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    • 2. 发明申请
    • Methods of Treating Neurological Diseases
    • 治疗神经疾病的方法
    • US20170042929A9
    • 2017-02-16
    • US13969252
    • 2013-08-16
    • Jokubas ZiburkusJason EriksenFeng Gu
    • Jokubas ZiburkusJason EriksenFeng Gu
    • A61K31/7076A61K45/06
    • A61K31/7076A61K45/06
    • The present invention is directed to novel treatment of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. Further provided is a method of treating a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of administering an amount of an adenosine A1 receptor agonist pharmacologically effective to block epileptogenetic activities without blocking excitatory synaptic transmission.
    • 本发明涉及在需要这种治疗的受试者中控制海马神经回路发生在与癫痫发生相关的神经疾病或病症中的过度兴奋性的新型治疗,其包括使所述受试者的海马与有效恢复兴奋性的化合物接触的步骤 /抑制剂平衡,从而控制神经回路的兴奋性。 还提供了一种在需要这种治疗的受试者中治疗与癫痫发生相关的神经系统疾病或病症的方法,其包括施用一定量的腺苷A1受体激动剂在药物学上有效阻断癫痫发作活性而不阻断兴奋性突触传递的步骤。
    • 3. 发明申请
    • Methods of Treating Neurological Diseases
    • 治疗神经疾病的方法
    • US20150051166A1
    • 2015-02-19
    • US13969252
    • 2013-08-16
    • Jokubas ZiburkusJason EriksenFeng Gu
    • Jokubas ZiburkusJason EriksenFeng Gu
    • A61K31/7076A61K45/06
    • A61K31/7076A61K45/06
    • The present invention is directed to novel treatment of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. Further provided is a method of treating a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of administering an amount of an adenosine A1 receptor agonist pharmacologically effective to block epileptogenetic activities without blocking excitatory synaptic transmission.
    • 本发明涉及在需要这种治疗的受试者中控制海马神经回路发生在与癫痫发生相关的神经疾病或病症中的过度兴奋性的新型治疗,其包括使所述受试者的海马与有效恢复兴奋性的化合物接触的步骤 /抑制剂平衡,从而控制神经回路的兴奋性。 还提供了一种在需要这种治疗的受试者中治疗与癫痫发生相关的神经系统疾病或病症的方法,其包括施用一定量的腺苷A1受体激动剂在药物学上有效阻断癫痫发作活性而不阻断兴奋性突触传递的步骤。
    • 6. 发明申请
    • Optical fiber coupling having liquid crystal adaptive coupler
    • 具有液晶自适应耦合器的光纤耦合器
    • US20050041919A1
    • 2005-02-24
    • US10948855
    • 2004-09-23
    • Dong-Feng GuDonald TaberBruce Winker
    • Dong-Feng GuDonald TaberBruce Winker
    • G02B6/32G02B6/35G02F1/139G02F1/29G02B6/26
    • G02F1/292G02B6/32G02B6/351G02B6/3556G02F1/1392
    • An apparatus for optically coupling a light source with a light-receiving end face of an optical waveguide comprises a lens for focusing a light beam emitted from the light source at a focal point on the light-receiving end face of the optical waveguide. An adaptive coupler, positioned in the optical path, is responsive to a beam steering control signal for steering and aligning the focal point relative to the light-receiving end face of the optical waveguide. In one form, the adaptive coupler comprises a pair of transparent substrates having confronting, parallel inner faces, the inner face of one of the pair of substrates carrying a beam intercepting, optically transparent, constant potential electrode and the inner face of the other of the pair of substrates carrying an electrically resistive, beam intercepting, optically transparent film. A pair of spaced apart electrodes in electrical contact with the film apply a linear voltage gradient along the film. An electro-optical phase shifting medium is disposed between the confronting inner faces of the substrates. The application of selected voltages to the electrodes creates a linear voltage gradient along the aforementioned film on the inner face of the one substrate resulting in a linearly varying electric field between that film and the constant potential electrode creating a corresponding linear variation in the refractive index of the liquid crystal medium and a linear wavefront tilt in the intercepting optical beam.
