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1. 发明申请

US20110312012A1 METHOD AND KIT FOR ASSESSING VIABLE CELLS 有权
标题翻译：用于评估可变细胞的方法和工具包
公开(公告)号：US20110312012A1
公开(公告)日：2011-12-22
申请号：US13003943
申请日：2009-07-13
申请人： Mette Elena Skinderso , Helle Frobøse Sørensen , Søren Kjærulff
发明人： Mette Elena Skinderso , Helle Frobøse Sørensen , Søren Kjærulff
IPC分类号： C12Q1/02
CPC分类号： G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途）。本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。

2. 发明申请

US20120045757A1 APPARATUS AND METHODS FOR ANALYSING FLUORESCENT PARTICLES 有权
标题翻译：用于分析荧光颗粒的装置和方法
公开(公告)号：US20120045757A1
公开(公告)日：2012-02-23
申请号：US13123560
申请日：2009-10-21
申请人： Søren Kjaerulff , Mette Elena Skindersø , Helle Frobøse Sørensen , Frans Ejner Ravn , Martin Glensbjerg
发明人： Søren Kjaerulff , Mette Elena Skindersø , Helle Frobøse Sørensen , Frans Ejner Ravn , Martin Glensbjerg
IPC分类号： G01N21/64 , C12Q1/68 , C12M1/34 , C12Q1/02
CPC分类号： G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
摘要： According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
摘要翻译：根据本发明的实施例，公开了一种从样品中检测荧光的装置。所述装置包括：样品布置在其上的样品平面，至少包括用于照射样品的光源的激发光单元;以及检测单元，其至少包括具有至少100,000个活性检测元件的检测器，以检测来自例子。

3. 发明申请

US20110312013A1 METHOD AND KIT FOR EXAMINATION OF CELLS USING N-(9-ACRIDINYL) MALEIMIDE (NAM) OR USING 7-DIETHYLAMINO-3-((4'-IODACETYL)AMINO)PHENYL)-4-METHYLKCOUMARIN (CPI) 有权
标题翻译：使用N-（9-吡啶基）马来酰亚胺（NAM）或使用7-二乙酰氨基-3 - （（4'-碘代氨基）氨基）苯基）-4-甲基喹啉（CPI）检测细胞的方法和试剂盒
公开(公告)号：US20110312013A1
公开(公告)日：2011-12-22
申请号：US13003982
申请日：2009-07-14
申请人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
发明人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
IPC分类号： C12Q1/02 , C07D311/18
CPC分类号： G01N1/30 , C07K1/13 , G01N33/5005 , G01N33/502
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI). The invention further relates to compositions used in methods for analyzing cells.
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，以下对细胞进行定量和定性评估。本发明涉及N-（9-吖啶基）马来酰亚胺（NAM）或7-二乙基氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）的用途，特别是与其在完整（例如活体）细胞中比在非完整（例如死细胞）中更高浓度存在的物质（例如，含硫物质）反应时可检测到。本发明还涉及使用NAM或7-二乙基氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）的用途，其特别可检测的与其存在于完整和/或不完整的细胞。此外，本发明涉及测量技术和/或仪器与使用NAM或使用7-二乙基氨基-3 - （（4' - （碘代乙酰基）氨基）苯基）-4-甲基香豆素（ CPI）。本发明还涉及用于分析细胞的方法中使用的组合物。

4. 发明授权

US09128097B2 Method and kit for assessing viable cells 有权
标题翻译：用于评估活细胞的方法和试剂盒
公开(公告)号：US09128097B2
公开(公告)日：2015-09-08
申请号：US13003943
申请日：2009-07-13
申请人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
发明人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
IPC分类号： C12Q1/02 , G01N33/58 , C09B15/00 , C09B57/00 , C09B57/02 , G01N33/50
CPC分类号： G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途）。本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。

5. 发明授权

US08860938B2 Apparatus and methods for analysing fluorescent particles 有权
标题翻译：用于分析荧光颗粒的装置和方法
公开(公告)号：US08860938B2
公开(公告)日：2014-10-14
申请号：US13123560
申请日：2009-10-21
申请人： Søren Kjærulff , Mette Elena Skindersø , Helle Frobøse Sørensen , Frans Ejner Ravn , Martin Glensbjerg
发明人： Søren Kjærulff , Mette Elena Skindersø , Helle Frobøse Sørensen , Frans Ejner Ravn , Martin Glensbjerg
IPC分类号： G01N1/10 , G02B27/09 , G01N21/64
CPC分类号： G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
摘要： According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
摘要翻译：根据本发明的实施例，公开了一种从样品中检测荧光的装置。所述装置包括：样品布置在其上的样品平面，至少包括用于照射样品的光源的激发光单元;以及检测单元，其至少包括具有至少100,000个活性检测元件的检测器，以检测来自例子。

6. 发明授权

US08697390B2 Method and kit for examination of cells using N-(9-acridinyl) maleimide (NAM) or using 7-diethylamino-3-((4′-iodacetyl)amino)phenyl)-4-methylkcoumarin (CPI) 有权
标题翻译：使用N-（9-吖啶基）马来酰亚胺（NAM）或使用7-二乙基氨基-3 - （（4'-碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）检测细胞的方法和试剂盒
公开(公告)号：US08697390B2
公开(公告)日：2014-04-15
申请号：US13003982
申请日：2009-07-14
申请人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjaerulff
发明人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjaerulff
IPC分类号： C12Q1/02
CPC分类号： G01N1/30 , C07K1/13 , G01N33/5005 , G01N33/502
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI). The invention further relates to compositions used in methods for analyzing cells.
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，以下对细胞进行定量和定性评估。本发明涉及N-（9-吖啶基）马来酰亚胺（NAM）或7-二乙基氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）的用途，特别是与其在完整（例如活体）细胞中比在非完整（例如死细胞）中更高浓度存在的物质（例如，含硫物质）反应时可检测到。本发明还涉及使用NAM或7-二乙基氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）的用途，其特别可检测的与其存在于完整和/或不完整的细胞。此外，本发明涉及测量技术和/或仪器与使用NAM或使用7-二乙基氨基-3 - （（4' - （碘代乙酰基）氨基）苯基）-4-甲基香豆素（ CPI）。本发明还涉及用于分析细胞的方法中使用的组合物。

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