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1. 发明授权

US09051333B2 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides 有权
标题翻译： 6,7-二氢咪唑并[2,1-b] [1,3]恶嗪类杀菌剂
公开(公告)号：US09051333B2
公开(公告)日：2015-06-09
申请号：US14111262
申请日：2012-04-13
申请人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
发明人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
IPC分类号： C07D498/04 , A61K31/5383
CPC分类号： C07D498/04
摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
摘要翻译：本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。本发明还提供含有上述物质的药物组合物。

2. 发明授权

US08975339B2 Surface treatment method for water-absorbent resin 有权
标题翻译：吸水树脂的表面处理方法
公开(公告)号：US08975339B2
公开(公告)日：2015-03-10
申请号：US12678856
申请日：2008-10-08
申请人： Yoshiro Mitsukami , Taku Iwamura , Makoto Matsumoto
发明人： Yoshiro Mitsukami , Taku Iwamura , Makoto Matsumoto
IPC分类号： C08J3/24 , C08F20/06 , C08F265/02
CPC分类号： C08J3/245 , C08J2300/14
摘要： Provided is a surface treatment method for a water-absorbent resin having excellent production efficiency, absorption capacity against pressure, fluid permeability or the like. Provided is a method for the surface treatment of a water-absorbent resin which comprises a) a step for mixing 0.1 to 20 parts by weight of an acid group-containing radically polymerizable compound and 5 to 20 parts by weight of water, relative to 100 parts by weight of a water-absorbent resin; and b) a step for polymerizing the acid group-containing radically polymerizable compound, wherein neutralization ratio of the acid group-containing radically polymerizable compound is 0 to 60% by mol, and is lower than neutralization ratio of the water-absorbent resin.
摘要翻译：提供了具有优异的生产效率，对压力的吸收能力，流体渗透性等的吸水性树脂的表面处理方法。本发明提供一种吸水性树脂的表面处理方法，该方法包括：a）将0.1〜20重量份含酸基的自由基聚合性化合物和5〜20重量份的水相对于100 吸水树脂重量份; 和b）使含酸基的自由基聚合性化合物的中和率为0〜60摩尔％，并且低于吸水性树脂的中和率的含有酸基的自由基聚合性化合物的工序。

3. 发明申请

US20140031342A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES 有权
标题翻译： 6,7-二氢吲哚并[2,1-b] [1,3]氧化物杀菌剂
公开(公告)号：US20140031342A1
公开(公告)日：2014-01-30
申请号：US14111262
申请日：2012-04-13
申请人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
发明人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
摘要翻译：本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。本发明还提供含有上述物质的药物组合物。

4. 发明授权

US08553880B2 Pseudorandom number generating system, encryption system, and decryption system 失效
标题翻译：伪随机数生成系统，加密系统和解密系统
公开(公告)号：US08553880B2
公开(公告)日：2013-10-08
申请号：US11920276
申请日：2006-05-12
申请人： Makoto Matsumoto , Takuji Nishimura , Mutsuo Saito , Mariko Hagita
发明人： Makoto Matsumoto , Takuji Nishimura , Mutsuo Saito , Mariko Hagita
IPC分类号： H04L9/00
CPC分类号： H04L9/0662
摘要： The pseudorandom number generating system repeatedly performs simple transformation of a non-secure pseudorandom number sequence that may be generated quickly, and thus may quickly generate a highly secure pseudorandom number sequence having a long period. Furthermore, the encryption system and the decryption system do not generate a large encryption function difficult to be deciphered based on a shared key 122, but prepare multiple functions 126, which perform fast, different types of transformation, and select a combination of functions determined based on information of the shared key 122, and make the selected functions transform a text multiple times, thereby encrypt the text. Each of the functions is fast, and thus transformation by the entire combination is also fast. Furthermore, since the combination of functions and repetitive count can be changed, future improvement in specification is easy. Moreover, security is high since which functions are applied in what order is unknown.
摘要翻译：伪随机数生成系统重复执行可以快速生成的非安全伪随机数序列的简单变换，从而可以快速生成具有长周期的高度安全的伪随机数序列。此外，加密系统和解密系统不产生基于共享密钥122难以被解密的大型加密功能，而是准备执行快速，不同类型的转换的多个功能126，并且选择基于确定的功能的组合在共享密钥122的信息上，并且使所选择的功能多次转换文本，从而加密文本。每个功能都很快，因此整个组合的转换也很快。此外，由于功能和重复计数的组合可以改变，因此规格的未来改进是容易的。此外，安全性很高，因为哪些功能以未知的顺序应用。

