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1. 发明申请

US20060051798A1 Bio-barcodes based on oligonucleotide-modified particles 有权
标题翻译：基于寡核苷酸修饰颗粒的生物条形码
公开(公告)号：US20060051798A1
公开(公告)日：2006-03-09
申请号：US11217106
申请日：2005-08-31
申请人： Chad Mirkin , So-Jung Park , Jwa-Min Nam
发明人： Chad Mirkin , So-Jung Park , Jwa-Min Nam
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00274 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2563/155 , C12Q2525/197 , C12Q2563/185
摘要： The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in one solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，蛋白质如抗体，在样品中。特别地，本发明涉及利用报道寡核苷酸作为生化条形码来检测一种溶液中多种蛋白质结构或其他目标分析物的方法。

2. 发明申请

US20060040286A1 Bio-barcode based detection of target analytes 审中-公开
标题翻译：基于生物条形码的目标分析物检测
公开(公告)号：US20060040286A1
公开(公告)日：2006-02-23
申请号：US11127808
申请日：2005-05-12
申请人： Chad Mirkin , Jwa-Min Nam , Byung-Keun Oh , C. Shad Thaxton , Dimitra Georganopoulou
发明人： Chad Mirkin , Jwa-Min Nam , Byung-Keun Oh , C. Shad Thaxton , Dimitra Georganopoulou
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , G01N33/54333 , C12Q2565/501 , C12Q2565/113 , C12Q2563/179 , C12Q2563/143 , C12Q2563/149 , C12Q2563/155
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。

3. 发明申请

US20050037397A1 Bio-barcode based detection of target analytes 审中-公开
标题翻译：基于生物条形码的目标分析物检测
公开(公告)号：US20050037397A1
公开(公告)日：2005-02-17
申请号：US10877750
申请日：2004-06-25
申请人： Chad Mirkin , Jwa-Min Nam , C. Thaxton
发明人： Chad Mirkin , Jwa-Min Nam , C. Thaxton
IPC分类号： C07B61/00 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： B82Y30/00 , B01J2219/005 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00743 , C07B2200/11 , C07H21/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6834 , C40B40/00 , C12Q2565/113 , C12Q2563/179
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。

4. 发明申请

US20130029360A1 DIMERIC CORE-SHELL NANOSTRUCTURE LABELED WITH RAMAN ACTIVE MOLECULE LOCALIZED AT INTERPARTICLE JUNCTION, USE THEREOF, AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用拉曼激活分子标记的二核心体纳米结构，其使用方法及其制备方法
公开(公告)号：US20130029360A1
公开(公告)日：2013-01-31
申请号：US13514920
申请日：2010-12-10
申请人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
发明人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
IPC分类号： G01N33/566 , C07K16/00 , C07H21/00 , C12N9/96 , C07K14/00 , B82Y15/00
CPC分类号： G01N33/54373 , C12Q1/6816 , C12Q1/6834 , C12Q2563/107 , C12Q2563/155 , C12Q2565/628 , G01N33/54346 , C12Q2565/632 , C12Q2563/143 , C12Q2537/125
摘要： The present invention relates to a nanoparticle dimer in which Raman-active molecules are located at a binding portion of the nanoparticle dimer, and more particularly, to a core-shell nanoparticle dimer comprising: a gold or silver core having a surface to which oligonucleotides are bonded; and a gold or silver shell covering the core. In addition, the present invention relates to the core-shell nanoparticle dimer, to a method for preparing same, and to the use thereof.
摘要翻译：本发明涉及纳米颗粒二聚体，其中拉曼活性分子位于纳米颗粒二聚体的结合部分，更具体地涉及核 - 壳纳米颗粒二聚体，其包含：具有寡核苷酸表面的金或银芯保税以及覆盖芯的金或银壳。此外，本发明涉及核 - 壳纳米颗粒二聚体，其制备方法及其用途。

5. 发明授权

US07323309B2 Bio-barcodes based on oligonucleotide-modified particles 有权
标题翻译：基于寡核苷酸修饰颗粒的生物条形码
公开(公告)号：US07323309B2
公开(公告)日：2008-01-29
申请号：US11217106
申请日：2005-08-31
申请人： Chad A. Mirkin , So-Jung Park , Jwa-Min Nam
发明人： Chad A. Mirkin , So-Jung Park , Jwa-Min Nam
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： B82Y30/00 , B01J2219/00274 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2563/155 , C12Q2525/197 , C12Q2563/185
摘要： The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in one solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，蛋白质如抗体，在样品中。特别地，本发明涉及利用报道寡核苷酸作为生化条形码来检测一种溶液中多种蛋白质结构或其他目标分析物的方法。

6. 发明申请

US20130330839A1 SINGLE NANOPARTICLE HAVING A NANOGAP BETWEEN A CORE MATERIAL AND A SHELL MATERIAL, AND PREPARATION METHOD THEREOF 有权
标题翻译：具有核心材料和壳材料的纳米粒子的单一纳米粒子及其制备方法
公开(公告)号：US20130330839A1
公开(公告)日：2013-12-12
申请号：US13989709
申请日：2011-11-24
申请人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
发明人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , A61K49/0002 , G01N33/54346 , G01N2021/653
摘要： The present invention is to provide a nanoparticle, which can be used effectively for Raman analysis based on very high amplification effect of electromagnetic signal by plasomonic coupling of nanogap formation inside thereof and high reproducibility, and which includes core and surrounding shell with nanogap formation between the same and the method of synthesis thereof. The present invention is also to provide the method for detecting the analyte using the above nanoparticle and the analyte detection kit including the above nanoparticle.
摘要翻译：本发明提供一种纳米颗粒，其可以基于电磁信号的非常高的放大效应而有效地用于拉曼分析，其通过等离子体耦合其内部的纳米孔隙形成和高重现性，并且其包括核和周围壳体之间的纳米隙形成相同的方法及其合成方法。本发明还提供使用上述纳米颗粒检测分析物的方法和包括上述纳米颗粒的分析物检测试剂盒。

