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1. 发明授权

US09120818B2 Process and intermediates for preparing macrolactams 有权
标题翻译：制备马来酰胺的方法和中间体
公开(公告)号：US09120818B2
公开(公告)日：2015-09-01
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D207/02 , C07D403/12 , C07D498/16 , C07C271/22 , C07C271/24 , C07C309/80 , C07C309/85 , C07C311/51 , C07D207/16 , C07D498/18 , C07D209/44 , C07K5/062 , C07C271/56 , C07C311/47
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译：本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。

2. 发明申请

US20150219793A1 Conditional Process-Aided Multiple-Points Statistics Modeling 审中-公开
标题翻译：条件过程辅助多点统计建模
公开(公告)号：US20150219793A1
公开(公告)日：2015-08-06
申请号：US14421372
申请日：2013-08-23
申请人： Hongmei Li , Tao Sun
发明人： Hongmei Li , Tao Sun
IPC分类号： G01V99/00 , G06F17/18
摘要： A method of simulating a hydrocarbon reservoir is disclosed. A process-based model is generated that mimics a depositional process of the reservoir. The process-based model is analyzed to extract statistics of geometries of a body that forms part of the reservoir, and depositional rules of the body. An object-based modeling method is applied to construct multiple unconditional geologic models of the body using the statistics and the depositional rules. Training images are constructed using the multiple unconditional geologic models. Well data and gross thickness data are assigned into a simulation grid. A single multiple-point geostatistical simulation is performed using the training images. A three-dimensional (3D) reservoir model is constructed using results of the multiple-point geostatistical simulation.
摘要翻译：公开了一种模拟烃储层的方法。生成基于过程的模型，其模拟储层的沉积过程。分析基于过程的模型，以提取形成储层的一部分的身体的几何体的统计数据，以及身体的沉积规则。应用基于对象的建模方法，利用统计学和沉积规则构建身体的多个无条件地质模型。使用多个无条件地质模型构建训练图像。井数据和总厚度数据被分配到模拟网格中。使用训练图像执行单个多点地统计模拟。使用多点地统计模拟的结果构建三维（3D）储层模型。

3. 发明授权

US08907086B2 Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors 有权
标题翻译：用作二肽基肽酶-IV抑制剂的稠合双环杂环
公开(公告)号：US08907086B2
公开(公告)日：2014-12-09
申请号：US14000641
申请日：2012-03-01
申请人： Chad E. Bennett , Duane A. Burnett , Hongmei Li , Yonggang Chen , Troy McCracken , Monica Vicarel
发明人： Chad E. Bennett , Duane A. Burnett , Hongmei Li , Yonggang Chen , Troy McCracken , Monica Vicarel
IPC分类号： C07D239/70 , C07D401/04 , C07D487/04 , A61K31/4523 , A61K31/517 , A61K31/52 , A61P3/10 , A61K45/06 , A61K31/155 , A61K31/427 , A61K31/519 , A61K31/64 , A61K31/522 , C07D473/28
CPC分类号： C07D487/04 , A61K31/155 , A61K31/427 , A61K31/519 , A61K31/522 , A61K31/64 , A61K45/06 , C07D473/18 , C07D473/28 , A61K2300/00
摘要： The present invention is directed to novel bicyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及结构式（I）的新型双环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

4. 发明授权

US08745571B2 Analysis of compensated layout shapes 失效
标题翻译：补偿布局形状分析
公开(公告)号：US08745571B2
公开(公告)日：2014-06-03
申请号：US13026451
申请日：2011-02-14
申请人： Hongmei Li , Richard Q. Williams
发明人： Hongmei Li , Richard Q. Williams
IPC分类号： G06F15/04
CPC分类号： G06F17/5018 , G06F17/5068
摘要： The disclosure relates to the analysis of compensated layout shapes. A method in accordance with an embodiment includes: analyzing a semiconductor layout using a bucket structure, the layout including a semiconductor device; and applying a pattern template to a content of the bucket structure to identify a shape adjacent to the semiconductor device; wherein the pattern template is derived from layout groundrules.
摘要翻译：本公开涉及补偿布局形状的分析。根据实施例的方法包括：使用铲斗结构分析半导体布局，所述布局包括半导体器件; 以及将图案模板应用到所述桶结构的内容以识别与所述半导体器件相邻的形状; 其中，图案模板是从布局基本原理中导出的。

5. 发明授权

US08569521B2 Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors 有权
标题翻译：苯磺酰基 - 苯并二氢吡喃，二氢苯并噻喃，四氢萘和相关的γ分泌酶抑制剂
公开(公告)号：US08569521B2
公开(公告)日：2013-10-29
申请号：US13267324
申请日：2011-10-06
申请人： Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Anne Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
发明人： Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Anne Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
IPC分类号： C07D493/00
CPC分类号： C07D311/22 , C07C317/14 , C07C317/20 , C07C317/44 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06 , C07D405/12 , C07D409/12 , C07D491/04 , C07D493/04
摘要： This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了具有下式的新型γ分泌酶抑制剂：R2和R3，或R2和R4，或R3和R4与它们所连接的原子一起可以形成稠合的环烷基或稠合的杂环烷基环。环烷基环或杂环烷基环可任选被一个或多个取代基取代。一种或多种式（I）化合物或包含这些化合物的制剂可以是有用的，例如，治疗阿尔茨海默病。

6. 发明申请

US20130237541A1 DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO 有权
公开(公告)号：US20130237541A1
公开(公告)日：2013-09-12
申请号：US13619137
申请日：2012-09-14
申请人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter Ian Dosa
发明人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter Ian Dosa
IPC分类号： C07D231/16 , C07D231/12
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D231/16 , C07D401/12 , C07D405/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders and the like.The present invention also relates to the method of prophylaxis or treatment of 5-HT2A serotonin receptor mediated disorders in combination with a dopamine D2 receptor antagonist such as haloperidol, administered separately or together.

