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1. 发明申请

US20100324415A1 PLATFORM FOR DETECTION OF TISSUE STRUCTURE CHANGE 审中-公开
标题翻译：用于检测组织结构变化的平台
公开(公告)号：US20100324415A1
公开(公告)日：2010-12-23
申请号：US12754490
申请日：2010-04-05
申请人： Darrel D. Drinan , Carl F. Edman , Naresh C. Bhavaraju
发明人： Darrel D. Drinan , Carl F. Edman , Naresh C. Bhavaraju
IPC分类号： A61B6/00
CPC分类号： A61B5/05 , A61B5/0002 , A61B5/0507 , A61B5/1075 , A61B5/413 , A61B8/08
摘要： Aspects include methods and apparatuses for determining change over time in one or more measured regions of a body using a plurality of data sets obtained by analysis of applied signals to said region. The method may include transmitting and receiving one or more of electromagnetic wave signals, applied acoustic wave signals and electrical signals transmitted through or reflected off of a portion of the measured body region.
摘要翻译：方面包括使用通过分析所施加的信号到所述区域获得的多个数据集来确定身体的一个或多个测量区域中随时间变化的方法和装置。所述方法可以包括发射和接收一个或多个电磁波信号，施加的声波信号以及通过测量的身体区域的一部分透射或反射的电信号。

2. 发明授权

US07204833B1 Multi-modal system for detection and control of changes in brain state 有权
标题翻译：用于检测和控制脑状态变化的多模态系统
公开(公告)号：US07204833B1
公开(公告)日：2007-04-17
申请号：US10909488
申请日：2004-08-02
申请人： Ivan Osorio , Naresh C. Bhavaraju
发明人： Ivan Osorio , Naresh C. Bhavaraju
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B5/031 , A61B5/0478 , A61B5/14553 , A61B5/4094 , A61F2007/0056 , A61F2007/0075
摘要： A multi-purpose device mechanism for sensing and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and/or the stimulation means to initiate or terminate the cooling therapy and/or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose device mechanism. A modified embodiment includes a least one spiral conduit and at least one return conduit for cycling coolant or refrigerant to and from the shaft portion and an external reservoir. Another modified embodiment includes pressurizing means for extending at least one extendable tube into brain tissue surrounding the shaft portion.
摘要翻译：用于感测和控制脑状态变化的多用途装置机构包括轴部分和被构造用于插入到受试者患者的脑的目标组织中的可延伸元件，构造成可操作地将冷却治疗应用于靶组织的刺激具有至少一个构造成可以对目标组织施加电刺激治疗的电触点的感测装置，感测装置，包括至少一个传感器，其监测对象患者的生物信号，响应于感测装置的控制装置，其中控制装置被构造成，响应于来自感测装置的指示预先确定的生理状况的存在或不期望的状态变化的发生的信号，自动使冷却装置和/或刺激装置启动或终止冷却治疗和/或电气刺激疗法和为能量供电的能量源的多用途设备机构的组件。改进的实施例包括至少一个螺旋导管和至少一个用于将冷却剂或制冷剂循环到轴部分和从轴部分循环的至少一个回流管道和外部储存器。另一个改进的实施例包括用于将至少一个可延伸管延伸到围绕轴部分的脑组织中的加压装置。

3. 发明授权

US07079977B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07079977B2
公开(公告)日：2006-07-18
申请号：US10687566
申请日：2003-10-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G04F1/00 , A61B5/00 , A61B1/36
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

4. 发明授权

US06934580B1 Stimulation methodologies and apparatus for control of brain states 有权
标题翻译：刺激方法和控制脑状态的装置
公开(公告)号：US06934580B1
公开(公告)日：2005-08-23
申请号：US10622239
申请日：2003-07-18
申请人： Ivan Osorio , Naresh C. Bhavaraju
发明人： Ivan Osorio , Naresh C. Bhavaraju
IPC分类号： A61B5/0484 , A61N1/36 , A61B5/04
CPC分类号： A61B5/0484 , A61B5/4094 , A61N1/36 , A61N1/36064 , A61N1/36067
摘要： A system of accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional stimulation thereof; second accessing means having a plurality of contact surfaces to operatively connect the control means to the brain of the subject to provide access thereto for the purposes of obtaining three-dimensional recordings of the brain electrical activity of the subject; and a waveform bank containing a plurality of stimulating waveforms. The control means is configured to operative apply a first at least one of the stimulating waveforms of the waveform bank to the brain of the subject through the first accessing means and to assess acceptability within defined limits, as determined by preset criteria, of the subject's response to the application of the at first least one of the stimulating waveforms.
摘要翻译：访问受试者脑部以记录和/或刺激其脑神经的系统。该系统包括控制装置，第一存取装置具有多个接触表面，其被配置为将控制装置可操作地连接到受试者的脑部以提供其三维刺激; 第二存取装置具有多个接触表面，以将控制装置可操作地连接到受试者的大脑以提供对其的访问，以获得对象的脑电活动的三维记录; 以及包含多个刺激波形的波形组。控制装置被配置为通过第一访问装置将波形组的刺激波形中的第一至少一个刺激波形应用于受试者的大脑，并且根据预设的标准来确定受试者的反应所确定的限定范围内的可接受性涉及至少一个刺激波形的应用。

