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1. 发明申请

US20210270783A1 AUTOSAMPLER 有权
公开(公告)号：US20210270783A1
公开(公告)日：2021-09-02
申请号：US17190120
申请日：2021-03-02
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： G01N30/24 , G01N30/18
摘要： Embodiments of the disclosure relate to chemical analysis systems, including autosampler systems. In some embodiments, an autosampler system can analyze gas phase samples using a single inlet for better consistency. The autosampler system can move the sample container closer to the sample introduction/preconcentration system prior to accessing the contents of the container to reduce exposure of the sample to reactive surfaces. The autosampler system is able to couple the sample containers to a sampling wand automatically, thereby eliminating the need to pre-attach each container using a gas transfer line. The autosampler system can be disposed on top of a chemical analysis system (e.g., a GC or GCMS), thereby conserving laboratory bench space. In some embodiments, the modules (e.g., sample trays, thermal conditioning systems, support legs) of the autosampler system can be coupled to the autosampler system using clamps that include magnetic codes associated with autocalibration information.

2. 发明申请

US20200378928A1 RECOVERY OF ORGANIC COMPOUNDS IN LIQUID SAMPLES USING FULL EVAPORATIVE VACUUM EXTRACTION, THERMAL DESORPTION, AND GCMS ANALYSIS 审中-公开
公开(公告)号：US20200378928A1
公开(公告)日：2020-12-03
申请号：US16892125
申请日：2020-06-03
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： G01N30/14 , G01N1/14 , G01N1/22
摘要： While sample extraction device including a sorbent is coupled to a sample vial containing a sample, a vacuum is drawn through the sample extraction device to evaporate the volatile matrix of the sample and carry volatilized target compounds of the sample to the sorbent. Optionally, once the volatile matrix is evaporated, the sample vial is heated and/or the vacuum level is increased to transfer heavier target compounds to the sorbent. Multiple sampling devices can be extracted in parallel. The sample extraction device can be inserted into a thermal desorption device that directly couples the sample extraction device to a gas chromatograph. In some embodiments, the sample is desorbed and analyzed using gas chromatography or another suitable technique. The techniques disclosed herein are used for analysis of volatile organic compounds and semi-volatile organic compounds in water, food, beverages, soils, and other matrices.

3. 发明授权

US11169124B2 System and method for real time monitoring of a chemical sample 有权
公开(公告)号：US11169124B2
公开(公告)日：2021-11-09
申请号：US16197791
申请日：2018-11-21
申请人： Entech Instruments Inc.
发明人： Daniel B. Cardin
IPC分类号： G01N30/08 , G01N30/10 , G01N30/46 , G01N30/40 , G01N30/06 , G01N30/88 , G01N30/02 , G01N30/72 , G01N30/60
摘要： The disclosed system and method improve measurement of trace volatile chemicals, such as by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GCMS). A first trapping system can include a plurality of capillary columns in series and a focusing column fluidly coupled to a first detector. The first trapping system can retain and separate compounds in a sample, including C3 hydrocarbons and compounds heavier than C3 hydrocarbons (e.g., up to C12 hydrocarbons, or compounds having a boiling point around 250° C.), and can transfer the compounds from the focusing column to the first detector. A second trapping system can receive compounds that the first trapping system does not retain, and can include a packed trap, a polar column and a PLOT column fluidly coupled to one or more second detectors. The second trapping system can remove water from the sample and can separate and detect compounds including C2 hydrocarbons and Formaldehyde.