7. 发明授权

US07812176B2 Processes for preparing substituted N-aryl-N′-[3-(1H-pyrazol-5-YL) phenyl] ureas and intermediates thereof 有权
标题翻译：取代的N-芳基-N' - [3-（1H-吡唑-5-基）苯基]脲的制备方法及其中间体
公开(公告)号：US07812176B2
公开(公告)日：2010-10-12
申请号：US10593847
申请日：2004-07-21
申请人： John Robert Fritch , Fiona M. Carleton , Edward A. Lally , Hongmei Li , Bradley Teegarden
发明人： John Robert Fritch , Fiona M. Carleton , Edward A. Lally , Hongmei Li , Bradley Teegarden
IPC分类号： C07D231/10
CPC分类号： C07D231/12 , C07C233/43 , C07D231/16
摘要： The present invention is directed to processes for the preparation of substituted phenylpyrazole ureas of Formula (I), that are useful as 5-HT2A serotonin receptor modulators for the treatment of disease.
摘要翻译：本发明涉及制备式（I）的取代的苯基吡唑脲的方法，其可用作治疗疾病的5-HT2A 5-羟色胺受体调节剂。

8. 发明申请

US20080237721A1 STRUCTURE AND CIRCUIT TECHNIQUE FOR UNIFORM TRIGGERING OF MULTIFINGER SEMICONDUCTOR DEVICES WITH TUNABLE TRIGGER VOLTAGE 有权
标题翻译：具有可调触发电压的多器件半导体器件的均匀触发的结构和电路技术
公开(公告)号：US20080237721A1
公开(公告)日：2008-10-02
申请号：US11692481
申请日：2007-03-28
申请人： Michel J. Abou-Khalil , Robert Gauthier , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
发明人： Michel J. Abou-Khalil , Robert Gauthier , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
IPC分类号： H01L23/60
CPC分类号： H01L27/0277 , H01L27/0262 , H01L2924/0002 , H01L2924/00
摘要： An external current injection source is provided to individual fingers of a multi-finger semiconductor device to provide the same trigger voltage across the multiple fingers. For example, the external injection current is supplied to the body of a MOSFET or the gate of a thyristor. The magnitude of the supplied current from each external current injection source is adjusted so that each finger has the same trigger voltage. The external current supply circuit may comprise diodes or an RC triggered MOSFET. The components of the external current supply circuit may be tuned to achieve a desired predetermined trigger voltage across all fingers of the multi-finger semiconductor device.
摘要翻译：外部电流注入源被提供给多指半导体器件的各个指状物，以跨多个指状物提供相同的触发电压。例如，外部注入电流被提供给MOSFET的主体或晶闸管的栅极。调整来自每个外部电流注入源的供给电流的大小，使得每个手指具有相同的触发电压。外部电流供应电路可以包括二极管或RC触发MOSFET。可以调谐外部电流供应电路的组件以实现多指半导体器件的所有指状物上期望的预定触发电压。

9. 发明授权

US10578767B2 Conditional process-aided multiple-points statistics modeling 有权
公开(公告)号：US10578767B2
公开(公告)日：2020-03-03
申请号：US14421372
申请日：2013-08-23
申请人： Hongmei Li , Tao Sun
发明人： Hongmei Li , Tao Sun
IPC分类号： G01V99/00 , G06F17/18 , G01V1/30
摘要： A method of simulating a hydrocarbon reservoir is disclosed. A process-based model is generated that mimics a depositional process of the reservoir. The process-based model is analyzed to extract statistics of geometries of a body that forms part of the reservoir, and depositional rules of the body. An object-based modeling method is applied to construct multiple unconditional geologic models of the body using the statistics and the depositional rules. Training images are constructed using the multiple unconditional geologic models. Well data and gross thickness data are assigned into a simulation grid. A single multiple-point geostatistical simulation is performed using the training images. A three-dimensional (3D) reservoir model is constructed using results of the multiple-point geostatistical simulation.

10. 发明授权

US08871797B2 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto 有权
标题翻译：二芳基和芳基杂芳基脲衍生物作为可用于预防和治疗与之相关的疾病的5-HT2A 5-羟色胺受体的调节剂
公开(公告)号：US08871797B2
公开(公告)日：2014-10-28
申请号：US13619137
申请日：2012-09-14
申请人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter I. Dosa
发明人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter I. Dosa
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D231/16 , C07D401/12 , C07D405/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders and the like.The present invention also relates to the method of prophylaxis or treatment of 5-HT2A serotonin receptor mediated disorders in combination with a dopamine D2 receptor antagonist such as haloperidol, administered separately or together.
摘要翻译：本发明涉及式（I）的某些吡唑衍生物及其药物组合物，其调节5-HT2A 5-羟色胺受体的活性。化合物及其药物组合物涉及可用于预防或治疗血小板凝集，冠状动脉疾病，心肌梗死，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘或其症状的方法，激动或症状，行为障碍，药物诱发的精神病，兴奋性精神病，杜蕾特勒杜勒特综合征，躁狂症，有机或非精神病精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症和精神分裂症以及相关疾病和睡眠障碍，睡眠障碍，糖尿病相关疾病等。本发明还涉及与单独或一起施用的多巴胺D2受体拮抗剂如氟哌啶醇组合预防或治疗5-HT2A 5-羟色胺受体介导的病症的方法。

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