    • 用于将光源与光波导的光接收端面光学耦合的装置包括用于将从光源发射的光束聚焦在光波导的光接收端面上的焦点处的透镜。 定位在光路中的自适应耦合器响应于光束转向控制信号,用于相对于光波导的光接收端面转向和对准焦点。 在一种形式中,自适应耦合器包括一对具有相对的平行内表面的透明基板,一对基板中的一个基板的内表面承载光束拦截,光学透明的恒定电位电极,另一个的内表面 一对基板承载电阻,光束截取的光学透明膜。 与膜电接触的一对间隔开的电极沿膜施加线性电压梯度。 电光移相介质设置在基板的相对的内表面之间。 将选择的电压施加到电极在一个衬底的内表面上沿着上述膜产生线性电压梯度,导致该膜和恒电位电极之间线性变化的电场产生相应的线性变化 液晶介质和截取光束中的线性波前倾斜。
    • 7. 发明申请
    • METHODS FOR CONTROLLING DENSITY, POROSITY, AND/OR GAP SIZE WITHIN NANOTUBE FABRIC LAYERS AND FILMS
    • 用于控制纳米纤维层和薄膜中密度,孔隙度和/或尺寸的方法
    • US20130052449A1
    • 2013-02-28
    • US13578691
    • 2011-02-14
    • Rahul SenJ. Thomas KocabFeng Gu
    • Rahul SenJ. Thomas KocabFeng Gu
    • H01B1/04B32B5/16B82Y30/00B82Y40/00
    • B82Y30/00C01B32/158C01B2202/02C01B2202/06C01B2202/22C01B2202/34C01B2202/36G11C13/025Y10S977/751Y10S977/752Y10T428/249921
    • A method for controlling density, porosity and/or gap size within a nanotube fabric layer is disclosed. In one aspect, this can be accomplished by controlling the degree of rafting in a nanotube fabric. In one aspect, the method includes adjusting the concentration of individual nanotube elements dispersed in a nanotube application solution. A high concentration of individual nanotube elements will tend to promote rafting in a nanotube fabric layer formed using such a nanotube application solution, whereas a lower concentration will tend to discourage rafting. In another aspect, the method includes adjusting the concentration of ionic particles dispersed in a nanotube application solution. A low concentration of ionic particles will tend to promote rafting in a nanotube fabric layer formed using such a nanotube application solution, whereas a higher concentration will tend to discourage rafting. In other aspects, both concentration parameters are adjusted.
    • 公开了一种用于控制纳米管织物层内的密度,孔隙率和/或间隙尺寸的方法。 在一个方面,这可以通过控制纳米管织物中漂流的程度来实现。 一方面,该方法包括调节分散在纳米管应用溶液中的单个纳米管元件的浓度。 单个纳米管元件的高浓度倾向于促进在使用这种纳米管施用溶液形成的纳米管织物层中的漂流,而较低浓度将倾向于阻止漂流。 另一方面,该方法包括调节分散在纳米管应用溶液中的离子颗粒的浓度。 低浓度的离子颗粒倾向于促进在使用这种纳米管施用溶液形成的纳米管织物层中的漂流,而较高的浓度将倾向于阻止漂流。 在其他方面,调整浓度参数。
    • 8. 发明申请
    • INDOOR TESTING DEVICE FOR A PLURALITY OF ROTOR-CONTAINING FLYING OBJECTS
    • 用于多种包含转子的飞行物体的室内测试装置
    • US20120221291A1
    • 2012-08-30
    • US13157286
    • 2011-06-09
    • Jianda HANYuqing HEFeng GUZheng WANG
    • Jianda HANYuqing HEFeng GUZheng WANG
    • G06F15/00G01N33/00
    • B64F5/0045B64F5/60
    • An indoor testing device for multiple rotor-containing flying objects including a main support having a plurality of linking members, a plurality of mechanical arms, a plurality of trays, and control units of the mechanical arms. The main support is disposed vertically. The mechanical arms are separately disposed on the linking members of the main support with different height. The trays are separately disposed on one end of the mechanical arms for receiving rotor-containing flying objects, and the control units are disposed on the mechanical arms and rotate therewith. The device can be used for the cooperation and coordination test of multiple rotor-containing flying objects and autonomous control experiments of a single rotor-containing flying object. The tests have high stimulation and improve the usability of the experimental results in the actual system.
    • 一种用于多转子飞行物体的室内测试装置,包括具有多个连接构件的主支撑件,多个机械臂,多个托盘和机械臂的控制单元。 主支架垂直放置。 机械臂分别设置在不同高度的主支架的连接构件上。 托盘分别设置在机械臂的一端,用于接收含转子的飞行物体,并且控制单元设置在机械臂上并与其一起旋转。 该装置可用于多个含转子的飞行物体的协调和协调测试以及单个转子飞行物体的自主控制实验。 测试具有较高的刺激性,提高了实际系统实验结果的可用性。