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1. 发明授权

US09610031B2 Transcutaneous analyte sensor 有权
公开(公告)号：US09610031B2
公开(公告)日：2017-04-04
申请号：US13086160
申请日：2011-04-13
申请人： Mark Brister , Paul V. Neale , James R. Petisce , James Patrick Thrower , Sean Saint , John Nolting
发明人： Mark Brister , Paul V. Neale , James R. Petisce , James Patrick Thrower , Sean Saint , John Nolting
IPC分类号： A61B5/1473 , A61B5/1495 , A61B5/1486 , A61M5/14 , A61B5/05 , A61B5/145 , A61B5/00 , A61B5/15 , A61B17/34 , A61M5/172 , A61M5/158 , A61M5/142
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/05 , A61B5/14 , A61B5/1411 , A61B5/145 , A61B5/14503 , A61B5/14507 , A61B5/14514 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6801 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/72 , A61B17/3468 , A61B2017/3492 , A61B2560/0223 , A61B2560/045 , A61M5/14 , A61M5/14244 , A61M5/1723 , A61M2005/1585 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host including a sensor; a mounting unit for placement on the skin of a host; a sensor introducer coupled to the sensor and to the mounting unit, the sensor introducer configured to transcutaneously introduce a portion of the sensor through a skin of the host to a first position relative to the mounting unit, and a data processing unit configured to couple to the mounting unit, the data processing unit displacing the sensor to a second position relative to the mounting unit upon coupling to the mounting unit.

2. 发明授权

US08615282B2 Analyte sensor 有权
公开(公告)号：US08615282B2
公开(公告)日：2013-12-24
申请号：US11360262
申请日：2006-02-22
申请人： Mark Brister , Steve Masterson , Sean Saint , Peter Simpson , Matthew D. Wightlin , James R. Petisce , Jack Pryor , Vance Swanson , John Nolting
发明人： Mark Brister , Steve Masterson , Sean Saint , Peter Simpson , Matthew D. Wightlin , James R. Petisce , Jack Pryor , Vance Swanson , John Nolting
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/7264 , A61B5/742 , A61B2560/0223 , A61B2560/0276 , A61B2560/028 , A61L2/12 , A61L2/206 , G06F19/00 , Y02A90/22 , Y02A90/26 , Y10T29/49004
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

3. 发明授权

US08430012B1 Braiding mechanism and methods of use 有权
标题翻译：编织机理及使用方法
公开(公告)号：US08430012B1
公开(公告)日：2013-04-30
申请号：US13570499
申请日：2012-08-09
申请人： Philippe Marchand , John Nolting , Darrin J Kent , Tan Q Dinh , Hung P Tran , James A Milburn , James M Thompson
发明人： Philippe Marchand , John Nolting , Darrin J Kent , Tan Q Dinh , Hung P Tran , James A Milburn , James M Thompson
IPC分类号： D04C3/00
CPC分类号： D04C3/42 , D04C1/06 , D04C3/40 , D04C3/48 , D04C5/00 , D10B2509/04 , D10B2509/06
摘要： A device and method for forming a tubular braid comprising a plurality of filaments. The braiding machine comprises a disc with a mandrel extending from the center in a perpendicular direction and a plurality of catch mechanisms arranged circumferentially around the edge of the disc. A plurality of filaments are temporarily affixed to the mandrel, each filament extending from the mandrel toward the edge of the disc and engaging the edge of the disc at a discrete point of engagement. The plurality of catch mechanisms are attached to actuators adapted to move the catch mechanisms in a generally radial direction relative to the edge of the disc to allow the catch mechanism to engage a subset of the filaments and move the engaged filaments beyond the circumferential edge of the disc.
摘要翻译：一种用于形成包括多个细丝的管状编织物的装置和方法。编织机包括具有从中心沿垂直方向延伸的心轴的盘和围绕盘的边缘周向布置的多个捕获机构。许多细丝临时固定在心轴上，每根细丝从心轴向盘的边缘延伸并且在离散的接合点处与盘的边缘接合。多个捕捉机构附接到致动器，其适于相对于盘的边缘在大致径向方向上移动捕获机构，以允许捕获机构接合细丝的一部分并且将所接合的细丝移动超过所述纤维的圆周边缘光盘。

4. 发明授权

US07946984B2 Transcutaneous analyte sensor 有权
公开(公告)号：US07946984B2
公开(公告)日：2011-05-24
申请号：US11077883
申请日：2005-03-10
申请人： Mark Brister , Paul V. Neale , James R. Petisce , James Patrick Thrower , Sean Saint , John Nolting
发明人： Mark Brister , Paul V. Neale , James R. Petisce , James Patrick Thrower , Sean Saint , John Nolting
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/05 , A61B5/14 , A61B5/1411 , A61B5/145 , A61B5/14503 , A61B5/14507 , A61B5/14514 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6801 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/72 , A61B17/3468 , A61B2017/3492 , A61B2560/0223 , A61B2560/045 , A61M5/14 , A61M5/14244 , A61M5/1723 , A61M2005/1585 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

