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1. 发明申请

US20090275528A1 ANTITUBERCULOUS COMPOSITION COMPRISING OXAZOLE COMPOUNDS 有权
标题翻译：包含奥沙唑化合物的抗菌组合物
公开(公告)号：US20090275528A1
公开(公告)日：2009-11-05
申请号：US12088867
申请日：2006-10-04
申请人： Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Yoshihiko Shimokawa
发明人： Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Yoshihiko Shimokawa
IPC分类号： A61K31/7042 , A61K31/445 , A61K31/4709 , A61K31/496 , A61K31/7008 , A61K31/4965
CPC分类号： A61K31/4965 , A61K31/133 , A61K31/424 , A61K31/427 , A61K31/451 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/536 , A61K45/06 , A61K2300/00
摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.
摘要翻译：本发明提供具有较高效力的抗结核药物。本发明还提供含有（I）通式（1）表示的恶唑化合物的抗结核药物：其中，R1表示氢原子或C1-6烷基，n表示0-6的整数，R2表示通式（A）等，其中R 3表示苯氧基（选自卤素原子，任选卤素取代的C 1-6烷基和任选卤素取代的C 1-6烷氧基的至少一个基团可以在苯环上取代）等]，其光学活性形式或其盐，以及药物（II）如初级抗结核药物。

2. 发明授权

US5999495A Timepiece movement 失效
标题翻译：钟表机芯
公开(公告)号：US5999495A
公开(公告)日：1999-12-07
申请号：US964588
申请日：1997-11-05
申请人： Hiroyuki Hashizume , Koji Baba
发明人： Hiroyuki Hashizume , Koji Baba
IPC分类号： G04C3/00 , G04C3/14 , G04C9/08 , G04B19/04 , G04B19/02
CPC分类号： G04C3/146 , G04C3/14
摘要： A timepiece movement comprises a first luminous element for emitting light, a second luminous element for emitting light, and a light-receiving element for receiving the light emitted by the first and second luminous elements. A second wheel has an aperture through which light from the first luminous element may pass and a reflecting portion. A first transmitting wheel transmits a rotational drive to the second wheel as a function of second time and has an aperture through which light from the first luminous element may pass and which is positioned to become aligned with the aperture of the second wheel. A rotational minute wheel has apertures disposed at equal angular intervals and through which light from the second luminous element may pass. A rotational hour wheel has apertures through which light from the second luminous element may pass. Each of the apertures of the hour wheel are positioned to become aligned with respective ones of the apertures of the minute wheel during rotation of the minute and hour wheels. A second transmitting wheel transmits a rotational drive to the minute wheel and the hour wheel as a function of minute time and hour time, respectively. The second transmitting wheel has a plurality of apertures disposed at equal angular intervals and through which light from the second luminous element may pass. The apertures of the minute wheel are positioned to become aligned with respective ones of the apertures of the second transmitting wheel during rotation thereof.
摘要翻译：钟表运动包括用于发光的第一发光元件，用于发光的第二发光元件和用于接收由第一和第二发光元件发射的光的光接收元件。第二轮具有通过第一发光元件的光可以通过的孔和反射部。第一传动轮作为第二次的函数将旋转驱动传递到第二轮，并且具有孔，来自第一发光元件的光可以穿过该孔，并且被定位成与第二轮的孔对准。旋转分轮具有以相等的角度间隔布置的孔，并且来自第二发光元件的光可以通过该孔。旋转时轮具有通过第二发光元件的光通过的孔。时针轮的每个孔定位成在分钟和小时轮的旋转期间与分针的相应的一个孔对齐。第二传动轮分别作为分钟时间和小时的时间将旋转驱动传递到分针轮和小时轮。第二传动轮具有以等角度间隔设置的多个孔，并且来自第二发光元件的光可以通过该孔。分轮的孔被定位成在其旋转期间与第二传动轮的相应的孔对准。