4. 发明授权

US11162925B2 High performance sub-ambient temperature multi-capillary column preconcentration system for volatile chemical analysis by gas chromatography 有权
公开(公告)号：US11162925B2
公开(公告)日：2021-11-02
申请号：US16175230
申请日：2018-10-30
申请人： Entech Instruments Inc.
发明人： Daniel B. Cardin
IPC分类号： G01N30/72 , G01N33/00 , G01N30/46 , G01N30/60 , G01N1/40 , G01N30/02 , G01N30/12 , G01N30/40
摘要： The disclosed system and method improve analysis of chemical samples for measurement of trace volatile chemicals, such as by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GCMS). The system can include two traps in series, the first of which removes most of the unwanted water vapor, while the second trap preconcentrates the sample using a series of capillary columns of increasing adsorption strength. The sample can be backflushed from the second trap directly to a chemical analyzer without splitting which can maximize sensitivity. The system improves elimination of water vapor and fixed gases from the sample prior to analysis, resulting in detection limits as low as 0.001 PPBb. The second trap allows faster release of the sample upon injection to the chemical analyzer without additional focusing, and can be cleaned up faster when exposed to high concentration samples relative to packed traps.

5. 发明申请

US20210325357A1 Flow Controller and Method of Use 有权
公开(公告)号：US20210325357A1
公开(公告)日：2021-10-21
申请号：US17231365
申请日：2021-04-15
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： G01N33/00 , G05D7/01
摘要： A flow controller for filling evacuated canisters can be operated at different reference pressures to produce substantially the same flow rates to facilitate inertness testing of the flow controller through demonstrated recovery of trace level chemicals in a challenge standard prior to using the flow controllers to collect air samples for measurement of VOCs during time weighted sampling events. The flow controller can include a first chamber and a second chamber divided by a diaphragm. The first chamber can be fluidly coupled to an inlet of the flow controller and an outlet of the flow controller. The second chamber can be coupled to a reference port of the flow controller. The outlet of the flow controller can be coupled to an initially (e.g., substantially) evacuated canister that can be used to collect a sample of ambient air or challenge standard (e.g., during testing).

6. 发明申请

US20190118171A1 SAMPLE PRECONCENTRATION SYSTEM AND METHOD FOR USE WITH GAS CHROMATOGRAPHY 审中-公开
公开(公告)号：US20190118171A1
公开(公告)日：2019-04-25
申请号：US16168605
申请日：2018-10-23
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： B01L3/00 , G01N1/40 , G01N1/44 , G01N30/12 , G01N30/14 , G01N30/30 , G01N30/46 , G01N30/72
摘要： The disclosed system and method concentrates and enriches a chemical sample while removing water and/or CO2 prior to analysis, improving detection limits and repeatability of quantitative chemical analysis without the need for cryogenic or sub-ambient cooling. The system can include a valve system, a dewpoint control zone, and a multi-capillary column trapping system (MCCTS). During a first time period, the valve system can couple the dewpoint control zone to the MCCTS. During a second time period, the valve system can couple the MCCTS to the chemical separation column such the dewpoint control zone is bypassed. Excess water included in the sample can condense in the dewpoint control zone as the sample transfers to the dewpoint control zone and MCCTS. When the sample is transferred from the MCCTS to the chemical separation column, the condensed water in the dewpoint control zone is not transferred to a chemical separation column.

7. 发明申请

US20170303900A1 BREATH CONDENSATE AND SALIVA ANALYSIS USING ORAL RINSE 审中-公开
公开(公告)号：US20170303900A1
公开(公告)日：2017-10-26
申请号：US15649480
申请日：2017-07-13
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： A61B10/00 , G01N33/497 , G01N33/487
CPC分类号： A61B10/00 , A61B10/0051 , A61B2010/0087 , A61B2217/005 , G01N1/20 , G01N1/2226 , G01N1/405 , G01N30/06 , G01N33/487 , G01N33/497 , G01N2001/2229 , G01N2001/2244 , G01N2001/2276 , G01N2001/4061 , G01N2030/009 , G01N2030/062
摘要： A sample extraction device and a desorption device for use in gas chromatography (GC), gas chromatography-mass spectrometry (GCMS), liquid chromatography (LC), and/or liquid chromatography-mass spectrometry (LCMS) are disclosed. In some examples, the sample extraction device includes a lower chamber holding a sorbent. The sample extraction device can extract sample headspace gas from a sample vial by placing the sorbent inside the vial and creating a vacuum to increase recovery of low volatility compounds, for example. Once the sample has been collected, the sample extraction device can be inserted into a desorption device. The desorption device can control the flow of a carrier fluid (e.g., a liquid or a gas) through the sorbent containing the sample and into a pre-column and/or a primary column of a chemical analysis device for performing GC, GCMS, LC, LCMS, and/or some other chemical analysis process.