5. 发明授权

US08163753B2 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis 有权
标题翻译： 2,3-二氢-6-硝基咪唑并（2,1-b）恶唑化合物，用于治疗结核病
公开(公告)号：US08163753B2
公开(公告)日：2012-04-24
申请号：US10574597
申请日：2004-10-29
申请人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
发明人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
IPC分类号： A61K31/497 , A61K31/47 , A61K31/445 , A61K31/42 , C07D419/06 , C07D215/04 , C07D213/72 , C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R1和 - （CH2）nR2可以与相邻的碳原子一起形成由下式（30）表示的螺环（在下式中，RRR表示哌啶基其可以在哌啶环上具有取代基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

6. 发明授权

US08012584B2 High-performance pressure vessel and carbon fiber for pressure vessel 有权
标题翻译：用于压力容器的高性能压力容器和碳纤维
公开(公告)号：US08012584B2
公开(公告)日：2011-09-06
申请号：US10569366
申请日：2004-08-26
申请人： Naoki Sugiura , Satoshi Nagatsuka , Hidehiro Takemoto , Makoto Matsumoto , Masayuki Sugiura
发明人： Naoki Sugiura , Satoshi Nagatsuka , Hidehiro Takemoto , Makoto Matsumoto , Masayuki Sugiura
IPC分类号： B32B9/00
CPC分类号： F17C1/16 , F17C1/06 , F17C2201/0109 , F17C2201/056 , F17C2203/0604 , F17C2203/0619 , F17C2203/0621 , F17C2203/0624 , F17C2203/0636 , F17C2203/0646 , F17C2203/0648 , F17C2203/066 , F17C2203/0665 , F17C2203/0668 , F17C2203/0673 , F17C2209/2154 , F17C2209/232 , F17C2223/0123 , F17C2223/036 , F17C2260/011 , F17C2260/012 , F17C2260/017 , F17C2270/0178 , Y10T428/1362 , Y10T428/30
摘要： A pressure vessel includes a vessel body and a fiber reinforced plastic layer formed on the surface of the vessel body, wherein the fiber reinforced plastic layer include fiber reinforced plastic in which reinforcing fibers are impregnated with plastic, a strand elastic modulus of the reinforcing fiber is 305 GPa or higher, and a tensile elongation of the reinforcing fiber is 1.45 to 1.70%. A carbon fiber for a pressure vessel has a strand elastic modulus of 305 GPa or higher and a tensile elongation of 1.45 to 1.70%.
摘要翻译：压力容器包括容器主体和形成在容器主体表面上的纤维增强塑料层，其中纤维增强塑料层包括纤维增强塑料，其中增强纤维用塑料浸渍，增强纤维的股线弹性模量为 305GPa以上，增强纤维的拉伸伸长率为1.45〜1.70％。用于压力容器的碳纤维的股线弹性模量为305GPa以上，拉伸伸长率为1.45〜1.70％。

7. 发明申请

US20100261850A1 SURFACE TREATMENT METHOD FOR WATER-ABSORBENT RESIN 有权
标题翻译：吸水树脂的表面处理方法
公开(公告)号：US20100261850A1
公开(公告)日：2010-10-14
申请号：US12678856
申请日：2008-10-08
申请人： Yoshiro Mitsukami , Taku Iwamura , Makoto Matsumoto
发明人： Yoshiro Mitsukami , Taku Iwamura , Makoto Matsumoto
IPC分类号： C08F120/06 , C08F2/46
CPC分类号： C08J3/245 , C08J2300/14
摘要： Provided is a surface treatment method for a water-absorbent resin having excellent production efficiency, absorption capacity against pressure, fluid permeability or the like. Provided is a method for the surface treatment of a water-absorbent resin which comprises a) a step for mixing 0.1 to 20 parts by weight of an acid group-containing radically polymerizable compound and 5 to 20 parts by weight of water, relative to 100 parts by weight of a water-absorbent resin; and b) a step for polymerizing the acid group-containing radically polymerizable compound, wherein neutralization ratio of the acid group-containing radically polymerizable compound is 0 to 60% by mol, and is lower than neutralization ratio of the water-absorbent resin.
摘要翻译：提供了具有优异的生产效率，对压力的吸收能力，流体渗透性等的吸水性树脂的表面处理方法。本发明提供一种吸水性树脂的表面处理方法，该方法包括：a）将0.1〜20重量份含酸基的自由基聚合性化合物和5〜20重量份的水相对于100 吸水树脂重量份; 和b）使含酸基的自由基聚合性化合物的中和率为0〜60摩尔％，并且低于吸水性树脂的中和率的含有酸基的自由基聚合性化合物的工序。