3. 发明授权

US5566140A Clock movement 失效
标题翻译：时钟运动
公开(公告)号：US5566140A
公开(公告)日：1996-10-15
申请号：US527286
申请日：1995-09-12
申请人： Shigeru Kohata , Hiroyuki Hashizume
发明人： Shigeru Kohata , Hiroyuki Hashizume
IPC分类号： G04C3/00 , G04C3/14 , G04C9/08 , G04B19/02 , G04C9/00 , G04C11/02
CPC分类号： G04C3/14 , G04C3/146
摘要： A clock movement includes a circuit board, first and second motors, a minute wheel connected to the first motor by a first gear train and an hour wheel connected to the second motor by a second gear train. The first and second gear trains preferably extend in a first direction, and the first and second motors are respectively disposed on opposite sides of the first and second gear trains and extend in a second direction transverse to the first direction. A first detection device detects when the minute hand is in a predetermined reference position and a second detection device detects when the hour wheel is in a predetermined reference position. The first detection device includes a minute detection sensor mounted on the circuit board and having a first light-emitting device and a first light-receiving device. The second detection device includes an hour detection sensor mounted on the circuit board and having a second light-emitting device and a second light-receiving device. The clock movement has a simple construction and is easy to manufacture, is suited to mass-production and can be manufactured at low cost.
摘要翻译：时钟运动包括电路板，第一和第二电动机，通过第一齿轮系连接到第一电动机的分轮和通过第二齿轮系连接到第二电动机的时轮。第一和第二齿轮系优选地在第一方向上延伸，并且第一和第二电动机分别设置在第一和第二齿轮系的相对侧上，并且在横向于第一方向的第二方向上延伸。第一检测装置检测分针在何时处于预定基准位置，而第二检测装置检测时轮何时处于预定基准位置。第一检测装置包括安装在电路板上并具有第一发光装置和第一光接收装置的微小检测传感器。第二检测装置包括安装在电路板上并具有第二发光装置和第二光接收装置的小时检测传感器。钟表机构结构简单，易于制造，适合批量生产，可以低成本制造。

4. 发明授权

US08987304B2 Antituberculous composition comprising oxazole compounds 有权
标题翻译：包含恶唑化合物的抗结核组合物
公开(公告)号：US08987304B2
公开(公告)日：2015-03-24
申请号：US12088867
申请日：2006-10-04
申请人： Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Yoshihiko Shimokawa
发明人： Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Yoshihiko Shimokawa
IPC分类号： A61K31/454 , A61K31/496 , A61K31/4409 , A61K31/133 , A61K31/70 , A61K31/50 , A61K31/451 , A61K31/424 , A61K45/06
CPC分类号： A61K31/4965 , A61K31/133 , A61K31/424 , A61K31/427 , A61K31/451 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/536 , A61K45/06 , A61K2300/00
摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.
摘要翻译：本发明提供具有较高效力的抗结核药物。本发明还提供含有（I）通式（1）表示的恶唑化合物的抗结核药物：其中，R1表示氢原子或C1-6烷基，n表示0-6的整数，R2表示通式（A）等，其中R 3表示苯氧基（选自卤素原子，任选卤素取代的C 1-6烷基和任选卤素取代的C 1-6烷氧基的至少一个基团可以在苯环上取代）等]，其光学活性形式或其盐，以及药物（II）如初级抗结核药物。

5. 发明申请

US20080119478A1 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis 有权
标题翻译： 2,3-二氢-6-硝基咪唑（2,1-b）恶唑化合物治疗结核病
公开(公告)号：US20080119478A1
公开(公告)日：2008-05-22
申请号：US10574597
申请日：2004-10-29
申请人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
发明人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
IPC分类号： A61K31/497 , A61K31/41 , A61K31/445 , C07D211/68 , C07D413/00 , C07D498/02 , C07D215/00 , A61P31/00 , A61K31/47
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R 1和 - （CH 2）n R 2可以与下述式（30）表示的螺环连同相邻的碳原子（在式中，RRR表示哌啶环上可具有取代基的哌啶基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

6. 发明授权

US07262212B2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles 有权
标题翻译： 2,3-二氢-6-硝基咪唑并[2,1-b]恶唑
公开(公告)号：US07262212B2
公开(公告)日：2007-08-28
申请号：US10530429
申请日：2003-10-10
申请人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Hideaki Kuroda , Motohiro Itotani , Takeshi Hasegawa , Yoshikazu Haraguchi , Takeshi Kuroda , Takayuki Matsuzaki , Kuninori Tai , Makoto Komatsu , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Yuji Seike , Masanori Kawasaki , Takumi Sumida , Shin Miyamura
发明人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Hideaki Kuroda , Motohiro Itotani , Takeshi Hasegawa , Yoshikazu Haraguchi , Takeshi Kuroda , Takayuki Matsuzaki , Kuninori Tai , Makoto Komatsu , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Yuji Seike , Masanori Kawasaki , Takumi Sumida , Shin Miyamura
IPC分类号： A61K31/424 , A61K31/438 , C07D498/04 , C07D401/14
CPC分类号： C07D498/04 , C07D498/20 , C07F7/0812
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group —OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and —(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由下列通式表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物：其中R 1表示氢原子或C 1 -C 6烷基，n表示0〜6的整数，R 2表示基团-OR 3等，R 3表示氢原子，C 1 -C 6烷基等，或R 1和 - （CH 2）n R 2 R 2，可以通过氮原子与与其相邻的碳原子彼此结合形成由通式（H）表示的螺环：其中R 41是氢，C 1 -C 6烷基或喜欢。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

