号：US11677360
申请日：2007-02-21
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61N1/00
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06F19/00 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delivery components prior to the expected delivery of therapy.
摘要翻译：公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。本发明的其它实施方案包括通过在预期的治疗递送之前预热治疗递送成分来准备递送治疗。

9. 发明授权

US07280867B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07280867B2
公开(公告)日：2007-10-09
申请号：US10687571
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

10. 发明授权

US07174206B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07174206B2
公开(公告)日：2007-02-06
申请号：US10687557
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

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