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1. 发明授权

US09659216B2 Method, computer program, and system for automated real-time signal analysis for detection, quanitification, and prediction of signal changes 有权
公开(公告)号：US09659216B2
公开(公告)日：2017-05-23
申请号：US13608551
申请日：2012-09-10
申请人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio , Ruslan L. Davidchack
发明人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio , Ruslan L. Davidchack
IPC分类号： G01N33/48 , G01N33/50 , G06K9/00 , G06F17/10 , G06F17/18 , G06F19/24 , G06F19/00
CPC分类号： G06K9/00536 , G06F17/10 , G06F17/18 , G06F19/24 , G16H50/20 , G16H50/50
摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

2. 发明授权

US08634922B1 Vagal nerve stimulation techniques for treatment of epileptic seizures 有权
标题翻译：迷走神经刺激技术治疗癫痫发作
公开(公告)号：US08634922B1
公开(公告)日：2014-01-21
申请号：US12313538
申请日：2008-11-22
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61N1/36
CPC分类号： A61B5/4094 , A61B5/02405 , A61B5/02455 , A61B5/0452 , A61B5/0456 , A61B5/686 , A61B5/7282 , A61B2560/0475 , A61N1/36053 , A61N1/36064 , A61N1/36114 , A61N1/36135
摘要： A system using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment includes an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. Heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. An alternative embodiment includes a modified pacemaker to maintain the heart in desired conditions during vagus nerve stimulation. In another embodiment, a modified pacemaker determines whether a vagus nerve is being stimulated, whereupon the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.
摘要翻译：使用电刺激迷走神经治疗癫痫的系统，其对心脏的影响最小或无影响。治疗包括可植入信号发生器，用于电刺激迷走神经的预定刺激部位的一个或多个可植入电极，以及用于感测心脏特征的传感器，例如心率。来自传感器的心率信息可用于确定迷走神经刺激是否对心脏有不利影响。一旦达到阈值参数，就可以停止或调整迷走神经刺激。替代实施例包括修改的起搏器，以在迷走神经刺激期间将心脏保持在期望的状态。在另一个实施例中，修改的起搏器确定迷走神经是否被刺激，于是修改的起搏器可以控制心脏在迷走神经刺激期间将其保持在期望的条件内。

3. 发明授权

US08187181B2 Scoring of sensed neurological signals for use with a medical device system 有权
标题翻译：感觉神经信号的评分与医疗器械系统一起使用
公开(公告)号：US08187181B2
公开(公告)日：2012-05-29
申请号：US10687389
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
发明人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
IPC分类号： A61B5/00
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种能够评估与神经系统疾病相关的感觉神经信号的严重性的医疗装置系统。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗设备系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度进行排名。

4. 发明授权

US07976465B2 Phase shifting of neurological signals in a medical device system 有权
标题翻译：医疗器械系统中的神经信号相移
公开(公告)号：US07976465B2
公开(公告)日：2011-07-12
申请号：US11550294
申请日：2006-10-17
申请人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/048 , A61B5/4094 , A61M5/14276 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N2/006 , G06F19/00
摘要： Method and apparatus for phase shifting neurological signals received from monitoring elements of a medical device. The medical device comprises a plurality of monitoring elements each receiving a neurological signal. The device processes the neurological signals and identifies a time shift of the neurological signal relative to each other. The neurological signals are then time shifted according to the time shift upon which the signals are utilized to provide closed-loop feedback control of a treatment therapy.
摘要翻译：用于从医疗装置的监视元件接收的相移神经信号的方法和装置。医疗装置包括多个监测元件，每个监测元件接收神经信号。该装置处理神经信号并识别神经信号相对于彼此的时间偏移。神经信号然后根据信号被用于提供治疗治疗的闭环反馈控制的时间偏移而被时移。

5. 发明授权

US07933646B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07933646B2
公开(公告)日：2011-04-26
申请号：US11837987
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