7. 发明授权

US5930205A Timepiece movement 失效
标题翻译：钟表机芯
公开(公告)号：US5930205A
公开(公告)日：1999-07-27
申请号：US954742
申请日：1997-10-20
申请人： Koji Baba , Hiroyuki Hashizume
发明人： Koji Baba , Hiroyuki Hashizume
IPC分类号： G04C3/00 , G04C3/14 , G04C9/08 , G04B19/04 , G04B19/02
CPC分类号： G04C3/146 , G04C3/14
摘要： A timepiece movement comprises a light-emitting device for emitting light and a light-receiving device for receiving the light emitted from the light-emitting device. An hour wheel has a plurality of apertures through which light from the light-emitting device may pass. A minute wheel has an aperture through which light from the light-emitting device may pass, the aperture being positioned to become aligned with respective ones of the apertures of the hour wheel during rotation of the minute and hour wheels. Minute and hour wheel gear trains respectively rotate the minute wheel and the hour wheel as a function of minute and hour time.
摘要翻译：钟表运动包括用于发射光的发光装置和用于接收从发光装置发射的光的光接收装置。一个时轮具有多个孔，来自发光装置的光可穿过该孔。分轮具有通过该开口，来自发光装置的光可以通过该孔，该孔被定位成在分针和小时轮的旋转期间与时针的各个孔对准。分钟和小时齿轮系分别作为分钟和小时的时间旋转分针轮和小时轮。

8. 发明授权

US4047846A Power-steering pump 失效
标题翻译：动力转向泵
公开(公告)号：US4047846A
公开(公告)日：1977-09-13
申请号：US687556
申请日：1976-05-18
申请人： Seiji Komamura , Hiroyuki Hashizume
发明人： Seiji Komamura , Hiroyuki Hashizume
IPC分类号： F04C14/26 , G05D7/01 , F04B49/08
CPC分类号： F04C14/26 , G05D7/014
摘要： The present invention discloses a power-steering pump which may reduce in a very stable manner the flow rate of the hydraulic liquid under pressure to be delivered to a power steering system with increase of the rotational speed of an engine beyond an idling speed and which may easily change the above rate reduction or attenuation characteristic depending upon the types of the automotive vehicles and power steering systems thereof. A flow-control valve which is disposed in parallel with the axis of a pump mechanism is provided with a variable-area orifice which determines the flow rate attenuation characteristic and which is defined by an orifice groove cut through a flange of a partition wall member and an enlarged-diameter portion at the free end of a control rod extended through the partition wall member from the front end of a control spool of the flow-control valve. The flow-control valve is so arranged as to be freely detached from the pump independently of the pump mechanism so that a partition wall member having a suitable orifice groove may be placed, thereby changing the flow-rate attenuation characteristic as needs demand.
摘要翻译：本发明公开了一种动力转向泵，其可以以非常稳定的方式减少压力下的液压液体的流量，以便随着发动机的转速超过怠速转速而传递到动力转向系统，并且可以根据机动车辆的类型和动力转向系统容易地改变上述速率降低或衰减特性。与泵机构的轴线平行设置的流量控制阀设置有可变面积孔口，该可变面积孔口确定流量衰减特性，其由通过隔壁构件的凸缘切割的孔槽限定，控制棒的自由端的扩径部分从流量控制阀的控制阀芯的前端延伸穿过分隔壁件。流量控制阀被设置为独立于泵机构从泵自由分离，从而可以放置具有合适的孔槽的隔壁构件，从而根据需要改变流量衰减特性。

9. 发明授权

US09051333B2 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides 有权
标题翻译： 6,7-二氢咪唑并[2,1-b] [1,3]恶嗪类杀菌剂
公开(公告)号：US09051333B2
公开(公告)日：2015-06-09
申请号：US14111262
申请日：2012-04-13
申请人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
发明人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
IPC分类号： C07D498/04 , A61K31/5383
CPC分类号： C07D498/04
摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
摘要翻译：本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。本发明还提供含有上述物质的药物组合物。

10. 发明申请

US20140031342A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES 有权
标题翻译： 6,7-二氢吲哚并[2,1-b] [1,3]氧化物杀菌剂
公开(公告)号：US20140031342A1
公开(公告)日：2014-01-30
申请号：US14111262
申请日：2012-04-13
申请人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
发明人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
摘要翻译：本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。本发明还提供含有上述物质的药物组合物。

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