5. 发明授权

US08579786B2 Screening techniques for management of a nervous system disorder 有权
标题翻译：用于管理神经系统疾病的筛查技术
公开(公告)号：US08579786B2
公开(公告)日：2013-11-12
申请号：US10687344
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
IPC分类号： A61N2/00
CPC分类号： A61N1/08 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/37217
摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.
摘要翻译：装置和方法支持用于医疗装置的神经事件筛查。医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。用户可以修改配置和治疗参数，以达到功效和验收。根据患者的接受程度，治疗以开环模式或闭环模式应用。医疗设备根据标准确定治疗是否成功。

6. 发明申请

US20110087316A1 Implantable Interface for a Medical Device System 审中-公开
标题翻译：医疗设备系统的植入式界面
公开(公告)号：US20110087316A1
公开(公告)日：2011-04-14
申请号：US12973306
申请日：2010-12-20
申请人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61M5/14276 , A61M5/16827 , A61M5/16881 , A61M2205/054 , A61M2205/3507 , A61M2210/0693 , A61N1/36082
摘要： An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.
摘要翻译：一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗，多余的治疗元素，而不需要额外的主要外科手术。

7. 发明授权

US07624293B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07624293B2
公开(公告)日：2009-11-24
申请号：US11355489
申请日：2006-02-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G06F1/12 , G06F1/14 , G06F1/04
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

8. 发明授权

US07551951B1 Unitized electrode with three-dimensional multi-site, multi-modal capabilities for detection and control of brain state changes 有权
标题翻译：单位电极具有三维多位点，多模态功能，用于检测和控制脑状态变化
公开(公告)号：US07551951B1
公开(公告)日：2009-06-23
申请号：US11360656
申请日：2006-02-23
申请人： Ivan Osorio , Naresh C. Bhavaraju
发明人： Ivan Osorio , Naresh C. Bhavaraju
IPC分类号： A61B5/042
CPC分类号： A61N1/0531 , A61B5/0478 , A61N1/0539 , A61N1/36017
摘要： An electrode with three-dimensional capabilities for detection and control of brain state changes of a subject. The electrode includes a disk portion having an upper surface and a lower surface, and a shaft portion secured to and extending perpendicularly outwardly from the lower surface of the disk portion; the shaft portion having an outer surface. The disk portion and shaft portion may include one or more recording or stimulating contact surfaces structured to operatively interact with the brain of a subject. Insulating material isolates each of the recording or stimulating contact surfaces from each other. At least one conductor operatively and separately connect each of the recording or stimulating contact surfaces in communication with external apparatus. The disk portion and shaft portion are structured relative to each other to operatively provide support and anchoring for each other while providing three-dimensional capabilities for detection and control of brain state changes of a subject. Modified embodiments include insertible/retractable electrode wires, both contained in channels and sheathed in axially displaceable cannulae; activating mechanisms for inserting/retracting the electrode wires and/or cannulae; and multiple shaft portions.
摘要翻译：具有检测和控制受试者脑状态变化的三维能力的电极。电极包括具有上表面和下表面的盘部分，以及从盘部分的下表面固定并垂直向外延伸的轴部分; 该轴部具有外表面。盘部分和轴部分可以包括一个或多个记录或刺激接触表面，其被构造成可操作地与受试者的脑部相互作用。绝缘材料隔离每个记录或刺激接触表面。至少一个导体可操作地且分开地连接与外部设备通信的每个记录或刺激接触表面。盘部分和轴部分相对于彼此构造以可操作地提供彼此的支撑和锚定，同时提供用于检测和控制对象的脑状态变化的三维能力。改进的实施例包括可插入/可缩回的电极线，两者都包含在通道中并且在轴向可移位插管中护套; 用于插入/缩回电极线和/或插管的启动机构; 和多个轴部。

9. 发明授权

US07282030B2 Timed delay for redelivery of treatment therapy for a medical device system 有权
标题翻译：为医疗器械系统重新交付治疗疗法的定时延迟
公开(公告)号：US07282030B2
公开(公告)日：2007-10-16
申请号：US10687567
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
发明人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method support a repetitive administration of a therapeutic treatment through a delivery unit during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

10. 发明授权

US07006859B1 Unitized electrode with three-dimensional multi-site, multi-modal capabilities for detection and control of brain state changes 有权
公开(公告)号：US07006859B1
公开(公告)日：2006-02-28
申请号：US10622238
申请日：2003-07-18
申请人： Ivan Osorio , Naresh C. Bhavaraju
发明人： Ivan Osorio , Naresh C. Bhavaraju
IPC分类号： A61B5/042 , A61N1/05
CPC分类号： A61N1/0531 , A61B5/0478 , A61N1/0539 , A61N1/36017
摘要： An electrode with three-dimensional capabilities for detection and control of brain state changes of a subject. The electrode includes a disk portion having an upper surface and a lower surface, and a shaft portion secured to and extending perpendicularly outwardly from the lower surface of the disk portion; the shaft portion having an outer surface. The disk portion and shaft portion may include one or more recording or stimulating contact surfaces structured to operatively interact with the brain of a subject. Insulating material isolates each of the recording or stimulating contact surfaces from each other. At least one conductor operatively and separately connect each of the recording or stimulating contact surfaces in communication with external apparatus. The disk portion and shaft portion are structured relative to each other to operatively provide support and anchoring for each other while providing three-dimensional capabilities for detection and control of brain state changes of a subject. Modified embodiments include insertible/retractable electrode wires, both contained in channels and sheathed in axially displaceable cannulae; activating mechanisms for inserting/retracting the electrode wires and/or cannulae; and multiple shaft portions.

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