6. 发明授权

US07727147B1 Method and system for implantable glucose monitoring and control of a glycemic state of a subject 有权
标题翻译：监测和控制受试者血糖状态的方法和系统
公开(公告)号：US07727147B1
公开(公告)日：2010-06-01
申请号：US11128600
申请日：2005-05-13
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/4839 , A61B5/14528 , A61B5/14532 , A61B5/686 , A61M5/14244 , A61M5/16877 , A61M5/1723 , A61M2205/50 , A61M2230/201
摘要： A method and system for monitoring and/or controlling a glycemic state of a subject, comprising a housing device having one or more chambers, extendable and retractable sensors, extendable and retractable catheters, insulin reservoir, neuroprotective agent reservoir, release mechanism for releasing insulin and neuroprotective agent into the subject, and a control mechanism with a processor for receiving and analyzing outputs from the sensors and for controlling the release mechanism, a clock mechanism for providing logging and/or circadian information to the processor, an internal analysis chamber, a byproduct storage chamber, a sampling mechanism, a transfer mechanism, a self-sealing membrane, a calibration chamber, a replacement sensor chamber, a prevention mechanism to prevent deposition of unwanted substances on a sensor or catheter, a removal mechanism to remove unwanted substances from a sensor or catheter, a warning mechanism, a real-time clock and non-volatile memory to store and log information processed by the processor, a failure detection mechanism, and wired and/or wireless communication linkages both internally and externally.
摘要翻译：一种用于监测和/或控制受试者血糖状态的方法和系统，包括具有一个或多个腔室，可伸缩和可伸缩传感器，可伸缩导管，胰岛素储存器，神经保护剂储存器，用于释放胰岛素的释放机构的壳体装置和神经保护剂，以及具有用于接收和分析来自传感器的输出和用于控制释放机构的处理器的控制机构，用于向处理器提供测井和/或昼夜信息的时钟机构，内部分析室，副产物存储室，采样机构，传送机构，自密封膜，校准室，替换传感器室，防止不想要的物质沉积在传感器或导管上的防止机构，用于从一个或多个传感器或导管中去除不需要的物质的去除机构传感器或导管，警告机制，实时时钟和非易失性存储器存储由处理器处理的日志信息，故障检测机制以及内部和外部的有线和/或无线通信链路。

7. 发明授权

US07401008B2 Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale 有权
标题翻译：方法，计算机程序和系统，用于任意原点或时间尺度信号的固有时间尺度分解，滤波和自动分析
公开(公告)号：US07401008B2
公开(公告)日：2008-07-15
申请号：US11415064
申请日：2006-05-01
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： G06F17/00 , G06F19/00
CPC分类号： G06K9/00503 , G06F17/14 , G06K9/00523
摘要： A method and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale including receiving an input signal, determining a baseline segment and a monotonic residual segment with strictly negative minimum and strictly positive maximum between two successive extrema of the input signal, and producing a baseline output signal and a residual output signal. The method and system also includes determining at least one instantaneous frequency estimate from a proper rotation signal, determining a zero-crossing and a local extremum of the proper rotation signal, and applying interpolation thereto to determine an instantaneous frequency estimate thereof. The method and system further includes determining at least one instantaneous frequency estimate from a proper rotation signal, extracting an amplitude-normalized half wave therefrom and applying an arcsine function to the amplitude-normalized half wave to determine an instantaneous frequency estimate of the proper rotation signal.
摘要翻译：用于固有时间尺度分解，过滤和任意来源或时间尺度信号的自动分析的方法和系统，包括接收输入信号，确定基线段和具有严格为负的最小值和严格正的最大值的两个连续极值之间的单调残差段输入信号，并产生基线输出信号和残留输出信号。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，确定适当旋转信号的过零点和局部极值，并对其进行插值以确定其瞬时频率估计。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，从其中提取幅度归一化的半波，并对所述幅度归一化的半波应用反正弦函数，以确定适当旋转信号的瞬时频率估计。

8. 发明授权

US07321837B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07321837B2
公开(公告)日：2008-01-22
申请号：US11355784
申请日：2006-02-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G01R35/00 , G04F10/00 , G04G15/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

9. 发明授权

US07280867B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07280867B2
公开(公告)日：2007-10-09
申请号：US10687571
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

10. 发明授权

US07174206B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07174206B2
公开(公告)日：2007-02-06
申请号：US10687557
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

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