8. 发明申请

US20090324702A1 NOVEL VIRAL VECTOR 有权
标题翻译：新的VIRAL VECTOR
公开(公告)号：US20090324702A1
公开(公告)日：2009-12-31
申请号：US12192927
申请日：2008-08-15
申请人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
发明人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
IPC分类号： A61K39/145 , C12N15/00 , C12N7/02 , C12N7/00 , A61K35/76 , A61K9/127
CPC分类号： A61K39/015 , A61K9/0043 , A61K9/007 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.
摘要翻译：本发明提供新型转移载体和重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物，其可用作传染病如疟疾和流感的预防或治疗药物; 以及预防和治疗疟疾和流感等传染病的方法。更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物; 以及用于预防和治疗诸如疟疾和流感的传染病的方法，包括向患者施用重组杆状病毒。

9. 发明申请

US20090298963A1 METHOD FOR PRODUCTION OF MODIFIED WATER ABSORBENT RESIN 审中-公开
标题翻译：生产改性吸水树脂的方法
公开(公告)号：US20090298963A1
公开(公告)日：2009-12-03
申请号：US11721285
申请日：2005-12-09
申请人： Makoto Matsumoto , Yoshiro Mitsukami , Hiroyuki Ikeuchi , Kazushi Torii , Taku Iwamura , Andreas Flohr , Torsten Lindner
发明人： Makoto Matsumoto , Yoshiro Mitsukami , Hiroyuki Ikeuchi , Kazushi Torii , Taku Iwamura , Andreas Flohr , Torsten Lindner
IPC分类号： C08J3/28 , C08F20/06
CPC分类号： C08L33/02 , C08F8/44 , C08J3/28 , C08J2300/14 , C08J2333/02 , C08F20/06 , C08L2666/04
摘要： This invention is to provide a method for producing a modified water absorbent resin excelling in water absorbing properties. This invention relates to a method for producing a modified water absorbent resin, which comprises a) mixing a water absorbent resin and a water-soluble radical polymerization initiator or a heat-degradable radical polymerization initiator without addition of an ethylenically unsaturated monomer and b) irradiating the resultant mixture with active energy rays. The method is particularly capable of exalting the absorbency against pressure and the saline flow conductivity.
摘要翻译：本发明提供一种制造吸水性优异的改性吸水性树脂的方法。本发明涉及一种改性吸水性树脂的制造方法，该方法包括：a）在不加入烯属不饱和单体的情况下，将吸水性树脂与水溶性自由基聚合引发剂或热降解自由基聚合引发剂混合，b）照射所得的具有活性能量射线的混合物。该方法特别能够提高抗压力和盐水流动导电性的吸收性。

10. 发明申请

US20090243421A1 ELECTRIC MOTOR STATOR AND PERMANENT MAGNET-TYPE ELECTRIC MOTOR USING THE SAME 有权
标题翻译：电机电机定子及使用该电动机的永久磁铁型电动机
公开(公告)号：US20090243421A1
公开(公告)日：2009-10-01
申请号：US12483143
申请日：2009-06-11
申请人： Kenji MATSUURA , Makoto Matsumoto
发明人： Kenji MATSUURA , Makoto Matsumoto
IPC分类号： H02K3/34 , H02K21/16
CPC分类号： H02K3/522 , H02K2203/12
摘要： An electric motor stator according to the present invention includes two resin insulation components, each resin insulation component including a long side portion, facing a side face of the teeth section, and two short side portions, extending from respective ends of the long side portion and facing respective end faces of the laminated core in a lamination direction. The laminated core is clamped by the two resin insulation components from a direction along surfaces of the electromagnetic steel plates, and fitting portions of the two short side portions of each of the two resin insulation components are used to fit the two resin insulation components to each other.
摘要翻译：根据本发明的电动机定子包括两个树脂绝缘部件，每个树脂绝缘部件包括面对齿部侧面的长边部分和从长边部分的两端延伸的两个短边部分，以及面对层叠铁芯的层叠方向的各端面。层叠铁芯由两个树脂绝缘部件沿着电磁钢板的表面的方向夹紧，并且使用两个树脂绝缘部件的两个短边部分的两个短边部分的装配部分将两个树脂绝缘部件装配到每个其他。

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