7. 发明申请

US20120225457A1 NANOPARTICLE-NUCLEIC ACID COMPLEX AND METHOD OF LINEARIZING TARGET NUCLEIC ACID 审中-公开
标题翻译：纳米核酸复合物和靶向核酸的线性化方法
公开(公告)号：US20120225457A1
公开(公告)日：2012-09-06
申请号：US13294596
申请日：2011-11-11
申请人： June-young LEE , Jwa-min NAM , Su-hyeon KIM , Woo-chang LEE , Jae-young KIM , Joo-won RHEE , Young-kwang LEE , Dong-kwon LIM , Jae-ho HWANG
发明人： June-young LEE , Jwa-min NAM , Su-hyeon KIM , Woo-chang LEE , Jae-young KIM , Joo-won RHEE , Young-kwang LEE , Dong-kwon LIM , Jae-ho HWANG
IPC分类号： C12P19/34 , B32B5/16 , C07H21/00 , B82Y99/00
CPC分类号： C07H21/00 , B82Y15/00 , C12P19/34 , Y10T428/2991
摘要： A nanoparticle-nucleic acid complex and a method of linearizing a target nucleic acid by using the nanoparticle-nucleic acid complex are disclosed. By using the nanoparticle-nucleic acid complex and the method, nucleotide sequence analysis and mapping of a target nucleic acid may be efficiently performed.
摘要翻译：公开了纳米颗粒 - 核酸复合物和通过使用纳米颗粒 - 核酸复合物线性化靶核酸的方法。通过使用纳米粒子 - 核酸复合物和该方法，可以有效地进行目标核酸的核苷酸序列分析和作图。

8. 发明授权

US07842344B2 Peptide and protein arrays and direct-write lithographic printing of peptides and proteins 有权
标题翻译：肽和蛋白质阵列和肽和蛋白质的直写平版印刷
公开(公告)号：US07842344B2
公开(公告)日：2010-11-30
申请号：US10788414
申请日：2004-03-01
申请人： Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
发明人： Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
IPC分类号： B05D1/36
CPC分类号： G03B27/42 , Y10S977/857 , Y10S977/884 , Y10S977/885 , Y10S977/886
摘要： The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.
摘要翻译：本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。图案可以是点直径和线宽小于1,000nm的点或线。尖端和底物表面可适用于肽和蛋白质光刻。

9. 发明授权

US06974669B2 Bio-barcodes based on oligonucleotide-modified nanoparticles 有权
标题翻译：基于寡核苷酸修饰的纳米粒子的生物条形码
公开(公告)号：US06974669B2
公开(公告)日：2005-12-13
申请号：US10108211
申请日：2002-03-27
申请人： Chad A. Mirkin , So-Jung Park , Jwa-Min Nam
发明人： Chad A. Mirkin , So-Jung Park , Jwa-Min Nam
IPC分类号： C07B61/00 , C07H21/00 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： B82Y30/00 , B01J2219/00274 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2563/155 , C12Q2525/197 , C12Q2563/185
摘要： The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in one solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，蛋白质如抗体，在样品中。特别地，本发明涉及利用报道寡核苷酸作为生化条形码来检测一种溶液中多种蛋白质结构或其他目标分析物的方法。

10. 发明申请

US20110124008A1 NOVEL Au/Ag CORE-SHELL COMPOSITE USEFUL FOR BIOSENSOR 审中-公开
标题翻译：新颖的Au / Ag芯壳复合材料可用于生物传感器
公开(公告)号：US20110124008A1
公开(公告)日：2011-05-26
申请号：US12991537
申请日：2009-05-07
申请人： Jwa-Min Nam , Dong-Kwon Lim , In-Jung Kim
发明人： Jwa-Min Nam , Dong-Kwon Lim , In-Jung Kim
IPC分类号： G01N33/53 , B32B1/00 , B01J19/00
CPC分类号： G01N21/658 , B82Y30/00 , G01N33/54346 , Y10T428/2991
摘要： In accordance with an aspect of the present invention, there is provided an Au/Ag core-shell composite including an Au nanoparticle; an Ag nanoparticle layer surrounding the Au nanoparticle; and a receptor having a target material recognition site bondable or reactable with a target material, wherein one end of the receptor is bonded on the surface of the Au nanoparticle, so that a portion of the receptor is embedded into the Ag nanoparticle layer, and the target material recognition site is exposed to the outside of the Ag nanoparticle layer. The Au/Ag core-shell composite can provide a stable bond between Au nanoparticle and organic molecule, and superior optical characteristics of Ag nanoparticle. Thus, a biosensor using the composite in accordance with an aspect of the present invention can effectively and efficiently detect target bio material and be variously used in medical and pharmaceutics.
摘要翻译：根据本发明的一个方面，提供一种包含Au纳米颗粒的Au / Ag核 - 壳复合材料; 围绕Au纳米颗粒的Ag纳米颗粒层; 以及具有可与靶材料结合或可与靶材料反应的靶材料识别位点的受体，其中所述受体的一端键合在所述Au纳米颗粒的表面上，使得所述受体的一部分嵌入到所述Ag纳米颗粒层中，并且靶材料识别位点暴露于Ag纳米颗粒层的外部。 Au / Ag核 - 壳复合材料可以在Au纳米颗粒和有机分子之间提供稳定的键合，并且具有优异的Ag纳米颗粒的光学特性。因此，使用根据本发明的一个方面的复合材料的生物传感器可以有效和高效地检测目标生物材料，并且可以在医疗和药物学中被多种用途。

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