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1. 发明申请

US20160376629A1 Use of Bacterial Beta-Lactamase for In Vitro Diagnostics and In Vivo Imaging, Diagnostics and Therapeutics 审中-公开
标题翻译：使用细菌β-内酰胺酶进行体外诊断和体内成像，诊断和治疗
公开(公告)号：US20160376629A1
公开(公告)日：2016-12-29
申请号：US15262374
申请日：2016-09-12
申请人： Jeffrey D. Cirillo , Jianghong Rao
发明人： Jeffrey D. Cirillo , Jianghong Rao
IPC分类号： C12Q1/18 , G01N21/64 , G01N21/78
CPC分类号： C12Q1/18 , A61K49/0013 , A61K49/0021 , A61K49/0028 , A61K49/0032 , A61K49/0041 , A61K49/0052 , C09B57/02 , C12Q1/04 , C12Q1/34 , C12Q1/66 , G01N21/6408 , G01N21/6428 , G01N21/78 , G01N2021/6417 , G01N2201/061 , G01N2333/986
摘要： Provided herein provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. Also provided is an in vitro method to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility.
摘要翻译：本文提供了一种用于监测病原细菌的药物敏感性的测定系统，其包括致病细菌的β-内酰胺酶的着色产生底物，用于可见地检测其底物上的β-内酰胺酶的产物和读数器配置为量化可见检测到的产品。还提供了一种体外方法来确定对具有β-内酰胺酶活性的致病细菌例如致病分枝杆菌有效的药物的易感性。在β-内酰胺酶底物的存在下，将激发波长输送到从具有病原菌感染的受试者获得的生物样品。在受试者的β-内酰胺酶的产物的发射波长处的信号强度，例如荧光，发光或比色信号与药物敏感性相关。

2. 发明授权

US08592227B2 Hybrid quantum dot/protein nanostructure, methods of making, and methods of use thereof 失效
标题翻译：杂交量子点/蛋白质纳米结构，制备方法及其使用方法
公开(公告)号：US08592227B2
公开(公告)日：2013-11-26
申请号：US13068174
申请日：2011-05-04
申请人： Nan Ma , Jianghong Rao
发明人： Nan Ma , Jianghong Rao
IPC分类号： H01L21/00
CPC分类号： G01N33/582 , B82Y5/00 , B82Y15/00 , G01N33/588
摘要： Embodiments of the present disclosure include hybrid quantum dot/protein nanostructure, hybrid quantum dot/protein nanostructure systems, methods of using hybrid quantum dot/protein nanostructures, and the like.
摘要翻译：本公开的实施方案包括杂交量子点/蛋白质纳米结构，杂交量子点/蛋白质纳米结构体系，使用混合量子点/蛋白质纳米结构的方法等。

3. 发明授权

US08530178B2 Hydrolase detection system with caged substrates 失效
标题翻译：水解酶检测系统与笼式底物
公开(公告)号：US08530178B2
公开(公告)日：2013-09-10
申请号：US12445378
申请日：2007-10-17
申请人： Daniel Sobek , Jianghong Rao
发明人： Daniel Sobek , Jianghong Rao
IPC分类号： C12Q1/42
CPC分类号： C12Q1/34
摘要： An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecule from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
摘要翻译：酶检测方法包括形成笼状基材; 通过从笼形基底切割笼状分子释放未起皮的底物; 并且从与未起始的底物反应的生物发光共振能量转移发光纳米晶体共轭物发射发光。

