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    • 2. 发明申请
    • METHODS FOR CONTROLLING DENSITY, POROSITY, AND/OR GAP SIZE WITHIN NANOTUBE FABRIC LAYERS AND FILMS
    • 用于控制纳米纤维层和薄膜中密度,孔隙度和/或尺寸的方法
    • US20130052449A1
    • 2013-02-28
    • US13578691
    • 2011-02-14
    • Rahul SenJ. Thomas KocabFeng Gu
    • Rahul SenJ. Thomas KocabFeng Gu
    • H01B1/04B32B5/16B82Y30/00B82Y40/00
    • B82Y30/00C01B32/158C01B2202/02C01B2202/06C01B2202/22C01B2202/34C01B2202/36G11C13/025Y10S977/751Y10S977/752Y10T428/249921
    • A method for controlling density, porosity and/or gap size within a nanotube fabric layer is disclosed. In one aspect, this can be accomplished by controlling the degree of rafting in a nanotube fabric. In one aspect, the method includes adjusting the concentration of individual nanotube elements dispersed in a nanotube application solution. A high concentration of individual nanotube elements will tend to promote rafting in a nanotube fabric layer formed using such a nanotube application solution, whereas a lower concentration will tend to discourage rafting. In another aspect, the method includes adjusting the concentration of ionic particles dispersed in a nanotube application solution. A low concentration of ionic particles will tend to promote rafting in a nanotube fabric layer formed using such a nanotube application solution, whereas a higher concentration will tend to discourage rafting. In other aspects, both concentration parameters are adjusted.
    • 公开了一种用于控制纳米管织物层内的密度,孔隙率和/或间隙尺寸的方法。 在一个方面,这可以通过控制纳米管织物中漂流的程度来实现。 一方面,该方法包括调节分散在纳米管应用溶液中的单个纳米管元件的浓度。 单个纳米管元件的高浓度倾向于促进在使用这种纳米管施用溶液形成的纳米管织物层中的漂流,而较低浓度将倾向于阻止漂流。 另一方面,该方法包括调节分散在纳米管应用溶液中的离子颗粒的浓度。 低浓度的离子颗粒倾向于促进在使用这种纳米管施用溶液形成的纳米管织物层中的漂流,而较高的浓度将倾向于阻止漂流。 在其他方面,调整浓度参数。
    • 6. 发明申请
    • Methods of Treating Neurological Diseases
    • 治疗神经疾病的方法
    • US20170042929A9
    • 2017-02-16
    • US13969252
    • 2013-08-16
    • Jokubas ZiburkusJason EriksenFeng Gu
    • Jokubas ZiburkusJason EriksenFeng Gu
    • A61K31/7076A61K45/06
    • A61K31/7076A61K45/06
    • The present invention is directed to novel treatment of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. Further provided is a method of treating a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of administering an amount of an adenosine A1 receptor agonist pharmacologically effective to block epileptogenetic activities without blocking excitatory synaptic transmission.
    • 本发明涉及在需要这种治疗的受试者中控制海马神经回路发生在与癫痫发生相关的神经疾病或病症中的过度兴奋性的新型治疗,其包括使所述受试者的海马与有效恢复兴奋性的化合物接触的步骤 /抑制剂平衡,从而控制神经回路的兴奋性。 还提供了一种在需要这种治疗的受试者中治疗与癫痫发生相关的神经系统疾病或病症的方法,其包括施用一定量的腺苷A1受体激动剂在药物学上有效阻断癫痫发作活性而不阻断兴奋性突触传递的步骤。
    • 7. 发明申请
    • Methods of Treating Neurological Diseases
    • 治疗神经疾病的方法
    • US20150051166A1
    • 2015-02-19
    • US13969252
    • 2013-08-16
    • Jokubas ZiburkusJason EriksenFeng Gu
    • Jokubas ZiburkusJason EriksenFeng Gu
    • A61K31/7076A61K45/06
    • A61K31/7076A61K45/06
    • The present invention is directed to novel treatment of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. Further provided is a method of treating a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of administering an amount of an adenosine A1 receptor agonist pharmacologically effective to block epileptogenetic activities without blocking excitatory synaptic transmission.
    • 本发明涉及在需要这种治疗的受试者中控制海马神经回路发生在与癫痫发生相关的神经疾病或病症中的过度兴奋性的新型治疗,其包括使所述受试者的海马与有效恢复兴奋性的化合物接触的步骤 /抑制剂平衡,从而控制神经回路的兴奋性。 还提供了一种在需要这种治疗的受试者中治疗与癫痫发生相关的神经系统疾病或病症的方法,其包括施用一定量的腺苷A1受体激动剂在药物学上有效阻断癫痫发作活性而不阻断兴奋性突触传递的步骤。