5. 发明申请

US20080200789A1 ANALYTE SENSOR 有权
标题翻译：分析传感器
公开(公告)号：US20080200789A1
公开(公告)日：2008-08-21
申请号：US12055203
申请日：2008-03-25
申请人： Mark Brister , Peter C. Simpson , Apurv Ullas Kamath , Jacob S. Leach , Vance Swanson , Sean Saint , John Nolting
发明人： Mark Brister , Peter C. Simpson , Apurv Ullas Kamath , Jacob S. Leach , Vance Swanson , Sean Saint , John Nolting
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/1495 , A61B5/412 , A61B5/6848 , A61B5/6849 , A61M5/14 , A61M5/16804 , A61M25/00 , A61M2230/201 , C12Q1/001 , C12Q1/006 , G06F19/3468 , G16H40/40 , Y02A90/26
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统包括血管通路装置，传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

6. 发明申请

US20070027530A1 Intraluminal device, catheter assembly, and method of use thereof 审中-公开
标题翻译：管腔内装置，导管组件及其使用方法
公开(公告)号：US20070027530A1
公开(公告)日：2007-02-01
申请号：US11189415
申请日：2005-07-26
申请人： Sean Saint , John Nolting
发明人： Sean Saint , John Nolting
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/07 , A61F2/91 , A61F2/958 , A61F2002/91541 , A61F2002/9155 , A61F2230/0013 , A61F2250/0067 , A61F2250/0068
摘要： An intraluminal device, an intraluminal stent delivery system, and a method of manufacturing the same. The device comprises a body including at least one strut. The strut comprises at least one raised portion positioned on an outer surface of the body. At least one therapeutic agent coating is positioned on the strut. The therapeutic agent coating comprises an effective therapeutic agent coating area greater than about 50 percent of a strut total surface area. The stent delivery system includes a catheter and the stent disposed on the catheter. The manufacturing method includes providing a body including at least one strut. The strut comprises at least one raised portion positioned on an outer surface of the body. At least one therapeutic agent coating is applied on the strut to an effective therapeutic agent coating area greater than about 50 percent of a strut total surface area.
摘要翻译：管腔内装置，腔内支架输送系统及其制造方法。该装置包括包括至少一个支柱的主体。支柱包括位于主体的外表面上的至少一个凸起部分。至少一种治疗剂涂层位于支柱上。治疗剂涂层包括大于支架总表面积的约50％的有效治疗剂涂层面积。支架输送系统包括导管和设置在导管上的支架。制造方法包括提供包括至少一个支柱的主体。支柱包括位于主体的外表面上的至少一个凸起部分。将至少一种治疗剂涂层施加到支柱上，以达到大于支柱总表面积的约50％的有效治疗剂涂覆面积。

7. 发明申请

US20060210600A1 Coated stent with timed release of multiple therapeutic agents to inhibit restenosis adjacent to the stent ends 审中-公开
标题翻译：涂层支架具有定时释放多种治疗剂以抑制支架末端附近的再狭窄
公开(公告)号：US20060210600A1
公开(公告)日：2006-09-21
申请号：US10563785
申请日：2004-07-01
申请人： John Nolting
发明人： John Nolting
IPC分类号： A61F2/00
CPC分类号： A61F2/86 , A61F2/0077 , A61F2/07 , A61F2/90 , A61F2002/30322 , A61F2250/0026 , A61F2250/003 , A61F2250/0035 , A61F2250/0067
摘要： The present invention provides a system for treating a vascular condition that inhibits restenosis adjacent to the ends of a stent by delivering a therapeutic agent to the vessel wall at and beyond the stent ends. The system comprises a catheter and a coated stent operably coupled to the catheter. The coated stent includes a plurality of therapeutic coatings disposed on the distal and proximal ends of a stent framework. A plurality of therapeutic agents is released from the plurality of therapeutic coatings, the therapeutic agents being released sequentially to inhibit restenosis adjacent to the ends of the stent. The system may further include a therapeutic agent and a timing coating disposed on a mid-portion of the stent framework.
摘要翻译：本发明提供了一种用于治疗血管状态的系统，该系统通过在支架端部和支架端部之上输送治疗剂到容器壁来抑制支架末端附近的再狭窄。该系统包括可操作地连接到导管的导管和涂层支架。涂覆的支架包括设置在支架框架的远端和近端的多个治疗涂层。从多个治疗涂层释放多种治疗剂，治疗剂被顺序释放以抑制与支架端部相邻的再狭窄。该系统还可以包括设置在支架框架的中部的治疗剂和定时涂层。