4. 发明申请

US20120269734A1 Self-Illuminating Dot Systems and Methods of Use Thereof 失效
标题翻译：自发光点系统及其使用方法
公开(公告)号：US20120269734A1
公开(公告)日：2012-10-25
申请号：US13495208
申请日：2012-06-13
申请人： Jianghong Rao , Min-kyung So , Chenjie Xu , Andreas M. Loening , Sanjiv S. Gambhir
发明人： Jianghong Rao , Min-kyung So , Chenjie Xu , Andreas M. Loening , Sanjiv S. Gambhir
IPC分类号： C12N9/96 , A61K38/44 , G01N21/76 , A61K49/00 , B82Y15/00
CPC分类号： G01N33/543 , B82Y15/00 , G01N21/763 , G01N33/588
摘要： Generally, aspects of the present disclosure are directed to conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like.
摘要翻译：通常，本公开的方面涉及共轭系统，自发光量子点缀合物，检测宿主中靶标的方法，治疗宿主中的疾病的方法等。

5. 发明申请

US20110278554A1 Hybrid quantum dot/protein nanostructure, methods of making, and methods of use thereof 失效
标题翻译：杂交量子点/蛋白质纳米结构，制备方法及其使用方法
公开(公告)号：US20110278554A1
公开(公告)日：2011-11-17
申请号：US13068174
申请日：2011-05-04
申请人： Nan Ma , Jianghong Rao
发明人： Nan Ma , Jianghong Rao
IPC分类号： H01L51/30 , H01L51/40
CPC分类号： G01N33/582 , B82Y5/00 , B82Y15/00 , G01N33/588
摘要： Embodiments of the present disclosure include hybrid quantum dot/protein nanostructure, hybrid quantum dot/protein nanostructure systems, methods of using hybrid quantum dot/protein nanostructures, and the like.
摘要翻译：本公开的实施方案包括杂交量子点/蛋白质纳米结构，杂交量子点/蛋白质纳米结构体系，使用混合量子点/蛋白质纳米结构的方法等。

6. 发明申请

US20110200529A1 ACTIVATABLE BIOLUMINESCENT PROBE SYSTEM AND METHOD OF USE THEREOF 审中-公开
标题翻译：可激活的生物发光探测系统及其使用方法
公开(公告)号：US20110200529A1
公开(公告)日：2011-08-18
申请号：US13119721
申请日：2009-09-17
申请人： Jianghong Rao , Zuyong Xia
发明人： Jianghong Rao , Zuyong Xia
IPC分类号： A61K49/00 , G01N21/76 , C12M1/34
CPC分类号： G01N33/542
摘要： A method of use of an activatable bioluminescent probe system includes: providing a bioluminescent protein and a quencher in a reaction environment; modifying a ligand between the quencher and the bioluminescent protein using a ligand interacting molecule; adding a bioluminescence initiating molecule to the reaction environment; and measuring light originating from the interaction between the bioluminescent protein and the bioluminescence initiating molecule.
摘要翻译：使用可激活的生物发光探针系统的方法包括：在反应环境中提供生物发光蛋白和猝灭剂; 使用配体相互作用分子修饰猝灭剂和生物发光蛋白质之间的配体; 在反应环境中加入生物发光引发分子; 并测量源自生物发光蛋白和生物发光起始分子之间相互作用的光。

7. 发明授权

US07867758B2 Bioluminogenic assay system for measuring beta-lactamase activity 有权
标题翻译：用于测量β-内酰胺酶活性的生物发光测定系统
公开(公告)号：US07867758B2
公开(公告)日：2011-01-11
申请号：US12060864
申请日：2008-04-01
申请人： Jianghong Rao , Min-kyung So , Hequan Yao
发明人： Jianghong Rao , Min-kyung So , Hequan Yao
IPC分类号： C12M1/00 , C12Q1/34
CPC分类号： C12Q1/66 , C12Q1/34 , G01N2333/986
摘要： A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic substrate; co-exposing the bioluminogenic substrate to a bioluminescence indicator reaction that employs the bioluminescence initiating compound as a substrate; and detecting a light from the bioluminescence indicator reaction as a measure of the activity of the beta-lactamase enzyme.
摘要翻译：生物发光测定系统，包括：提供掺入β-内酰胺抗生素的生物发光底物，生物发光引发化合物和将β-内酰胺抗生素与生物发光引发化合物连接的化学键; 将生物发光底物暴露于催化生物发光起始化合物从生物发光底物释放的β-内酰胺酶; 将生物发光底物共同暴露于采用生物发光引发化合物作为底物的生物发光指示剂反应; 并检测来自生物发光指示剂反应的光作为β-内酰胺酶活性的量度。

