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1. 发明授权

US06427084B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06427084B2
公开(公告)日：2002-07-30
申请号：US09514813
申请日：2000-02-28
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

2. 发明授权

US06920355B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06920355B2
公开(公告)日：2005-07-19
申请号：US10150297
申请日：2002-05-17
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

3. 发明授权

US07110816B2 Reduction of left-ventricular offset interaction with tachyarrhythmia detection 有权
公开(公告)号：US07110816B2
公开(公告)日：2006-09-19
申请号：US10878953
申请日：2004-06-28
申请人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. A reversion pacing mode is provided in order to prevent tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.

4. 发明授权

US06757562B2 Reduction of left-ventricular offset interaction with tachyarrhythmia detection 有权
标题翻译：减慢与心律失常检测的左心室偏移相互作用
公开(公告)号：US06757562B2
公开(公告)日：2004-06-29
申请号：US10037444
申请日：2001-10-25
申请人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. A reversion pacing mode is provided in order to prevent tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.
摘要翻译：通过向两个心室分配指定的偏移间隔来逐步重新同步心室，从而改善快速性心律失常检测的装置和方法。逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。提供回波起搏模式，以便当速率心室在另一脑室之后起搏时，防止快速性心律失常检测受到损害。

5. 发明授权

US07801609B2 Reduction of left-ventricular offset interaction with tachyarrhythmia detection 有权
标题翻译：减慢与心律失常检测的左心室偏移相互作用
公开(公告)号：US07801609B2
公开(公告)日：2010-09-21
申请号：US11522691
申请日：2006-09-18
申请人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Kenneth L. Baker , David L. Perschbacher , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. A reversion pacing mode is provided in order to prevent tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.
摘要翻译：通过向两个心室分配指定的偏移间隔来逐步重新同步心室，从而改善快速性心律失常检测的装置和方法。逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。提供回波起搏模式，以便当速率心室在另一脑室之后起搏时，防止快速性心律失常检测受到损害。

6. 发明授权

US07801606B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07801606B2
公开(公告)日：2010-09-21
申请号：US11674758
申请日：2007-02-14
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

7. 发明授权

US06687539B2 Implantable defibrillators with programmable cross-chamber blanking 有权
公开(公告)号：US06687539B2
公开(公告)日：2004-02-03
申请号：US09981326
申请日：2001-10-16
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Therapy decisions are typically based on the time between successive beats of various chambers of the heart, such as the left atrium and left ventricle. To prevent confusing a left ventricle beat for a left atrium beat, some devices use cross-chamber blanking, a technique which disables sensing of atrial beats for a certain time period after sensing. Conventionally, these devices lack any mechanism for adjusting length of this period. Accordingly, the inventor devised a implantable device including a mechanism for adjusting this time period. This mechanism ultimately allows tailoring of the cross-chamber blanking period to fit the needs of individual patients.

8. 发明申请

US20110257699A1 IMPLANTABLE PULSE GENERATOR AND METHOD HAVING ADJUSTABLE SIGNAL BLANKING 有权
标题翻译：可植入脉冲发生器和具有可调信号滤波的方法
公开(公告)号：US20110257699A1
公开(公告)日：2011-10-20
申请号：US13174136
申请日：2011-06-30
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

9. 发明授权

US08214037B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和具有可调信号消隐的方法
公开(公告)号：US08214037B2
公开(公告)日：2012-07-03
申请号：US13174136
申请日：2011-06-30
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲将被传递，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

10. 发明授权

US06381494B1 Response to ambient noise in implantable pulse generator 有权
标题翻译：可植入脉冲发生器对环境噪声的响应
公开(公告)号：US06381494B1
公开(公告)日：2002-04-30
申请号：US09378321
申请日：1999-08-20
申请人： James O. Gilkerson , David L. Perschbacher , Doug M. Birkholz , Thomas J. Harris
发明人： James O. Gilkerson , David L. Perschbacher , Doug M. Birkholz , Thomas J. Harris
IPC分类号： A61N136
CPC分类号： A61N1/37 , A61N1/3718
摘要： A method and system for response to ambient noise in implantable pulse generator. At least one cardiac signal is sensed with an implantable pulse generator. Cardiac depolarizations are identified in the at least one cardiac signal and cardiac depolarization markers are generated. The at least one cardiac signals are then analyzed for a noise event during a refractory period following the detected cardiac depolarization. The refractory period includes a noise window interval during which noise events are recognized. When a noise event, or events, occur during the noise window interval a first noise marker is generated. The noise window interval is then repeated as long as noise is detected in the noise window intervals. When the noise persists for a predetermined time interval a second noise marker is generated.
摘要翻译：一种可植入式脉冲发生器中环境噪声响应的方法和系统。用可植入脉冲发生器检测至少一个心脏信号。在至少一个心脏信号中鉴定心脏去极化，并且产生心脏去极化标记。然后在检测到的心脏去极化之后的不应期内，分析至少一个心脏信号的噪声事件。不良期间包括噪声窗间隔，在此期间噪声事件被识别。当在噪声窗间隔期间发生噪声事件或事件时，产生第一噪声标记。只要在噪声窗间隔中检测到噪声，噪声窗口间隔就被重复。当噪声持续预定的时间间隔时，产生第二噪声标记。

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