8. 发明申请

US20170284978A1 Multi-Capillary Column Pre-Concentration System for Enhanced Sensitivity in Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GCMS) 审中-公开
公开(公告)号：US20170284978A1
公开(公告)日：2017-10-05
申请号：US15479122
申请日：2017-04-04
申请人： Entech Instruments Inc.
发明人： Daniel B. CARDIN
IPC分类号： G01N30/14 , G01N30/46 , G01N1/44 , G01N1/40 , B01L3/00 , G01N30/72 , G01N30/30
CPC分类号： G01N30/14 , B01L3/502 , B01L2200/10 , B01L2300/0627 , B01L2300/0838 , B01L2300/16 , B01L2300/18 , G01N1/405 , G01N1/44 , G01N30/12 , G01N30/30 , G01N30/40 , G01N30/461 , G01N30/6078 , G01N30/7206 , G01N2030/121 , G01N2030/128 , G01N2030/143
摘要： A multi-capillary column pre-concentration trap for use in various chromatography techniques (e.g., gas chromatography (GC) or gas chromatography-mass spectrometry (GCMS)) is disclosed. In some examples, the trap can include a plurality of capillary columns connected in series in order of increasing strength (i.e., increasing chemical affinity for one or more sample compounds). A sample can enter the trap, flowing from a sample vial to a relatively weak column to the relatively strongest column of the trap by way of any additional columns included in the trap, for example. In some examples, the trap can be heated and backflushed so that the sample exits the trap through the head of the relatively weak column. Next, the sample can be injected into a chemical analysis device for performing the chromatography technique (e.g., GC or GCMS) or it can be injected into a secondary multi-capillary column trap for further concentration.

9. 发明授权

US11549921B2 System and method for real time monitoring of a chemical sample 有权
公开(公告)号：US11549921B2
公开(公告)日：2023-01-10
申请号：US16593934
申请日：2019-10-04
申请人： Entech Instruments Inc.
发明人： Daniel B. Cardin
IPC分类号： G01N30/46 , G01N30/20 , G01N30/10 , G01N30/60 , G01N30/02
摘要： The disclosed system and method improve measurement of trace volatile chemicals, such as by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GCMS). A first trapping system can include a plurality of capillary columns in series and a focusing column fluidly coupled to a first detector. The first trapping system can retain and separate compounds in a sample, including C3 hydrocarbons and compounds heavier than C3 hydrocarbons (e.g., up to C12 hydrocarbons, or compounds having a boiling point around 250° C.), and can transfer the compounds from the focusing column to the first detector. A second trapping system can receive compounds that the first trapping system does not retain, and can include a packed trap and two columns. The second trapping system can remove water from the sample and can separate and detect compounds including C2 hydrocarbons and Formaldehyde.

10. 发明授权

US11536703B2 System and method of pressure-controlled splitting of a chemical sample 有权
公开(公告)号：US11536703B2
公开(公告)日：2022-12-27
申请号：US16663268
申请日：2019-10-24
申请人： Entech Instruments Inc.
发明人： Daniel B. Cardin
IPC分类号： G01N30/72 , G01N30/20 , G01N30/10
摘要： Pressure-controlled splitting can be used to inject a chemical sample from an injection source to a detector (e.g., a mass spectrometer) for chemical analysis (e.g., gas chromatography or gas chromatography-mass spectrometry) with reduced peak widths. For example, the sample is first transferred to a first compression volume; then pressure in the system is increased to compress the sample to split it between a second compression volume and a column. The fraction of the sample split to the column can have reduced peak widths compared to the peak widths prior to compression and splitting yet can maintain the same peak height to preserve high sensitivity for trace level analysis. This portion of the sample can traverse the column and elute to the detector for analysis with reduced chemical noise. Faster injection rates can allow faster analysis times, as less separation of chemicals is needed before the sample reaches the detector.

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