8. 发明授权

US09078626B2 Transcutaneous analyte sensor 有权
公开(公告)号：US09078626B2
公开(公告)日：2015-07-14
申请号：US13077884
申请日：2011-03-31
申请人： Mark Brister , Paul V. Neale , James R. Pestisce , James Patrick Thrower , Sean Saint , John Nolting
发明人： Mark Brister , Paul V. Neale , James R. Pestisce , James Patrick Thrower , Sean Saint , John Nolting
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/15 , A61B5/1495 , A61B5/05 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/05 , A61B5/14 , A61B5/1411 , A61B5/145 , A61B5/14503 , A61B5/14507 , A61B5/14514 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6801 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/72 , A61B17/3468 , A61B2017/3492 , A61B2560/0223 , A61B2560/045 , A61M5/14 , A61M5/14244 , A61M5/1723 , A61M2005/1585 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

9. 发明授权

US08826791B2 Braiding mechanism and methods of use 有权
标题翻译：编织机理及使用方法
公开(公告)号：US08826791B2
公开(公告)日：2014-09-09
申请号：US13608882
申请日：2012-09-10
申请人： James M. Thompson , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
发明人： James M. Thompson , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
IPC分类号： D04C3/40 , D04C3/48 , D04C1/00 , D04C3/42
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments. The braiding machine includes a circular array of filament guiding members defining a plane; a mandrel defining an axis and adapted to carry one or more filaments extending from the mandrel to the circular array; a plurality of filaments extending from the mandrel in a radial array; a plurality of actuator mechanisms disposed operably about the disc; and a rotating mechanism adapted to rotate one or more filaments. The actuator mechanisms and rotating mechanism are configured to move each of the one or more filaments about the mandrel axis in a path comprising a series of arcs and radial movements. The braiding machine may alternately first and second annular members, a mandrel, first and second plurality of tubular wire guides, and a plurality of wires extending from the mandrel.
摘要翻译：用于形成包括多根细丝的管状编织物的装置和方法。编织机包括限定平面的细丝引导构件的圆形阵列; 定义轴线并适于承载从所述心轴延伸到所述圆形阵列的一个或多个细丝的心轴; 从心轴以径向阵列延伸的多根细丝; 多个致动器机构围绕盘可操作地设置; 以及适于旋转一个或多个细丝的旋转机构。致动器机构和旋转机构被构造成在包括一系列弧和径向运动的路径中围绕心轴轴线移动一个或多个细丝中的每一个。编织机可以交替地选择第一和第二环形构件，心轴，第一和第二多个管状导线引导件以及从心轴延伸的多个线。

10. 发明申请

US20130092013A1 BRAIDING MECHANISM AND METHODS OF USE 有权
标题翻译：制动机制及使用方法
公开(公告)号：US20130092013A1
公开(公告)日：2013-04-18
申请号：US13608882
申请日：2012-09-10
申请人： JAMES M. THOMPSON , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
发明人： JAMES M. THOMPSON , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
IPC分类号： D04C3/40 , D04C1/00
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments. The braiding machine includes a circular array of filament guiding members defining a plane; a mandrel defining an axis and adapted to carry one or more filaments extending from the mandrel to the circular array; a plurality of filaments extending from the mandrel in a radial array; a plurality of actuator mechanisms disposed operably about the disc; and a rotating mechanism adapted to rotate one or more filaments. The actuator mechanisms and rotating mechanism are configured to move each of the one or more filaments about the mandrel axis in a path comprising a series of arcs and radial movements. The braiding machine may alternately first and second annular members, a mandrel, first and second plurality of tubular wire guides, and a plurality of wires extending from the mandrel.
摘要翻译：用于形成包括多根细丝的管状编织物的装置和方法。编织机包括限定平面的细丝引导构件的圆形阵列; 定义轴线并适于承载从所述心轴延伸到所述圆形阵列的一个或多个细丝的心轴; 从心轴以径向阵列延伸的多根细丝; 多个致动器机构围绕盘可操作地设置; 以及适于旋转一个或多个细丝的旋转机构。致动器机构和旋转机构被构造成在包括一系列弧和径向运动的路径中围绕心轴轴线移动一个或多个细丝中的每一个。编织机可以交替地选择第一和第二环形构件，心轴，第一和第二多个管状导线引导件以及从心轴延伸的多个线。

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