8. 发明申请

US20100068741A1 ASSAY SYSTEM FOR ADENOSINE TRIPHOSPHATE AND CREATINE KINASE 审中-公开
标题翻译：腺苷三磷酸和发酵激酶的测定系统
公开(公告)号：US20100068741A1
公开(公告)日：2010-03-18
申请号：US12445384
申请日：2007-10-17
申请人： Daniel Sobek , Jianghong Rao
发明人： Daniel Sobek , Jianghong Rao
IPC分类号： C12Q1/48
CPC分类号： G01N33/587 , G01N33/542 , G01N33/5735 , G01N2333/9123
摘要： An assay method includes providing a luminescent nanocrystal; combining a solution having an adenosine triphosphate molecule; and displaying a light emission by the luminescent nanocrystal and the solution combined.
摘要翻译：测定方法包括提供发光纳米晶体; 组合具有三磷酸腺苷分子的溶液; 并且通过发光纳米晶体显示发光并且将所述溶液组合。

9. 发明申请

US20090004117A1 Self-Illiminating Dot Systems and Methods of Use Thereof 有权
标题翻译：自我点点系统及其使用方法
公开(公告)号：US20090004117A1
公开(公告)日：2009-01-01
申请号：US12159150
申请日：2007-01-04
申请人： Jianghong Rao , Min-kyung So , Chenjie Xu , Andreas M. Loening , Sanjiv S. Gambhir
发明人： Jianghong Rao , Min-kyung So , Chenjie Xu , Andreas M. Loening , Sanjiv S. Gambhir
IPC分类号： A61K49/00 , C12Q1/02
CPC分类号： G01N33/543 , B82Y15/00 , G01N21/763 , G01N33/588
摘要： Generally, aspects of the present disclosure are directed to conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like.
摘要翻译：通常，本公开的方面涉及共轭系统，自发光量子点缀合物，检测宿主中靶标的方法，治疗宿主中的疾病的方法等。

10. 发明授权

US07396926B2 Beta-lactamase substrates having phenolic ethers 有权
标题翻译：具有酚醚的β-内酰胺酶底物
公开(公告)号：US07396926B2
公开(公告)日：2008-07-08
申请号：US10044486
申请日：2002-01-11
申请人： Roger Y. Tsien , Jianghong Rao
发明人： Roger Y. Tsien , Jianghong Rao
IPC分类号： C07D501/34 , C07D501/30 , C07D501/28 , C07D501/24 , C07D505/18 , C07D505/20 , C07D519/06 , G01N33/573 , C07D463/22 , C07D463/20 , C07D463/18
CPC分类号： C12Q1/6897 , C07D463/18 , C07D501/00 , C07D505/00 , C07F9/65613 , C12Q1/34
摘要： Provided are fluorescent substrates for β-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, β-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula I.
摘要翻译：提供具有通式I的β-内酰胺酶的荧光底物：其中R是苄基，2-噻吩基甲基或氰基甲基; R'选自H，生理上可接受的盐或金属，酯基，铵阳离子，-CHR 2 OCO（CH 2）n，（CH 3）3，酰基硫甲基，酰氧基-α- 苄基，异丙基丁内酰胺，甲氧基羰氧基甲基，苯基，甲基亚磺酰基甲基，β-吗啉代乙基，二烷基氨基乙基和二烷基氨基羰基氧基甲基，其中R 2选自H和低级烷基; A选自S，O，SO，SO 2和CH 2; Z是供体荧光部分。还提供了通式I化合物的使用方法。

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